Proximal tubular NHEs: Sodium, protons and calcium?

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 3, 2013, Pages

  Alexander, R Todd ^a,b   Dimke, Henrik ^b   Cordat, Emmanuelle ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Calcium; Paracellular; Parathyroid hormone; Proximal tubule; Sodium hydrogen exchanger isoform 3

Indexed keywords

BICARBONATE; CALCIUM; NUCLEIC ACID BASE; PROTON; SODIUM; SODIUM PROTON EXCHANGE PROTEIN 3;

GENE DELETION; GENE OVEREXPRESSION; HUMAN; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; OSTEOPENIA; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 84880984831     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00065.2013     Document Type: Review

References (130)

1. Abuazza G, Becker A, Williams SS, Chakravarty S, Truong HT, Lin F, Baum M. Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins. Am J Physiol Renal Physiol 291: F1132-F1141, 2006.
2. Agus ZS, Gardner LB, Beck LH, Goldberg M. Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am J Physiol 224: 1143-1148, 1973.
3. Agus ZS, Puschett JB, Senesky D, Goldberg M. Mode of action of parathyroid hormone and cyclic adenosine 3=,5=-monophosphate on renal tubular phosphate reabsorption in the dog. J Clin Invest 50: 617-626, 1971.
4. + exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells. Am J Physiol Cell Physiol 283: C927-C940, 2002.
5. + exchangers and the regulation of volume. Acta Physiol (Oxf) 187: 159-167, 2006.
6. + exchanger. EMBO J 30: 679-691, 2011.
7. Amemiya M, Yamaji Y, Cano A, Moe OW, Alpern RJ. Acid incubation increases NHE-3 mRNA abundance in OKP cells. Am J Physiol Cell Physiol 269: C126-C133, 1995.
8. Angelow S, Ahlstrom R, Yu AS. Biology of claudins. Am J Physiol Renal Physiol 295: F867-F876, 2008.
9. +, HCO3 and Cltransport in the renal proximal tubule. J Nephrol 19, Suppl 9: S3-S10, 2006.
10. Aronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochem Biophys 36: 147-153, 2002.
11. + exchanger isoform 5 (NHE5) from human brain. J Biol Chem 274: 4377-4382, 1999.
12. -/mice. Am J Physiol Renal Physiol 303: F1495-F1502, 2012.
13. Beck LH, Goldberg M. Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium, and phosphate. Am J Physiol 224: 1136-1142, 1973.
14. Becker AM, Zhang J, Goyal S, Dwarakanath V, Aronson PS, Moe OW, Baum M. Ontogeny of NHE8 in the rat proximal tubule. Am J Physiol Renal Physiol 293: F255-F261, 2007.
15. Bezerra CN, Girardi AC, Carraro-Lacroix LR, Reboucas NA. Mechanisms underlying the long-term regulation of NHE3 by parathyroid hormone. Am J Physiol Renal Physiol 294: F1232-F1237, 2008.
16. + exchanger isoform NHE3 in the proximal tubule. J Biol Chem 274: 17518-17524, 1999.
17. + exchanger isoform of renal brush border. Am J Physiol Renal Fluid Electrolyte Physiol 265: F736-F742, 1993.
18. Biemesderfer D, Rutherford PA, Nagy T, Pizzonia JH, Abu-Alfa AK, Aronson PS. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Am J Physiol Renal Physiol 273: F289-F299, 1997.
19. + exchange by 1,25-dihydroxyvitamin D3; interaction with parathyroid-hormone-dependent inhibition. Pflügers Arch 424: 391-397, 1993.
20. + exchange in the proximal tubule. Pflügers Arch 458: 5-21, 2009.
21. Bourgeois S, Meer LV, Wootla B, Bloch-Faure M, Chambrey R, Shull GE, Gawenis LR, Houillier P. NHE4 is critical for the renal handling of ammonia in rodents. J Clin Invest 120: 1895-1904, 2010.
22. Brennan S, Hering-Smith K, Hamm LL. Effect of pH on citrate reabsorption in the proximal convoluted tubule. Am J Physiol Renal Fluid Electrolyte Physiol 255: F301-F306, 1988.
23. Brett CL, Donowitz M, Rao R. Evolutionary origins of eukaryotic sodium/proton exchangers. Am J Physiol Cell Physiol 288: C223-C239, 2005.
24. + exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol Cell Physiol 282: C1031-C1041, 2002.
25. + exchanger isoform NHE2 in rat kidney. Am J Physiol Renal Physiol 275: F379-F386, 1998.
26. Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, Baum M. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest 105: 1141-1146, 2000.
27. + exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis. J Biol Chem 275: 31601-31608, 2000.
28. + exchanger (NHE-2). Proc Natl Acad Sci USA 90: 3938-3942, 1993.
29. + exchanger 3 accumulates and is functional in recycling endosomes. J Biol Chem 273: 2035-2043, 1998.
30. de Rouffignac C, Morel F, Moss N, Roinel N. Micropuncture study of water and electrolyte movements along the loop of Henle in psammomys with special reference to magnesium, calcium and phosphorus. Pflügers Arch 344: 309-326, 1973.
31. Dennis VW. Actions of parathyroid hormone on isolated renal tubules. Ann NY Acad Sci 372: 552-557, 1981.
32. Dennis VW, Stead WW, Myers JL. Renal handling of phosphate and calcium. Annu Rev Physiol 41: 257-271, 1979.
33. + exchanger NHE5. Mol Biol Cell 22: 2246-2257, 2011.
34. + excretion. Am J Physiol Renal Physiol 304: F761-F769, 2013.
35. Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. NHE3 regulatory complexes. J Exp Biol 212: 1638-1646, 2009.
36. Duarte CG, Watson JF. Calcium reabsorption in proximal tubule of the dog nephron. Am J Physiol 212: 1355-1360, 1967.
37. Edwards BR, Baer PG, Sutton RA, Dirks JH. Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron. J Clin Invest 52: 2418-2427, 1973.
38. Edwards BR, Sutton RA, Dirks JH. Effect of calcium infusion on renal tubular reabsorption in the dog. Am J Physiol 227: 13-18, 1974.
39. Elkouby-Naor L, Ben-Yosef T. Functions of claudin tight junction proteins and their complex interactions in various physiological systems. Int Rev Cell Mol Biol 279: 1-32, 2010.
40. Fliser D, Franek E, Fode P, Stefanski A, Schmitt CP, Lyons M, Ritz E. Subacute infusion of physiological doses of parathyroid hormone raises blood pressure in humans. Nephrol Dial Transplant 12: 933-938, 1997.
41. Friedman PA. Basal and hormone-activated calcium absorption in mouse renal thick ascending limbs. Am J Physiol Renal Fluid Electrolyte Physiol 254: F62-F70, 1988.
42. Friedman PA, Gesek FA. Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol Rev 75: 429-471, 1995.
43. Fromter E, Rumrich G, Ullrich KJ. Phenomenologic description of Na, Cl and HCO3 absorption from proximal tubules of rat kidney. Pflügers Arch 343: 189-220, 1973.
44. Garvin JL, Knepper MA. Bicarbonate and ammonia transport in isolated perfused rat proximal straight tubules. Am J Physiol Renal Fluid Electrolyte Physiol 253: F277-F281, 1987.
45. + exchanger. J Biol Chem 280: 12781-12789, 2005.
46. Gawenis LR, Stien X, Shull GE, Schultheis PJ, Woo AL, Walker NM, Clarke LL. Intestinal NaCl transport in NHE2 and NHE3 knockout mice. Am J Physiol Gastrointest Liver Physiol 282: G776-G784, 2002.
47. Gekle M, Drumm K, Mildenberger S, Freudinger R, Gassner B, Silbernagl S. Inhibition of Na-H exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum. J Physiol 520: 709-721, 1999.
48. Gekle M, Freudinger R, Mildenberger S. Inhibition of Na-H exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion. J Physiol 531: 619-629, 2001.
49. + exchanger supports proximal tubular protein reabsorption in vivo. Am J Physiol Renal Physiol 287: F469-F473, 2004.
50. Gill R, Nazir TM, Wali R, Sitrin M, Brasitus TA, Ramaswamy K, Dudeja PK. Regulation of rat ileal NHE3 by 1,25(OH)2-vitamin D3. Dig Dis Sci 47: 1169-1174, 2002.
51. Girardi AC, Titan SM, Malnic G, Reboucas NA. Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Kidney Int 58: 1623-1631, 2000.
52. 2 transport in response to CaSR signalling via a novel microRNA pathway. EMBO J 31: 1999-2012, 2012.
53. Goyal S, Mentone S, Aronson PS. Immunolocalization of NHE8 in rat kidney. Am J Physiol Renal Physiol 288: F530-F538, 2005.
54. + exchanger isoform NHE8. Am J Physiol Renal Physiol 284: F467-F473, 2003.
55. 3H-inulin and electrolyte concentrations in Bowman's capsule in rat kidney. Comparison with artificial ultrafiltration. Pflügers Arch 354: 117-131, 1975.
56. Haas HG, Dambacher MA, Guncaga J, Lauffenbruger T. Renal effects of calcitonin and parathyroid extract in man. Studies in hypoparathyroidism. J Clin Invest 50: 2689-2702, 1971.
57. + exchanger NHE3. J Biomed Biotechnol 2010: 238080, 2010.
58. + exchangers NHE6 and NHE9. J Neurosci 26: 9944-9955, 2006.
59. Hochberg Z, Moses AM, Richman RA. Parathyroid hormone infusion test in children and adolescents. Miner Electrolyte Metab 10: 113-116, 1984.
60. Hou J, Goodenough DA. Claudin-16 and claudin-19 function in the thick ascending limb. Curr Opin Nephrol Hypertens 19: 483-488, 2010.
61. Hou J, Renigunta A, Konrad M, Gomes AS, Schneeberger EE, Paul DL, Waldegger S, Goodenough DA. Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest 118: 619-628, 2008.
62. Howlin KJ, Alpern RJ, Rector FC Jr. Amiloride inhibition of proximal tubular acidification. Am J Physiol Renal Fluid Electrolyte Physiol 248: F773-F778, 1985.
63. Hulter HN, Melby JC, Peterson JC, Cooke CR. Chronic continuous PTH infusion results in hypertension in normal subjects. J Clin Hypertens 2: 360-370, 1986.
64. + exchanger via modulating membrane surface potential. Channels (Austin) 5: 308-313, 2011.
65. Joseph C, Twombley K, Gattineni J, Zhang Q, Dwarakanath V, Baum M. Acid increases NHE8 surface expression and activity in NRK cells. Am J Physiol Renal Physiol 302: F495-F503, 2012.
66. Karlen J, Aperia A, Zetterstrom R. Renal excretion of calcium and phosphate in preterm and term infants. J Pediatr 106: 814-819, 1985.
67. Kinsella JL, Aronson PS. Interaction of NH4 and Li with the renal microvillus membrane Na-H exchanger. Am J Physiol Cell Physiol 241: C220-C226, 1981.
68. Kinsella JL, Aronson PS. Properties of the Na-H exchanger in renal microvillus membrane vesicles. Am J Physiol Renal Fluid Electrolyte Physiol 238: F461-F469, 1980.
69. Kiuchi-Saishin Y, Gotoh S, Furuse M, Takasuga A, Tano Y, Tsukita S. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol 13: 875-886, 2002.
70. Kleeman CR, Bohannan J, Bernstein D, Ling S, Maxwell MH. Effect of variations in sodium intake on calcium excretion in normal humans. Proc Soc Exp Biol Med 115: 29-32, 1964.
71. Kuntziger H, Amiel C, Roinel N, Morel F. Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium. Am J Physiol 227: 905-911, 1974.
72. Lassiter WE, Gottschalk CW, Mylle M. Micropuncture study of renal tubular reabsorption of calcium in normal rodents. Am J Physiol 204: 771-775, 1963.
73. + exchanger but not in mice lacking NHE2. Am J Physiol Renal Physiol 281: F718-F727, 2001.
74. Leong PK, Yang LE, Lin HW, Holstein-Rathlou NH, McDonough AA. Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol 287: R878-R885, 2004.
75. Liu FY, Cogan MG. Angiotensin II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic adenosine monophosphate. J Clin Invest 84: 83-91, 1989.
76. Liu FY, Cogan MG. Axial heterogeneity in the rat proximal convoluted tubule. I. Bicarbonate, chloride, and water transport. Am J Physiol Renal Fluid Electrolyte Physiol 247: F816-F821, 1984.
77. Lorenz JN, Schultheis PJ, Traynor T, Shull GE, Schnermann J. Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am J Physiol Renal Physiol 277: F447-F453, 1999.
78. Loupy A, Ramakrishnan SK, Wootla B, Chambrey R, de la Faille R, Bourgeois S, Bruneval P, Mandet C, Christensen EI, Faure H, Cheval L, Laghmani K, Collet C, Eladari D, Dodd RH, Ruat M, Houillier P. PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest 122: 3355-3367, 2012.
79. Marone CC, Wong NL, Sutton RA, Dirks JH. Effects of metabolic alkalosis on calcium excretion in the conscious dog. J Lab Clin Med 101: 264-273, 1983.
80. McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol 298: R851-R861, 2010.
81. Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, Mihara K. NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276: 49221-49227, 2001.
82. Moe OW. Cohesion of epithelial ion homeostasis: implementing calcium transport with sodium transporters? Am J Physiol Renal Physiol 302: F941-F942, 2012.
83. Morel F, Roinel N, Le Grimellec C. Electron probe analysis of tubular fluid composition. Nephron 6: 350-364, 1969.
84. Murayama Y, Morel F, Le Grimellec C. Phosphate, calcium and magnesium transfers in proximal tubules and loops of Henle, as measured by single nephron microperfusion experiments in the rat. Pflügers Arch 333: 1-16, 1972.
85. Murer H, Hopfer U, Kinne R. Sodium/proton antiport in brush-bordermembrane vesicles isolated from rat small intestine and kidney. Biochem J 154: 597-604, 1976.
86. Muto S, Hata M, Taniguchi J, Tsuruoka S, Moriwaki K, Saitou M, Furuse K, Sasaki H, Fujimura A, Imai M, Kusano E, Tsukita S, Furuse M. Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci USA 107: 8011-8016, 2010.
87. Nagami GT. Ammonia production and secretion by the proximal tubule. Am J Kidney Dis 14: 258-261, 1989.
88. Nagami GT. Luminal secretion of ammonia in the mouse proximal tubule perfused in vitro. J Clin Invest 81: 159-164, 1988.
89. + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280: 1561-1572, 2005.
90. Ng RC, Rouse D, Suki WN. Calcium transport in the rabbit superficial proximal convoluted tubule. J Clin Invest 74: 834-842, 1984.
91. 2 channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 115: 1651-1658, 2005.
92. + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines. J Cell Sci 109: 929-939, 1996.
93. Noonan WT, Woo AL, Nieman ML, Prasad V, Schultheis PJ, Shull GE, Lorenz JN. Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine. Am J Physiol Regul Integr Comp Physiol 288: R685-R691, 2005.
94. + exchanger localized to the trans-Golgi network. J Biol Chem 276: 17387-17394, 2001.
95. Orlowski J, Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflügers Arch 447: 549-565, 2004.
96. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
97. Pan W, Borovac J, Spicer Z, Hoenderop JG, Bindels RJ, Shull GE, Doschak MR, Cordat E, Alexander RT. The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol 302: F943-F956, 2012.
98. + exchanger-deficient mice. J Biol Chem 276: 27042-27050, 2001.
99. + exchanger isoform NHE4. Am J Physiol Renal Physiol 275: F510-F517, 1998.
100. + antiporter in rat proximal tubule bicarbonate absorption. J Clin Invest 80: 970-978, 1987.
101. Rector FC Jr. Sodium, bicarbonate, and chloride absorption by the proximal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 244: F461-F471, 1983.
102. Rotin D, Grinstein S. Impaired cell volume regulation in Na -H exchange-deficient mutants. Am J Physiol Cell Physiol 257: C1158-C1165, 1989.
103. Rouse D, Ng RC, Suki WN. Calcium transport in the pars recta and thin descending limb of Henle of the rabbit, perfused in vitro. J Clin Invest 65: 37-42, 1980.
104. Rutherford PA, Pizzonia JH, Biemesderfer D, Abu-Alfa A, Reilly R, Aronson PS. Expression of Na-H exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Exp Nephrol 5: 490-497, 1997.
105. + antiporter. Cell 56: 271-280, 1989.
106. Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, Verkman AS. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci USA 95: 9660-9664, 1998.
107. Schor N, Ichikawa I, Brenner BM. Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat. Kidney Int 20: 442-451, 1981.
108. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest 101: 1243-1253, 1998.
109. + exchanger. Nat Genet 19: 282-285, 1998.
110. Sekine T, Cha SH, Hosoyamada M, Kanai Y, Watanabe N, Furuta Y, Fukuda K, Igarashi T, Endou H. Cloning, functional characterization, and localization of a rat renal Na-dicarboxylate transporter. Am J Physiol Renal Physiol 275: F298-F305, 1998.
111. Seldin DW. Renal handling of calcium. Nephron 81, Suppl 1: 2-7, 1999.
112. Suki WN. Calcium transport in the nephron. Am J Physiol Renal Fluid Electrolyte Physiol 237: F1-F6, 1979.
113. Suki WN, Rouse D, Ng RC, Kokko JP. Calcium transport in the thick ascending limb of Henle. Heterogeneity of function in the medullary and cortical segments. J Clin Invest 66: 1004-1009, 1980.
114. Suki WN, Schwettmann RS, Rector FC Jr, Seldin DW. Effect of chronic mineralocorticoid administration on calcium excretion in the rat. Am J Physiol 215: 71-74, 1968.
115. Sutton RA, Dirks JH. The renal excretion of calcium: a review of micropuncture data. Can J Physiol Pharmacol 53: 979-988, 1975.
116. Sutton RA, Wong NL, Dirks JH. Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kidney Int 15: 520-533, 1979.
117. Tsukita S, Furuse M. Occludin and claudins in tight-junction strands: leading or supporting players? Trends Cell Biol 9: 268-273, 1999.
118. Twombley K, Gattineni J, Bobulescu IA, Dwarakanath V, Baum M. Effect of metabolic acidosis on neonatal proximal tubule acidification. Am J Physiol Regul Integr Comp Physiol 299: R1360-R1368, 2010.
119. Wali RK, Baum CL, Bolt MJ, Brasitus TA, Sitrin MD. 1,25-dihydroxyvitamin D3 inhibits Na-H exchange by stimulating membrane phosphoinositide turnover and increasing cytosolic calcium in CaCo-2 cells. Endocrinology 131: 1125-1133, 1992.
120. Wang T, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Giebisch G, Aronson PS. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am J Physiol Renal Physiol 277: F298-F302, 1999.
121. Wang W, Kwon TH, Li C, Frokiaer J, Knepper MA, Nielsen S. Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats. Am J Physiol Renal Physiol 282: F34-F44, 2002.
122. Wang W, Li C, Kwon TH, Miller RT, Knepper MA, Frokiaer J, Nielsen S. Reduced expression of renal Na transporters in rats with PTH-induced hypercalcemia. Am J Physiol Renal Physiol 286: F534-F545, 2004.
123. + exchanger 3 affects transport property of H /oligopeptide transporter 1. Drug Metab Pharmacokinet 20: 443-451, 2005.
124. 2 transport in the cortical thick ascending limb of Henle's loop of the mouse: evidence for a change in the paracellular pathway permeability. Pflügers Arch 423: 387-396, 1993.
125. Worcester EM, Coe FL, Evan AP, Bergsland KJ, Parks JH, Willis LR, Clark DL, Gillen DL. Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients. Am J Physiol Renal Physiol 295: F1286-F1294, 2008.
126. Xu H, Zhang B, Li J, Wang C, Chen H, Ghishan FK. Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice. Am J Physiol Gastrointest Liver Physiol 303: G335-G343, 2012.
127. Yang LE, Maunsbach AB, Leong PK, McDonough AA. Differential traffic of proximal tubule Na transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol 287: F896-F906, 2004.
128. Yeh BI, Sun TJ, Lee JZ, Chen HH, Huang CL. Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem 278: 51044-51052, 2003.
129. + exchanger NHE8 in cultured renal epithelial cells. Am J Physiol Renal Physiol 293: F761-F766, 2007.
130. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol Renal Physiol 276: F711-F719, 1999.