Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L)

Biochemical Pharmacology

Volumn 57, Issue 10, 1999, Pages 1199-1208

  Xia, Zhenlei ^a   Lundgren, Bo ^a   Bergstrand, Anders ^b   DePierre, Joseph W ^a   Nässberger, Lennart ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antidepressants; Apoptosis; Bcl 2; Bcl X(L); HL 60 cells; Mitochondrial membrane potential; Reactive oxygen species

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; CLOMIPRAMINE; IMIPRAMINE; PROTEIN BCL 2; PROTEIN BCL X; REACTIVE OXYGEN METABOLITE;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ELECTRON MICROSCOPY; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIDEPRESSIVE AGENTS; APOPTOSIS; BCL-X PROTEIN; CELL SURVIVAL; CITALOPRAM; CLOMIPRAMINE; HL-60 CELLS; HUMANS; IMIPRAMINE; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRANSFECTION;

EID: 0033562841     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00009-X     Document Type: Article

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