-
1
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received highdose recombinant interleukin-2 therapy
-
Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received highdose recombinant interleukin-2 therapy. J Clin Oncol. 1995;13:688-696.
-
(1995)
J Clin Oncol
, vol.13
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
Sznol, M.4
Parkinson, D.R.5
Louie, A.C.6
-
4
-
-
77649134498
-
New strategies in kidney cancer: Therapeutic advances through understanding the molecular basis of response and resistance
-
Rini BI. New strategies in kidney cancer: therapeutic advances through understanding the molecular basis of response and resistance. Clin Cancer Res. 2010;16:1348-1354.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1348-1354
-
-
Rini, B.I.1
-
5
-
-
65949115921
-
Sequential therapy in renal cell carcinoma
-
Escudier B, Goupil MG, Massard C, Fizazi K. Sequential therapy in renal cell carcinoma. Cancer. 2009;115(10 suppl):2321-2326.
-
(2009)
Cancer
, vol.115
, Issue.10 SUPPL.
, pp. 2321-2326
-
-
Escudier, B.1
Goupil, M.G.2
Massard, C.3
Fizazi, K.4
-
6
-
-
78649568788
-
Sunitinib rechallenge in metastatic renal cell carcinoma patients
-
Zama IN, Hutson TE, Elson P, et al. Sunitinib rechallenge in metastatic renal cell carcinoma patients. Cancer. 2010;116:5400-5406.
-
(2010)
Cancer
, vol.116
, pp. 5400-5406
-
-
Zama, I.N.1
Hutson, T.E.2
Elson, P.3
-
7
-
-
74749099130
-
Assessing tumor response and detecting recurrence in metastatic renal cell carcinoma on targeted therapy: Importance of size and attenuation on contrast-enhanced CT
-
Smith AD, Lieber ML, Shah SN. Assessing tumor response and detecting recurrence in metastatic renal cell carcinoma on targeted therapy: importance of size and attenuation on contrast-enhanced CT. AJR Am J Roentgenol. 2010;194:157-165.
-
(2010)
AJR Am J Roentgenol
, vol.194
, pp. 157-165
-
-
Smith, A.D.1
Lieber, M.L.2
Shah, S.N.3
-
8
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
9
-
-
50649099256
-
Clinical effect and future considerations for molecularlytargeted therapy in renal cell carcinoma
-
Rini BI, Flaherty K. Clinical effect and future considerations for molecularlytargeted therapy in renal cell carcinoma. Urol Oncol. 2008;26:543-549.
-
(2008)
Urol Oncol
, vol.26
, pp. 543-549
-
-
Rini, B.I.1
Flaherty, K.2
-
10
-
-
1342311454
-
A changing paradigm for cancer treatment: The advent of new oral chemotherapy agents
-
Bedell CH. A changing paradigm for cancer treatment: the advent of new oral chemotherapy agents. Clin J Oncol Nurs. 2003;7:5-9.
-
(2003)
Clin J Oncol Nurs
, vol.7
, pp. 5-9
-
-
Bedell, C.H.1
-
11
-
-
0027240519
-
Identification of the von hippel-lindau disease tumor suppressor gene
-
Latif F, Tory K, Gnarra J, et al. Identification of the von hippel-lindau disease tumor suppressor gene. Science. 1993;260:1317-1320.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
-
12
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet. 1994;7:85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
13
-
-
0032970571
-
Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
-
Gallou C, Joly D, Mejean A, et al. Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC. Hum Mutat. 1999;13:464-475.
-
(1999)
Hum Mutat
, vol.13
, pp. 464-475
-
-
Gallou, C.1
Joly, D.2
Mejean, A.3
-
14
-
-
0036154040
-
VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
-
Schraml P, Struckmann K, Hatz F, et al. VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. J Pathol. 2002;196:186-193.
-
(2002)
J Pathol
, vol.196
, pp. 186-193
-
-
Schraml, P.1
Struckmann, K.2
Hatz, F.3
-
15
-
-
0031255567
-
The Heidelberg classification of renal cell tumours
-
Kovacs G, Akhtar M, Beckwith BJ, et al. The Heidelberg classification of renal cell tumours. J Pathol. 1997;183:131-133.
-
(1997)
J Pathol
, vol.183
, pp. 131-133
-
-
Kovacs, G.1
Akhtar, M.2
Beckwith, B.J.3
-
16
-
-
0031776704
-
Inactivation of the von hippel-lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
-
Clifford SC, Prowse AH, Affara NA, Buys CH, Maher ER. Inactivation of the von hippel-lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosomes Cancer. 1998;22:200-209.
-
(1998)
Genes Chromosomes Cancer
, vol.22
, pp. 200-209
-
-
Clifford, S.C.1
Prowse, A.H.2
Affara, N.A.3
Buys, C.H.4
Maher, E.R.5
-
17
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol. 2004;22:4991-5004.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
18
-
-
0029039195
-
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
-
Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem. 1995;270:13333-13340.
-
(1995)
J Biol Chem
, vol.270
, pp. 13333-13340
-
-
Levy, A.P.1
Levy, N.S.2
Wegner, S.3
Goldberg, M.A.4
-
19
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/ pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/ pharmacodynamic relationship. Clin Cancer Res. 2003;9:327-337.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
20
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
21
-
-
46849093651
-
Perfusion MDCT enables early detection of therapeutic response to antiangiogenic therapy
-
Sabir A, Schor-Bardach R, Wilcox CJ, et al. Perfusion MDCT enables early detection of therapeutic response to antiangiogenic therapy. AJR Am J Roentgenol. 2008;191:133-139.
-
(2008)
AJR Am J Roentgenol
, vol.191
, pp. 133-139
-
-
Sabir, A.1
Schor-Bardach, R.2
Wilcox, C.J.3
-
22
-
-
67049132896
-
Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model?
-
Schor-Bardach R, Alsop DC, Pedrosa I, et al. Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model? Radiology. 2009;251:731-742.
-
(2009)
Radiology
, vol.251
, pp. 731-742
-
-
Schor-Bardach, R.1
Alsop, D.C.2
Pedrosa, I.3
-
23
-
-
48649098245
-
Von hippel-lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
Choueiri TK, Vaziri SA, Jaeger E, et al. Von hippel-lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol. 2008;180:860-865.
-
(2008)
J Urol
, vol.180
, pp. 860-865
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
-
24
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
25
-
-
33645738458
-
Complexity of the TOR signaling network
-
Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol. 2006;16:206-212.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 206-212
-
-
Inoki, K.1
Guan, K.L.2
-
26
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
27
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22:7004-7014.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
28
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas GV, Tran C, Mellinghoff IK, et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006;12:122-127.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
-
29
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006;22:159-168.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
-
30
-
-
0037617447
-
Loss of von hippel-lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor
-
Baba M, Hirai S, Yamada-Okabe H, et al. Loss of von hippel-lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene. 2003;22:2728-2738.
-
(2003)
Oncogene
, vol.22
, pp. 2728-2738
-
-
Baba, M.1
Hirai, S.2
Yamada-Okabe, H.3
-
31
-
-
0036645091
-
Identification of cyclin D1 and other novel targets for the von hippel-lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von hippel-lindau disease
-
Zatyka M, da Silva NF, Clifford SC, et al. Identification of cyclin D1 and other novel targets for the von hippel-lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von hippel-lindau disease. Cancer Res. 2002;62:3803-3811.
-
(2002)
Cancer Res
, vol.62
, pp. 3803-3811
-
-
Zatyka, M.1
da Silva, N.F.2
Clifford, S.C.3
-
32
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov. 2006;5:37-50.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
33
-
-
38449100788
-
Expression profile of class I histone deacetylases in human cancer tissues
-
Nakagawa M, Oda Y, Eguchi T, et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep. 2007;18:769-774.
-
(2007)
Oncol Rep
, vol.18
, pp. 769-774
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
-
34
-
-
4644364508
-
The histone deacetylase inhibitor NVPLAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth receptor tyrosine kinase inhibitor PTK787/ ZK222584
-
Qian DZ, Wang X, Kachhap SK, et al. The histone deacetylase inhibitor NVPLAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth receptor tyrosine kinase inhibitor PTK787/ ZK222584. Cancer Res. 2004;64:6626-6634.
-
(2004)
Cancer Res
, vol.64
, pp. 6626-6634
-
-
Qian, D.Z.1
Wang, X.2
Kachhap, S.K.3
-
35
-
-
20944436158
-
Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma
-
Wang XF, Qian DZ, Ren M, et al. Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma. Clin Cancer Res. 2005;11:3535-3542.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3535-3542
-
-
Wang, X.F.1
Qian, D.Z.2
Ren, M.3
-
36
-
-
84873099378
-
Combination of the histone deacetylase inhibitor vorinostat with bevacizumab in pretreated patients with renal cell carcinoma: Safety, efficacy, and pharmacodynamic results
-
Paper presented at:, March 5-7, 2010; San Francisco, CA. Abstract #350
-
Pili R, Lodge M, Verheul H, et al. Combination of the histone deacetylase inhibitor vorinostat with bevacizumab in pretreated patients with renal cell carcinoma: safety, efficacy, and pharmacodynamic results. Paper presented at: American Society of Clinical Oncology 2010 Genitourinary Cancers Symposium; March 5-7, 2010; San Francisco, CA. Abstract #350.
-
American Society of Clinical Oncology 2010 Genitourinary Cancers Symposium
-
-
Pili, R.1
Lodge, M.2
Verheul, H.3
-
37
-
-
0036014978
-
Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia
-
Gorre ME, Sawyers CL. Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Curr Opin Hematol. 2002;9:303-307.
-
(2002)
Curr Opin Hematol
, vol.9
, pp. 303-307
-
-
Gorre, M.E.1
Sawyers, C.L.2
-
38
-
-
37349021709
-
Drug resistance in cancer-searching for mechanisms, markers and therapeutic agents
-
O'Connor R, Clynes M, Dowling P, O'Donovan N, O'Driscoll L. Drug resistance in cancer-searching for mechanisms, markers and therapeutic agents. Expert Opin Drug Metab Toxicol. 2007;3:805-817.
-
(2007)
Expert Opin Drug Metab Toxicol
, vol.3
, pp. 805-817
-
-
O'Connor, R.1
Clynes, M.2
Dowling, P.3
O'Donovan, N.4
O'Driscoll, L.5
-
39
-
-
0025717523
-
Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
-
Kerbel RS. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays. 1991;13:31-36.
-
(1991)
Bioessays
, vol.13
, pp. 31-36
-
-
Kerbel, R.S.1
-
40
-
-
0034685016
-
Incipient angiogenesis
-
Folkman J. Incipient angiogenesis. J Natl Cancer Inst. 2000;92:94-95.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 94-95
-
-
Folkman, J.1
-
42
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
43
-
-
16644394469
-
Can tumor angiogenesis be inhibited without resistance?
-
Miller KD, Sweeney CJ, Sledge GW Jr. Can tumor angiogenesis be inhibited without resistance? EXS. 2005;94:95-112.
-
(2005)
EXS
, vol.94
, pp. 95-112
-
-
Miller, K.D.1
Sweeney, C.J.2
Sledge Jr., G.W.3
-
44
-
-
37549013776
-
A microenvironmental model of carcinogenesis
-
Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 2008;8:56-61.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 56-61
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
45
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005;8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
46
-
-
39849102836
-
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
-
Du R, Lu KV, Petritsch C, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008;13:206-220.
-
(2008)
Cancer Cell
, vol.13
, pp. 206-220
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
-
47
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
-
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS. Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci U S A. 2007;104:17069-17074.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaers, A.J.4
Kerbel, R.S.5
-
48
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
49
-
-
77953033291
-
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic metaanalysis
-
Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD, Motzer RJ. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic metaanalysis. Cancer Chemother Pharmacol. 2010;66:357-371.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
Rosen, L.S.4
Demetri, G.D.5
Motzer, R.J.6
-
50
-
-
34547820876
-
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
-
Shojaei F, Wu X, Malik AK. et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol. 2007;25:911-920.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 911-920
-
-
Shojaei, F.1
Wu, X.2
Malik, A.K.3
-
51
-
-
24744438663
-
Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells
-
Mizukami Y, Jo WS, Duerr EM, et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med. 2005;11:992-997.
-
(2005)
Nat Med
, vol.11
, pp. 992-997
-
-
Mizukami, Y.1
Jo, W.S.2
Duerr, E.M.3
-
52
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M, et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res. 2010;70:1063-1071.
-
(2010)
Cancer Res
, vol.70
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
-
53
-
-
35548982639
-
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
-
Fischer C, Jonckx B, Mazzone M, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 2007;131:463-475.
-
(2007)
Cell
, vol.131
, pp. 463-475
-
-
Fischer, C.1
Jonckx, B.2
Mazzone, M.3
-
54
-
-
18444413531
-
Loss of placental growth factor protects mice against vascular permeability in pathological conditions
-
Luttun A, Brusselmans K, Fukao H, et al. Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun. 2002;295:428-434.
-
(2002)
Biochem Biophys Res Commun
, vol.295
, pp. 428-434
-
-
Luttun, A.1
Brusselmans, K.2
Fukao, H.3
-
55
-
-
0141721621
-
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: Novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
-
Autiero M, Luttun A, Tjwa M, Carmeliet P. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost. 2003;1:1356-1370.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 1356-1370
-
-
Autiero, M.1
Luttun, A.2
Tjwa, M.3
Carmeliet, P.4
-
56
-
-
0036962410
-
Placental growth factor (PlGF) and its receptor flt-1 (VEGFR-1): Novel therapeutic targets for angiogenic disorders
-
Luttun A, Tjwa M, Carmeliet P. Placental growth factor (PlGF) and its receptor flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann N Y Acad Sci. 2002;979:80-93.
-
(2002)
Ann N Y Acad Sci
, vol.979
, pp. 80-93
-
-
Luttun, A.1
Tjwa, M.2
Carmeliet, P.3
-
57
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007;11:83-95.
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
-
58
-
-
34548703367
-
Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma
-
Xu L, Jain RK. Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma. Mol Cancer Res. 2007;5:873-880.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 873-880
-
-
Xu, L.1
Jain, R.K.2
-
59
-
-
30944452436
-
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
-
Willett CG, Boucher Y, Duda DG, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005;23:8136-8139.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8136-8139
-
-
Willett, C.G.1
Boucher, Y.2
Duda, D.G.3
-
60
-
-
33846821872
-
Targeted therapy for metastatic renal cell carcinoma
-
Motzer RJ, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma. J Clin Oncol. 2006;24:5601-5608.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5601-5608
-
-
Motzer, R.J.1
Bukowski, R.M.2
-
61
-
-
0038376002
-
Molecular regulation of vessel maturation
-
Jain RK. Molecular regulation of vessel maturation. Nat Med. 2003;9:685-693.
-
(2003)
Nat Med
, vol.9
, pp. 685-693
-
-
Jain, R.K.1
-
62
-
-
0038376000
-
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
-
Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med. 2003;9:702-712.
-
(2003)
Nat Med
, vol.9
, pp. 702-712
-
-
Rafii, S.1
Lyden, D.2
-
63
-
-
4143052506
-
Endothelial progenitor cells: Characterization and role in vascular biology
-
Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 2004;95:343-353.
-
(2004)
Circ Res
, vol.95
, pp. 343-353
-
-
Urbich, C.1
Dimmeler, S.2
-
64
-
-
14544282964
-
Endothelial progenitor cells
-
Khakoo AY, Finkel T. Endothelial progenitor cells. Annu Rev Med. 2005;56:79-101.
-
(2005)
Annu Rev Med
, vol.56
, pp. 79-101
-
-
Khakoo, A.Y.1
Finkel, T.2
-
65
-
-
0031019745
-
Isolation of putative progenitor endothelial cells for angiogenesis
-
Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-967.
-
(1997)
Science
, vol.275
, pp. 964-967
-
-
Asahara, T.1
Murohara, T.2
Sullivan, A.3
-
66
-
-
26944437515
-
PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005;7:870-879.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
Werb, Z.4
Bergers, G.5
-
67
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst MW, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer. 2008;8:425-437.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
68
-
-
30344437303
-
VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells
-
Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell. 2006;124:175-189.
-
(2006)
Cell
, vol.124
, pp. 175-189
-
-
Grunewald, M.1
Avraham, I.2
Dor, Y.3
-
69
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996;87:1171-1180.
-
(1996)
Cell
, vol.87
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.F.2
Patan, S.3
-
70
-
-
0029001244
-
Distinct roles of the receptor tyrosine kinases tie-1 and tie-2 in blood vessel formation
-
Sato TN, Tozawa Y, Deutsch U, et al. Distinct roles of the receptor tyrosine kinases tie-1 and tie-2 in blood vessel formation. Nature. 1995;376:70-74.
-
(1995)
Nature
, vol.376
, pp. 70-74
-
-
Sato, T.N.1
Tozawa, Y.2
Deutsch, U.3
-
71
-
-
0028122465
-
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
-
Dumont DJ, Gradwohl G, Fong GH, et al. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994;8:1897-1909.
-
(1994)
Genes Dev
, vol.8
, pp. 1897-1909
-
-
Dumont, D.J.1
Gradwohl, G.2
Fong, G.H.3
-
72
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003;111:1287-1295.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
73
-
-
0346727319
-
What brings pericytes to tumor vessels?
-
Jain RK, Booth MF. What brings pericytes to tumor vessels? J Clin Invest. 2003;112:1134-1136.
-
(2003)
J Clin Invest
, vol.112
, pp. 1134-1136
-
-
Jain, R.K.1
Booth, M.F.2
-
74
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
75
-
-
33749441325
-
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
-
Mancuso MR, Davis R, Norberg SM, et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest. 2006;116:2610-2621.
-
(2006)
J Clin Invest
, vol.116
, pp. 2610-2621
-
-
Mancuso, M.R.1
Davis, R.2
Norberg, S.M.3
-
76
-
-
34250365240
-
Mechanisms of adverse effects of anti-VEGF therapy for cancer
-
Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007;96:1788-1795.
-
(2007)
Br J Cancer
, vol.96
, pp. 1788-1795
-
-
Kamba, T.1
McDonald, D.M.2
-
77
-
-
0031834239
-
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
-
Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 1998;125:1591-1598.
-
(1998)
Development
, vol.125
, pp. 1591-1598
-
-
Benjamin, L.E.1
Hemo, I.2
Keshet, E.3
-
78
-
-
0242456268
-
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
-
Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003;264:275-288.
-
(2003)
Dev Biol
, vol.264
, pp. 275-288
-
-
Darland, D.C.1
Massingham, L.J.2
Smith, S.R.3
Piek, E.4
Saint-Geniez, M.5
D'Amore, P.A.6
-
79
-
-
0030639167
-
Control of angiogenesis by the pericyte: Molecular mechanisms and significance
-
Hirschi KK, D'Amore PA. Control of angiogenesis by the pericyte: molecular mechanisms and significance. EXS. 1997;79:419-428.
-
(1997)
EXS
, vol.79
, pp. 419-428
-
-
Hirschi, K.K.1
D'Amore, P.A.2
-
80
-
-
0023585264
-
Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells
-
Orlidge A, D'Amore PA. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. J Cell Biol. 1987;105:1455-1462.
-
(1987)
J Cell Biol
, vol.105
, pp. 1455-1462
-
-
Orlidge, A.1
D'Amore, P.A.2
-
81
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericytemediated endothelial cell survival mechanisms
-
Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericytemediated endothelial cell survival mechanisms. FASEB J. 2004;18:338-340.
-
(2004)
FASEB J
, vol.18
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
-
82
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003;111:1287-1295.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
-
83
-
-
25444491756
-
Absence of smooth muscle actinpositive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients
-
Yonenaga Y, Mori A, Onodera H, et al. Absence of smooth muscle actinpositive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients. Oncology. 2005;69:159-166.
-
(2005)
Oncology
, vol.69
, pp. 159-166
-
-
Yonenaga, Y.1
Mori, A.2
Onodera, H.3
-
84
-
-
33846296619
-
Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications
-
Yao X, Qian CN, Zhang ZF, et al. Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. Clin Cancer Res. 2007;13:161-169.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 161-169
-
-
Yao, X.1
Qian, C.N.2
Zhang, Z.F.3
-
85
-
-
77953467629
-
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: Evidence from a Xenograft Study
-
Hammers HJ, Verheul HM, Salumbides B, et al. Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a Xenograft Study. Mol Cancer Ther. 2010;9:1525-1535.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1525-1535
-
-
Hammers, H.J.1
Verheul, H.M.2
Salumbides, B.3
-
86
-
-
34848826864
-
Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression
-
Hugo H, Ackland ML, Blick T, et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol. 2007;213:374-383.
-
(2007)
J Cell Physiol
, vol.213
, pp. 374-383
-
-
Hugo, H.1
Ackland, M.L.2
Blick, T.3
-
87
-
-
34250711876
-
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma
-
Frederick BA, Helfrich BA, Coldren CD, et al. Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. Mol Cancer Ther. 2007;6:1683-1691.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1683-1691
-
-
Frederick, B.A.1
Helfrich, B.A.2
Coldren, C.D.3
-
88
-
-
35148825636
-
Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
-
Kajiyama H, Shibata K, Terauchi M, et al. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int J Oncol. 2007;31:277-283.
-
(2007)
Int J Oncol
, vol.31
, pp. 277-283
-
-
Kajiyama, H.1
Shibata, K.2
Terauchi, M.3
-
89
-
-
38449096259
-
Roles of molecules involved in epithelial/mesenchymal transition during angiogenesis
-
Ghersi G. Roles of molecules involved in epithelial/mesenchymal transition during angiogenesis. Front Biosci. 2008;13:2335-2355.
-
(2008)
Front Biosci
, vol.13
, pp. 2335-2355
-
-
Ghersi, G.1
-
90
-
-
36349006961
-
Development and characterization of gemcitabine-resistant pancreatic tumor cells
-
Shah AN, Summy JM, Zhang J, Park SI, Parikh NU, Gallick GE. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol. 2007;14:3629-3637.
-
(2007)
Ann Surg Oncol
, vol.14
, pp. 3629-3637
-
-
Shah, A.N.1
Summy, J.M.2
Zhang, J.3
Park, S.I.4
Parikh, N.U.5
Gallick, G.E.6
-
91
-
-
28344444026
-
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
-
Mironchik Y, Winnard PT Jr, Vesuna F, et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res. 2005;65:10801-10809.
-
(2005)
Cancer Res
, vol.65
, pp. 10801-10809
-
-
Mironchik, Y.1
Winnard Jr., P.T.2
Vesuna, F.3
-
92
-
-
39849084165
-
Matrix metalloproteinase-2 regulates vascular patterning and growth affecting cell survival and invasion of GBM
-
Du R, Petritsch C, Lu K, et al. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting cell survival and invasion of GBM. Neuro Oncol. 2008;10:254-264.
-
(2008)
Neuro Oncol
, vol.10
, pp. 254-264
-
-
Du, R.1
Petritsch, C.2
Lu, K.3
-
93
-
-
4644363095
-
The Von Hipple-Lindau tumor suppressor gene and kidney cancer
-
Kaelin WG. The Von Hipple-Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res. 2004;10:6290s-6295s.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Kaelin, W.G.1
|