The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function

Diabetologia

Volumn 55, Issue 6, 2012, Pages 1709-1720

  Dai, X Q ^a   Manning Fox, J E ^a   Chikvashvili, D ^b   Casimir, M ^a   Plummer, G ^a   Hajmrle, C ^a   Spigelman, A F ^a   Kin, T ^c   Singer Lahat, D ^b   Kang, Y ^d   Shapiro, A M J ^c   Gaisano, H Y ^d   Lotan, I ^b   MacDonald, P E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Exocytosis; Human; Insulin; Ion channel; Islets of langerhans; Kv2.1; SNARE

Indexed keywords

CALCIUM ION; GLUCOSE; INSULIN; POTASSIUM CHANNEL; SNARE PROTEIN; SYNTAXIN 1A; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT POTASSIUM CHANNEL SUBUNIT KV2.1; SHAB POTASSIUM CHANNEL; SYNTAXIN 1;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXOCYTOSIS; FLUORESCENCE ANALYSIS; HORMONAL REGULATION; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UPREGULATION; WHOLE CELL; WILD TYPE; ANIMAL; CELL CULTURE; GENETICS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; PANCREAS ISLET; RAT; SECRETION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; ELECTROPHYSIOLOGY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN; ISLETS OF LANGERHANS; MICE; PROTEIN BINDING; RATS; SHAB POTASSIUM CHANNELS; SYNTAXIN 1;

EID: 84865425929     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2512-6     Document Type: Article

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