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Volumn 69, Issue 11, 2008, Pages 2237-2244

Metabolite profiling of Panax notoginseng using UPLC-ESI-MS

Author keywords

Electrospray ionization (ESI); Metabolite profiling; Multivariate statistical analysis; Panax notoginseng; Quadrupole time of flight mass spectrometer (QtofMS); Saponin; Ultra performance liquid chromatography (UPLC)

Indexed keywords

BIOLOGICAL MARKER;

EID: 48049107321     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2008.04.015     Document Type: Article
Times cited : (116)

References (43)
  • 1
    • 0026695316 scopus 로고
    • WHO guidelines for the assessment of herbal medicines
    • Akerele O. WHO guidelines for the assessment of herbal medicines. Fitoterapia 63 (1992) 99-104
    • (1992) Fitoterapia , vol.63 , pp. 99-104
    • Akerele, O.1
  • 2
    • 0036798592 scopus 로고    scopus 로고
    • Trends in lignin modification: a comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity
    • Anterola A.M., and Lewis N.G. Trends in lignin modification: a comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity. Phytochemistry 61 (2002) 221-294
    • (2002) Phytochemistry , vol.61 , pp. 221-294
    • Anterola, A.M.1    Lewis, N.G.2
  • 3
    • 33847126285 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng
    • Chan E.C.Y., Yap S.L., Lau A.J., Leow P.C., Toh D.F., and Koh H.L. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rap. Commun. Mass Spectrom. 21 (2007) 519-528
    • (2007) Rap. Commun. Mass Spectrom. , vol.21 , pp. 519-528
    • Chan, E.C.Y.1    Yap, S.L.2    Lau, A.J.3    Leow, P.C.4    Toh, D.F.5    Koh, H.L.6
  • 5
    • 12844289137 scopus 로고    scopus 로고
    • Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites
    • Choi D.W., Jung J., Ha Y.I., Park H.W., In D.S., Chung H.J., and Liu J.R. Analysis of transcripts in methyl jasmonate-treated ginseng hairy roots to identify genes involved in the biosynthesis of ginsenosides and other secondary metabolites. Plant Cell Rep. 23 (2005) 557-566
    • (2005) Plant Cell Rep. , vol.23 , pp. 557-566
    • Choi, D.W.1    Jung, J.2    Ha, Y.I.3    Park, H.W.4    In, D.S.5    Chung, H.J.6    Liu, J.R.7
  • 6
    • 0037328536 scopus 로고    scopus 로고
    • Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet
    • Cicero A.F.G., Vitale G., Savino G., and Arletti R. Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet. Phytother. Res. 17 (2003) 174-178
    • (2003) Phytother. Res. , vol.17 , pp. 174-178
    • Cicero, A.F.G.1    Vitale, G.2    Savino, G.3    Arletti, R.4
  • 8
    • 0035028644 scopus 로고    scopus 로고
    • Metal ion adducts in the structural analysis of ginsenosides by electrospray ionization with multi-stage mass spectrometry
    • Cui M., Song F., Liu Z., and Liu S. Metal ion adducts in the structural analysis of ginsenosides by electrospray ionization with multi-stage mass spectrometry. Rap. Commun. Mass Spectrom. 15 (2001) 586-595
    • (2001) Rap. Commun. Mass Spectrom. , vol.15 , pp. 586-595
    • Cui, M.1    Song, F.2    Liu, Z.3    Liu, S.4
  • 9
    • 33749631555 scopus 로고    scopus 로고
    • Application of metabonomics in clinical nutrition
    • Dong L.G., and He G.Z. Application of metabonomics in clinical nutrition. Chin. J. Clin. Nutr. 14 (2006) 238-242
    • (2006) Chin. J. Clin. Nutr. , vol.14 , pp. 238-242
    • Dong, L.G.1    He, G.Z.2
  • 11
    • 33846228393 scopus 로고    scopus 로고
    • Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS
    • Farag M.A., Huhman D.V., Lei Z., and Sumner L.W. Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Phytochemistry 68 (2007) 342-354
    • (2007) Phytochemistry , vol.68 , pp. 342-354
    • Farag, M.A.1    Huhman, D.V.2    Lei, Z.3    Sumner, L.W.4
  • 12
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics - the link between genotypes and phenotypes
    • Fiehn O. Metabolomics - the link between genotypes and phenotypes. Plant Mol. Biol. 48 (2002) 155-171
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 13
    • 33646540097 scopus 로고    scopus 로고
    • Metabolic fingerprinting and profiling of Arabidopsis thaliana leaf and its cultured cells T87 by GC/MS
    • Fukusaki E., Jumtee K., Bamba T., Yamaji T., and Kobayashi A. Metabolic fingerprinting and profiling of Arabidopsis thaliana leaf and its cultured cells T87 by GC/MS. Z. Naturforschung 61 (2006) 267-272
    • (2006) Z. Naturforschung , vol.61 , pp. 267-272
    • Fukusaki, E.1    Jumtee, K.2    Bamba, T.3    Yamaji, T.4    Kobayashi, A.5
  • 14
    • 34547136499 scopus 로고    scopus 로고
    • A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra-performance liquid chromatography
    • Guan J., Lai C.M., and Li S.P. A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra-performance liquid chromatography. J. Pharm. Biomed. Anal. 44 (2007) 996-1000
    • (2007) J. Pharm. Biomed. Anal. , vol.44 , pp. 996-1000
    • Guan, J.1    Lai, C.M.2    Li, S.P.3
  • 16
    • 0037138280 scopus 로고    scopus 로고
    • Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer
    • Huhman D.V., and Sumner L.W. Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Phytochemistry 59 (2002) 347-360
    • (2002) Phytochemistry , vol.59 , pp. 347-360
    • Huhman, D.V.1    Sumner, L.W.2
  • 17
    • 33947728881 scopus 로고    scopus 로고
    • Characterization of the variation in the imidazole alkaloid profile of Pilocarpus microphyllus in different seasons and parts of the plant by electrospray ionization mass spectrometry fingerprinting and identification of novel alkaloids by tandem mass spectrometry
    • IIka N.A., Paulo M., Marcos N.E., Marco António T.Z., and Alexandra C.H.F.S. Characterization of the variation in the imidazole alkaloid profile of Pilocarpus microphyllus in different seasons and parts of the plant by electrospray ionization mass spectrometry fingerprinting and identification of novel alkaloids by tandem mass spectrometry. Rap. Commun. Mass Spectrom. 21 (2007) 1205-1213
    • (2007) Rap. Commun. Mass Spectrom. , vol.21 , pp. 1205-1213
    • IIka, N.A.1    Paulo, M.2    Marcos, N.E.3    Marco António, T.Z.4    Alexandra, C.H.F.S.5
  • 18
    • 0032708331 scopus 로고    scopus 로고
    • Anti-carcinogenic activity of the roots of Panax notoginseng II
    • Konoshima T., Takasaki M., and Tokuda H. Anti-carcinogenic activity of the roots of Panax notoginseng II. Biol. Pharm. Bull. 22 (1999) 1150-1152
    • (1999) Biol. Pharm. Bull. , vol.22 , pp. 1150-1152
    • Konoshima, T.1    Takasaki, M.2    Tokuda, H.3
  • 19
    • 19444377453 scopus 로고    scopus 로고
    • Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method
    • Li L., Zhang J.L., Sheng Y.X., Guo D.A., Wang Q., and Guo H.Z. Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method. J. Pharm. Biomed. Anal. 38 (2005) 45-51
    • (2005) J. Pharm. Biomed. Anal. , vol.38 , pp. 45-51
    • Li, L.1    Zhang, J.L.2    Sheng, Y.X.3    Guo, D.A.4    Wang, Q.5    Guo, H.Z.6
  • 20
    • 17144406340 scopus 로고    scopus 로고
    • Detection of saponins in extract of Panax notoginseng by liquid chromatography-electrospray ionisation-mass spectrometry
    • Li L., Tsao R., Dou J., Song F., Liu Z., and Liu S. Detection of saponins in extract of Panax notoginseng by liquid chromatography-electrospray ionisation-mass spectrometry. Anal. Chim. Acta 536 (2005) 21-28
    • (2005) Anal. Chim. Acta , vol.536 , pp. 21-28
    • Li, L.1    Tsao, R.2    Dou, J.3    Song, F.4    Liu, Z.5    Liu, S.6
  • 21
    • 33645549119 scopus 로고    scopus 로고
    • Analysis of the constituents in the Chinese drug notoginseng by liquid chromatography-electrospray mass spectrometry
    • Liu J.H., Wang X., Cat S.Q., Komatsu K., and Namba T. Analysis of the constituents in the Chinese drug notoginseng by liquid chromatography-electrospray mass spectrometry. J. Chin. Pharm. Sci. 13 (2004) 225-237
    • (2004) J. Chin. Pharm. Sci. , vol.13 , pp. 225-237
    • Liu, J.H.1    Wang, X.2    Cat, S.Q.3    Komatsu, K.4    Namba, T.5
  • 22
    • 33747343480 scopus 로고    scopus 로고
    • Chemical investigation on Sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS
    • Liu Y., Yang J., and Cai Z. Chemical investigation on Sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS. J. Pharm. Biomed. Anal. 41 (2006) 1642-1647
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 1642-1647
    • Liu, Y.1    Yang, J.2    Cai, Z.3
  • 23
    • 33747351648 scopus 로고    scopus 로고
    • Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: identification of a high antioxidant fruit line
    • Long M., Millar D.J., Kimura Y., Donovan G., Rees J., Fraser P.D., Bramley P.M., and Bolwell G.P. Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: identification of a high antioxidant fruit line. Phytochemistry 67 (2006) 1750-1757
    • (2006) Phytochemistry , vol.67 , pp. 1750-1757
    • Long, M.1    Millar, D.J.2    Kimura, Y.3    Donovan, G.4    Rees, J.5    Fraser, P.D.6    Bramley, P.M.7    Bolwell, G.P.8
  • 24
    • 49349091293 scopus 로고    scopus 로고
    • Effects of PNS on blood supply and on energy metabolism in mice's brain tissues
    • Ma L.Y.W.C.L., Zhang Q., Du L.J., Chen J.M., and Xiao P.G. Effects of PNS on blood supply and on energy metabolism in mice's brain tissues. Chin. Pharmacol. Bull. 14 (1998) 27-29
    • (1998) Chin. Pharmacol. Bull. , vol.14 , pp. 27-29
    • Ma, L.Y.W.C.L.1    Zhang, Q.2    Du, L.J.3    Chen, J.M.4    Xiao, P.G.5
  • 25
    • 11144226519 scopus 로고    scopus 로고
    • A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds
    • Murch S.J., Rupasinghe H.P.V., Goodenowe D., and Saxena P.K. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. Plant Cell Rep. 23 (2004) 419-425
    • (2004) Plant Cell Rep. , vol.23 , pp. 419-425
    • Murch, S.J.1    Rupasinghe, H.P.V.2    Goodenowe, D.3    Saxena, P.K.4
  • 26
    • 33747072624 scopus 로고    scopus 로고
    • Pharmacological activity of Sanchi-Ginseng (Panax notoginseng)
    • Ng T.B. Pharmacological activity of Sanchi-Ginseng (Panax notoginseng). J. Pharm. Pharmacol. 58 (2006) 1007-1019
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 1007-1019
    • Ng, T.B.1
  • 27
    • 30544454201 scopus 로고    scopus 로고
    • Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research
    • Rochfort S. Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research. J. Nat. Prod. 68 (2005) 1813-1820
    • (2005) J. Nat. Prod. , vol.68 , pp. 1813-1820
    • Rochfort, S.1
  • 28
    • 28444457369 scopus 로고    scopus 로고
    • Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng
    • Sun H., Yang Z., and Ye Y. Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng. Int. Immunopharmacol. 6 (2006) 14-25
    • (2006) Int. Immunopharmacol. , vol.6 , pp. 14-25
    • Sun, H.1    Yang, Z.2    Ye, Y.3
  • 29
    • 0036959970 scopus 로고    scopus 로고
    • A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula
    • Suzuki H., Achnine L., Xu R., Matsuda S.P.T., and Dixon R.A. A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. Plant J. 32 (2002) 1033-1048
    • (2002) Plant J. , vol.32 , pp. 1033-1048
    • Suzuki, H.1    Achnine, L.2    Xu, R.3    Matsuda, S.P.T.4    Dixon, R.A.5
  • 30
    • 0020065755 scopus 로고
    • Dammarane saponins of flower buds of Panax notoginseng (Sanchi-Ginseng)
    • Taniyasu S., Tanaka O., Yang T.R., and Zhou J. Dammarane saponins of flower buds of Panax notoginseng (Sanchi-Ginseng). Planta Med. 44 (1982) 124-125
    • (1982) Planta Med. , vol.44 , pp. 124-125
    • Taniyasu, S.1    Tanaka, O.2    Yang, T.R.3    Zhou, J.4
  • 31
    • 33747369909 scopus 로고    scopus 로고
    • Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD
    • Wan J.B., Yang F.Q., Li S.P., Wang Y.T., and Cui X.M. Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. J. Pharm. Biomed. Anal. 41 (2006) 1596-1601
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 1596-1601
    • Wan, J.B.1    Yang, F.Q.2    Li, S.P.3    Wang, Y.T.4    Cui, X.M.5
  • 32
    • 0037354141 scopus 로고    scopus 로고
    • 1 on long-term potentiation in the dentate gyrus of anaesthetized rats
    • 1 on long-term potentiation in the dentate gyrus of anaesthetized rats. J. Asian Nat. Prod. Res. 5 (2003) 1-4
    • (2003) J. Asian Nat. Prod. Res. , vol.5 , pp. 1-4
    • Wang, X.Y.1    Zhang, J.T.2
  • 33
    • 9344257332 scopus 로고    scopus 로고
    • Normalization of cDNA microarray data using wavelet regressions
    • Wang J., Ma J.Z., and Li M.D. Normalization of cDNA microarray data using wavelet regressions. Comb. Chem. High Throughput Screen. 7 (2004) 783-791
    • (2004) Comb. Chem. High Throughput Screen. , vol.7 , pp. 783-791
    • Wang, J.1    Ma, J.Z.2    Li, M.D.3
  • 34
    • 11144354344 scopus 로고    scopus 로고
    • Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.)
    • Wang Y., Tang H., Nicholson J.K., Hylands P.J., Sampson J., Whitcombe I., Stewart C.G., Caiger S., Oru I., and Holmes E. Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.). Planta Med. 70 (2004) 250-255
    • (2004) Planta Med. , vol.70 , pp. 250-255
    • Wang, Y.1    Tang, H.2    Nicholson, J.K.3    Hylands, P.J.4    Sampson, J.5    Whitcombe, I.6    Stewart, C.G.7    Caiger, S.8    Oru, I.9    Holmes, E.10
  • 36
    • 33745889215 scopus 로고    scopus 로고
    • Phytochemical and analytical studies of Panax notoginseng (Burk.) F.H. Chen
    • Wang C.Z.M.E., Wicks S., Wu J.A., and Yuan C.S. Phytochemical and analytical studies of Panax notoginseng (Burk.) F.H. Chen. J. Nat. Med. 60 (2006) 97-106
    • (2006) J. Nat. Med. , vol.60 , pp. 97-106
    • Wang, C.Z.M.E.1    Wicks, S.2    Wu, J.A.3    Yuan, C.S.4
  • 37
    • 33644824335 scopus 로고    scopus 로고
    • Separation and on-line concentration of saponins from Panax notoginseng by micellar electrokinetic chromatography
    • Wang S., Ye S., and Cheng Y. Separation and on-line concentration of saponins from Panax notoginseng by micellar electrokinetic chromatography. J. Chromatogr. A 1109 (2006) 279-284
    • (2006) J. Chromatogr. A , vol.1109 , pp. 279-284
    • Wang, S.1    Ye, S.2    Cheng, Y.3
  • 40
    • 17444404226 scopus 로고    scopus 로고
    • High resolution ultra-performance liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • Wilson I.D., Nicholson J.K., Castro-Perez J., Granger J.H., Johnson K.A., Smith B.W., and Plumb R.S. High resolution ultra-performance liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 4 (2005) 591-598
    • (2005) J. Proteome Res. , vol.4 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 42
    • 14944354572 scopus 로고    scopus 로고
    • 3 on activation of strychnine-sensitive glycine receptors in hippocampal neurons of rat
    • 3 on activation of strychnine-sensitive glycine receptors in hippocampal neurons of rat. Brain Res. 1037 (2005) 99-106
    • (2005) Brain Res. , vol.1037 , pp. 99-106
    • Xu, Y.X.1    Shi, J.S.2    Jiang, Z.L.3
  • 43
    • 0042343835 scopus 로고    scopus 로고
    • Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins
    • Yoshikawa M., Morikawa T., Kashima Y., Ninomiya K., and Matsuda H. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins. J. Nat. Prod. 66 (2003) 922-927
    • (2003) J. Nat. Prod. , vol.66 , pp. 922-927
    • Yoshikawa, M.1    Morikawa, T.2    Kashima, Y.3    Ninomiya, K.4    Matsuda, H.5


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