Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5064-5075

  Chen, Yi Fong ^a   Lin, Yi Chien ^a   Huang, Po Kai ^a   Chan, Hsu Chin ^b   Kuo, Sheng Chu ^c   Lee, Kuo Hsiung ^c,d   Huang, Li Jiau ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

4 Phenylquinolin 2(1H) one (4 PQ); Anticancer agent; Apoptosis; Podophyllotoxin; Structure activity relationships (SAR)

Indexed keywords

4 (2 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 2 (1H)ONE; 4 (3 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 2 (1H)ONE; 4 (4 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (2 METHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (2,4 DIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (2,4,6 TRIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (2,5 DIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (2,6 DIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (3 METHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (3,4 DIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (3,4,5 TRIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (3,5 DIMETHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 (4 METHOXYPHENYL)QUINOLIN 2 (1H)ONE; 6,7 METHYLENEDIOXY 4 PHENYLQUINOLIN 2 (1H)ONE; ANTINEOPLASTIC AGENT; CASPASE 3; ETOPOSIDE; FLUOROURACIL; PHENYLQUINOLIN 2 (1H)ONE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INTRAMOLECULAR CYCLIZATION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; WESTERN BLOTTING;

4-PHENYLQUINOLIN-2(1H)-ONE (4-PQ); ANTICANCER AGENT; APOPTOSIS; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIPS (SAR);

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; HL-60 CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881374909     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.046     Document Type: Article

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