Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 983-993

  Castro, Ma Ángeles ^a   Miguel Del Corral, José Ma ^a   García, Pablo A ^a   Rojo, Ma Victoria ^a   De La Iglesia Vicente, Janis ^a   Mollinedo, Faustino ^a   Cuevas, Carmen ^b   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b PHARMAMAR S A   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 BROMOPROPYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; 3 BROMOPROPYL PICROPODOPHYLLATE; 3,4,5 TRIMETHOXYBENZYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; 3,4,5 TRIMETHOXYBENZYL 9 DEOXY 9 PROPYLIMINE ALPHA APOPICROPODOPHYLLATE; 3,4,5 TRIMETHOXYBENZYL PICROPODOPHYLLATE; 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLIC ACID PYRROLIDINYL AMIDE; ALLYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; ALLYL PICROPODOPHYLLATE; ANTINEOPLASTIC AGENT; CINNAMYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; CINNAMYL PICROPODOPHYLLATE; ETHOXYCARBONYLMETHYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; ETHOXYCARBONYLMETHYL PICROPODOPHYLLATE; ETHYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; ETHYL 9 DEOXY 9 PROPYLIMINO ALPHA APOPICROPODOPHYLLATE; ETHYL 9 PROPYLAMINO 9 DEOXY ALPHA APOPICROPODOPHYLLATE; ETHYL PICROPODOPHYLLATE; HEPTYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLATE; HEPTYL PICROPODOPHYLLATE; METHYL 9 (4 METHOXYPHENYL)AMINO 9 DEOXY ALPHA APOPICROPODOPHYLLATE; METHYL 9 (4 METHYLPHENYL)AMINO 9 DEOXY ALPHA APOPICROPODOPHYLLATE; METHYL 9 ETHYLAMINO 9 DEOXY ALPHA APOPICROPODOPHYLLATE; METHYL 9 PROPYLAMINO 9 DEOXY ALPHA APOPICROPODOPHYLLATE; N (4 METHOXYPHENYL) 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLAMIDE; N ETHYL 9 DEOXY 9 OXO ALPHA APOPICROPODOPHYLLAMIDE; N ETHYL PICROPODOPHYLLAMIDE; PCROPODOPHYLLIC ACID PYRROLIDINYL AMIDE; PODOPHYLLIC ALDEHYDE DERIVATIVE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE ARREST; CELL DEATH; CELL STRAIN HT29; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; TUMOR CELL LINE;

ALDEHYDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; TUMOR CELLS, CULTURED;

EID: 77249177128     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901373w     Document Type: Article

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