Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver

Journal of Lipid Research

Volumn 54, Issue 8, 2013, Pages 2060-2068

  Hashimoto, Mari ^a   Kobayashi, Kaoru ^a   Watanabe, Mio ^a   Kazuki, Yasuhiro ^b,c   Takehara, Shoko ^c   Inaba, Asumi ^a   Nitta, Shin Ichiro ^a,d   Senda, Naoto ^d   Oshimura, Mitsuo ^b,c   Chiba, Kan ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d LSI MEDIENCE CORPORATION   (Japan)

Author keywords

25 hydroxy cholesterol; Cytochrome P450 3A; HMG CoA synthase 1; Squalene epoxidase; Sterol regulatory element binding protein 2

Indexed keywords

7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; BILE ACID; CHOLESTEROL; CYTOCHROME P450 3A; LATHOSTEROL; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYP3A GENE; ENZYME ACTIVATION; FEMALE; GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE INACTIVATION; GENETIC ANALYSIS; HMGCS1 GENE; IN VIVO STUDY; LIVER; LIVER LEVEL; MALE; MOUSE; NONHUMAN; P450 OXIDOREDUCTASE DEFICIENCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING;

EID: 84881257183     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M033464     Document Type: Article

References (51)

1. Miller, W. L. 1988.Molecular biology of steroid hormone synthesis. Endocr. Rev. 9 : 295-318.
2. Schroepfer, G. J. 2000.Oxysterols: Modulators of cholesterol metabolism and other processes. Physiol. Rev. 80 : 361-554.
3. Bloch, K., B. N. Berg, and D. Rittenberg. 1943.The biological conversion of cholesterol to cholic acid. J. Biol. Chem. 149 : 511-517.
4. Wiseman, H. 1993.Vitamin D is a membrane antioxidant. Ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett. 326 : 285-288.
5. Brown, M. S., and J. L. Goldstein.1997.The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor. Cell.89 : 331-340.
6. Horton, J. D., J. L. Goldstein, and M. S. Brown.2002.SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109 : 1125-1131.
7. Wang, D. Q. 2007.Regulation of intestinal cholesterol absorption. Annu. Rev. Physiol. 69 : 221-248.
8. Davis, H. R., L. J. Zhu, L. M. Hoos, G. Tetzloff, M. Maguire, J. Liu, X. Yao, S. P. Iyer, M. H. Lam, E. G. Lund, et al.2004.Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J. Biol. Chem. 279 : 33586-33592.
9. Attie, A. D. 2007.ABCA1: At the nexus of cholesterol, HDL and atherosclerosis. Trends Biochem. Sci. 32 : 172-179.
10. Berge, K. E., H. Tian, G. A. Graf, L. Yu, N. V. Grishin, J. Schultz, P. Kwiterovich, B. Shan, R. Barnes, and H. H. Hobbs.2000. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science.290 : 1771-1775.
11. Wittenburg, H., and M. C. Carey.2002.Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8. J. Clin. Invest. 110 : 605-609.
12. Dietschy, J. M., S. D. Turley, and D. K. Spady.1993.Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34 : 1637-1659.
13. Russell, D. W. 2003.The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72 : 137-174.
14. Guengerich, F. P. 1999.Cytochrome P-450 3A4: Regulation and role in drug metabolism. Annu. Rev. Pharmacol. Toxicol. 39 : 1-17.
15. Deb, S., M. Pandey, H. Adomat, and E. S. Guns.2012.Cytochrome P450 3A-mediated microsomal biotransformation of 1-, 25-dihydroxyvitamin D3 in mouse and human liver: Drug-related induction and inhibition of catabolism. Drug Metab. Dispos. 40 : 907-918.
16. Huang, P., B. Zhu, L. S. Wang, D. S. Ouyang, S. L. Huang, X. P. Chen, and H. H. Zhou.2003.Relationship between CYP3A activity and breast cancer susceptibility in Chinese Han women. Eur. J. Clin. Pharmacol. 59 : 471-476
17. Honda, A., G. Salen, Y. Matsuzaki, A. K. Batta, G. Xu, E. Leitersdorf, G. S. Tint, S. K. Erickson, N. Tanaka, and S. Shefer.2001.Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/-mice but not in cerebrotendinous xanthomatosis. J. Biol. Chem. 276 : 34579-34585.
18. Diczfalusy, U., H. Nylén, P. Elander, and L. Bertilsson.2011.4 ?-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans. Br. J. Clin. Pharmacol. 71 : 183-189.
19. Bodin, K., U. Andersson, E. Rystedt, E. Ellis, M. Norlin, I. Pikuleva, G. Eggertsen, I. Björkhem, and U. Diczfalusy.2002.Metabolism of 4 beta-hydroxycholesterol in humans. J. Biol. Chem. 277 : 31534-31540.
20. Bodin, K., L. Bretillon, Y. Aden, L. Bertilsson, U. Broomé, C. Einarsson, and U. Diczfalusy.2001.Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: Evidence for involvement of cytochrome p450 3A4. J. Biol. Chem. 276 : 38685-38689.
21. Honda, A., T. Miyazaki, T. Ikegami, J. Iwamoto, T. Maeda, T. Hirayama, Y. Saito, T. Teramoto, and Y. Matsuzaki.2011.Cholesterol 25-hydroxylation activity of CYP3A. J. Lipid Res. 52 : 1509-1516.
22. Swell, L., C. C. Schwartz, J. Gustafsson, H. Danielsson, and Z. R. Vlahcevic.1981.A quantitative evaluation of the conversion of 25-hydroxycholesterol to bile acids in man. Biochim. Biophys. Acta.663 : 163-168.
23. Adams, C. M., J. Reitz, J. K. De Brabander, J. D. Feramisco, L. Li, M. S. Brown, and J. L. Goldstein.2004.Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J. Biol. Chem. 279 : 52772-52780.
24. Radhakrishnan, A., Y. Ikeda, H. J. Kwon, M. S. Brown, and J. L. Goldstein.2007.Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig. Proc. Natl. Acad. Sci. USA.104 : 6511-6518.
25. van Herwaarden, A. E., E. Wagenaar, C. M. van der Kruijssen, R. A. van Waterschoot, J. W. Smit, J. Y. Song, M. A. van der Valk, O. van Tellingen, J. W. van der Hoorn, H. Rosing, et al.2007.Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J. Clin. Invest. 117 : 3583-3592.
26. Engels, F. K., A. Sparreboom, R. A. Mathot, and J. Verweij.2005. Potential for improvement of docetaxel-based chemotherapy: A pharmacological review. Br. J. Cancer.93 : 173-177.
27. Kazuki, Y., K. Kobayashi, S. Aueviriyavit, T. Oshima, Y. Kuroiwa, Y. Tsukazaki, N. Senda, H. Kawakami, S. Ohtsuki, S. Abe, et al.2013. Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Hum. Mol. Genet. 22 : 578-592.
28. Perloff, M. D., L. L. von Moltke, M. H. Court, T. Kotegawa, R. I. Shader, and D. J. Greenblatt.2000.Midazolam and triazolam biotransformation in mouse and human liver microsomes: Relative contribution of CYP3A and CYP2C isoforms. J. Pharmacol. Exp. Ther. 292 : 618-628.
29. Bligh, E. G., and W. J. Dyer. 1959.A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 : 911-917.
30. Lenicek, M., M. Juklova, J. Zelenka, J. Kovar, M. Lukas, M. Bortlik, and L. Vitek.2008.Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption. Clin. Chem. 54 : 1087-1088.
31. Dooley, K. A., S. Millinder, and T. F. Osborne.1998.Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y. J. Biol. Chem. 273 : 1349-1356.
32. Miettinen, T. A., R. S. Tilvis, and Y. A. Kesäniemi.1990.Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am. J. Epidemiol. 131 : 20-31.
33. Li, T., and J. Y. Chiang.2005.Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am. J. Physiol. Gastrointest. Liver Physiol. 288 : G74-G84.
34. Ma, Y., and D. Liu.2012.Activation of pregnane X receptor by pregnenolone 16 ?-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. PLoS ONE.7 : E38734.
35. Spady, D. K., J. A. Cuthbert, M. N. Willard, and R. S. Meidell. 1995.Adenovirus-mediated transfer of a gene encoding cholesterol 7 alpha-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J. Clin. Invest. 96 : 700-709.
36. Pullinger, C. R., C. Eng, G. Salen, S. Shefer, A. K. Batta, S. K. Erickson, A. Verhagen, C. R. Rivera, S. J. Mulvihill, M. J. Malloy, et al.2002.Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J. Clin. Invest. 110 : 109-117.
37. Chiang, J. Y., R. Kimmel, and D. Stroup.2001.Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene.262 : 257-265.
38. Repa, J. J., K. E. Berge, C. Pomajzl, J. A. Richardson, H. Hobbs, and D. J. Mangelsdorf.2002.Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 277 : 18793-18800.
39. Forman, B. M., E. Goode, J. Chen, A. E. Oro, D. J. Bradley, T. Perlmann, D. J. Noonan, L. T. Burka, T. McMorris, W. W. Lamph, et al.1995.Identification of a nuclear receptor that is activated by farnesol metabolites. Cell.81 : 687-693.
40. Lu, T. T., M. Makishima, J. J. Repa, K. Schoonjans, T. A. Kerr, J. Auwerx, and D. J. Mangelsdorf.2000.Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell.6 : 507-515.
41. Nury, T., M. Samadi, A. Varin, T. Lopez, A. Zarrouk, M. Boumhras, J. M. Riedinger, D. Masson, A. Vejux, and G. Lizard.2013.Biological activities of the LXR ? and ? agonist, 4 ?-hydroxycholesterol, and of its isomer, 4 ?-hydroxycholesterol, on oligodendrocytes: Effects on cell growth and viability, oxidative and inflammatory status. Biochimie.95 : 518-530.
42. Lund, E. G., T. A. Kerr, J. Sakai, W. P. Li, and D. W. Russell.1998. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J. Biol. Chem. 273 : 34316-34327.
43. Li, X., W. M. Pandak, S. K. Erickson, Y. Ma, L. Yin, P. Hylemon, and S. Ren.2007.Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate, in hepatocytes. J. Lipid Res. 48 : 2587-2596.
44. Lund, E., I. Björkhem, C. Furster, and K. Wikvall.1993.24-, 25-and 27-hydroxylation of cholesterol by a purifi ed preparation of 27-hydroxylase from pig liver. Biochim. Biophys. Acta.1166 : 177-182.
45. Smith, L. L. 1981.Cholesterol Autoxidation. Plenum Press, New York.
46. Schwarz, M., E. G. Lund, R. Lathe, I. Björkhem, and D. W. Russell. 1997.Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J. Biol. Chem. 272 : 23995-24001.
47. Kandutsch, A. A., H. J. Heiniger, and H. W. Chen.1977.Effects of 25-hydroxycholesterol and 7-ketocholesterol, inhibitors of sterol synthesis, administered orally to mice. Biochim. Biophys. Acta.486 : 260-272.
48. Horton, J. D., I. Shimomura, M. S. Brown, R. E. Hammer, J. L. Goldstein, and H. Shimano.1998.Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 101 : 2331-2339.
49. Inoue, S., K. Yoshinari, M. Sugawara, and Y. Yamazoe.2011. Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Mol. Pharmacol. 79 : 148-156.
50. Hunt, C. M., W. R. Westerkam, G. M. Stave, and J. A. Wilson.1992. Hepatic cytochrome P-4503A (CYP3A) activity in the elderly. Mech. Ageing Dev. 64 : 189-199.
51. Sonoda, J., L. W. Chong, M. Downes, G. D. Barish, S. Coulter, C. Liddle, C. H. Lee, and R. M. Evans.2005.Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc. Natl. Acad. Sci. USA.102 : 2198-2203.