Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (Perforin-2) encoded by macrophage-expressed gene 1

Journal of Innate Immunity

Volumn 5, Issue 2, 2013, Pages 185-194

  McCormack, Ryan ^a   De Armas, Lesley R ^a   Shiratsuchi, Motoaki ^a   Ramos, Jahir E ^a   Podack, Eckhard R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Bactericidal activity; Immune defense; Innate immunity; Intracellular bacterial replication; Non phagocytic cells

Indexed keywords

LYSOZYME; MESSENGER RNA; PERFORIN; PERFORIN 2; RED FLUORESCENT PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACID FAST BACTERIUM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL DAMAGE; CELL WALL; CHANNEL GATING; CONTROLLED STUDY; CORRELATIONAL STUDY; EMBRYO; FIBROBLAST; INTRACELLULAR BACTERIUM; LYSIS; MACROPHAGE EXPRESSED GENE 1; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL INFECTIONS; CELL LINE; DNA, BACTERIAL; FIBROBLASTS; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SPACE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PORE FORMING CYTOTOXIC PROTEINS; PRIMARY CELL CULTURE; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; TRANSGENES;

EID: 84876159597     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000345249     Document Type: Article

References (25)

1. Spilsbury K, O'Mara MA, Wu WM, Rowe PB, Symonds G, Takayama Y: Isolation of a novel macrophage-specific gene by differential cDNA analysis. Blood 1995; 85: 1620-1629.
2. Wiens M, Korzhev M, Krasko A, Thakur NL, Perovic-Ottstadt S, Breter HJ, Ushijima H, Diehl-Seifert B, Muller IM, Muller WE: Innate immune defense of the sponge suberites domuncula against bacteria involves a myd88-dependent signaling pathway. Induction of a perforin-like molecule. J Biol Chem 2005; 280: 27949-27959.
3. D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI: Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evol Biol 2012; 12: 59.
4. DiScipio RG, Gehring MR, Podack ER, Kan CC, Hugli TE, Fey GH: Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9. Proc Natl Acad Sci USA 1984; 81: 7298-7302.
5. Podack ER, Tschopp J: Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. Proc Natl Acad Sci USA 1982; 79: 574-578.
6. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H: Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 1994; 369: 31-37.
7. Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H, Podack ER: Structure and function of human perforin. Nature 1988; 335: 448-451.
8. Shinkai Y, Takio K, Okumura K: Homology of perforin to the ninth component of complement (C9). Nature 1988; 334: 525-527.
9. Podack ER, Dennert G: Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells. Nature 1983; 302: 442-445.
10. Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA: The molecular basis for perforin oligomerization and transmembrane pore assembly. Immunity 2009; 30: 684-695.
11. Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC: The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature 2010; 468: 447-451.
12. Wan YY, Flavell RA: Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA 2005; 102: 5126-5131.
13. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ: Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001; 7: 1165-1176.
14. Elkins KL, Cowley SC, Conlan JW (eds): Mesurement of Macrophage-Mediated Killing of Intracellular Bacteria including Francisella and Mycobacteria. Hoboken, Wiley, 2011, vol 14.25.1-14.25.13.
15. Kuballa P, Nolte WM, Castoreno AB, Xavier RJ: Autophagy and the immune system. Annu Rev Immunol 2012; 30: 611-646.
16. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-5728.
17. Birmingham CL, Smith AC, Bakowski MA, Yoshimori T, Brumell JH: Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem 2006; 281: 11374-11383.
18. Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T: The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Mol Biol Cell 2011; 22: 2290-2300.
19. Bukholm G, Berdal BP, Haug C, Degre M: Mouse fibroblast interferon modifies Salmonella typhimurium infection in infant mice. Infect Immun 1984; 45: 62-66.
20. He X, Zhang Y, Yu Z: An Mpeg (macrophage expressed gene) from the Pacific oyster Crassostrea gigas: molecular characterization and gene expression. Fish Shellfish Immunol 2011; 30: 870-876.
21. Kemp IK, Coyne VE: Identification and characterisation of the Mpeg1 homologue in the South African abalone, Haliotis midae. Fish Shellfish Immunol 2011; 31: 754-764.
22. Mah SA, Moy GW, Swanson WJ, Vacquier VD: A perforin-like protein from a marine mollusk. Biochem Biophys Res Commun 2004; 316: 468-475.
23. Wang GD, Zhang KF, Zhang ZP, Zou ZH, Jia XW, Wang SH, Lin P, Wang YL: Molecular cloning and responsive expression of macrophage expressed gene from small abalone Haliotis diversicolor supertexta. Fish Shellfish Immunol 2008; 24: 346-359.
24. Schreiber RD, Morrison DC, Podack ER, Muller-Eberhard HJ: Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins. J Exp Med 1979; 149: 870-882.
25. Saitoh T, Fujita N, Yoshimori T, Akira S: Autophagy and innate immunity (in Japanese). Tanpakushitsu Kakusan Koso 2008; 53: 2279-2285.