Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells

Toxicology

Volumn 175, Issue 1-3, 2002, Pages 123-142

  Tseng, Chia Jen ^a   Wang, Ying Jan ^b   Liang, Yu Chih ^c   Jeng, Jiiang Huei ^d   Lee, Wen Sen ^c   Lin, Jen Kun ^d   Chen, Chien Ho ^a   Liu, I Chun ^a   Ho, Yuan Soon ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bcl 2; Cyclin Bl cdc2; G2 M arrest; Podophyllotoxin

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 7; CYTOCHROME C; PODOPHYLLOTOXIN; PROTEIN; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN WEE 1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G2 PHASE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOLIC FRACTION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CYCLIN B; CYTOCHROME C GROUP; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; G2 PHASE; HL-60 CELLS; HT29 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICROTUBULES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOSIS; NUCLEAR PROTEINS; PODOPHYLLOTOXIN; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0037076856     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00073-2     Document Type: Article

References (65)

1. Etoposide. Current and future status
2. Human ICE/CED-3 protease nomenclature (letter)
3. Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway
4. Raf-l/bcl-2 phosphorylation: A step from microtubule damage to cell death
5. Bcl-x a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
6. Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines
7. Correlation between structure of Bcl-2 and its inhibitory function of JNK and caspase activity in dopaminergic neuronal apoptosis
8. Podophyllotoxins: Current status and recent developments
9. Microtubule inhibitors
10. Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: A link between the apoptosome and the proteasome pathway
11. Caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
12. 2+ ions
13. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
14. Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells
15. Tubulin/microtubules: Still a promising target for new chemotherapeutic agents (editorial; Comment)
16. Bcl2 is the guardian of microtubule integrity
17. Induction of p53 and p21 /WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells
18. Suppression of nitric oxide-induced apoptosis by N-acetyl-L-cysteine through modulation of glutathione, bcl-2 and bax protein levels
19. Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines
20. Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines
21. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells
22. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
23. Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis
24. Weel (+)-like gene in human cells
25. Effects of vinblastine podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis
26. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
27. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
28. Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis
29. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity
30. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
31. Dual cytotoxic mechanisms of submicromolar taxol on human leukemia HL-60 cells
32. CDllc/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen
33. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Racl
34. Brain biopsy in Indiana AIDS patients
35. Mitochondria and apoptosis
36. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol
37. Apoptotic cell death induced by baccatin III, a precursor of paclitaxel, may occur without G(2)/M arrest
38. Induction of apoptosis by cryptophycin 1 a new antimicrotubule agent
39. Clinical studies with a new podophyllotoxin derivative, epipodophyllotoxin, 4′-demethyl-9-(4,6-O-2-thenylidine-D-glucopyranoside) (NSC-122819)
40. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
41. Mitochondria and programmed cell death: Back to the future
42. On the mechanism of action of 4′-[(9-acridinyl)-amino] methanesulphon-m-anisidide
43. Clinical and pharmacokinetic phase I trial of oral dimethylaminoetoposide (NK611) administered for 21 days every 35 days
44. Bcl-2 family proteins and mitochondria
45. The weel protein kinase is required for radiation-induced mitotic delay
46. Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest
47. The effect of podophyllotoxin on microtubule dynamics
48. C-Jun NH2-terminal kinase-mediated activation of interleukin-lbeta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis
49. Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway
50. Podophyllotoxin-induced modifications of the nuclear envelope
51. Ordering the cytochrome c-initiated caspase cascade; Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
52. Phosphorylation of Bcl-2 and mitochondrial changes are associated with apoptosis of lymphoblastoid cells induced by normal immunoglobulin G
53. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
54. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
55. Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors
56. Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis
57. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2on sites phosphorylated at mitosis
58. High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells
59. Requirement of INK for stress-induced activation of the cytochrome c-mediated death pathway
60. Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937)
61. BCL-2 is phosphorylated and inactivated by an ASKl/Jun N-terminal protein kinase pathway normally activated at G(2)/M
62. Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives
63. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked (see comments)
64. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 (see comments)
65. An APAF-1. cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9