PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor

Journal of Clinical Investigation

Volumn 122, Issue 9, 2012, Pages 3355-3367

  Loupy, Alexandre ^a,b,c,d   Ramakrishnan, Suresh Krishna ^a,b,c   Wootla, Bharath ^a,b,c,d   Chambrey, Régine ^a,b,c   De La Faille, Renaud ^a,c,d,e   Bourgeois, Soline ^f   Bruneval, Patrick ^d,e   Mandet, Chantal ^d,e   Christensen, Erik Ilso ^g   Faure, Hélène ^h   Cheval, Lydie ^a,b,c,d   Laghmani, Kamel ^a,b,c,d   Collet, Corinne ⁱ   Eladari, Dominique ^a,c,d,e   Dodd, Robert H ^c   Ruat, Martial ^h   Houillier, Pascal ^a,c,d,e  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^f UNIVERSITY OF ZURICH   (Switzerland)

^g AARHUS UNIVERSITY   (Denmark)

^h Signal Transduction and Developmental Neuropharmacology Group   (France)

ⁱ HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 6 [3 [1,1 DIMETHYL 2 (2 NAPHTHYL)ETHYLAMINO] 2 HYDROXYPROPOXY]BENZONITRILE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM SENSING RECEPTOR; CREATININE; PARATHYROID HORMONE; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; PLACEBO; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM ABSORPTION; CALCIUM METABOLISM; CELL STRAIN HEK293; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE URINE LEVEL; DIET THERAPY; DRUG EFFECT; HENLE LOOP; HORMONAL REGULATION; HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOPARATHYROIDISM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TUBULE ABSORPTION; LOW CALCIUM DIET; MALE; NONHUMAN; PERFUSION; PHOSPHATE URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URINARY EXCRETION; WESTERN BLOTTING;

AMINO ACIDS; ANIMALS; BONE DENSITY CONSERVATION AGENTS; CALCIUM; CREATININE; DIPHOSPHONATES; HYPOPARATHYROIDISM; LOOP OF HENLE; MALE; NAPHTHALENES; OSTEOCALCIN; PARATHYROID HORMONE; PARATHYROIDECTOMY; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCIUM-SENSING; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84865979527     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI57407     Document Type: Article

References (56)

1. Jaeger P, et al. Animal model of primary hyperparathyroidism. Am J Physiol. 1987;252(6 pt 1):E790-E798.
2. Brown EM, et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 1993;366(6455):575-580. (Pubitemid 24035999)
3. Riccardi D, Brown EM. Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol. 2010;298(3):F485-F499.
4. Brown EM. Clinical lessons from the calcium-sensing receptor. Nat Clin Pract Endocrinol Metab. 2007;3(2):122-133. (Pubitemid 46146965)
5. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2005;90(1):135-141. (Pubitemid 40116646)
6. Block GA, et al. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med. 2004;350(15):1516-1525. (Pubitemid 38477776)
7. Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles LD. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest. 2003;111(7):1029-1037. (Pubitemid 36397479)
8. Kos CH, et al. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003;111(7):1021-1028. (Pubitemid 36397478)
9. Egbuna O, et al. The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Am J Physiol Renal Physiol. 2009;297(3):F720-F728.
10. Kantham L, et al. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab. 2009;297(4):E915-E923.
11. Gowen M, et al. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J Clin Invest. 2000;105(11):1595-1604. (Pubitemid 30390310)
12. Jara A, Lee E, Stauber D, Moatamed F, Felsenfeld AJ, Kleeman CR. Phosphate depletion in the rat: effect of bisphosphonates and the calcemic response to PTH. Kidney Int. 1999;55(4):1434-1443. (Pubitemid 29157142)
13. Lee CT, Huynh VM, Lai LW, Lien YH. Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild-type mice. Kidney Int. 2002;62(6):2055-2061. (Pubitemid 35366159)
14. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001;81(1):239-297. (Pubitemid 32096177)
15. Yang T, Hassan S, Huang YG, Smart AM, Briggs JP, Schnermann JB. Expression of PTHrP, PTH/PTHrP receptor, and Ca(2+)-sensing receptor mRNAs along the rat nephron. Am J Physiol. 1997;272(6 pt 2):F751-F758.
16. Braden GL, Sharon GC, Marconi TC. Immunolocalization of the calcium-sensing receptor in developing and adult human kidney [ASN abstract PO673]. J Am Soc Nephrol. 2009;20:269A. http://www.asn-online.org/education-and- meetings/kidneyweek/archives.
17. Ho C, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995;11(4):389-394.
18. Parfitt AM. Equilibrium and disequilibrium hypercalcemia: new light on an old concept. Metab Bone Dis Rel Res. 1979;1:279-293.
19. Maruani G, Hertig A, Paillard M, Houillier P. Normocalcemic primary hyperparathyroidism: evidence for a generalized target-tissue resistance to parathyroid hormone. J Clin Endocrinol Metab. 2003;88(10):4641-4648. (Pubitemid 37357505)
20. Law WM, James EM Jr, Charboneau JW, Purnell DC, Heath H. High-resolution parathyroid ultrasonography in familial benign hypercalcemia (familial hypocalciuric hypercalcemia). Mayo Clin Proc. 1984;59(3):153-155. (Pubitemid 14163365)
21. Abugassa S, Nordenstrom J, Jarhult J. Bone mineral density in patients with familial hypocalciuric hypercalcaemia (FHH). Eur J Surg. 1992;158(8):397-402.
22. Sands JM, et al. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest. 1997;99(6):1399-1405. (Pubitemid 27142778)
23. Levi M, Peterson L, Berl T. Mechanism of concentrating defect in hypercalcemia. Kidney Int. 1983;23(3):489-497.
24. Earm JH, et al. Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats. J Am Soc Nephrol. 1998;9(12):2181-2193.
25. Renkema KY, et al. The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis. J Am Soc Nephrol. 2009;20(8):1705- 1713.
26. De Jesus Ferreira MC, Bailly C. Extracellular Ca2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol. 1998;275(2 pt 2):F198-F203.
27. Desfleurs E, et al. Calcium-sensing receptor: regulation of electrolyte transport in the thick ascending limb of Henle's loop. Kidney Blood Press Res. 1998;21(6):401-412.
28. Wittner M, Mandon B, Roinel N, de Rouffignac C, Di Stefano A. Hormonal stimulation of Ca2+ and Mg2+ transport in the cortical thick ascending limb of Henle's loop of the mouse: evidence for a change in the paracellular pathway permeability. Pflugers Arch. 1993;423(5-6):387-396. (Pubitemid 23172394)
29. Motoyama HI, Friedman PA. Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs. Am J Physiol Renal Physiol. 2002;283(3):F399-F406.
30. Tan SQ, Thomas D, Jao W, Bourdeau JE, Lau K. Surgical thyroparathyroidectomy of the rabbit. Am J Physiol. 1987;252(4 pt 2):F761-F767.
31. Ibrahim MM, Forte LR, Thomas ML. Maintenance of normocalcemia by continuous infusion of the synthetic bovine parathyroid hormone (1-34) in parathyroidectomized rats. Calcif Tissue Int. 1982;34(6):553-557. (Pubitemid 13172954)
32. Mohebbi N, Kovacikova J, Nowik M, Wagner CA. Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney. Am J Physiol Renal Physiol. 2007;293(1):F416-F427. (Pubitemid 47345043)
33. Cheval L, et al. Atlas of gene expression in the mouse kidney: new features of glomerular parietal cells. Physiol Genomics. 2011;43(3):161-173.
34. Bourgeois S, et al. Differentiated thick ascending limb (TAL) cultured cells derived from SV40 transgenic mice express functional apical NHE2 isoform: effect of nitric oxide. Pflugers Arch. 2003;446(6):672-683. (Pubitemid 37215003)
35. Duong Van Huyen JP, et al. GDF15 triggers homeostatic proliferation of acid-secreting collecting duct cells. J Am Soc Nephrol. 2008;19(10):1965-1974.
36. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest. 1999;104(7):R19-R23. (Pubitemid 29536348)
37. Chambrey R, et al. Immunolocalization of the Na+/H+ exchanger isoform NHE2 in rat kidney. Am J Physiol. 1998;275(3 pt 2):F379-F386.
38. McCulloch F, Chambrey R, Eladari D, Peti-Peterdi J. Localization of connexin 30 in the luminal membrane of cells in the distal nephron. Am J Physiol Renal Physiol. 2005;289(6):F1304-F1312. (Pubitemid 41681365)
39. Quentin F, et al. The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol. 2004;287(6):F1179-F1188. (Pubitemid 39507227)
40. Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A. 2001;98(16):9425-9430. (Pubitemid 32743933)
41. Jaisser F. [Molecular and functional diversity of NA,K-ATPase and renal H,K-ATPases]. Nephrologie. 1996;17(7):401-408.
42. Goldsmith PK, et al. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J Biol Chem. 1999;274(16):11303-11309.
43. Petrel C, et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem. 2003;278(49):49487-49494.
44. Quentin F, et al. Regulation of the Cl-/HCO3-exchanger AE2 in rat thick ascending limb of Henle's loop in response to changes in acid-base and sodium balance. J Am Soc Nephrol. 2004;15(12):2988-2997. (Pubitemid 39578830)
45. Chambrey R, et al. Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. Am J Physiol Renal Physiol. 2001;281(4):F707-F717.
46. Eladari D, et al. Expression of RhCG, a new putative NH(3)/NH(4)(+) transporter, along the rat nephron. J Am Soc Nephrol. 2002;13(8):1999-2008. (Pubitemid 34790775)
47. Quentin F, et al. RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron. J Am Soc Nephrol. 2003;14(3):545-554. (Pubitemid 36245997)
48. Burg M, Grantham J, Abramow M, Orloff J. Preparation and study of fragments of single rabbit nephrons. Am J Physiol. 1966;210(6):1293-1298.
49. Lerolle N, Bourgeois S, Leviel F, Lebrun G, Paillard M, Houillier P. Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb. Am J Physiol Renal Physiol. 2004;287(3):F404-F410. (Pubitemid 39095953)
50. Picard N, et al. Defective ENaC processing and function in tissue kallikrein-deficient mice. J Biol Chem. 2008;283(8):4602-4611.
51. Champigneulle A, Siga E, Vassent G, Imbert-Teboul M. V2-like vasopressin receptor mobilizes intracellular Ca2+ in rat medullary collecting tubules. Am J Physiol. 1993;265(1 pt 2):F35-F45. (Pubitemid 23221549)
52. Nemeth EF, et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci U S A. 1998;95(7):4040-4045. (Pubitemid 28173250)
53. Harrington PE, Fotsch C. Calcium sensing receptor activators: calcimimetics. Curr Med Chem. 2007;14(28):3027-3034. (Pubitemid 350226971)
54. Poumarat JS, et al. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Kidney Int. 2002;62(2):434-445.
55. Zhelyaskov VR, Liu S, Broderick MP. Analysis of nanoliter samples of electrolytes using a flowthrough microfluorometer. Kidney Int. 2000;57(4):1764-1769. (Pubitemid 30207936)
56. Bourdeau JE, Burg MB. Voltage dependence of calcium transport in the thick ascending limb of Henle's loop. Am J Physiol. 1979;236(4):F357-F364. (Pubitemid 9176171)