Effect of light exposure on metalloporphyrin-treated newborn mice

Pediatric Research

Volumn 72, Issue 2, 2012, Pages 161-168

  Schulz, Stephanie ^a   Wong, Ronald J ^a   Kalish, Flora S ^a   Zhao, Hui ^a   Jang, Kyu Yun ^b   Vreman, Hendrik J ^a   Stevenson, David K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Chonbuk National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CHROMIUM MESOPORPHYRIN; METALLOPORPHYRIN; UNCLASSIFIED DRUG; ZINC DEUTEROPORPHYRIN BIS GLYCOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATAXIA; BODY TEMPERATURE DISORDER; CONTROLLED STUDY; CYANOSIS; DRUG SAFETY; HISTOPATHOLOGY; HYPERBILIRUBINEMIA; KYPHOSIS; LETHALITY; LETHARGY; LIGHT EXPOSURE; LIVER INJURY; LOCAL SKIN REACTION; MORTALITY; MOUSE; NEWBORN; NONHUMAN; PAIN; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; SURVIVAL; WEIGHT REDUCTION;

ANIMALS; ANIMALS, NEWBORN; BILIRUBIN; DEUTEROPORPHYRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE (DECYCLIZING); HYPERBILIRUBINEMIA, NEONATAL; LETHAL DOSE 50; LIGHT; MESOPORPHYRINS; MICE; PHOTOSENSITIZING AGENTS; SURVIVAL ANALYSIS;

EID: 84864368089     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.62     Document Type: Article

References (39)

1. American Academy of Pediatrics. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297-316.
2. Morris BH, Oh W, Tyson JE, et al. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med 2008;359:1885-96.
3. Hintz SR, Stevenson DK, Yao Q, et al. Is phototherapy exposure associated with better or worse outcomes in 501-to 1000-g-birth-weight infants? Acta Paediatr 2011;100:960-5.
4. Kurt A, Aygun AD, Kurt AN, Godekmerdan A, Akarsu S, Yilmaz E. Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets. Neonatology 2009;95:262-6.
5. Drummond GS, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci USA 1981;78:6466-70. (Pubitemid 12179733)
6. Maines MD. Zinc. protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Biochim Biophys Acta 1981;673:339-50.
7. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968;61:748-55.
8. Balla G, Jacob HS, Balla J, et al. Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem 1992;267:18148-53.
9. Tenhunen R, Ross ME, Marver HS, Schmid R. Reduced nicotinamideadenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization. Biochemistry 1970;9:298-303.
10. Appleton SD, Chretien ML, McLaughlin BE, et al. Selective inhibition of heme oxygenase, without inhibition of nitric oxide synthase or soluble guanylyl cyclase, by metalloporphyrins at low concentrations. Drug Metab Dispos 1999;27:1214-9. (Pubitemid 29463610)
11. Luo D, Vincent SR. Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo. Eur J Pharmacol 1994;267:263-7.
12. Zhang W, Contag PR, Hardy J, et al. Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-J Mol Med 2002;80:655-64. (Pubitemid 35471730)
13. Fort FL, Gold J. Phototoxicity of tin protoporphyrin, tin mesoporphyrin, and tin diiododeuteroporphyrin under neonatal phototherapy conditions. Pediatrics 1989;84:1031-7. (Pubitemid 20003337)
14. McDonagh AF, Palma LA. Tin-protoporphyrin: a potent photosensitizer of bilirubin destruction. Photochem Photobiol 1985;42:261-4.
15. Vreman HJ, Gillman MJ, Downum KR, Stevenson DK. In vitro generation of carbon monoxide from organic molecules and synthetic metalloporphyrins mediated by light. Dev Pharmacol Ther 1990;15:112-24.
16. Kappas A, Drummond GS, Manola T, Petmezaki S, Valaes T. Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility. Pediatrics 1988;81:485-97.
17. Valaes T, Petmezaki S, Henschke C, Drummond GS, Kappas A. Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics 1994;93:1-11. (Pubitemid 24012121)
18. Hintz SR, Vreman HJ, Stevenson DK. Mortality of metalloporphyrin-treated neonatal rats after light exposure. Dev Pharmacol Ther 1990;14:187-92. (Pubitemid 20161913)
19. Morioka I, Wong RJ, Abate A, Vreman HJ, Contag CH, Stevenson DK. Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice. Pediatr Res 2006;59:667-72. (Pubitemid 43740008)
20. Vreman HJ, Ekstrand BC, Stevenson DK. Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr Res 1993;33:195-200. (Pubitemid 23095754)
21. He CX, Campbell CM, Zhao H, et al. Effects of zinc deuteroporphyrin bis glycol on newborn mice after heme loading. Pediatr Res 2011;70:467-72.
22. Vreman HJ, Wong RJ, Sanesi CA, Dennery PA, Stevenson DK. Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system. Can J Physiol Pharmacol 1998;76:1057-65. (Pubitemid 29254235)
23. Lutton JD, Abraham NG, Drummond GS, Levere RD, Kappas A. Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow. Proc Natl Acad Sci USA 1997;94:1432-6. (Pubitemid 27087868)
24. Wong RJ, Vreman HJ, Schulz S, Kalish FS, Pierce NW, Stevenson DK. In vitro inhibition of heme oxygenase isoenzymes by metalloporphyrins. J Perinatol 2011;31:Suppl 1:S35-41.
25. Scheingraber S, Messner S, Matt S, et al. Metalloporphyrins, used for HO-1 inhibition, themselves affect hepatic microcirculation, liver function, and hepatocellular integrity. Microcirculation 2009;16:355-63.
26. Silva RF, Lopes RA, Sala MA, et al. Action of trivalent chromium on rat liver structure. Histometric and haematological studies. Int J Morphol 2006;24:197-203. (Pubitemid 44155280)
27. Vreman HJ, Lee OK, Stevenson DK. In vitro and in vivo characteristics of a heme oxygenase inhibitor: ZnBG. Am J Med Sci 1991;302:335-41.
28. Scott J, Quirke JM, Vreman HJ, Stevenson DK, Downum KR. Metalloporphyrin phototoxicity. J Photochem Photobiol B, Biol 1990;7:149-57.
29. Vreman HJ, Stevenson DK. Metalloporphyrin-enhanced photodegradation of bilirubin in vitro. Am J Dis Child 1990;144:590-4. (Pubitemid 20153419)
30. Vreman HJ, Cipkala DA, Stevenson DK. Characterization of porphyrin heme oxygenase inhibitors. Can J Physiol Pharmacol 1996;74:278-85. (Pubitemid 26227499)
31. Valenzeno DP. Photomodification of biological membranes with emphasis on singlet oxygen mechanisms. Photochem Photobiol 1987;46: 147-60.
32. Delaney JK, Mauzerall D, Drummond GS, Kappas A. Photophysical properties of Sn-porphyrins: potential clinical implications. Pediatrics 1988;81:498-504.
33. Cernq D, Lekic N, Vaove K, et al. Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system. Fitoterapia 2011;82:786-91.
34. Kain V, Kumar S, Puranik AS, Sitasawad SL. Azelnidipine protects myocardium in hyperglycemia-induced cardiac damage. Cardiovasc Diabetol 2010;9:82.
35. Simionatto CS, Anderson KE, Drummond GS, Kappas A. Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production. J Clin Invest 1985;75:513-21. (Pubitemid 15143491)
36. Fishman WH, Wayne A, Homburger F. The evaluation of diagnostic tests for cancer; inhibition of serum alkaline phosphate by zinc ion; the Roche test. Cancer Res 1949;9:681-3.
37. Dennery PA, Vreman HJ, Rodgers PA, Stevenson DK. Role of lipid peroxidation in metalloporphyrin-mediated phototoxic reactions in neonatal rats. Pediatr Res 1993;33:87-91. (Pubitemid 23094133)
38. Vreman HJ, Wong RJ, Murdock JR, Stevenson DK. Standardized bench method for evaluating the efficacy of phototherapy devices. Acta Paediatr 2008;97:308-16. (Pubitemid 351514160)
39. Vreman HJ, Stevenson DK. Detection of heme oxygenase activity by measurement of CO. Unit 9.2. In: Maines MD, Costa G, Reed DJ, Sassa S, Sipes IG, eds. Current Protocols in Toxicology. New York: Wiley; 1999:9.2. 1-9.30.