Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function

Journal of Virology

Volumn 76, Issue 2, 2002, Pages 697-706

  Garvey, T L ^a   Bertin, J ^a   Siegel, R M ^a   Wang, G H ^a   Lenardo, M J ^a   Cohen, J I ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CASPASE 8; FAS ANTIBODY; FAS ASSOCIATED DEATH DOMAIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; APOPTOSIS; ARTICLE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLLUSCIPOXVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CELL LINE; CONSERVED SEQUENCE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HELA CELLS; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MOLLUSCUM CONTAGIOSUM VIRUS; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS;

EID: 0036139833     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.2.697-706.2002     Document Type: Article

References (30)

1. Death receptors: Signaling and modulation
2. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
3. TRAIL receptor-2 signals apoptosis through FADD and caspase-8
4. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
5. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
6. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
7. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
8. Gene splicing by overlap extension: Tailor-made genes using the polymerase chain reaction
9. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
10. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
11. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis
12. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
13. The TNF and TNF receptor superfamilies: Integrating mammalian biology
14. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
15. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
16. FLICE, a novel FADD-homologous ICE/CED-3-1ike protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
17. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
18. E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE
19. The death receptors
20. Genome sequence of a human tumorigenic poxvirus: Prediction of specific host response-evasion genes
21. Molluscum contagiosum virus of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein
22. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
23. Death-effector filaments: Novel cytoplasmic structures that recruit caspases and trigger apoptosis
24. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
25. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
26. Requirement of cooperative functions of two repeated death effector domains in caspase-8 and in MC159 for induction and inhibition of apoptosis, respectively
27. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
28. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
29. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
30. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1