Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5670-5678

  Tu, Huang Yao ^a   Huang, A Mei ^b   Teng, Chi Huang ^a   Hour, Tzyh Chyuan ^b   Yang, Shyh Chyun ^a   Pu, Yeong Shiau ^c   Lin, Chun Nan ^a,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Anthraquinone; Anticancer; Bax; CyclinB1; p21; p53; Reactive oxygen species; Synthesis

Indexed keywords

1 HYDROXY 3 [3 (2 HYDROXYPROPYLAMINO)PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (4 METHYLPIPERAZIN 1 YL)PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (CYCLOHEXYLAMINO)PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (ETHYLAMINO)PROPOXYL] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (MORPHOLIN 4 YL)PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (PIPERIDIN 1 YL)PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (PROPYLAMINO)PROPOXYL] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 (PYRROLIDIN 1 YL)PROPOXYL] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 [(2 HYDROXYETHYL)METHYLAMINO]PROPXY] 9,10 ANTHRAQUINONE; 1 HYDROXY 3 [3 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL]PROPXY] 9,10 ANTHRAQUINONE; 3 [3 (DIMETHYLAMINO)PROPOXYL] 9,10 ANTHRAQUINONE; 3 [3 (ETHYLAMINO)PROPOXYL] 9,10 ANTHRAQUINONE; 4 [3 (4 HYDROXY 9,10 DIOXO 9,10 DIHYDRO ANTHRACEN 2 YLOXY)PROPYL]PIPERAZINE 1 CARBOXYLIC ACID ETHYL ESTER; ANTHRAQUINONE DERIVATIVE; CYCLIN B1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN BAX; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DEATH; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOXICITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNOFLUORESCENCE; QUANTITATIVE ANALYSIS; UPREGULATION;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052571005     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.021     Document Type: Article

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