Camptothecin disrupts androgen receptor signaling and suppresses prostate cancer cell growth

Biochemical and Biophysical Research Communications

Volumn 394, Issue 2, 2010, Pages 297-302

  Liu, Shicheng ^a   Yuan, Yiming ^b   Okumura, Yutaka ^a   Shinkai, Norihiro ^a   Yamauchi, Hitoshi ^a  

^a Nipro Corporation   (Japan)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Androgen receptor; Camptothecin; Prostate cancer; PSA

Indexed keywords

ANDROGEN RECEPTOR; CAMPTOTHECIN; METRIBOLONE; PROSTATE SPECIFIC ANTIGEN; TANESPIMYCIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANDROGEN ANTAGONISTS; ANDROGENS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 77950187693     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.164     Document Type: Article

References (15)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics. CA Cancer J. Clin. 57 (2007) 43-66
2. Khan N., Asim M., Afaq F., Abu Zaid M., and Mukhtar H. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 68 (2008) 8555-8563
3. Forster T.H., Stoffel F., and Gasser T.C. Hormone therapy in advanced prostate cancer. Front. Radiat. Ther. Oncol. 36 (2002) 49-65
4. Heinlein C.A., and Chang C. Androgen receptor in prostate cancer. Endocr. Rev. 25 (2004) 276-308
5. Wall M.E., Wani M.C., Cooke C.E., Palmer K.H., McPhail A.T., and Slim G.A. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminate. J. Am. Chem. Soc. 88 (1966) 3888-3890
6. Hsiang Y.H., Lihou M.G., and Liu L.F. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49 (1989) 5077-5082
7. Hsiang Y.H., Hertzberg R., Hecht S., and Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260 (1985) 14873-14878
8. Shao R.G., Cao C.X., Zhang H., Kohn K.W., Wold M.S., and Pommier Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J. 18 (1999) 1397-1406
9. Liu S., and Yamauchi H. Etoposide induces growth arrest and disrupts androgen receptor signaling in prostate cancer cells. Oncol. Rep. 23 (2010) 165-170
10. Chang C., Saltzman A., Yeh S., Young W., Keller E., Lee H.J., Wang C., and Mizokami A. Androgen receptor: an overview. Crit. Rev. Eukaryot. Gene Expr. 5 (1995) 97-125
11. Gobinet J., Poujol N., and Sultan C. Molecular action of androgens. Mol. Cell. Endocrinol. 198 (2002) 15-24
12. Gelmann E.P. Molecular biology of the androgen receptor. J. Clin. Oncol. 20 (2002) 3001-3015
13. Huggins C., and Hodges C.V. Studies on prostatic cancer, effect of castration, of estrogen and of androgen injection on serum phosphatase in metastatic carcinoma of the prostate. Cancer Res. 1 (1941) 293-297
14. Ai J., Wang Y., Dar J.A., Liu J., Liu L., Nelson J.B., and Wang Z. HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer. Mol. Endocrinol. 23 (2009) 1963-1972
15. Dixon S.C., Knopf K.B., and Figg W.D. The control of prostate-specific antigen expression and gene regulation by pharmacological agents. Pharmacol. Rev. 53 (2001) 73-91