CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells

Cellular Immunology

Volumn 272, Issue 2, 2012, Pages 230-241

  Kumar, Romsha ^a   Tripathi, Vishwas ^a   Ahmad, Mubashir ^a   Nath, Neera ^a   Mir, Riyaz Ahmad ^a   Chauhan, Shyam S ^a   Luthra, Kalpana ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Chemokine receptor; CXCL12; CXCR4; CXCR7; Jurkat T cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CELL SURVIVAL; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CXCL12; CHEMOTAXIS; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; JURKAT CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 83955163771     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.09.015     Document Type: Article

References (54)

1. Mackay C.R. Chemokines: immunology's high impact factors. Nat. Immunol. 2001, 2:95-101.
2. Rotondi M., Chiovato L., Romagnani S., Serio M., Romagnani P. Role of chemokines in endocrine autoimmune diseases. Endocr. Rev. 2007, 28:492-520.
3. Raman D., Sobolik-Delmaire T., Richmond A. Chemokines in health and disease. Exp Cell Res. 2011, 317(5):575-589.
4. Speyer C.L., Ward P.A. Role of endothelial chemokines and their receptors during inflammation. J. Invest. Surg. 2011, 24(1):18-27.
5. Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C.C., Yoshie O., Matsushima K., Yoshida N., Springer T.A., Kishimoto T. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl. Acad. Sci. USA 1996, 93:14726-14729.
6. Aiuti A., Webb I.J., Bleul C., Springer T., Gutierrez-Ramos J.C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J. Exp. Med. 1997, 185:111-120.
7. Bleul C.C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., Springer T.A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996, 382:829-833.
8. Infantino S., Moepps B., Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J. Immunol. 2006, 176:2197-2207.
9. Mazzinghi B., Ronconi E., Lazzeri E., Sagrinati C., Ballerini L., Angelotti M.L., Parente E., Mancina R., Netti G.S., Becherucci F., Gacci M., Carini M., Gesualdo L., Rotondi M., Maggi E., Lasagni L., Serio M., Romagnani S., Romagnani P. Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J. Exp. Med. 2008, 205:479-490.
10. Miao Z., Luker K.E., Summers B.C., Berahovich R., Bhojani M.S., Rehemtulla A., Kleer C.G., Essner J.J., Nasevicius A., Luker G.D., Howard M.C., Schall T.J. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc. Natl. Acad. Sci. USA 2007, 104:15735-15740.
11. Schonemeier B., Kolodziej A., Schulz S., Jacobs S., Hoellt V., Stumm R. Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J. Comp. Neurol. 2008, 510:207-220.
12. Burns J.M., Summers B.C., Wang Y., Melikian A., Berahovich R., Miao Z., Penfold M.E., Sunshine M.J., Littman D.R., Kuo C.J., Wei K., McMaster B.E., Wright K., Howard M.C., Schall T.J. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J. Exp. Med. 2006, 203:2201-2213.
13. Sierro F., Biben C., Martinez-Munoz L., Mellado M., Ransohoff R.M., Li M., Woehl B., Leung H., Groom J., Batten M., Harvey R.P., Martinez A.C., Mackay C.R., Mackay F. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc. Natl. Acad. Sci. USA 2007, 104:14759-14764.
14. Balabanian K., Lagane B., Infantino S., Chow K.Y., Harriague J., Moepps B., Arenzana-Seisdedos F., Thelen M., Bachelerie F. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 2005, 280:35760-35766.
15. Jones S.W., Brockbank S.M., Mobbs M.L., Le Good N.J., Soma-Haddrick S., Heuze A.J., Langham C.J., Timms D., Newham P., Needham M.R. The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Osteoarthritis Cartilage 2006, 14:597-608.
16. Tripathi V., Verma R., Dinda A., Malhotra N., Kaur J., Luthra K. Differential expression of RDC1/CXCR7 in the human placenta. J. Clin. Immunol. 2009, 29:379-386.
17. Vlahakis S.R., Villasis-Keever A., Gomez T., Vanegas M., Vlahakis N., Paya C.V. G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways. J. Immunol. 2002, 169:5546-5554.
18. Ganju R.K., Brubaker S.A., Meyer J., Dutt P., Yang Y., Qin S., Newman W., Groopman J.E. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J. Biol. Chem. 1998, 273:23169-23175.
19. Bleul C.C., Wu L., Hoxie J.A., Springer T.A., Mackay C.R. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 1997, 94:1925-1930.
20. Hesselgesser J., Liang M., Hoxie J., Greenberg M., Brass L.F., Orsini M.J., Taub D., Horuk R. Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. J. Immunol. 1998, 160:877-883.
21. Shimizu N., Soda Y., Kanbe K., Liu H.Y., Mukai R., Kitamura T., Hoshino H. A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. J. Virol. 2000, 74:619-626.
22. Boldajipour B., Mahabaleshwar H., Kardash E., Reichman-Fried M., Blaser H., Minina S., Wilson D., Xu Q., Raz E. Control of chemokine-guided cell migration by ligand sequestration. Cell 2008, 132:463-473.
23. Hartmann T.N., Grabovsky V., Pasvolsky R., Shulman Z., Buss E.C., Spiegel A., Nagler A., Lapidot T., Thelen M., Alon R. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol. 2008, 84:1130-1140.
24. Cubedo N., Cerdan E., Sapede D., Rossel M. CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons. Mol. Cell. Neurosci. 2009, 40:474-484.
25. Levoye A., Balabanian K., Baleux F., Bachelerie F., Lagane B. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 2009, 113:6085-6093.
26. Yoshida D., Nomura R., Teramoto A. Signaling pathway mediated by CXCR7, an alternative chemokine receptor for stromal-cell derived factor-1alpha, in AtT20 mouse ACTH-secreting pituitary adenoma cells. J. Neuroendocrinol. 2009.
27. Castellone M.D., Guarino V., De Falco V., Carlomagno F., Basolo F., Faviana P., Kruhoffer M., Orntoft T., Russell J.P., Rothstein J.L., Fusco A., Santoro M., Melillo R.M. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene 2004, 23:5958-5967.
28. Ao M., Franco O.E., Park D., Raman D., Williams K., Hayward S.W. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res. 2007, 67:4244-4253.
29. Ottaiano A., di Palma A., Napolitano M., Pisano C., Pignata S., Tatangelo F., Botti G., Acquaviva A.M., Castello G., Ascierto P.A., Iaffaioli R.V., Scala S. Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells. Cancer Immunol. Immunother. 2005, 54:781-791.
30. Taichman R.S., Cooper C., Keller E.T., Pienta K.J., Taichman N.S., McCauley L.K. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 2002, 62:1832-1837.
31. Weisel K.C., Bautz F., Seitz G., Yildirim S., Kanz L., Mohle R. Modulation of CXC chemokine receptor expression and function in human neutrophils during aging in vitro suggests a role in their clearance from circulation. Mediators Inflamm. 2009, 2009:790174.
32. Zheng J., Ghorpade A., Niemann D., Cotter R.L., Thylin M.R., Epstein L., Swartz J.M., Shepard R.B., Liu X., Nukuna A., Gendelman H.E. Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J. Virol. 1999, 73:8256-8267.
33. Anderson J., Banerjea A., Akkina R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides 2003, 13:303-312.
34. Majka M., Ratajczak J., Kowalska M.A., Ratajczak M.Z. Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur. J. Haematol. 2000, 64:164-172.
35. Bach T.L., Chen Q.M., Kerr W.T., Wang Y., Lian L., Choi J.K., Wu D., Kazanietz M.G., Koretzky G.A., Zigmond S., Abrams C.S. Phospholipase cbeta is critical for T cell chemotaxis. J. Immunol. 2007, 179:2223-2227.
36. Means T.K., Pavlovich R.P., Roca D., Vermeulen M.W., Fenton M.J. Activation of TNF-alpha transcription utilizes distinct MAP kinase pathways in different macrophage populations. J. Leukoc. Biol. 2000, 67:885-893.
37. Cross M.J., Stewart A., Hodgkin M.N., Kerr D.J., Wakelam M.J. Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 1995, 270:25352-25355.
38. Powell D.J., Hajduch E., Kular G., Hundal H.S. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol. Cell. Biol. 2003, 23:7794-7808.
39. Joshi S.A., Fan K.P., Ho V.W., Wong Y.H. Chimeric Galpha(q) mutants harboring the last five carboxy-terminal residues of Galpha(i2) or Galpha(o) are resistant to pertussis toxin-catalyzed ADP-ribosylation. FEBS Lett. 1998, 441:67-70.
40. Strizki J.M., Turner J.D., Collman R.G., Hoxie J., Gonzalez-Scarano F. A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB). J. Virol. 1997, 71:5678-5683.
41. Hesselgesser J., Taub D., Baskar P., Greenberg M., Hoxie J., Kolson D.L., Horuk R. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr. Biol. 1998, 8:595-598.
42. Nagata Y., Todokoro K. Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Blood 1999, 94:853-863.
43. Berra E., Diaz-Meco M.T., Moscat J. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J. Biol. Chem. 1998, 273:10792-10797.
44. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331.
45. Goswami R., Kilkus J., Dawson S.A., Dawson G. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. J. Neurosci. Res. 1999, 57:884-893.
46. Costoya J.A., Finidori J., Moutoussamy S., Searis R., Devesa J., Arce V.M. Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway. Endocrinology 1999, 140:5937-5943.
47. Chalecka-Franaszek E., Chuang D.M. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. USA 1999, 96:8745-8750.
48. Francois F., Grimes M.L. Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis. J. Neurochem. 1999, 73:1773-1776.
49. Shimoke K., Yamagishi S., Yamada M., Ikeuchi T., Hatanaka H. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res. Dev. Brain Res. 1999, 112:245-253.
50. Wang J., Shiozawa Y., Wang Y., Jung Y., Pienta K.J., Mehra R., Loberg R., Taichman R.S. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J. Biol. Chem. 2008, 283:4283-4294.
51. Goldmann T., Dromann D., Radtke J., Marwitz S., Lang D.S., Schultz H., Vollmer E. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy. Virchows Arch. 2008, 452:347-348.
52. Schutyser E., Su Y., Yu Y., Gouwy M., Zaja-Milatovic S., Van Damme J., Richmond A. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells. Eur. Cytokine Netw. 2007, 18:59-70.
53. Comerford I., Litchfield W., Harata-Lee Y., Nibbs R.J., McColl S.R. Regulation of chemotactic networks by 'atypical' receptors. BioEssays 2007, 29:237-247.
54. Thelen M., Thelen S. CXCR7, CXCR4 and CXCL12: an eccentric trio?. J. Neuroimmunol. 2008, 198:9-13.