Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016

Oncogene

Volumn 23, Issue 3, 2004, Pages 646-653

  Xia, Wenle ^a   Liu, Lei Hua ^a   Ho, Peter ^a   Spector, Neil L ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

ErbB3; Heregulin; Heterodimers; Truncated ErbB2; Tyrosine kinase

Indexed keywords

CYCLIN D; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; NEU DIFFERENTIATION FACTOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN P185; PROTEIN TYROSINE KINASE; TRASTUZUMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TUMOR XENOGRAFT;

BREAST NEOPLASMS; CELL LINE, TUMOR; DIMERIZATION; ENZYME INHIBITORS; HUMANS; NEUREGULIN-1; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3;

ANIMALIA;

EID: 1242273590     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207166     Document Type: Article

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