Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

Oncogene

Volumn 24, Issue 41, 2005, Pages 6213-6221

  Xia, Wenle ^a   Gerard, Catherine M ^b   Liu, Leihua ^a   Baudson, Nathalie M ^b   Ory, Thierry L ^b   Spector, Neil L ^a  

^a GLAXOSMITHKLINE   (United States)

^b GSK   (Belgium)

Author keywords

Antibodies; Breast cancer; ErbB2; Survivin; Tyrosine kinase; Vaccine

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYCLONAL ANTISERUM; PROTEIN KINASE B; SURVIVIN; TRASTUZUMAB;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS INHIBITION; STEADY STATE; TRANSACTIVATION; TUMOR CELL;

ANTIBODIES, MONOCLONAL; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

ORYCTOLAGUS CUNICULUS;

EID: 30544450275     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208774     Document Type: Article

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