MicroRNAs in the Diagnosis and Treatment of Unstable Angina

Current Topics in Medicinal Chemistry

Volumn 13, Issue 13, 2013, Pages 1596-1604

  Latsios, George ^a   Tousoulis, Dimitris ^a   Androulakis, Emmanuel ^a   Papageorgiou, Nikolaos ^a   Synetos, Andreas ^a   Toutouzas, Konstantinos ^a   Siasos, Gerasimos ^a   Oikonomou, Evangelos ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Atherosclerosis; Biomarkers treatment; Diagnosis; microRNAs; Unstable angina

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MATRIX METALLOPROTEINASE; MICRORNA; MICRORNA 1; MICRORNA 126; MICRORNA 133; MICRORNA 133A; MICRORNA 143; MICRORNA 146; MICRORNA 155; MICRORNA 21; MICRORNA 221; MICRORNA 33; MICRORNA 92A; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE CORONARY SYNDROME; ANGIOGENESIS; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL MIGRATION; CELL PROLIFERATION; DISEASE ASSOCIATION; GENE REPRESSION; HEART MUSCLE OXYGEN CONSUMPTION; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; INFLAMMATION; LIPID METABOLISM; MICROEMBOLISM; REAL TIME POLYMERASE CHAIN REACTION; UNSTABLE ANGINA PECTORIS; VASCULAR SMOOTH MUSCLE;

ANGINA, UNSTABLE; HUMANS; MICRORNAS;

EID: 84881346737     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/15680266113139990108     Document Type: Article

References (82)

1. Mitchell, M. E.; Sidawy, A. N. The pathophysiology of atherosclerosis. Semin. Vasc. Surg., 1998, 11(3), 134-141.
2. Tousoulis, D.; Charakida, M.; Stefanadis, C. Endothelial function and inflammation in coronary artery disease. Postgrad. Med. J., 2008, 84(993), 368-371.
3. Tousoulis, D.; Kampoli, A. M.; Papageorgiou, N.; Androulakis, E.; Antoniades, C.; Toutouzas, K.; Stefanadis, C. Pathophysiology of atherosclerosis: the role of inflammation. Curr. Pharm. Des., 2011, 17(37), 4089-4110.
4. Papageorgiou, N.; Tousoulis, D.; Androulakis, E.; Giotakis, A.; Siasos, G.; Latsios, G.; Stefanadis, C. Lifestyle factors and endothelial function. Curr. Vasc. Pharmaco. l, 2012, 10(1), 94-106.
5. Sandoo, A.; van Zanten, J. J.; Metsios, G. S.; Carroll, D.; Kitas, G. D. The endothelium and its role in regulating vascular tone. Open Cardiovasc. Med. J., 2010, 4, 302-312.
6. Kasprzak, J. D.; Klosinska, M.; Drozdz, J. Clinical aspects of assessment of endothelial function. Pharmacol. Rep., 2006, 58, 33-40.
7. API expert consensus document on management of ischemic heart disease. J. Assoc. Physicians India, 2006, 54, 469-480.
8. Wiviott, S. D.; Braunwald, E. Unstable angina and non-STsegment elevation myocardial infarction: part I. Initial evaluation and management, and hospital care. Am. Fam. Physician, 2004, 70(3), 525-532.
9. Thum, T.; Catalucci, D.; Bauersachs, J. MicroRNAs: novel regulators in cardiac development and disease. Cardiovasc. Res., 2008, 79(4), 562-570.
10. Pan, Z. W.; Lu, Y. J.; Yang, B. F. MicroRNAs: a novel class of potential therapeutic targets for cardiovascular diseases. Acta. Pharmacol. Sin., 2010, 31(1), 1-9.
11. Foreman, R.D. Mechanisms of visceral pain: from nociception to targets. Drug Discovery Today: Disease Mechanisms, 2004, 1, 457-463.
12. Libby, P.; Theroux, P. Pathophysiology of coronary artery disease. Circulation, 2005, 111(25), 3481-3488.
13. Pepine, C. J.; Nichols, W. W. The pathophysiology of chronic ischemic heart disease. Clin. Cardiol., 2007, 30(2 Suppl 1), I4-9.
14. Tousoulis, D.; Charakida, M.; Stefanadis, C. Endothelial function and inflammation in coronary artery disease. Heart, 2006, 92(4), 441-444.
15. Kubes, P.; Suzuki, M.; Granger, D. N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U S A, 1991, 88(11), 4651-4655.
16. Cannon, R. O. 3rd Role of nitric oxide in cardiovascular disease: focus on the endothelium. Clin. Chem., 1998, 44(8 Pt 2), 1809-1819.
17. Kanner, J.; Harel, S.; Granit, R. Nitric oxide as an antioxidant. Arch. Biochem. Biophys., 1991, 289(1), 130-136.
18. Wassmann, S.; Wassmann, K.; Nickenig, G. Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension, 2004, 44(4), 381-386.
19. Briasoulis, A.; Tousoulis, D.; Androulakis, E. S.; Papageorgiou, N.; Latsios, G.; Stefanadis, C. Endothelial dysfunction and atherosclerosis: focus on novel therapeutic approaches. Recent Pat. Cardiovasc. Drug Discov., 2012, 7(1), 21-32.
20. Ross, R. Atherosclerosis--an inflammatory disease. N. Engl. J. Med., 1999, 340(2), 115-126.
21. Tousoulis, D.; Kampoli, A. M.; Papageorgiou, N.; Papaoikonomou, S.; Antoniades, C.; Stefanadis, C. The impact of diabetes mellitus on coronary artery disease: new therapeutic approaches. Curr. Pharm. Des., 2009, 15(17), 2037-2048.
22. Wassmann, S.; Wassmann, K.; Nickenig, G. Regulation of antioxidant and oxidant enzymes in vascular cells and implications for vascular disease. Curr. Hypertens. Rep., 2006, 8(1), 69-78.
23. Tousoulis, D.; Papageorgiou, N.; Androulakis, E.; Paroutoglou, K.; Stefanadis, C. Novel therapeutic strategies targeting vascular endothelium in essential hypertension. Expert Opin. Investig. Drugs, 2010, 19(11), 1395-1412.
24. Spagnoli, L. G.; Bonanno, E.; Sangiorgi, G.; Mauriello, A. Role of inflammation in atherosclerosis. J. Nucl. Med., 2007, 48(11), 1800-1815.
25. Tousoulis, D.; Androulakis, E.; Kontogeorgou, A.; Papageorgiou, N.; Charakida, M.; Siama, K.; Latsios, G.; Siasos, G.; Kampoli, A. M.; Tourikis, P.; Tsioufis, K.; Stefanadis, C. Insight to the pathophysiology of stable angina pectoris. Curr Pharm Des, 2013, 19(9), 1593-1600.
26. Drakopoulou, M.; Toutouzas, K.; Michelongona, A.; Tousoulis, D.; Stefanadis, C. Vulnerable plaque and inflammation: potential clinical strategies. Curr Pharm Des, 2011, 17(37), 4190-4209.
27. Kampoli, A. M.; Tousoulis, D.; Papageorgiou, N.; Antoniades, C.; Androulakis, E.; Tsiamis, E.; Latsios, G.; Stefanadis, C. Matrix metalloproteinases in acute coronary syndromes: current perspectives. Curr. Top Med. Chem., 2012, 12(10), 1192-1205.
28. Moreno, P. R.; Purushothaman, K. R.; Zias, E.; Sanz, J.; Fuster, V. Neovascularization in human atherosclerosis. Curr. Mol. Med., 2006, 6(5), 457-477.
29. Tousoulis, D.; Hatzis, G.; Papageorgiou, N.; Androulakis, E.; Bouras, G.; Giolis, A.; Bakogiannis, C.; Siasos, G.; Latsios, G.; Antoniades, C.; Stefanadis, C. Assessment of acute coronary syndromes: focus on novel biomarkers. Curr. Med. Chem., 2012, 19(16), 2572-2587.
30. Kampoli, A. M.; Tousoulis, D.; Papageorgiou, N.; Pallatza, Z.; Vogiatzi, G.; Briasoulis, A.; Androulakis, E.; Toutouzas, C.; Stougianos, P.; Tentolouris, C.; Stefanadis, C. Clinical utility of biomarkers in premature atherosclerosis. Curr. Med. Chem., 2012, 19(16), 2521-2533.
31. Zhang, R.; Su, B. Small but influential: the role of microRNAs on gene regulatory network and 3'UTR evolution. J. Genet. Genomics., 2009, 36(1), 1-6.
32. Lee, R. C.; Feinbaum, R. L.; Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5), 843-854.
33. Papageorgiou, N.; Tousoulis, D.; Androulakis, E.; Siasos, G.; Briasoulis, A.; Vogiatzi, G.; Kampoli, A. M.; Tsiamis, E.; Tentolouris, C.; Stefanadis, C. The role of microRNAs in cardiovascular disease. Curr. Med. Chem., 2012, 19(16), 2605-2610.
34. Quintavalle, M.; Elia, L.; Condorelli, G.; Courtneidge, S. A. MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J. Cell. Biol., 2010, 189(1), 13-22.
35. Catalucci, D.; Gallo, P.; Condorelli, G. MicroRNAs in cardiovascular biology and heart disease. Circ. Cardiovasc. Genet., 2009, 2(4), 402-408.
36. Maniataki, E.; Mourelatos, Z. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev., 2005, 19(24), 2979-2990.
37. Ruby, J. G.; Jan, C. H.; Bartel, D. P. Intronic microRNA precursors that bypass Drosha processing. Nature, 2007, 448(7149), 83-86.
38. Zhang, C. MicroRNomics: a newly emerging approach for disease biology. Physiol. Genomics, 2008, 33(2), 139-147.
39. Zeng, Y.; Cullen, B. R. Sequence requirements for micro RNA processing and function in human cells. RNA, 2003, 9(1), 112-123.
40. Lim, L. P.; Lau, N. C.; Garrett-Engele, P.; Grimson, A.; Schelter, J. M.; Castle, J.; Bartel, D. P.; Linsley, P. S.; Johnson, J. M. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 2005, 433(7027), 769-773.
41. Chen, P. Y.; Manninga, H.; Slanchev, K.; Chien, M.; Russo, J. J.; Ju, J.; Sheridan, R.; John, B.; Marks, D. S.; Gaidatzis, D.; Sander, C.; Zavolan, M.; Tuschl, T. The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes Dev., 2005, 19(11), 1288-1293.
42. Baskerville, S.; Bartel, D. P. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA, 2005, 11(3), 241-247.
43. Krichevsky, A. M.; King, K. S.; Donahue, C. P.; Khrapko, K.; Kosik, K. S. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA, 2003, 9(10), 1274-1281.
44. Sayed, D.; Hong, C.; Chen, I. Y.; Lypowy, J.; Abdellatif, M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ. Res., 2007, 100(3), 416-424.
45. Tatsuguchi, M.; Seok, H. Y.; Callis, T. E.; Thomson, J. M.; Chen, J. F.; Newman, M.; Rojas, M.; Hammond, S. M.; Wang, D. Z. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J. Mol. Cell Cardiol., 2007, 42(6), 1137-1141.
46. Gilad, S.; Meiri, E.; Yogev, Y.; Benjamin, S.; Lebanony, D.; Yerushalmi, N.; Benjamin, H.; Kushnir, M.; Cholakh, H.; Melamed, N.; Bentwich, Z.; Hod, M.; Goren, Y.; Chajut, A. Serum microRNAs are promising novel biomarkers. PLoS One, 2008, 3(9), e3148.
47. Hunter, M. P.; Ismail, N.; Zhang, X.; Aguda, B. D.; Lee, E. J.; Yu, L.; Xiao, T.; Schafer, J.; Lee, M. L.; Schmittgen, T. D.; Nana-Sinkam, S. P.; Jarjoura, D.; Marsh, C. B. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One, 2008, 3(11), e3694.
48. Zhu, N.; Zhang, D.; Chen, S.; Liu, X.; Lin, L.; Huang, X.; Guo, Z.; Liu, J.; Wang, Y.; Yuan, W.; Qin, Y. Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis, 2011, 215(2), 286-293.
49. van Rooij, E.; Sutherland, L. B.; Thatcher, J. E.; DiMaio, J. M.; Naseem, R. H.; Marshall, W. S.; Hill, J. A.; Olson, E. N. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl. Acad. Sci. U S A, 2008, 105(35), 13027-13032.
50. Harris, T. A.; Yamakuchi, M.; Ferlito, M.; Mendell, J. T.; Lowenstein, C. J. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc. Natl. Acad. Sci. U S A, 2008, 105(5), 1516-1521.
51. Ono, K.; Kuwabara, Y.; Han, J. MicroRNAs and cardiovascular diseases. FEBS J., 2011, 278(10), 1619-1633.
52. Tousoulis, D.; Kampoli, A. M.; Tentolouris, C.; Papageorgiou, N.; Stefanadis, C. The role of nitric oxide on endothelial function. Curr. Vasc. Pharmacol., 2012, 10(1), 4-18.
53. Weber, M.; Baker, M. B.; Moore, J. P.; Searles, C. D. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem. Biophys. Res. Commun., 2010, 393(4), 643-648.
54. Li, Y.; Song, Y. H.; Li, F.; Yang, T.; Lu, Y. W.; Geng, Y. J. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem. Biophys. Res. Commun., 2009, 381(1), 81-83.
55. Chen, T.; Huang, Z.; Wang, L.; Wang, Y.; Wu, F.; Meng, S.; Wang, C. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc. Res., 2009, 83(1), 131-139.
56. Huang, R. S.; Hu, G. Q.; Lin, B.; Lin, Z. Y.; Sun, C. C. MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages. J. Investig. Med., 2010, 58(8), 961-967.
57. Rayner, K. J.; Suarez, Y.; Davalos, A.; Parathath, S.; Fitzgerald, M. L.; Tamehiro, N.; Fisher, E. A.; Moore, K. J.; Fernandez-Hernando, C. MiR-33 contributes to the regulation of cholesterol homeostasis. Science, 2010, 328(5985), 1570-1573.
58. Minami, Y.; Satoh, M.; Maesawa, C.; Takahashi, Y.; Tabuchi, T.; Itoh, T.; Nakamura, M. Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease. Eur. J. Clin. Invest., 2009, 39(5), 359-367.
59. Pasterkamp, G.; Van Keulen, J. K.; De Kleijn, D. P. Role of Tolllike receptor 4 in the initiation and progression of atherosclerotic disease. Eur. J. Clin. Invest., 2004, 34(5), 328-334.
60. Haver, V. G.; Slart, R. H.; Zeebregts, C. J.; Peppelenbosch, M. P.; Tio, R. A. Rupture of vulnerable atherosclerotic plaques: microRNAs conducting the orchestra? Trends Cardiovasc. Med., 2010, 20(2), 65-71.
61. Urbich, C.; Kuehbacher, A.; Dimmeler, S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc. Res., 2008, 79(4), 581-588.
62. Chen, Y.; Banda, M.; Speyer, C. L.; Smith, J. S.; Rabson, A. B.; Gorski, D. H. Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol. Cell Biol., 2010, 30(15), 3902-3913.
63. Papageorgiou, N.; Tousoulis, D.; Androulakis, E.; Kontogeorgou, A.; Charakida, M.; Giolis, A.; Siama, K.; Trikas, A.; Briasoulis, A.; Pitsavos, C.; Stefanadis, C. The role of microRNAs in the initiation and progression of stable atheromatous plaque. Curr. Pharm. Des., 2013, 19(9), 1651-1657.
64. Ji, R.; Cheng, Y.; Yue, J.; Yang, J.; Liu, X.; Chen, H.; Dean, D. B.; Zhang, C. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ. Res., 2007, 100(11), 1579-1588.
65. O'Sullivan, J. F.; Martin, K.; Caplice, N. M. Microribonucleic acids for prevention of plaque rupture and in-stent restenosis: "a finger in the dam". J. Am. Coll. Cardiol., 2011, 57(4), 383-389.
66. Kuwabara, Y.; Ono, K.; Horie, T.; Nishi, H.; Nagao, K.; Kinoshita, M.; Watanabe, S.; Baba, O.; Kojima, Y.; Shizuta, S.; Imai, M.; Tamura, T.; Kita, T.; Kimura, T. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ. Cardiovasc. Genet., 2011, 4(4), 446-454.
67. Widera, C.; Gupta, S. K.; Lorenzen, J. M.; Bang, C.; Bauersachs, J.; Bethmann, K.; Kempf, T.; Wollert, K. C.; Thum, T. Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome. J. Mol. Cell Cardiol., 2011, 51(5), 872-875.
68. Yao, R.; Ma, Y.; Du, Y.; Liao, M.; Li, H.; Liang, W.; Yuan, J.; Ma, Z.; Yu, X.; Xiao, H.; Liao, Y. The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome. Cell Mol. Immunol., 2011, 8(6), 486-495.
69. Hoekstra, M.; van der Lans, C. A.; Halvorsen, B.; Gullestad, L.; Kuiper, J.; Aukrust, P.; van Berkel, T. J.; Biessen, E. A. The peripheral blood mononuclear cell microRNA signature of coronary artery disease. Biochem. Biophys. Res. Commun, 2010, 394(3), 792-797.
70. Rothman, A.M.K.; Morton, A.C.; Chico, T.J.; Crossman, D.C.; Milo M. Peripheral whole blood microRNA signature differentiates between myocardial infarction and unstable angina. Heart, 2011, 97:e7
71. Xu, J.; Zhao, J.; Evan, G.; Xiao, C.; Cheng, Y.; Xiao, J. Circulating microRNAs: novel biomarkers for cardiovascular diseases. J. Mol. Med. (Berl), 2012, 90(8), 865-875.
72. Yin, C.; Salloum, F. N.; Kukreja, R. C. A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circ. Res., 2009, 104(5), 572-575.
73. Poliseno, L.; Tuccoli, A.; Mariani, L.; Evangelista, M.; Citti, L.; Woods, K.; Mercatanti, A.; Hammond, S.; Rainaldi, G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood, 2006, 108(9), 3068-3071.
74. Fasanaro, P.; Greco, S.; Lorenzi, M.; Pescatori, M.; Brioschi, M.; Kulshreshtha, R.; Banfi, C.; Stubbs, A.; Calin, G. A.; Ivan, M.; Capogrossi, M. C.; Martelli, F. An integrated approach for experimental target identification of hypoxia-induced miR-210. J. Biol. Chem., 2009, 284(50), 35134-35143.
75. Martin, K.; O'Sullivan, J. F.; Caplice, N. M. New therapeutic potential of microRNA treatment to target vulnerable atherosclerotic lesions and plaque rupture. Curr. Opin. Cardiol., 2011, 26(6), 569-575.
76. Cheng, Y.; Liu, X.; Yang, J.; Lin, Y.; Xu, D. Z.; Lu, Q.; Deitch, E. A.; Huo, Y.; Delphin, E. S.; Zhang, C. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ. Res., 2009, 105(2), 158-166.
77. Elia, L.; Quintavalle, M.; Zhang, J.; Contu, R.; Cossu, L.; Latronico, M. V.; Peterson, K. L.; Indolfi, C.; Catalucci, D.; Chen, J.; Courtneidge, S. A.; Condorelli, G. The knockout of miR-143 and-145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ., 2009, 16(12), 1590-1598.
78. Weiler, J.; Hunziker, J.; Hall, J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther., 2006, 13(6), 496-502.
79. Boettger, T.; Beetz, N.; Kostin, S.; Schneider, J.; Kruger, M.; Hein, L.; Braun, T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J. Clin. Invest., 2009, 119(9), 2634-2647.
80. Zernecke, A.; Bidzhekov, K.; Noels, H.; Shagdarsuren, E.; Gan, L.; Denecke, B.; Hristov, M.; Koppel, T.; Jahantigh, M. N.; Lutgens, E.; Wang, S.; Olson, E. N.; Schober, A.; Weber, C. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci. Signal., 2009, 2(100), ra81.
81. Fernandez-Hernando, C.; Suarez, Y.; Rayner, K. J.; Moore, K. J. MicroRNAs in lipid metabolism. Curr. Opin. Lipidol., 2011, 22(2), 86-92.
82. Thum, T. MicroRNA therapeutics in cardiovascular medicine. EMBO Mol. Med., 2012, 4(1), 3-14.