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Volumn 52, Issue 1, 2008, Pages 91-98

Predictive markers in breast cancer - The future

Author keywords

Clinical trial; Predictive biomarkers; PTEN; RTK inhibitors; Topoisomerase II; Trastuzumab

Indexed keywords

ANASTROZOLE; ANTHRACYCLINE; AROMATASE INHIBITOR; BEVACIZUMAB; BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); EPIDERMAL GROWTH FACTOR RECEPTOR; EPIRUBICIN; EXEMESTANE; GEFITINIB; GEMCITABINE; HORMONE; IMATINIB; PACLITAXEL; PHOSPHATASE; PROTEIN KINASE B; TAMOXIFEN; TAXANE DERIVATIVE; TOPOISOMERASE II ALPHA; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 37249078187     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02896.x     Document Type: Review
Times cited : (33)

References (66)
  • 1
    • 33845929000 scopus 로고    scopus 로고
    • Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
    • Jordan VC, Brodie AM. Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer. Steroids 2007 72 7 25.
    • (2007) Steroids , vol.72 , pp. 7-25
    • Jordan, V.C.1    Brodie, A.M.2
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987 235 177 182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 3
    • 37249034586 scopus 로고    scopus 로고
    • Biological predictors of tumour response: Natural selection or intelligent design?
    • Bartlett JMS. Biological predictors of tumour response: natural selection or intelligent design? Advances Breast Cancer 2005 2 11 15.
    • (2005) Advances Breast Cancer , vol.2 , pp. 11-15
    • Bartlett, J.M.S.1
  • 5
    • 29144475553 scopus 로고    scopus 로고
    • Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials
    • Clarke M, Collins R, Darby S et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005 366 2087 2106.
    • (2005) Lancet , vol.366 , pp. 2087-2106
    • Clarke, M.1    Collins, R.2    Darby, S.3
  • 6
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 2000 406 747 752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 7
    • 37249056445 scopus 로고    scopus 로고
    • Translational research and the development of novel biomarkers in breast cancer
    • Bartlett JMS. Translational research and the development of novel biomarkers in breast cancer. Advan Breast Cancer 2006 3 76 85.
    • (2006) Advan Breast Cancer , vol.3 , pp. 76-85
    • Bartlett, J.M.S.1
  • 8
    • 33845929000 scopus 로고    scopus 로고
    • Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
    • Jordan VC, Brodie AM. Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer. Steroids 2007 72 7 25.
    • (2007) Steroids , vol.72 , pp. 7-25
    • Jordan, V.C.1    Brodie, A.M.2
  • 9
    • 26044478813 scopus 로고    scopus 로고
    • Can molecular markers predict when to implement treatment with aromatase inhibitors in invasive breast cancer?
    • Tovey SM, Dunne B, Witton CJ, Forsyth A, Cooke TG, Bartlett JMS. Can molecular markers predict when to implement treatment with aromatase inhibitors in invasive breast cancer? Clin. Cancer Res. 2005 11 4835 4842.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4835-4842
    • Tovey, S.M.1    Dunne, B.2    Witton, C.J.3    Forsyth, A.4    Cooke, T.G.5    Bartlett, J.M.S.6
  • 10
    • 0037241504 scopus 로고    scopus 로고
    • Integration of signal transduction inhibitors with endocrine therapy: An approach to overcoming hormone resistance in breast cancer
    • Johnston SRD, Head J, Pancholi S et al. Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer. Clin. Cancer Res. 2003 9 524S 532S.
    • (2003) Clin. Cancer Res. , vol.9
    • Johnston, S.R.D.1    Head, J.2    Pancholi, S.3
  • 11
  • 12
    • 33947432483 scopus 로고    scopus 로고
    • Amplified in breast cancer 1 in human epidermal growth factor receptor-positive tumors of tamoxifen-treated breast cancer patients
    • Kirkegaard T, McGlynn LM, Campbell FM et al. Amplified in breast cancer 1 in human epidermal growth factor receptor-positive tumors of tamoxifen-treated breast cancer patients. Clin. Cancer Res. 2007 13 1405 1411.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1405-1411
    • Kirkegaard, T.1    McGlynn, L.M.2    Campbell, F.M.3
  • 13
    • 26044443105 scopus 로고    scopus 로고
    • AKT activation predicts outcome in breast cancer patients treated with tamoxifen
    • Kirkegaard T, Witton CJ, McGlynn LM et al. AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J. Pathol. 2005 207 139 146.
    • (2005) J. Pathol. , vol.207 , pp. 139-146
    • Kirkegaard, T.1    Witton, C.J.2    McGlynn, L.M.3
  • 15
    • 33646429471 scopus 로고    scopus 로고
    • Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen
    • Bergqvist J, Elmberger G, Ohd J et al. Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen. Eur. J. Cancer 2006 42 1104 1112.
    • (2006) Eur. J. Cancer , vol.42 , pp. 1104-1112
    • Bergqvist, J.1    Elmberger, G.2    Ohd, J.3
  • 16
    • 17844398046 scopus 로고    scopus 로고
    • Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
    • Gutierrez MC, Detre S, Johnston S et al. Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J. Clin. Oncol. 2005 23 2469 2476.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2469-2476
    • Gutierrez, M.C.1    Detre, S.2    Johnston, S.3
  • 17
    • 0021151237 scopus 로고
    • Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
    • Tewey KM, Rowe TC, Yang L, Halligan BD, Liu LF. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984 226 466 468.
    • (1984) Science , vol.226 , pp. 466-468
    • Tewey, K.M.1    Rowe, T.C.2    Yang, L.3    Halligan, B.D.4    Liu, L.F.5
  • 18
    • 4043131642 scopus 로고    scopus 로고
    • HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
    • Di Leo A, Chan S, Paesmans M et al. HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel. Breast Cancer Res. Treat. 2004 86 197 206.
    • (2004) Breast Cancer Res. Treat. , vol.86 , pp. 197-206
    • Di Leo, A.1    Chan, S.2    Paesmans, M.3
  • 19
    • 0036091354 scopus 로고    scopus 로고
    • HER-2 Amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil
    • Di Leo A, Gancberg D, Larsimont D et al. HER-2 Amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin. Cancer Res. 2002 8 1107 1116.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1107-1116
    • Di Leo, A.1    Gancberg, D.2    Larsimont, D.3
  • 20
    • 17944375163 scopus 로고    scopus 로고
    • HER-2 and topo-isomerase II alpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide
    • Di Leo A, Larsimont D, Gancberg D et al. HER-2 and topo-isomerase II alpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. Ann. Oncol. 2001 12 1081 1089.
    • (2001) Ann. Oncol. , vol.12 , pp. 1081-1089
    • Di Leo, A.1    Larsimont, D.2    Gancberg, D.3
  • 21
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase II alpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TAH, Tanner M, Rantanen V et al. Amplification and deletion of topoisomerase II alpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am. J. Pathol. 2000 156 839 847.
    • (2000) Am. J. Pathol. , vol.156 , pp. 839-847
    • Jarvinen, T.A.H.1    Tanner, M.2    Rantanen, V.3
  • 22
    • 0029665095 scopus 로고    scopus 로고
    • Expression of topoisomerase II alpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer
    • Jarvinen TAH, Kononen J, Peltohuikko M, Isola J. Expression of topoisomerase II alpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer. Am. J. Pathol. 1996 148 2073 2082.
    • (1996) Am. J. Pathol. , vol.148 , pp. 2073-2082
    • Jarvinen, T.A.H.1    Kononen, J.2    Peltohuikko, M.3    Isola, J.4
  • 23
    • 32944475493 scopus 로고    scopus 로고
    • Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin and fluorouracil: Danish breast cancer cooperative group
    • Knoop AS, Knudsen H, Balslev E et al. Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin and fluorouracil: Danish breast cancer cooperative group. J. Clin. Oncol. 2005 23 7483 7490.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7483-7490
    • Knoop, A.S.1    Knudsen, H.2    Balslev, E.3
  • 24
    • 33646681444 scopus 로고    scopus 로고
    • HER2 and responsiveness of breast cancer to adjuvant chemotherapy
    • Pritchard KI, Shepherd LE, O'Malley FP et al. HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N. Engl. J. Med. 2006 354 2103 2111.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2103-2111
    • Pritchard, K.I.1    Shepherd, L.E.2    O'Malley, F.P.3
  • 25
    • 0035878845 scopus 로고    scopus 로고
    • Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer
    • Tanner M, Jarvinen P, Isola J. Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer. Cancer Res. 2001 61 5345 5348.
    • (2001) Cancer Res. , vol.61 , pp. 5345-5348
    • Tanner, M.1    Jarvinen, P.2    Isola, J.3
  • 26
    • 0034694659 scopus 로고    scopus 로고
    • HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15
    • Paik S, Bryant J, Tan-Chiu E et al. HER2 and choice of adjuvant chemotherapy for invasive breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-15. J. Natl Cancer Inst. 2000 92 1991 1998.
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1991-1998
    • Paik, S.1    Bryant, J.2    Tan-Chiu, E.3
  • 27
    • 0037317929 scopus 로고    scopus 로고
    • HER2 overexpression and doxorubicin in adjuvant chemotherapy for resectable breast cancer
    • Moliterni A, Menard S, Valagussa P et al. HER2 overexpression and doxorubicin in adjuvant chemotherapy for resectable breast cancer. J. Clin. Oncol. 2003 21 458 462.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 458-462
    • Moliterni, A.1    Menard, S.2    Valagussa, P.3
  • 28
    • 33750502656 scopus 로고    scopus 로고
    • Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer
    • Poole CJ, Earl HM, Hiller L et al. Epirubicin and cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy for early breast cancer. N. Engl. J. Med. 2006 355 1851 1862.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1851-1862
    • Poole, C.J.1    Earl, H.M.2    Hiller, L.3
  • 29
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • Fukuoka M, Yano S, Giaccone G et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J. Clin. Oncol. 2003 21 2237 2246.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 30
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003 290 2149 2158.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 31
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004 350 2129 2139.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 32
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl Acad. Sci. U. S. A. 2004 101 13306 13311.
    • (2004) Proc. Natl Acad. Sci. U. S. A. , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 33
    • 0043132288 scopus 로고    scopus 로고
    • Gefitinib in pretreated non-small-cell lung cancer (NSCLC): Analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC
    • Cappuzzo F, Gregorc V, Rossi E et al. Gefitinib in pretreated non-small-cell lung cancer (NSCLC): analysis of efficacy and correlation with HER2 and epidermal growth factor receptor expression in locally advanced or metastatic NSCLC. J. Clin. Oncol. 2003 21 2658 2663.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2658-2663
    • Cappuzzo, F.1    Gregorc, V.2    Rossi, E.3
  • 34
    • 3843116718 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer
    • Parra HS, Cavina R, Latteri F et al. Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer. Br. J. Cancer 2004 91 208 212.
    • (2004) Br. J. Cancer , vol.91 , pp. 208-212
    • Parra, H.S.1    Cavina, R.2    Latteri, F.3
  • 35
    • 0344453811 scopus 로고    scopus 로고
    • The clinical evaluation of HER-2 status: Which test to use?
    • Bartlett J, Mallon E, Cooke T. The clinical evaluation of HER-2 status: which test to use? J. Pathol. 2003 199 411 417.
    • (2003) J. Pathol. , vol.199 , pp. 411-417
    • Bartlett, J.1    Mallon, E.2    Cooke, T.3
  • 36
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch FR, Varella-Garcia M, McCoy J et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J. Clin. Oncol. 2005 23 6838 6845.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3
  • 38
    • 0026571910 scopus 로고
    • The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: A review on 5232 patients
    • Klijn JG, Berns PM, Schmitz PI, Foekens JA. The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr. Rev. 1992 13 3 17.
    • (1992) Endocr. Rev. , vol.13 , pp. 3-17
    • Klijn, J.G.1    Berns, P.M.2    Schmitz, P.I.3    Foekens, J.A.4
  • 39
    • 0028330743 scopus 로고
    • The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients
    • Fox SB, Smith K, Hollyer J, Greenall M, Hastrich D, Harris AL. The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients. Breast Cancer Res. Treat. 1994 29 41 49.
    • (1994) Breast Cancer Res. Treat. , vol.29 , pp. 41-49
    • Fox, S.B.1    Smith, K.2    Hollyer, J.3    Greenall, M.4    Hastrich, D.5    Harris, A.L.6
  • 40
    • 3142773290 scopus 로고    scopus 로고
    • Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling
    • Tovey SM, Witton CJ, Bartlett JMS, Stanton PD, Reeves JR, Cooke TG. Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling. Breast Cancer Res. 2004 6 R246 R251.
    • (2004) Breast Cancer Res. , vol.6
    • Tovey, S.M.1    Witton, C.J.2    Bartlett, J.M.S.3    Stanton, P.D.4    Reeves, J.R.5    Cooke, T.G.6
  • 41
    • 1842530544 scopus 로고    scopus 로고
    • Epidermal growth factor receptor status in operable invasive breast cancer: Is it of any prognostic value?
    • Rampaul RS, Pinder SE, Wencyk PM et al. Epidermal growth factor receptor status in operable invasive breast cancer: is it of any prognostic value? Clin. Cancer Res. 2004 10 2578.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2578
    • Rampaul, R.S.1    Pinder, S.E.2    Wencyk, P.M.3
  • 42
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin. Cancer Res. 2004 10 5367 5374.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 43
    • 33749022506 scopus 로고    scopus 로고
    • Basal-like breast cancer and the BRCA1 phenotype
    • Turner NC, Reis-Filho JS. Basal-like breast cancer and the BRCA1 phenotype. Oncogene 2006 25 5846 5853.
    • (2006) Oncogene , vol.25 , pp. 5846-5853
    • Turner, N.C.1    Reis-Filho, J.S.2
  • 44
    • 33746911642 scopus 로고    scopus 로고
    • EGFR amplification and lack of activating mutations in metaplastic breast carcinomas
    • Reis-Filho JS, Pinheiro C, Lambros MB et al. EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. J. Pathol. 2006 209 445 453.
    • (2006) J. Pathol. , vol.209 , pp. 445-453
    • Reis-Filho, J.S.1    Pinheiro, C.2    Lambros, M.B.3
  • 45
    • 32844457996 scopus 로고    scopus 로고
    • Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression
    • Kersting C, Kuijper A, Schmidt H et al. Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression. Lab. Invest. 2006 86 54 61.
    • (2006) Lab. Invest. , vol.86 , pp. 54-61
    • Kersting, C.1    Kuijper, A.2    Schmidt, H.3
  • 46
    • 34447295638 scopus 로고    scopus 로고
    • Chromogenic and fluorescent in situ hybridization in breast cancer
    • Lambros MB, Natrajan R, Reis-Filho JS. Chromogenic and fluorescent in situ hybridization in breast cancer. Hum. Pathol. 2007 38 1105 1122.
    • (2007) Hum. Pathol. , vol.38 , pp. 1105-1122
    • Lambros, M.B.1    Natrajan, R.2    Reis-Filho, J.S.3
  • 48
    • 34548537574 scopus 로고    scopus 로고
    • A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
    • Smith IE, Walsh G, Skene A et al. A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J. Clin. Oncol. 2007 25 3816 3822.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 3816-3822
    • Smith, I.E.1    Walsh, G.2    Skene, A.3
  • 50
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • Burris HA III., Hurwitz HI, Dees EC et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 2005 23 5305 5313.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5305-5313
    • Burris Iii., H.A.1    Hurwitz, H.I.2    Dees, E.C.3
  • 51
    • 23344440655 scopus 로고    scopus 로고
    • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    • Carter TA, Wodicka LM, Shah NP et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc. Natl Acad. Sci. U. S. A. 2005 102 11011 11016.
    • (2005) Proc. Natl Acad. Sci. U. S. A. , vol.102 , pp. 11011-11016
    • Carter, T.A.1    Wodicka, L.M.2    Shah, N.P.3
  • 52
    • 31444444131 scopus 로고    scopus 로고
    • PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer
    • Fujita T, Doihara H, Kawasaki K et al. PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer. Br. J. Cancer 2006 94 247 252.
    • (2006) Br. J. Cancer , vol.94 , pp. 247-252
    • Fujita, T.1    Doihara, H.2    Kawasaki, K.3
  • 53
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004 6 117 127.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 54
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997 275 1943 1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 55
    • 0037099532 scopus 로고    scopus 로고
    • Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
    • Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S, Arteaga CL. Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Res. 2002 62 4132 4141.
    • (2002) Cancer Res. , vol.62 , pp. 4132-4141
    • Yakes, F.M.1    Chinratanalab, W.2    Ritter, C.A.3    King, W.4    Seelig, S.5    Arteaga, C.L.6
  • 56
    • 33947230755 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines
    • Hollestelle A, Elstrodt F, Nagel JH, Kallemeijn WW, Schutte M. Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. Mol. Cancer Res. 2007 5 195 201.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 195-201
    • Hollestelle, A.1    Elstrodt, F.2    Nagel, J.H.3    Kallemeijn, W.W.4    Schutte, M.5
  • 57
    • 0042197413 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A new molecular target for breast cancer
    • Mita MM, Mita A, Rowinsky EK. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin. Breast Cancer 2003 4 126 137.
    • (2003) Clin. Breast Cancer , vol.4 , pp. 126-137
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 58
    • 18144399578 scopus 로고    scopus 로고
    • MTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann. Oncol. 2005 16 525 537.
    • (2005) Ann. Oncol. , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 59
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006 124 471 484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 60
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005 307 1098 1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 61
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005 8 179 183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 62
    • 7944223834 scopus 로고    scopus 로고
    • Targeting the mammalian target of rapamycin (mTOR): A new approach to treating cancer
    • Chan S. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br. J. Cancer 2004 91 1420 1424.
    • (2004) Br. J. Cancer , vol.91 , pp. 1420-1424
    • Chan, S.1
  • 63
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
    • Ellis MJ, Coop A, Singh B et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J. Clin. Oncol. 2001 19 3808 3816.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 64
    • 34249292099 scopus 로고    scopus 로고
    • Predictors of early relapse in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial
    • Mauriac L, Keshaviah A, Debled M et al. Predictors of early relapse in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial. Ann. Oncol. 2007 18 859 867.
    • (2007) Ann. Oncol. , vol.18 , pp. 859-867
    • Mauriac, L.1    Keshaviah, A.2    Debled, M.3
  • 65
    • 0036277226 scopus 로고    scopus 로고
    • Issues and barriers to development of clinically useful tumor markers: A development pathway proposal
    • Hammond MEH, Taube SE. Issues and barriers to development of clinically useful tumor markers: a development pathway proposal. Semin. Oncol. 2002 29 213 221.
    • (2002) Semin. Oncol. , vol.29 , pp. 213-221
    • Hammond, M.E.H.1    Taube, S.E.2


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