Synthesis and Biological Evaluation of New Selective Cytotoxic Cyclolignans Derived from Podophyllotoxin

Journal of Medicinal Chemistry

Volumn 47, Issue 5, 2004, Pages 1214-1222

  Castro, María Angeles ^a   Miguel Del Corral, Jose María ^a   Gordaliza, Marina ^a   García, Pablo A ^a   Gómez Zurita, María Antonia ^a   García Grávalos, María Dolores ^b   De La Iglesia Vicente, Janis ^c   Gajate, Consuelo ^c   An, Feiyun ^c   Mollinedo, Faustino ^c   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b Instituto Biomar SA   (Spain)

^c Centro de Investigacion del Cancer   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOLIGNAN DERIVATIVE; LIGNAN DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CHEMICAL REACTION; COLON CARCINOMA; CYTOTOXICITY; DEPOLYMERIZATION; DRUG ACTIVITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMINES; MICE; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10744221342     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030978h     Document Type: Article

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