Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs

European Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2011, Pages 6046-6056

  Chen, Chien Ting ^a   Hsu, Mei Hua ^a   Cheng, Yung Yi ^a   Liu, Chin Yu ^a   Chou, Li Chen ^a   Huang, Li Jiau ^a   Wu, Tian Shung ^b,c   Yang, Xiaoming ^d   Lee, Kuo Hsiung ^b,d   Kuo, Sheng Chu ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

Anticancer activity; Melanoma; Quinolin 4 one analogs; Selenophene; Structure activity relationships (SAR)

Indexed keywords

2 (2 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (3 FLUOROPHENYL) 5 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (5 METHYLFURAN 2 YL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (5 METHYLSELENOPHEN 2 YL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (5 METHYLTHIOPHEN 2 YL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (FURAN 2 YL) 6,7 METHYLENEDIOXYQUINOLIN 4 ON; 2 (FURAN 3 YL) 6,7 METHYLENEDIOXYQUINOLIN 4 ON; 5 HYDROXY 2 (5 METHYLSELENOPHEN 2 YL) 6 METHOXYQUINOLIN 4 ONE; 5 HYDROXY 6 METHOXY 2 (SELENOPHEN 3 YL)QUINOLIN 4 ONE; 5,6 DIMETHOXY 2 (5 METHYLSELENOPHEN 2 YL)QUINOLIN 4 ONE; 5,6 DIMETHOXY 2 (SELENOPHEN 2 YL)QUINOLIN 4 ONE; 5,6 DIMETHOXY 2 (SELENOPHEN 3 YL)QUINOLIN 4 ON; 6 DIMETHOXY 2 (SELENOPHEN 2 YL)QUINOLIN 4 ONE; 6 METHOXY 2 (5 METHYLSELENOPHEN 2 YL)QUINOLIN 4 ONE; 6 METHOXY 2 (SELENOPHEN 3 YL)QUINOLIN 4 ONE; 6,7 METHYLENEDIOXY 2 (5 METHYLSELENOPHEN 2YL)QUINOLIN 4 ONE; 6,7 METHYLENEDIOXY 2 (SELENOPHEN 2 YL)QUINOLIN 4 ONE; 6,7 METHYLENEDIOXY 2 (SELENOPHEN 3 YL)QUINOLIN 4 ONE; 6,7 METHYLENEDIOXY 2 (THIOPHEN 2 YL)QUINOLIN 4 ONE; 6,7 METHYLENEDIOXY 2 (THIOPHEN 3 YL)QUINOLIN 4 ONE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; DIDEMNIN B; PACLITAXEL; S TRITYLCYSTEINE; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; ORGANOSELENIUM COMPOUNDS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80955151714     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.017     Document Type: Article

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