Vestibular hair bundles control pH with (Na+, K +)/H+ exchangers NHE6 and NHE9

Journal of Neuroscience

Volumn 26, Issue 39, 2006, Pages 9944-9955

  Hill, Jennifer K ^a,d   Brett, Christopher L ^b   Chyou, Anthony ^b   Kallay, Laura M ^b   Sakaguchi, Masao ^c   Rao, Rajini ^b   Gillespie, Peter G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF HYOGO   (Japan)

^d Bldg 142   (United States)

Author keywords

H+; Hair cells; Ion transport; Mechanotransduction; NHE; pH

Indexed keywords

BICARBONATE; CALCIUM ION; ISOPROTEIN; POTASSIUM CHLORIDE; POTASSIUM ION; PROTON; RUBIDIUM ION; SODIUM CHLORIDE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 6; SODIUM PROTON EXCHANGE PROTEIN 9; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE; COCHLEA POTENTIAL; CONTROLLED STUDY; ENDOLYMPH; HAIR CELL; ION EXCHANGE; ION TRANSPORT; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SACCULUS; YEAST;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM SIGNALING; CALCIUM-TRANSPORTING ATPASES; CERCOPITHECUS AETHIOPS; COS CELLS; FLUORESCEINS; FLUORESCENT DYES; GENETIC COMPLEMENTATION TEST; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, INNER; HAIR CELLS, VESTIBULAR; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOTOBLEACHING; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASES; POTASSIUM; PROTEIN TRANSPORT; PROTONS; RANA CATESBEIANA; RHODAMINES; SACCHAROMYCES CEREVISIAE; SODIUM; SODIUM-HYDROGEN ANTIPORTER; TRANSFECTION;

EID: 33749163557     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2990-06.2006     Document Type: Article

References (48)

1. Abacioglu YH, Fouts TR, Laman JD, Claassen E, Pincus SH, Moore JP, Roby CA, Kamin-Lewis R, Lewis GK (1994) Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies. AIDS Res Hum Retroviruses 10:371-381.
2. + exchanger. Annu Rev Physiol 47:545-560.
3. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S (1989) Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245:855-857.
4. Bond BR, Ng LL, Schulte BA (1998) Identification of mRNA transcripts and immunohistochemical localization of Na/H exchanger isoforms in gerbil inner ear. Hear Res 123:1-9.
5. Bowman EJ, Siebers A, Altendorf K (1988) Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci USA 85:7972-7976.
6. i through voltage-sensitive calcium channels. Eur J Neurosci 10:971-975.
7. 2+ homeostasis in hair cells. J Neurosci 21:2640-2650.
8. + exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol Cell Physiol 282:C1031-C1041.
9. Brett CL, Donowitz M, Rao R (2005a) Evolutionary origins of eukaryotic sodium/proton exchangers. Am J Physiol Cell Physiol 288:C223-C239.
10. + exchanger Nhx1 regulates cellular pH to control vesicle trafficking. Mol Biol Cell 16:1396-1405.
11. + exchanger protein. Detergent-resistant aggregation and membrane microdistribution. Eur J Biochem 269:4887-4895.
12. 2+ pump of the plasma membrane. J Biol Chem 267:2115-2118.
13. Chabbert CH (1997) Heterogeneity of hair cells in the bullfrog sacculus. Pflügers Arch 435:82-90.
14. Chesler M (2003) Regulation and modulation of pH in the brain. Physiol Rev 83:1183-1221.
15. Dechesne CJ, Winsky L, Kim HN, Goping G, Vu TD, Wenthold RJ, Jacobowitz DM (1991) Identification and ultrastructural localization of a calretinin-like calcium-binding protein (protein 10) in the guinea pig and rat inner ear Brain Res 560:139-148.
16. Dechesne CJ, Rabejac D, Desmadryl G (1994) Development of calretinin immunoreactivity in the mouse inner ear. J Comp Neurol 346:517-529.
17. 2+-ATPase isoform 2a is the PMCA of hair bundles. J Neurosci 21:5066-5078.
18. Edmonds B, Reyes R, Schwaller B, Roberts WM (2000) Calretinin modifies presynaptic calcium signaling in frog saccular hair cells. Nat Neurosci 3:786-790.
19. + exchanger in the guinea pig cochlea. Hear Res 128:89-96.
20. Goyal S, Mentone S, Aronson PS (2005) Immunolocalization of NHE8 in rat kidney. Am J Physiol Renal Physiol 288:F530-F538.
21. + countertransport and electrogenicity in proteoliposomes containing erythrocyte plasma membrane Ca-ATPase and exogenous lipids. J Biol Chem 269:14268-14275.
22. 2+-ATPase isoform 2 to hair bundles. J Neurosci 26:6172-6180.
23. Hirono M, Denis CS, Richardson GP, Gillespie PG (2004) Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation. Neuron 44:309-320.
24. Ikeda K, Saito Y, Nishiyama A, Takasaka T (1992) Intracellular pH regulation in isolated cochlear outer hair cells of the guinea-pig. J Physiol (Lond) 447:627-648.
25. Kasai H, Neher E (1992) Dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels in a mammalian neuroblastoma-glioma cell line. J Physiol (Lond) 448:161-188.
26. 2+-ATPase isoform 2. J Biol Chem 273:18693-18696.
27. Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, Mihara K (2001) NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276:49221-49227.
28. Mroz EA, Lechene C (1993) Extracellular N-methyl-D-glucamine leads to loss of hair-cell sodium, potassium, and chloride. Hear Res 70:146-150.
29. Mukherjee S, Kallay L, Brett CL, Rao R (2006) Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homeostasis and vesicle trafficking. Biochem J 398:97-105.
30. +]ATPase in secretory vesicles. A new strategy for directed mutagenesis. J Biol Chem 266:7940-7949.
31. + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280:1561-1572.
32. + exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis. J Biol Chem 273:21054-21060.
33. + exchanger localized to the trans-Golgi network. J Biol Chem 276:17387-17394.
34. + exchanger. J Biol Chem 273:6951-6959.
35. Orlowski J, Grinstein S (2004) Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflügers Arch 447:549-565.
36. Ritucci NA, Chambers-Kersh L, Dean JB, Putnam RW (1998) Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. Am J Physiol 275:R1152-R1163.
37. - cotransporters: cloning and physiology. Annu Rev Physiol 61:699-723.
38. - transporters. Pflügers Arch 447:495-509.
39. Roos A, Boron WF (1981) Intracellular pH. Physiol Rev 61:296-434.
40. Sagne C, Isambert MF, Henry JP, Gasnier B (1996) SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter. Biochem J 316:825-831.
41. + countertransport and net charge displacement. J Biol Chem 273:18230-18234.
42. + influx triggers bleb formation on inner hair cells. Am J Physiol Cell Physiol 288:C1332-C1341.
43. +-ATPases: regulation and role in pathophysiological states. Am J Physiol 276:F799-F811.
44. 2+-ATPase gene cause deafness in deafwaddler mice. Nat Genet 19:390-394.
45. + transport in reconstituted liposomes. J Biol Chem 277:2413-2418.
46. + cycling and the endocochlear potential. Hear Res 165:1-9.
47. 2+ from hair cell stereocilia. J Neurosci 18:610-624.
48. Zhou Y, Marcus EM, Haugland RP, Opas M (1995) Use of a new fluorescent probe, seminaphthofluorescein-calcein, for determination of intracellular pH by simultaneous dual-emission imaging laser scanning confocal microscopy. J Cell Physiol 164:9-16.