Bax releases cytochrome c preferentially from a complex between porin and adenine nucleotide translocator. Hexokinase activity suppresses this effect

Molecular Biology Reports

Volumn 29, Issue 1-2, 2002, Pages 93-96

  Vyssokikh, Mikhail Y ^a   Zorova, Ljubava ^a   Zorov, Dmitry ^a   Heimlich, Gerd ^b   Jürgensmeier, Juliane M ^b   Brdiczka, Dieter ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Apoptosis; Growth factor; Mitochondria; Protein kinase B Akt; Structure

Indexed keywords

FORMICIDAE;

ADENINE NUCLEOTIDE TRANSLOCASE; CYTOCHROME C; HEXOKINASE; ONCOPROTEIN; PORIN; PROTEIN BAX; PROTEIN BCL 2; VOLTAGE DEPENDENT ANION CHANNEL;

ARTICLE; BINDING SITE; BRAIN; GENETICS; MACROMOLECULE; METABOLISM; MITOCHONDRION; PROTEIN BINDING;

BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; BRAIN; CYTOCHROME C GROUP; HEXOKINASE; MACROMOLECULAR SUBSTANCES; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; PORINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 0036042248     PISSN: 03014851     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020383108620     Document Type: Article

References (8)

1. Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore
2. ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by 31P nuclear magnetic resonance
3. Localization of the ATP/ADP translocator in the inner membrane and regulation of contact sites between mitochondrial envelope membranes by ADP. A study on freeze fractured isolated liver mitochondria
4. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
5. Reconsidering mitochondrial structure: New views of an old organelle
6. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
7. Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilinD
8. Effect of macromolecules on the structure of the mitochondrial inter-membrane space and the regulation of hexokinase