A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer

Cancer Research

Volumn 69, Issue 20, 2009, Pages 8017-8024

  Alaoui Jamali, Moulay A ^a   Bismar, Tarek A ^b   Gupta, Ajay ^c   Szarek, Walter A ^d   Jie, Su ^a   Wei, Song ^a   Yingjie, Xu ^a   Bin, Xu ^a   Guoan, Liu ^a   Vlahakis, Jason Z ^d   Roman, Gheorghe ^d   Jiao, Jinsong ^a   Schipper, Hyman M ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c Osta Biotechnologies Inc   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; HORMONE; MITOGEN ACTIVATED PROTEIN KINASE P38; OB 24; PACLITAXEL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BENIGN TUMOR; CANCER CELL; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; DRUG SELECTIVITY; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; LYMPH NODE; MALE; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTEIN CARBONYLATION; REDUCTION; STROMA CELL; TISSUE MICROARRAY; TUMOR GROWTH; TUMOR LOCALIZATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE THERAPY; HEME OXYGENASE-1; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NEOPLASMS, HORMONE-DEPENDENT; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; TUMOR CELLS, CULTURED;

EID: 70350221874     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0419     Document Type: Article

References (48)

1. Jozkowicz A, Was H, Dulak J. Heme oxygenase-1 in tumors: is it a false friend? Antioxid Redox Signal 2007;9:2099-2117
2. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006;86:583-650.
3. Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-869 (Pubitemid 32267078)
4. Leslie NR. The redox regulation of PI 3-kinase-dependent signaling. Antioxid Redox Signal 2006;8:1765-1774
5. Baranano DE, Snyder SH. Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc Natl Acad Sci U S A 2001;98:10996-11002 (Pubitemid 32928673)
6. Durante W. Heme oxygenase-1 in growth control and its clinical application to vascular disease. J Cell Physiol 2003;195:373-382 (Pubitemid 36529865)
7. Duckers HJ, Boehm M, True AL, et al. Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med 2001;7:693-698 (Pubitemid 32588025)
8. Abraham NG, Lavrovsky Y, Schwartzman ML, et al. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A 1995;92:6798-6802
9. Loboda A, Jazwa A, Grochot-Przeczek A, et al. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2008;10:1767-1812
10. Torisu-Itakura H, Furue M, Kuwano M, Ono M. Coexpression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res 2000;91:906-910 (Pubitemid 30774565)
11. Goodman AI, ChoudhuryM, da Silva JL, Schwartzman ML, Abraham NG. Overexpression of the heme oxygenase gene in renal cell carcinoma. Proc Soc Exp Biol Med 1997;214:54-61. (Pubitemid 27051921)
12. Maines MD, Abrahamsson PA. Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology 1996;47:727-733
13. Kikuchi A, Yamaya M, Suzuki S, et al. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum Genet 2005;116:354-360 (Pubitemid 40521111)
14. Roman G, Riley JG, Vlahakis JZ, et al. Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem 2007;15:3225-3234 (Pubitemid 46484332)
15. Thalmann GN, Sikes RA, Wu TT, et al. LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate 2000;44:91-103. (Pubitemid 30419183)
16. Pettaway CA, Pathak S, Greene G, et al. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res 1996;2:1627-1636 (Pubitemid 126447459)
17. Zhang X, Shan P, Jiang D, et al. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion- induced lung apoptosis. J Biol Chem 2004;279:10677-10684 (Pubitemid 38372680)
18. Benlimame N, He Q, Jie S, et al. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. J Cell Biol 2005;171:505-516 (Pubitemid 41586939)
19. Ryter SW, Kvam E, Tyrrell RM. Heme oxygenase activity. Current methods and applications. Methods Mol Biol 2000;99:369-391
20. Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999;27:612-616 (Pubitemid 29408648)
21. Winterbourn CC, Buss IH. Protein carbonyl measurement by enzyme-linked immunosorbent assay. Methods Enzymol 1999;300:106-111
22. Tonra JR, Prewett M, Corcoran E, Hicklin DJ, Zhu Z. In vivo method for establishing synergy between antibodies to epidermal growth factor receptor and vascular endothelial growth factor receptor-2. Methods Mol Biol 2009;525:545-557
23. Darnel AD, Behmoaram E, Vollmer RT, et al. Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer. Clin Cancer Res 2009;15:1376-1383
24. Nowsheen S, Wukovich RL, Aziz K, et al. Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues. Mutat Res 2009;674:131-136
25. Cooke MS, Osborne JE, Singh R, et al. Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients. Free Radic Biol Med 2007;43:1328-1334 (Pubitemid 47432900)
26. Radisky DC, Levy DD, Littlepage LE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005;436:123-127
27. Yossepowitch O, Pinchuk I, Gur U, et al. Advanced but not localized prostate cancer is associated with increased oxidative stress. J Urol 2007;178:1238-1243 (Pubitemid 47368405)
28. Sacca P, Meiss R, Casas G, et al. Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer. Br J Cancer 2007;97:1683-1689 (Pubitemid 350249355)
29. Chaiswing L, Zhong W, Cullen JJ, Oberley LW, Oberley TD. Extracellular redox state regulates features associated with prostate cancer cell invasion. Cancer Res 2008;68:5820-5826
30. Bostwick DG, Alexander EE, Singh R, et al. Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer. Cancer 2000;89:123-134 (Pubitemid 30451282)
31. Schipper HM. Brain iron deposition and the free radical-mitochondrial theory of ageing. Ageing Res Rev 2004;3:265-301.
32. Schipper HM. Heme oxygenase expression in human central nervous system disorders. Free Radic Biol Med 2004;37:1995-2011. (Pubitemid 39491319)
33. Ryter SW, Tyrrell RM. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med 2000;28:289-309.
34. Keum YS, Yu S, Chang PP, et al. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase- 1 in human hepatoma HepG2 cells. Cancer Res 2006;66:8804-8813 (Pubitemid 44449198)
35. Ryter SW, Xi S, Hartsfield CL, Choi AM. Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells. Antioxid Redox Signal 2002;4:587-592 (Pubitemid 35001442)
36. Zhang X, Bedard EL, Potter R, et al. Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am J Physiol Lung Cell Mol Physiol 2002;283:L815-29. (Pubitemid 35052677)
37. Smith SD, Jaffer ZM, Chernoff J, Ridley AJ. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci 2008;121:3729-3736
38. Sieg DJ, Hauck CR, Ilic D, et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2000;2:249-256 (Pubitemid 30781108)
39. Alexandre J, Hu Y, Lu W, Pelicano H, Huang P. Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Res 2007;67:3512-3517 (Pubitemid 46762129)
40. Nogales E, Whittaker M, Milligan RA, Downing KH. High-resolution model of the microtubule. Cell 1999;96:79-88.
41. Wilson L, Panda D, Jordan MA. Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators. Cell Struct Funct 1999;24:329-335
42. Zimmer SM, Liu J, Clayton JL, Stephens DS, Snyder JP. Paclitaxel binding to human and murine MD-2. J Biol Chem 2008;283:27916-27926
43. Islam MN, Song Y, Iskander MN. Investigation of structural requirements of anticancer activity at the paclitaxel/tubulin binding site using CoMFA and CoMSIA. J Mol Graph Model 2003;21:263-272 (Pubitemid 35441324)
44. Prudova A, Albin M, Bauman Z, et al. Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells. Antioxid Redox Signal 2007;9:1875-1881 (Pubitemid 47622347)
45. Tian J, Zheng Y, Yang C. Effect of sex hormones on heme oxygenase expression in rat ventral prostate. Sheng Li Xue Bao 2004;56:54-59
46. Garmey EG, Sartor O, Halabi S, Vogelzang NJ. Second-line chemotherapy for advanced hormonerefractory prostate cancer. Clin Adv Hematol Oncol 2008;6:118-22, 127-132
47. Harris WP, Mostaghel EA, Nelson PS, Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 2009;6:76-85.
48. Van Allen EM, Ryan CJ. Novel secondary hormonal therapy in advanced prostate cancer: an update. Curr Opin Urol 2009;19:315-321