Application of plant metabonomics in quality assessment for large-scale production of traditional Chinese medicine

Planta Medica

Volumn 79, Issue 11, 2013, Pages 897-908

  Ning, Zhangchi ^a   Lu, Cheng ^b   Zhang, Yuxin ^a   Zhao, Siyu ^a   Liu, Baoqin ^c   Xu, Xuegong ^c   Liu, Yuanyan ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c Traditional Chinese Medicine Hospital   (China)

Author keywords

discrimination; large scale production; pharmaceutics; plant metabonomics; processing

Indexed keywords

ANALYTIC METHOD; BIOLOGICAL ACTIVITY; BIOMICS; CHEMOMETRICS; CHINESE MEDICINE; DATA PROCESSING; METABONOMICS; QUALITY CONTROL; REVIEW;

DRUGS, CHINESE HERBAL; MEDICINE, CHINESE TRADITIONAL; METABOLOMICS; PLANTS; QUALITY CONTROL;

EID: 84881101448     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328656     Document Type: Review

References (114)

1. Nicholson J. K., Wilson I. D. Opinion: understanding global systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov: 2003; 2 668 676 (Pubitemid 37361770)
2. Hui-Ru T., Yu-Lan W. Metabonomics: a revolution in progress. Prog Biochem Biophys: 2006; 33 401 417
3. Dong J., Xu L., Cao H., Dai X., Li X., Yang S., Chen Z. A new data processing method for metabonomic and its application in a study of diabetes. Chin J Magn Reson: 2007; 24 393
4. Lu Y. H., Hao H. P., Wang G. J., Chen X. H., Zhu X. X., Xiang B. R., Huang Q. A JY Metabolomics approach to the biochemical differentiation of Traditional Chinese Medicine syndrome types of hypertension. Chin J Clin Pharmacol Ther: 2007; 12 1144 1150
5. Cheng L. L., Chang I. W., Louis D. N., Gonzalez R. G. Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. Cancer Res: 1998; 58 1825 1832 (Pubitemid 28217454)
6. Cheng L., Ma M., Becerra L., Ptak T., Tracey I., Lackner A., Gonzalez R. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A: 1997; 94 6408 6413 (Pubitemid 27270698)
7. Lao Y. M., Jiang J. G., Yan L. Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine. Br J Pharmacol: 2009; 157 1128 1141
8. Kim N., Kim K., Choi B. Y., Lee D. H., Shin Y. S., Bang K. H., Cha S. W., Lee J. W., Choi H. K., Jang D. S. Metabolomic approach for age discrimination of Panax ginseng using UPLC-Q-Tof MS. J Agric Food Chem: 2011; 59 10435 10441
9. Holmes E., Wilson I. D., Nicholson J. K. Metabolic phenotyping in health and disease. Cell: 2008; 134 714 717
10. Yuliana N. D., Khatib A., Choi Y. H., Verpoorte R. Metabolomics for bioactivity assessment of natural products. Phytother Res: 2010; 25 157 169
11. Nobeli I., Thornton J. M. A bioinformaticians view of the metabolome. Bioessays: 2006; 28 534 545
12. Wold S., Sjöström M., Eriksson L. PLS-regression: a basic tool of chemometrics. Chemom Intell Lab Syst: 2001; 58 109 130 (Pubitemid 33033283)
13. Gabrielsson J., Jonsson H., Airiau C., Schmidt B., Escott R., Trygg J. OPLS methodology for analysis of pre-processing effects on spectroscopic data. Chemom Intell Lab Syst: 2006; 84 153 158 (Pubitemid 44708406)
14. Wold S., Trygg J., Berglund A., Antti H. Some recent developments in PLS modeling. Chemom Intell Lab Syst: 2001; 58 131 150 (Pubitemid 33033284)
15. Ceglarek U., Leichtle A., Brügel M., Kortz L., Brauer R., Bresler K., Thiery J., Fiedler G. M. Challenges and developments in tandem mass spectrometry based clinical metabolomics. Mol Cell Endocrinol: 2009; 301 266 271
16. Hastings C. A., Norton S. M., Roy S. New algorithms for processing and peak detection in liquid chromatography/mass spectrometry data. Rapid Commun Mass Spectrom: 2002; 16 462 467 (Pubitemid 34174686)
17. Danielsson R., Bylund D., Markides K. E. Matched filtering with background suppression for improved quality of base peak chromatograms and mass spectra in liquid chromatography-mass spectrometry. Anal Chim Acta: 2002; 454 167 184 (Pubitemid 34185417)
18. Andreev V. P., Rejtar T., Chen H. S., Moskovets E. V., Ivanov A. R., Karger B. L. A universal denoising and peak picking algorithm for LC-MS based on matched filtration in the chromatographic time domain. Anal Chem: 2003; 75 6314 6326 (Pubitemid 37420627)
19. Bueschl C., Kluger B., Berthiller F., Lirk G., Winkler S., Krska R., Schuhmacher R. MetExtract: a new software tool for the automated comprehensive extraction of metabolite-derived LC/MS signals in metabolomics research. Bioinformatics: 2012; 28 736 738
20. Mok D. KW, Chau F. T. Chemical information of Chinese medicines: A challenge to chemist. Chemom Intell Lab Syst: 2006; 82 210 217
21. Xie P., Chen S., Liang Y. Z., Wang X., Tian R., Upton R. Chromatographic fingerprint analysis-a rational approach for quality assessment of traditional Chinese herbal medicine. J Chromatogr A: 2006; 1112 171 180
22. Li L., Sun B., Zhang Q., Fang J., Ma K., Li Y., Chen H., Dong F., Gao Y., Li F., Yan X. Metabonomic study on the toxicity of Hei-Shun-Pian, the processed lateral root of Aconitum carmichaelii Debx. (Ranunculaceae). J Ethnopharmacol: 2008; 116 561 568 (Pubitemid 351335197)
23. Zhang A., Sun H., Wang P., Han Y., Wang X. Recent and potential developments of biofluid analyses in metabolomics. J Proteom: 2012; 75 1079 1088
24. Duan L. X., Chen T. L., Li M., Chen M., Zhou Y. Q., Cui G. H., Zhao A. H., Jia W., Huang L. Q., Qi X. Use of the metabolomics approach to characterize Chinese medicinal material Huangqi. Mol Plant: 2012; 5 376 386
25. Xie G., Plumb R., Su M., Xu Z., Zhao A., Qiu M., Long X., Liu Z., Jia W. Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. J Sep Sci: 2008; 31 1015 1026 (Pubitemid 351649827)
26. Yi L., Yuan D., Liang Y., Xie P., Zhao Y. Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods. Anal Chim Acta: 2009; 649 43 51
27. Wang L., Wang X., Kong L. Automatic authentication and distinction of Epimedium koreanum and Epimedium wushanense with HPLC fingerprint analysis assisted by pattern recognition techniques. Biochem Syst Ecol: 2012; 40 138 145
28. Francisco C. S., Messiano G. B., Lopes L. M., Tininis A. G., de Oliveira J. E., Capellari L. Jr. Classification of Aristolochia species based on GC-MS and chemometric analyses of essential oils. Phytochemistry: 2008; 69 168 175 (Pubitemid 350256792)
29. Sun H., Wang M., Zhang A., Ni B., Dong H., Wang X. UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach. Phytochem Anal: 2013; 24 263 276
30. Liu N. Q., Cao M., Frederich M., Choi Y. H., Verpoorte R., van der Kooy F. Metabolomic investigation of the ethnopharmacological use of Artemisia afra with NMR spectroscopy and multivariate data analysis. J Ethnopharmacol: 2010; 128 230 235
31. Lucio-Gutiérrez J. R., Coello J., Maspoch S. Application of near infrared spectral fingerprinting and pattern recognition techniques for fast identification of Eleutherococcus senticosus. Food Res Int: 2011; 44 557 565
32. Lu G. H., Chan K., Liang Y. Z., Leung K., Chan C. L., Jiang Z. H., Zhao Z. Z. Development of high performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related Umbelliferae herbs. J Chromatogr A: 2005; 1073 383 392 (Pubitemid 40544514)
33. Tistaert C., Dejaegher B., Chataigne G., Van Minh C., Quetin-Leclercq J., Vander Heyden Y. Dissimilar chromatographic systems to indicate and identify antioxidants from Mallotus species. Talanta: 2011; 83 1198 1208
34. Qin X., Dai Y., Liu N. Q., Li Z., Liu X., Hu J., Choi Y. H., Verpoorte R. Metabolic fingerprinting by (1)H-NMR for discrimination of the two species used as Radix Bupleuri. Planta Med: 2012; 78 926 933
35. Tian R. T., Xie P. S., Liu H. P. Evaluation of traditional Chinese herbal medicine: Chaihu (Bupleuri Radix) by both high-performance liquid chromatographic and high-performance thin-layer chromatographic fingerprint and chemometric analysis. J Chromatogr A: 2009; 1216 2150 2155
36. Fukuda E., Baba M., Iwasaki N., Uesawa Y., Arifuku K., Kamoe O., Tsubono K., Okada Y. Identification of Glycyrrhiza species by direct analysis in real time mass spectrometry. Nat Prod Commun: 2010; 5 1755 1758
37. Pan R., Guo F., Lu H., Feng W. W., Liang Y. Z. Development of the chromatographic fingerprint of Scutellaria barbatan D. Don by GC-MS combined with chemometrics methods. J Pharm Biomed Anal: 2011; 55 391 396
38. Zhao Y. Y., Zhang Y., Lin R. C., Sun W. J. An expeditious HPLC method to distinguish Aconitum kusnezoffii from related species. Fitoterapia: 2009; 80 333 338
39. Xiang Z., Wang X. Q., Cai X. J., Zeng S. Metabolomics study on quality control and discrimination of three Curcuma species based on gas chromatograph-mass spectrometry. Phytochem Anal: 2011; 22 411 418
40. Wu H. W. Studies on warm and cold nature of JiangHuang and YuJin based on metabonomics [dissertation]. Beijing Chinese Academy of Chinese Medical Sciences: 2011
41. Grubesić R. J., Vukovic J., Kremer D., Vladimir-Knezevic S. Spectrophotometric method for polyphenols analysis: prevalidation and application on Plantago L. species. J Pharm Biomed Anal: 2005; 39 837 842 (Pubitemid 41196109)
42. Dan M., Su M., Gao X., Zhao T., Zhao A., Xie G., Qiu Y., Zhou M., Liu Z., Jia W. Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry: 2008; 69 2237 2244
43. Fukuda E., Yoshida M., Baba M., Uesawa Y., Suzuki R., Kamo O., Tsubono K., Arifuku K., Yatsunami K., Okada Y. Application to classification of mulberry leaves using multivariate analysis of proton NMR metabolomic data. Nat Prod Commun: 2011; 6 1621 1625
44. Kong W. J., Zhao Y. L., Xiao X. H., Jin C., Li Z. L. Quantitative and chemical fingerprint analysis for quality control of rhizoma Coptidischinensis based on UPLC-PAD combined with chemometrics methods. Phytomedicine: 2009; 16 950 959
45. Lai Y., Ni Y., Kokot S. Discrimination of Rhizoma Corydalis from two sources by near-infrared spectroscopy supported by the wavelet transform and least-squares support vector machine methods. Vib Spectrosc: 2011; 56 154 160
46. Zou P., Hong Y., Koh H. L. Chemical fingerprinting of Isatis indigotica root by RP-HPLC and hierarchical clustering analysis. J Pharm Biomed Anal: 2005; 38 514 520 (Pubitemid 40733189)
47. Chen Y., Xie M. Y., Yan Y., Zhu S. B., Nie S. P., Li C., Wang Y. X., Gong X. F. Discrimination of Ganoderma lucidum according to geographical origin with near infrared diffuse reflectance spectroscopy and pattern recognition techniques. Anal Chim Acta: 2008; 618 121 130
48. Gong F., Liang Y. Z., Xu Q. S., Chau F. T. Gas chromatography-mass spectrometry and chemometric resolution applied to the determination of essential oils in Cortex cinnamomi. J Chromatogr A: 2001; 905 193 205 (Pubitemid 33646387)
49. Guo F. Q., Liang Y. Z., Xu C. J., Li X. N., Huang L. F. Analyzing of the volatile chemical constituents in Artemisia capillaris herba by GC-MS and correlative chemometric resolution methods. J Pharm Biomed Anal: 2004; 35 469 478
50. Jung J. H., Hong J. GC/MS combined with chemometrics methods for quality control of Schizonepeta tenuifolia Briq: Determination of essential oils. Microchem J: 2011; 97 274 281
51. Li W., Xing L., Cai Y., Qu H. Classification and quantification analysis of Radix scutellariae from different origins with near infrared diffuse reflection spectroscopy. Vib Spectrosc: 2011; 55 58 64
52. Ioset K. N., Nyberg N. T., Van Diermen D., Malnoe P., Hostettmann K., Shikov A. N., Jaroszewski J. W. Metabolic profiling of Rhodiola rosea rhizome s by (1)H-NMR spectroscopy. Phytochem Anal: 2011; 22 158 165
53. Zhao C., Chan H. Y., Yuan D., Liang Y., Lau T. Y., Chau F. T. Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. Phytochem Anal: 2011; 22 503 508
54. Tianniam S., Bamba T., Fukusaki E. Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots. J Biosci Bioeng: 2010; 109 89 93
55. Wang H. L., Yao W. F., Zhu D. N., Hu Y. Z. Chemical fingerprinting by HPLC-DAD-ELSD and principal component analysis of Polygala japonica from different locations in China. Chin J Nat Med: 2010; 8 343 348
56. Suzuki R., Ikeda Y., Yamamoto A., Saima T., Fujita T., Fukuda T., Fukuda E., Baba M., Okada Y., Shirataki Y. Classification using NMR-based metabolomics of Sophora flavescens grown in Japan and China. Nat Prod Commun: 2012; 7 1453 1455
57. Kim N., Kim K., Choi B. Y., Lee D., Shin Y. S., Bang K. H., Cha S. W., Lee J. W., Choi H. K., Jang D. S. Metabolomic approach for age discrimination of Panax ginseng using UPLC-Q-Tof MS. J Agric Food Chem: 2011; 59 10435 10441
58. Yang S. O., Shin Y. S., Hyun S. H., Cho S., Bang K. H., Lee D., Choi S. P., Choi H. K. NMR-based metabolic profiling and differentiation of ginseng roots according to cultivation ages. J Pharm Biomed Anal: 2012; 58 19 26
59. Xue S. Y., Wang X. J., Sun H. F., Zhang L. Z., Qin X. M., Li Z. Y. Metabolomic study of flower buds of Tussilago farfara in different development stages by GC-MS. Zhongguo Zhong Yao Za Zhi: 2012; 37 2863 2869
60. Wang J. H., Wang Z. H. Studies on enhancing therapeutic action of processing Chinese crude drugs. Lishizhen J Tradit Chin Med Res: 1997; 8 67 68
61. Sun H., Ni B., Zhang A., Wang M., Dong H., Wang X. Metabolomics study on Fuzi and its processed products using ultra-performance liquid-chromatography/ electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition analysis. Analyst: 2012; 137 170 185
62. Kim S. H., Hyun S. H., Yang S. O., Choi H. K., Lee B. Y. (1)H-NMR-based discrimination of thermal and vinegar treated ginseng roots. J Food Sci: 2010; 75 C577 C581
63. Angelova N., Kong H. W., van der Heijden R., Yang S. Y., Choi Y. H., Kim H. K., Wang M., Hankemeier T., van der Greef J., Xu G., Verpoorte R. Recent methodology in the phytochemical analysis of ginseng. Phytochem Anal: 2008; 19 2 16 (Pubitemid 351247238)
64. Zhang H. M., Li S. L., Zhang H., Wang Y., Zhao Z. L., Chen S. L., Xu H. X. Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach. J Pharm Biomed Anal: 2012; 62 258 273
65. Lee J. I., Ha Y. W., Choi T. W., Kim H. J., Kim S. M., Jang H. J., Choi J. H., Choi M. H., Chung B. C., Sethi G., Kim S. H., Ahn K. S., Choi S. H., Shim B. S. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med: 2011; 77 133 140
66. Kim S. N., Ha Y. W., Shin H., Son S. H., Wu S. J., Kim Y. S. Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J Pharm Biomed Anal: 2007; 45 164 170 (Pubitemid 47376958)
67. Leung K. W., Wong A. ST. Pharmacology of ginsenosides: a literature review. Chin Med: 2010; 5 20
68. Yun T. K., Lee Y. S., Lee Y. H., Kim S. I., Yun H. Y. Anticarcinogenic effect of Panax ginseng CA Meyer and identification of active compounds. J Korean Med Sci: 2001; 16 6 18
69. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci: 2001; 16 S28 S37
70. Kim W. Y., Kim J. M., Han S. B., Lee S. K., Kim N. D., Park M. K., Kim C. K., Park J. H. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod: 2000; 63 1702 1704 (Pubitemid 32038624)
71. Kwon S. W., Han S. B., Park I. H., Kim J. M., Park M. K., Park J. H. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A: 2001; 921 335 339 (Pubitemid 32537840)
72. Park I. H., Kim N. Y., Han S. B., Kim J. M., Kwon S. W., Kim H. J., Park M. K., Park J. H. Three new dammarane glycosides from heat processed ginseng. Arch Pharm Res: 2002; 25 428 432
73. Lee S. M., Shon H. J., Choi C. S., Hung T. M., Min B. S., Bae K. H. Ginsenosides from heat processed ginseng. Chem Pharm Bull: 2009; 57 92 94
74. Park I. H., Han S. B., Kim J. M., Piao L., Kwon S. W., Kim N. Y., Kang T. L., Park M. K., Park J. H. Four new acetylated ginsenosides from processed ginseng (sun ginseng). Arch Pharm Res: 2002; 25 837 841 (Pubitemid 43066573)
75. Chan E. C., Yap S. L., Lau A. J., Leow P. C., Toh D. F., Koh H. L. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Commun Mass Spectrom: 2007; 21 519 528 (Pubitemid 46294300)
76. Toh D. F., New L. S., Koh H. L., Chan E. C. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng. J Pharm Biomed Anal: 2010; 52 43 50
77. Li S. L., Song J. Z., Qiao C. F., Zhou Y., Qian K., Lee K. H., Xu H. X. A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. J Pharm Biomed Anal: 2010; 51 812 823
78. Guo N., Fan B., Peng J., Yan H., Ma F., Yu Y. Ultra-performance LC/TOF MS analysis of fruits of Ligustrum lucidum for metabolomic research. Chin J Exp Tradit Med F: 2010; 10 131 133
79. Wang X. J. Based on NMR/UPLC plant metabonomics study on quality control of Polygala tenuifolia Willd [dissertation]. Shanxi Shanxi University: 2012
80. Ruan G. H., Li G. K. The study on the chromatographic fingerprint of Fructus xanthii by microwave assisted extraction coupled with GC-MS. J Chromatogr B Analyt Technol Biomed Life Sci: 2007; 850 241 248
81. Ni Y., Peng Y., Kokot S. Fingerprinting of complex mixtures with the use of high performance liquid chromatography, inductively coupled plasma atomic emission spectroscopy and chemometrics. Anal Chim Acta: 2008; 616 19 27
82. Tanaka K., Tamura T., Fukuda S., Batkhuu J., Sanchir C., Komatsu K. Quality evaluation of Astragali Radix using a multivariate statistical approach. Phytochemistry: 2008; 69 2081 2087
83. Okada T., Afendi F. M., Altaf-Ul-Amin M., Takahashi H., Nakamura K., Kanaya S. Metabolomics of medicinal plants: the importance of multivariate analysis of analytical chemistry data. Curr Comput Aided Drug Des: 2010; 6 179 196
84. Tang J. C., Zhang J. N., Wu Y. T., Li Z. X. Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity. Phytother Res: 2006; 20 1046 1051
85. Li H. B., Jiang Y., Wong C. C., Cheng K. W., Chen F. Evaluation of two methods for the extraction of antioxidants from medicinal plants. Anal Bioanal Chem: 2007; 388 483 488 (Pubitemid 46675987)
86. Martin J., Stöger E. A., Wiebrecht A. Praxisleitfaden TCM-Drogen-Vorbehandlung-Zubereitung-Sondervorschriften. Dtsch Zeitschrift Akupunktur (DZA): 2009; 52 72 74
87. Ding Y., Wu E. Q., Liang C., Chen J., Tran M. N., Hong C. H., Jang Y., Park K. L., Bae K., Kim Y. H., Kang J. S. Discrimination of cinnamon bark and cinnamon twig samples sourced from various countries using HPLC-based fingerprint analysis. Food Chem: 2011; 127 755 760
88. Ni Y., Zhang L., Churchill J., Kokot S. Application of high performance liquid chromatography for the profiling of complex chemical mixtures with the aid of chemometrics. Talanta: 2007; 72 1533 1539 (Pubitemid 46734136)
89. Li Y., Wu T., Zhu J., Wan L., Yu Q., Li X., Cheng Z., Guo C. Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. Pharm Biomed Anal: 2010; 52 597 602
90. Peng J. B., Jia H. M., Liu Y. T., Zhang H. W., Dong S., Zou Z. M. Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer. J Pharm Biomed Anal: 2011; 55 984 995
91. Yang C. F. Application of UPLC/RRLC/UFLC in study on Chinese materia medica and its preparation. Chin Tradit Herb Drugs: 2009; 39 1259 1263
92. Zhang L. J. The development of NMR. J Hebei Morm Univ: 2000; 24 224 227
93. Daolio C., Beltrame F. L., Ferreira A. G., Cass Q. B., Cortez D. A., Ferreira M. M. Classification of commercial Catuaba samples by NMR, HPLC and chemometrics. Phytochem Anal: 2008; 19 218 228 (Pubitemid 351722095)
94. Lin Y., Schiavo S., Orjala J., Vouros P., Kautz R. Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites. Anal Chem: 2008; 80 8045 8054
95. Ali K., Iqbal M., Korthout H. A., Maltese F., Fortes A. M., Pais M. S., Verpoorte R., Choi Y. H. NMR spectroscopy and chemometrics as a tool for anti-TNFalpha activity screening in crude extracts of grapes and other berries. Metabolomics: 2012; 8 1148 1161
96. Yang J., Xu G., Kong H., Zheng Y., Pang T., Yang Q. Artificial neural network classification based on high-performance liquid chromatography of urinary and serum nucleosides for the clinical diagnosis of cancer. J Chromatogr B Analyt Technol Biomed Life Sci: 2002; 780 27 33 (Pubitemid 35279740)
97. Yang J., Xu G., Zheng Y., Kong H., Pang T., Lv S., Yang Q. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases. J Chromatogr B Analyt Technol Biomed Life Sci: 2004; 813 59 65 (Pubitemid 39535429)
98. Yang J., Xu G., Zheng Y., Kong H., Wang C., Zhao X., Pang T. Strategy for metabonomics research based on high-performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry. J Chromatogr A: 2005; 1084 214 221 (Pubitemid 40966931)
99. Pham-Tuan H., Kaskavelis L., Daykin C. A., Janssen H. G. Method development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples. J Chromatogr B Analyt Technol Biomed Life Sci: 2003; 789 283 301 (Pubitemid 36549198)
100. Lenz E. M., Wilson I. D. Analytical strategies in metabonomics. J Proteome Res: 2007; 6 443 458 (Pubitemid 46340149)
101. Chace D. H., Kalas T. A. A biochemical perspective on the use of tandem mass spectrometry for newborn screening and clinical testing. Clin Biochem: 2005; 38 296 309 (Pubitemid 40342860)
102. Fan T. W., Lorkiewicz P. K., Sellers K., Moseley H. N., Higashi R. M., Lane A. N. Stable isotope-resolved metabolomics and applications for drug development. Pharmacol Ther: 2012; 133 366 391
103. Gad H. A., El-Ahmady S. H., Abou-Shoer M. I., Al-Azizi M. M. Application of chemometrics in authentication of herbal medicines: a review. Phytochem Anal: 2013; 24 1 24
104. Dharmaraj S., Jamaludin A. S., Razak H. M., Valliappan R., Ahmad N. A., Harn G. L., Ismail Z. The classification of Phyllanthus niruri Linn. according to location by infrared spectroscopy. Vib Spectrosc: 2006; 41 68 72
105. Vlachos N., Skopelitis Y., Psaroudaki M., Konstantinidou V., Chatzilazarou A., Tegou E. Applications of Fourier transform-infrared spectroscopy to edible oils. Anal Chim Acta: 2006; 573-574 459 465 (Pubitemid 44066965)
106. Kokalj M., Kolar J., Trafela T., Kreft S. Differences among Epilobium and Hypericum species revealed by four IR spectroscopy modes: transmission, KBr tablet, diffuse reflectance and ATR. Phytochem Anal: 2011; 22 541 546
107. Debonneville C., Thome M. A., Chaintreau A. Hyphenation of quadrupole MS to GC and comprehensive two-dimensional GC for the analysis of suspected allergens: review and improvement. J Chromatogr Sci: 2004; 42 450 455
108. Ronda F., Rodríguez-Nogales J. M., Sancho D. Multivariate optimisation of a capillary electrophoretic method for the separation of glutenins. Application to quantitative analysis of the endosperm storage proteins in wheat. Food Chem: 2008; 108 287 296
109. Ou L. J., Sun X. P., Liu Q. D., Mi S. Q., Wang N. S. Effects of Rhizoma Zingiberis and Pericarpium Citri reticulatae extracts on myocardial ischemia in rats. Zhong Yao Cai: 2009; 32 1723 1726
110. Ooi L. S., Li Y., Kam S. L., Wang H., Wong E. Y., Ooi V. E. Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume. Am J Chin Med: 2006; 34 511 522 (Pubitemid 43740987)
111. de Sousa D. P., Nobrega F. F., de Lima M. R., de Almeida R. N. Pharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Z Naturforsch C: 2011; 66 353 359
112. Zhang G. C., Fang S. M. Antioxidation of Pueraria lobata iIsoflavones. Zhong Yao Cai: 1997; 26 340 343
113. Qi C. F., Song S. W., Liu D. F., Du X. F., Wan X. C., Song L. H. Effects of total isoflavones of Pueraria DC. on bone mineral density and Ca in ovariectomized rats. J Biol: 2007; 24 22 24
114. Gao D., Li Q., Li Y., Liu Z., Fan Y., Zhao H., Li J., Han Z. Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan-induced diabetic rats. Phytother Res: 2009; 23 1257 1262