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Volumn 330, Issue 2, 2013, Pages 241-249

Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis

Author keywords

Angiogenesis; Innate anti tumor immunity; Metronomic chemotherapy; Pigment epithelium derived factor (PEDF); Thrombospondin 1

Indexed keywords

CYCLOPHOSPHAMIDE; PIGMENT EPITHELIUM DERIVED FACTOR; THROMBOSPONDIN 1;

EID: 84873080485     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.11.055     Document Type: Article
Times cited : (25)

References (55)
  • 1
    • 81255188940 scopus 로고    scopus 로고
    • Tumor angiogenesis: molecular pathways and therapeutic targets
    • Weis S.M., Cheresh D.A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 2011, 17:1359-1370.
    • (2011) Nat. Med. , vol.17 , pp. 1359-1370
    • Weis, S.M.1    Cheresh, D.A.2
  • 2
    • 60749091126 scopus 로고    scopus 로고
    • Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies
    • Isenberg J.S., Martin-Manso G., Maxhimer J.B., Roberts D.D. Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies. Nat. Rev. Cancer 2009, 9:182-194.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 182-194
    • Isenberg, J.S.1    Martin-Manso, G.2    Maxhimer, J.B.3    Roberts, D.D.4
  • 3
    • 84867268459 scopus 로고    scopus 로고
    • Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2
    • Lawler P.R., Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb. Perspect. Med. 2012, 2:a006627.
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Lawler, P.R.1    Lawler, J.2
  • 6
    • 33846598411 scopus 로고    scopus 로고
    • Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)
    • Greenaway J., Lawler J., Moorehead R., Bornstein P., Lamarre J., Petrik J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J. Cell. Physiol. 2007, 210:807-818.
    • (2007) J. Cell. Physiol. , vol.210 , pp. 807-818
    • Greenaway, J.1    Lawler, J.2    Moorehead, R.3    Bornstein, P.4    Lamarre, J.5    Petrik, J.6
  • 7
    • 52049083001 scopus 로고    scopus 로고
    • Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells
    • Martin-Manso G., Galli S., Ridnour L.A., Tsokos M., Wink D.A., Roberts D.D. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Res. 2008, 68:7090-7099.
    • (2008) Cancer Res. , vol.68 , pp. 7090-7099
    • Martin-Manso, G.1    Galli, S.2    Ridnour, L.A.3    Tsokos, M.4    Wink, D.A.5    Roberts, D.D.6
  • 8
    • 80053963249 scopus 로고    scopus 로고
    • ABT-898 induces tumor regression and prolongs survival in a mouse model of epithelial ovarian cancer
    • Campbell N., Greenaway J., Henkin J., Petrik J. ABT-898 induces tumor regression and prolongs survival in a mouse model of epithelial ovarian cancer. Mol. Cancer Ther. 2011, 10:1876-1885.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1876-1885
    • Campbell, N.1    Greenaway, J.2    Henkin, J.3    Petrik, J.4
  • 9
    • 58149521990 scopus 로고    scopus 로고
    • ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer
    • Greenaway J., Henkin J., Lawler J., Moorehead R., Petrik J. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol. Cancer Ther. 2009, 8:64-74.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 64-74
    • Greenaway, J.1    Henkin, J.2    Lawler, J.3    Moorehead, R.4    Petrik, J.5
  • 11
    • 84862786502 scopus 로고    scopus 로고
    • Overexpression of thrombospondin-1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma
    • Lin X.D., Chen S.Q., Qi Y.L., Zhu J.W., Tang Y., Lin J.Y. Overexpression of thrombospondin-1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma. J. Surg. Oncol. 2012, 106:94-100.
    • (2012) J. Surg. Oncol. , vol.106 , pp. 94-100
    • Lin, X.D.1    Chen, S.Q.2    Qi, Y.L.3    Zhu, J.W.4    Tang, Y.5    Lin, J.Y.6
  • 14
    • 65349165784 scopus 로고    scopus 로고
    • Characterization of PEDF: a multi-functional serpin family protein
    • Filleur S., Nelius T., de Riese W., Kennedy R.C. Characterization of PEDF: a multi-functional serpin family protein. J. Cell. Biochem. 2009, 106:769-775.
    • (2009) J. Cell. Biochem. , vol.106 , pp. 769-775
    • Filleur, S.1    Nelius, T.2    de Riese, W.3    Kennedy, R.C.4
  • 15
    • 78651423549 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis
    • Manalo K.B., Choong P.F.M., Dass C.R. Pigment epithelium-derived factor as an impending therapeutic agent against vascular epithelial growth factor-driven tumor-angiogenesis. Mol. Carcinog. 2011, 50:67-72.
    • (2011) Mol. Carcinog. , vol.50 , pp. 67-72
    • Manalo, K.B.1    Choong, P.F.M.2    Dass, C.R.3
  • 17
    • 71249084294 scopus 로고    scopus 로고
    • PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation
    • Elayappan B., Ravinarayannan H., Pasha S.P., Lee K.J., Gurunathan S. PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation. Angiogenesis 2009, 12:313-324.
    • (2009) Angiogenesis , vol.12 , pp. 313-324
    • Elayappan, B.1    Ravinarayannan, H.2    Pasha, S.P.3    Lee, K.J.4    Gurunathan, S.5
  • 18
    • 2342566543 scopus 로고    scopus 로고
    • Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor
    • Guan M., Pang C.P., Yam H.F., Cheung K.F., Liu W.W., Lu Y. Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor. Cancer Gene Ther. 2004, 11:325-332.
    • (2004) Cancer Gene Ther. , vol.11 , pp. 325-332
    • Guan, M.1    Pang, C.P.2    Yam, H.F.3    Cheung, K.F.4    Liu, W.W.5    Lu, Y.6
  • 19
    • 33745214608 scopus 로고    scopus 로고
    • Decreased pigment epithelium-derived factor expression in human breast cancer progression
    • Cai J., Parr C., Watkins G., Jiang W.G., Boulton M. Decreased pigment epithelium-derived factor expression in human breast cancer progression. Clin. Cancer Res. 2006, 12:3510-3517.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3510-3517
    • Cai, J.1    Parr, C.2    Watkins, G.3    Jiang, W.G.4    Boulton, M.5
  • 21
    • 79960107886 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis
    • Ladhani O., Sanchez-Martinez C., Orgaz J.L., Jimenez B., Volpert O.V. Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis. Neoplasia 2011, 13:633-642.
    • (2011) Neoplasia , vol.13 , pp. 633-642
    • Ladhani, O.1    Sanchez-Martinez, C.2    Orgaz, J.L.3    Jimenez, B.4    Volpert, O.V.5
  • 22
    • 4143122398 scopus 로고    scopus 로고
    • Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors
    • Halin S., Wikstrom P., Rudolfsson S.H., Stattin P., Doll J.A., Crawford S.E., Bergh A. Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. Cancer Res. 2004, 64:5664-5671.
    • (2004) Cancer Res. , vol.64 , pp. 5664-5671
    • Halin, S.1    Wikstrom, P.2    Rudolfsson, S.H.3    Stattin, P.4    Doll, J.A.5    Crawford, S.E.6    Bergh, A.7
  • 24
    • 34250352217 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis
    • Ek E.T., Dass C.R., Contreras K.G., Choong P.F. Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis. Cancer Gene Ther. 2007, 14:616-626.
    • (2007) Cancer Gene Ther. , vol.14 , pp. 616-626
    • Ek, E.T.1    Dass, C.R.2    Contreras, K.G.3    Choong, P.F.4
  • 25
    • 33845907661 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor as a multifunctional antitumor factor
    • Fernandez-Garcia N.I., Volpert O.V., Jimenez B. Pigment epithelium-derived factor as a multifunctional antitumor factor. J. Mol. Med. (Berl) 2007, 85:15-22.
    • (2007) J. Mol. Med. (Berl) , vol.85 , pp. 15-22
    • Fernandez-Garcia, N.I.1    Volpert, O.V.2    Jimenez, B.3
  • 26
    • 77951675551 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment
    • Halin S., Rudolfsson S.H., Doll J.A., Crawford S.E., Wikstrom P., Bergh A. Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. Neoplasia 2010, 12:336-345.
    • (2010) Neoplasia , vol.12 , pp. 336-345
    • Halin, S.1    Rudolfsson, S.H.2    Doll, J.A.3    Crawford, S.E.4    Wikstrom, P.5    Bergh, A.6
  • 27
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D., Bergers G., Bergsland E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J. Clin. Invest. 2000, 105:1045-1047.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 28
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., Man S., Clark K., Hicklin D.J., Bohlen P., Kerbel R.S. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 2000, 105:R15-24.
    • (2000) J. Clin. Invest. , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 29
    • 77955172181 scopus 로고    scopus 로고
    • Metronomic chemotherapy: new rationale for new directions
    • Pasquier E., Kavallaris M., Andre N. Metronomic chemotherapy: new rationale for new directions. Nat. Rev. Clin. Oncol. 2010, 7:455-465.
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 455-465
    • Pasquier, E.1    Kavallaris, M.2    Andre, N.3
  • 33
    • 84857723974 scopus 로고    scopus 로고
    • VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression
    • Doloff J.C., Waxman D.J. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Res. 2012, 72:1103-1115.
    • (2012) Cancer Res. , vol.72 , pp. 1103-1115
    • Doloff, J.C.1    Waxman, D.J.2
  • 34
    • 0242331613 scopus 로고    scopus 로고
    • Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
    • Bocci G., Francia G., Man S., Lawler J., Kerbel R.S. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc. Natl. Acad Sci. USA 2003, 100:12917-12922.
    • (2003) Proc. Natl. Acad Sci. USA , vol.100 , pp. 12917-12922
    • Bocci, G.1    Francia, G.2    Man, S.3    Lawler, J.4    Kerbel, R.S.5
  • 35
    • 1642368865 scopus 로고    scopus 로고
    • Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
    • Hamano Y., Sugimoto H., Soubasakos M.A., Kieran M., Olsen B.R., Lawler J., Sudhakar A., Kalluri R. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res. 2004, 64:1570-1574.
    • (2004) Cancer Res. , vol.64 , pp. 1570-1574
    • Hamano, Y.1    Sugimoto, H.2    Soubasakos, M.A.3    Kieran, M.4    Olsen, B.R.5    Lawler, J.6    Sudhakar, A.7    Kalluri, R.8
  • 36
    • 36749068990 scopus 로고    scopus 로고
    • Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment
    • Ma J., Waxman D.J. Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment. Mol. Cancer Ther. 2007, 6:2879-2890.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2879-2890
    • Ma, J.1    Waxman, D.J.2
  • 37
    • 33744503923 scopus 로고    scopus 로고
    • The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin
    • Damber J.-E., Vallbo C., Albertsson P., Lennernas B., Norrby K. The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin. Cancer Chemother. Pharmacol. 2006, 58:354-360.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 354-360
    • Damber, J.-E.1    Vallbo, C.2    Albertsson, P.3    Lennernas, B.4    Norrby, K.5
  • 40
    • 33645466808 scopus 로고    scopus 로고
    • Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11
    • Jounaidi Y., Chen C.S., Veal G.J., Waxman D.J. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Mol. Cancer Ther. 2006, 5:541-555.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 541-555
    • Jounaidi, Y.1    Chen, C.S.2    Veal, G.J.3    Waxman, D.J.4
  • 42
    • 0035360868 scopus 로고    scopus 로고
    • Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy
    • Jounaidi Y., Waxman D.J. Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. Cancer Res. 2001, 61:4437-4444.
    • (2001) Cancer Res. , vol.61 , pp. 4437-4444
    • Jounaidi, Y.1    Waxman, D.J.2
  • 43
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • Ma J., Waxman D.J. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol. Cancer Ther. 2008, 7:3670-3684.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 44
    • 59449106047 scopus 로고    scopus 로고
    • Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib
    • Ma J., Waxman D.J. Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib. Clin. Cancer Res. 2009, 15:578-588.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 578-588
    • Ma, J.1    Waxman, D.J.2
  • 46
    • 75749111061 scopus 로고    scopus 로고
    • Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis
    • Yang H., Grossniklaus H.E. Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. Invest. Ophthalmol. Vis. Sci. 2010, 51:28-34.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 28-34
    • Yang, H.1    Grossniklaus, H.E.2
  • 47
    • 34548231729 scopus 로고    scopus 로고
    • Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2
    • Guan M., Jiang H., Xu C., Xu R., Chen Z., Lu Y. Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2. Cancer Biol. Ther. 2007, 6:419-425.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 419-425
    • Guan, M.1    Jiang, H.2    Xu, C.3    Xu, R.4    Chen, Z.5    Lu, Y.6
  • 49
    • 77949621084 scopus 로고    scopus 로고
    • The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer
    • Campbell N.E., Greenaway J., Henkin J., Moorehead R.A., Petrik J. The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer. Neoplasia 2010, 12:275-283.
    • (2010) Neoplasia , vol.12 , pp. 275-283
    • Campbell, N.E.1    Greenaway, J.2    Henkin, J.3    Moorehead, R.A.4    Petrik, J.5
  • 51
    • 79953330322 scopus 로고    scopus 로고
    • Antiangiogenesis enhances intratumoral drug retention
    • Ma J., Chen C.S., Blute T., Waxman D.J. Antiangiogenesis enhances intratumoral drug retention. Cancer Res. 2011, 71:2675-2685.
    • (2011) Cancer Res. , vol.71 , pp. 2675-2685
    • Ma, J.1    Chen, C.S.2    Blute, T.3    Waxman, D.J.4
  • 53
    • 38349145379 scopus 로고    scopus 로고
    • Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib
    • Ma J., Waxman D.J. Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Mol. Cancer Ther. 2008, 7:79-89.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 79-89
    • Ma, J.1    Waxman, D.J.2
  • 54
    • 77954396771 scopus 로고    scopus 로고
    • Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis
    • Yang J., Chen S., Huang X., Han J., Wang Q., Shi D., Cheng R., Gao G., Yang X. Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis. Cancer Biol. Ther. 2010, 9:967-974.
    • (2010) Cancer Biol. Ther. , vol.9 , pp. 967-974
    • Yang, J.1    Chen, S.2    Huang, X.3    Han, J.4    Wang, Q.5    Shi, D.6    Cheng, R.7    Gao, G.8    Yang, X.9
  • 55
    • 84872084645 scopus 로고    scopus 로고
    • Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models
    • Hackl C., Man S., Francia G., Milsom C., Xu P., Kerbel R.S. Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models. Gut 2012, 62:259-271.
    • (2012) Gut , vol.62 , pp. 259-271
    • Hackl, C.1    Man, S.2    Francia, G.3    Milsom, C.4    Xu, P.5    Kerbel, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.