Novel targeted therapies to overcome trastuzumab resistance in HER2-overexpressing metastatic breast cancer

Current Drug Targets

Volumn 14, Issue 8, 2013, Pages 889-898

  Huang, Yuan ^a   Fu, Peifen ^b   Fan, Weimin ^a,c  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

bsABs; HER2 vaccines; HER2 overexpressing MBC; MABs; TKIs; Trastuzumab resistance

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL) IMIDAZO [4, 5 C] QUINOLIN 2 (1H, 3H) ONE; 1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 8 [4 (1 AMINOCYCLOBUTYL) PHENYL] 9 PHENYL 1, 2, 4 TRIAZOLO [3, 4 F] [1, 6] NAPHTHYRIDIN 3 (2H) ONE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BEVACIZUMAB; BUPARLISIB; CAPECITABINE; CIXUTUMUMAB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERTUMAXOMAB; EVEROLIMUS; LAPATINIB; LUMINESPIB; MAMMALIAN TARGET OF RAPAMYCIN; NAVELBINE; NERATINIB; PACLITAXEL; PERTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PLACEBO; PROTEIN KINASE B; RETASPIMYCIN; SUNITINIB; TANESPIMYCIN; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANEMIA; ANOREXIA; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; BRAIN ISCHEMIA; BREAST METASTASIS; CANCER PROGNOSIS; CARDIOTOXICITY; DIARRHEA; DISEASE COURSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; HEADACHE; HUMAN; HYPERTENSION; IMMUNE RESPONSE; IMMUNOTHERAPY; MULTICENTER STUDY (TOPIC); NAUSEA; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEINURIA; PRURITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; REVIEW; SIDE EFFECT; THROMBOCYTOPENIA; UPREGULATION; VOMITING;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 84881325579     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990161     Document Type: Review

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