Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 8047-8058

  Chou, Li Chen ^a   Tsai, Meng Tung ^a   Hsu, Mei Hua ^a   Wang, Sheng Hung ^b   Way, Tzong Der ^a   Huang, Chi Hung ^c   Lin, Hui Yi ^a   Qian, Keduo ^d   Dong, Yizhou ^d   Lee, Kuo Hsiung ^d   Huang, Li Jiau ^a   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^c Taiwan Advance Biopharm Inc   (Taiwan)

^d University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 FLUOROPHENYL) 5 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (2 FLUOROPHENYL) 5,6 DIHYDROXYQUINOLIN 4 ONE; 2 (2 FLUOROPHENYL) 5,6 DIMETHOXYQUINOLIN 4 ONE; 2 (2 FLUOROPHENYL) 5,6 METHYLENEDIOXYQUINOLINE 4 ONE; 2 (2 FLUOROPHENYL) 6,7 METHYLENEDIOXYQUINOLIN 4 ONE MONOSODIUM PHOSPHATE; 2 (2 FLUOROPHENYL) 7 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (3 FLUOROPHENYL) 5 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (3 FLUOROPHENYL) 5,6 DIHYDROXYQUINOLIN 4 ONE; 2 (3 FLUOROPHENYL) 5,6 DIMETHYLQUINOLINE 4 ONE; 2 (3 FLUOROPHENYL) 5,6 METHYLENEDIOXYQUINOLINE 4 ONE; 2 (3 FLUOROPHENYL) 7 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (4 FLUOROPHENYL) 5 HYDROXY 6 METHOXYQUINOLIN 4 ONE; 2 (4 FLUOROPHENYL) 5,6 DIHYDROXYQUINOLIN 4 ONE; 2 (4 FLUOROPHENYL) 5,6 DIMETHOXYQUINOLIN 4 ONE; 2 (4 FLUOROPHENYL) 5,6 METHYLENEDIOXYQUINOLIN 4 ONE; 2 (4 FLUOROPHENYL) 7 HYDROXY 6 METHOXYQUINOLIN 4 ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; QUINOLONE DERIVATIVE; SODIUM 2 (3 FLUOROPHENYL) 6 METHOXY 4 OXO 1,4 DIHYDROQUINOLIN 5 YL PHOSPHATE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; MALE; MICE; MICE, NUDE; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; PHOSPHORIC ACID ESTERS; PHOSPHORYLATION; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 78649500865     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100780c     Document Type: Article

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