ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line

Biochemical and Biophysical Research Communications

Volumn 409, Issue 4, 2011, Pages 738-744

  Bogurcu, Nuray ^a   Sevimli Gur, Canan ^a   Ozmen, Besra ^a   Bedir, Erdal ^a   Korkmaz, Kemal Sami ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

H2AX; Apoptosis; ATM(S1981) phosphorylation; DNA damage; ROS; Topoisomerase I inhibition

Indexed keywords

(2,2 DIMETHYLACRYL)ALKANNIN; 5 METHOXY BETA,BETA DIMETHYLACRYLALKANNIN; 5 METHOXYACETYLALKANNIN; 5 METHOXYDEOXYALKANNIN; 8 METHOXYDEOXYALKANNIN; ACETYLALKANNIN; ACETYLCYSTEINE; ALKANNIN; ANTINEOPLASTIC AGENT; ATM PROTEIN; CASPASE 3; CHECKPOINT KINASE 2; DEOXYALKANNIN; DNA TOPOISOMERASE; DOXORUBICIN; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALKANNA CAPPADOCICA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; IN VITRO STUDY; LEUKEMIA CELL LINE; MEDICINAL PLANT; MITOCHONDRION; PLASMID; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BORAGINACEAE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; HISTONES; HUMANS; MITOCHONDRIA; NAPHTHOQUINONES; REACTIVE OXYGEN SPECIES; TOPOISOMERASE I INHIBITORS;

ALKANNA;

EID: 79959206293     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.078     Document Type: Article

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