Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5145-5153

  Salerno, Loredana ^a   Pittalà, Valeria ^a   Romeo, Giuseppe ^a   Modica, Maria N ^a   Siracusa, Maria A ^a   Di Giacomo, Claudia ^a   Acquaviva, Rosaria ^a   Barbagallo, Ignazio ^a   Tibullo, Daniele ^a   Sorrenti, Valeria ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

1,2,4 Triazole; Antitumor properties; HO 1inhibitors; Imatinib; Imidazole

Indexed keywords

1 (3 PHENOXYPROPYL) 1H 1,2,4 TRIAZOLE; 1 (3 PHENOXYPROPYL) 1H IMIDAZOLE; 1 (4 PHENOXYBUTYL) 1H 1,2,4 TRIAZOLE; 1 (4 PHENOXYBUTYL) 1H IMIDAZOLE; 1 [3 (3 BROMOPHENOXY)BUTYL] 1H 1,2,4 TRIAZOLE; 1 [3 (3 BROMOPHENOXY)BUTYL] 1H IMIDAZOLE; 1 [3 (4 IODOPHENOXY)PROPYL] 1H 1,2,4 TRIAZOLE; 1 [3 (4 IODOPHENOXY)PROPYL] 1H IMIDAZOLE; 1 [3 (4 NITROPHENOXY)PROPYL] 1H 1,2,4 TRIAZOLE; 1 [3 (4 NITROPHENOXY)PROPYL] 1H IMIDAZOLE; 1 [4 (3 BROMOPHENOXY)BUTYL] 1H 1,2,4 TRIAZOLE; 1 [4 (4 IODOPHENOXY)PROPYL] 1H 1,2,4 TRIAZOLE; 1 [4 (4 IODOPHENOXY)PROPYL] 1H IMIDAZOLE; 1 [4 (4 NITROPHENOXY)BUTYL] 1H 1,2,4 TRIAZOLE; 1 [4 (4 NITROPHENOXY)BUTYL] 1H IMIDAZOLE; 1,2,4 TRIAZOLE DERIVATIVE; HEME OXYGENASE 1; HEME OXYGENASE 2; HEME OXYGENASE INHIBITOR; IMATINIB; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CANCER CELL CULTURE; CELL CYCLE; CELL STRAIN LAMA 84 R; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG DESIGN; DRUG RESISTANCE; DRUG SENSITIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN;

1,2,4-TRIAZOLE; ANTITUMOR PROPERTIES; HO-1INHIBITORS; IMATINIB; IMIDAZOLE;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; CELL CYCLE CHECKPOINTS; CELL LINE; CELL SURVIVAL; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IMIDAZOLES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPLEEN; TRIAZOLES;

EID: 84881378183     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.040     Document Type: Article

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