XQ2, a Novel TPZ derivative, induced G2/M phase arrest and apoptosis under hypoxia in non-small cell lung cancer cells

Bioscience, Biotechnology and Biochemistry

Volumn 74, Issue 6, 2010, Pages 1181-1187

  Lou, Jianshu ^a   Zhou, Xinglu ^a   Weng, Qinjie ^a   Wang, Duo Duo ^a   Xia, Qing ^a   Hu, Yongzhou ^a   He, Qiaojun ^a   Yang, Bo ^a   Luo, Peihua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Caspase dependent apoptosis; Hypoxia; NSCLC; ROS; XQ2

Indexed keywords

A549 CELLS; ANTICANCER ACTIONS; ANTICANCER EFFECTS; APOPTOSIS; CANCER CELL LINES; CASPASES; CELL-CYCLE ARREST; INHIBITORY EFFECT; NON SMALL CELL LUNG CANCER; PHASE ARREST; REACTIVE OXYGEN SPECIES; TUMOR PROGRESSIONS; WESTERN BLOTS;

CELL CULTURE; CELL PROLIFERATION; CHEMOTHERAPY; FLOW CYTOMETRY; OXYGEN; TUMORS;

CELL DEATH;

AMINE OXIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; N ETHOXYMETHYL 3 AMINO 1,2,4 BENZOTRIAZINE 1,4 DIOXIDE; N-ETHOXYMETHYL-3-AMINO-1,2,4-BENZOTRIAZINE-1,4-DIOXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TIRAPAZAMINE; TRIAZINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL HYPOXIA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; LUNG NON SMALL CELL CANCER; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; DRUG EFFECTS; NON SMALL CELL LUNG CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CASPASE 9; CELL DIVISION; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC N-OXIDES; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRIAZINES;

EID: 77953982390     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.90889     Document Type: Article

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