Mechanisms underlying the long-term regulation of NHE3 by parathyroid hormone

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 5, 2008, Pages

  Bezerra, Camila Nogueira Alves ^a   Girardi, Adriana Castello Costa ^a   Carraro Lacroix, Luciene Regina ^a   Rebouças, Nancy Amaral ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hyperparathyroidism; Na+ H+ exchange; Promoter activity; Proximal tubule; Surface expression

Indexed keywords

KT 5720; MESSENGER RNA; PARATHYROID HORMONE; SODIUM PROTON EXCHANGE PROTEIN 3; CARBAZOLE DERIVATIVE; ENZYME INHIBITOR; INDOLE DERIVATIVE; LUCIFERASE; PYRROLE DERIVATIVE; SODIUM; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; GENE EXPRESSION; HALF LIFE TIME; HORMONAL REGULATION; KIDNEY CELL; KIDNEY EPITHELIUM; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA STABILITY; SODIUM TRANSPORT; ANIMAL; BIOSYNTHESIS; BIOTINYLATION; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; PHYSIOLOGY; PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BIOTINYLATION; CARBAZOLES; CELL LINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INDOLES; KIDNEY; LUCIFERASES; OPOSSUMS; PARATHYROID HORMONE; PLASMIDS; PROMOTER REGIONS (GENETICS); PYRROLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM; SODIUM-HYDROGEN ANTIPORTER;

EID: 45149129484     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00025.2007     Document Type: Article

References (36)

1. Arruda JA, Nascimento L, Westenfelder C, Kurtzman NA. Effect of parathyroid hormone on urinary acidification. Am J Physiol Renal Fluid Electrolyte Physiol 232: F429-F433, 1977.
2. Bank N, Aynedjian HS. A micropuncture study of the effect of parathyroid hormone on renal bicarbonate reabsorption. J Clin Invest 58: 336-344, 1976.
3. Cano A. Characterization of the rat NHE3 promoter. Am J Physiol Renal Fluid Electrolyte Physiol 271: F629-F636, 1996.
4. Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, Baum M. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest 105: 1141-1146, 2000.
5. Cole JA, Forte LR, Krause WJ, Thorne PK. Clonal sublines that are morphologically and functionally distinct from parental OK cells. Am J Physiol Renal Fluid Electrolyte Physiol 256: F672-F679, 1989.
6. + exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis. J Biol Chem 275: 31601-31608, 2000.
7. Ellsworth R, Nicholson WM. Further observations upon the changes in the electrolytes of the urine following the injection of parathyroid extract. J Clin Invest 14: 823-827, 1935.
8. Gao XH, Dwivedi PP, Choe S, Alba F, Morris HA, Omdahl JL, Ma BK. Basal and parathyroid hormone induced expression of the human 25-hydroxyvitamin D 1α-hydroxylase gene promoter in kidney AOK-B50 cells: role of Sp1, Ets and CCAAT box protein binding sites. Int J Biochem Cell Biol 34: 921-930, 2002.
9. Gentili C, Morelli S, De Boland AR. 1α,25(OH)2D3 and parathyroid hormone (PTH) signaling in rat intestinal cells: activation of cytosolic PLA2. J Steroid Biochem Mol Biol 89-90(1-5): 297-301, 2004.
10. Gentili C, Morelli S, Russo De Boland A. Involvement of PI3-kinase and its association with c-Src in PTH-stimulated rat enterocytes. J Cell Biochem 86: 773-783, 2002.
11. + exchanger isoform NHE3 in proximal tubule cells. Am J Physiol Cell Physiol 287: C1238-C1245, 2004.
12. Girardi ACC, Titan SMO, Malnic G, Rebouças NA. Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules. Kidney Int 58: 1623-1631, 2000.
13. Halladay DL, Miles RR, Thirunavukkarasu K, Chandraekhar S, Martin TJ, Onyia JE. Identification of signal transduction pathways and promoter sequences that mediate parathyroid hormone 1-38 inhibition of osteoprotegerin gene expression. J Cell Biochem 84: 1-11, 2002.
14. Hellman DE, Au WY, Bartter FC. Evidence for a direct effect of parathyroid hormone on urinary acidification. Am J Physiol 209: 643-650, 1965.
15. Iino Y, Burg MB. Effect of parathyroid hormone on bicarbonate absorption by proximal tubules in vitro. Am J Physiol Renal Fluid Electrolyte Physiol 236: F387-F391, 1979.
16. + exchanger Nhe3 gene. J Biol Chem 271: 10551-10559, 1996.
17. Karlinsky ML, Sager DS, Kurtzman NA, Dillay VKG. Effect of parathormone and cyclic adenosine monophosphate on renal bicarbonate reabsorption. Am J Physiol 227: 1226-1231, 1974.
18. Kawane T, Mimura J, Yanagawa T, Fujii-Kuriyama Y, Horiuchi N. Parathyroid hormone (PTH) downregulates PTH/PTH-related protein receptor gene expression in UMR-106 osteoblast-like cells via a 3′,5′-cyclic adenosine monophosphate-dependent, protein kinase A-independent pathway. J Endocrinol 178: 247-256, 2003.
19. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nat Biotechnol 227: 680-685, 1970.
20. + transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol 287: R878-R885, 2004.
21. Lorenz JN, Schultheis PJ, Traynor T, Shull GE, Schnermann J. Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am J Physiol Renal Physiol 277: F447-F453, 1999.
22. + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417: 858-861, 2002.
23. Mahon MJ, Segre GV. Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J Biol Chem 279: 23550-23558, 2004.
24. Malakooti J, Sandoval R, Amin MR, Clark J, Dudeja PK, Ramaswamy K. Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1. Biochem J 396: 327-336, 2006.
25. Mrkic B, Forgo J, Murer H, Helmle-Kolb C. Apical and basolateral Na/H exchange in cultured murine proximal tubule cells (MCT): effect of parathyroid hormone (PTH). J Membr Biol 130: 205-217, 1992.
26. Mrkic B, Tse CM, Forgo J, Helmle-Kolb C, Donowitz M, Murer H. Identification of PTH-responsive Na/H-exchanger isoforms in a rabbit proximal tubule cell line (RKPC-2). Pflügers Arch 424: 377-384, 1993.
27. + antiporter activity in a cultured renal cell line. Am J Physiol Renal Fluid Electrolyte Physiol 250: F217-F225, 1986.
28. Rodman JS, Heinemann HO. Parathyroid hormone and the regulation of acid-base balance. Am J Med Sci 270: 481-489, 1975.
29. + exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3. Am J Physiol Renal Physiol 278: F375-F379, 2000.
30. Wang B, Bisello A, Yang Y, Romero GG, Friedman PA. NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem 282: 36214-36222, 2007.
31. Wang T, Hropot M, Aronson PS, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Am J Physiol Renal Physiol 281: F1117-F1122, 2001.
32. Wang T, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Giebisch G, Aronson PS. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am J Physiol Renal Physiol 277: F298-F302, 1999.
33. + exchange. Adaptation to metabolic acidosis. J Biol Chem 271: 32749-32752, 1996.
34. + transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol 287: F896-F906, 2004.
35. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol Renal Physiol 276: F711-F719, 1999.
36. Zhao H, Wiederkehr MR, Fan L, Collazo RL, Crowder LA, Moe OW. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605. J Biol Chem 274: 3978-3987, 1999.