Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion

Journal of Biological Chemistry

Volumn 288, Issue 32, 2013, Pages 23128-23140

  Jensen, Mette V ^a,b   Haldeman, Jonathan M ^a,b   Zhang, Hengtao ^a,b   Lu, Danhong ^a   Huising, Mark O ^c,d   Vale, Wylie W ^c   Hohmeier, Hans E ^a,b   Rosenberg, Paul ^a,b   Newgard, Christopher B ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DYSFUNCTION; CHANNEL ACTIVITY; GLUCOSE-STIMULATED INSULIN SECRETIONS; IN-CONTROL; ISLET CELLS; NEGATIVE REGULATORS; TYPE-2 DIABETES; VOLTAGE-GATED POTASSIUM CHANNELS;

GLUCOSE; PHYSIOLOGY; POTASSIUM;

INSULIN;

GLUCOSE; INSULIN; ISOCITRIC ACID; MESSENGER RNA; OLEIC ACID; PALMITIC ACID; POTASSIUM CHANNEL KV2.1; POTASSIUM CHANNEL KV2.2; PYRUVIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE; GENE OVEREXPRESSION; GENE SILENCING; HORMONAL REGULATION; INSULIN RELEASE; INSULINOMA; KV2.1 GENE; KV2.2 GENE; LIPOTOXICITY; LONG TERM EXPOSURE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM;

DIABETES; GLUCOSE METABOLISM; INSULIN SECRETION; ION CHANNELS; PANCREATIC ISLETS;

ANIMALS; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ION CHANNEL GATING; ION TRANSPORT; ISOCITRATE DEHYDROGENASE; ISOCITRATES; MALE; MODELS, BIOLOGICAL; PEPTIDES; POTASSIUM; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SHAB POTASSIUM CHANNELS; SPIDER VENOMS;

EID: 84881392465     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.491654     Document Type: Article

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