Claudin-16 and claudin-19 function in the thick ascending limb

Current Opinion in Nephrology and Hypertension

Volumn 19, Issue 5, 2010, Pages 483-488

  Hou, Jianghui ^a   Goodenough, Daniel A ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

claudin; hypomagnesemia; thick ascending limb; tight junction; transepithelial voltage

Indexed keywords

CLAUDIN; CLAUDIN 16; CLAUDIN 19; INTACT PARATHYROID HORMONE; MAGNESIUM; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

FAMILIAL HYPOMAGNESEMIA; GENE MUTATION; GENE VECTOR; HUMAN; HYPERCALCIURIA; HYPERURICEMIA; HYPOCITRATURIA; HYPOMAGNESEMIA; KIDNEY CALCIFICATION; KIDNEY TUBULE ACIDOSIS; MAGNESIUM METABOLISM; METABOLIC DISORDER; MOUSE; NEPHROLITHIASIS; NONHUMAN; POLYDIPSIA; POLYURIA; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TRANSPORT; REVIEW; TETANY; THICK ASCENDING LIMB; TIGHT JUNCTION; URINARY TRACT INFECTION;

ABSORPTION; ANIMALS; HUMANS; HYPERCALCIURIA; ION TRANSPORT; LOOP OF HENLE; MAGNESIUM; MEMBRANE PROTEINS; NEPHROCALCINOSIS; SODIUM; TIGHT JUNCTIONS;

EID: 77955926292     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32833b7125     Document Type: Review

References (39)

1. Giebisch G, Klose RM, Windhager EE. Micropuncture study of hypertonic sodium chloride loading in the rat. Am J Physiol 1964; 206:687-693.
2. Cole DEC, Quamme GA. Inherited disorders of renal magnesium handling. J Am Soc Nephrol 2000; 11:1937-1947.
3. Hebert SC. Calcium and salinity sensing by the thick ascending limb: a journey from mammals to fish and back again. Kidney Int 2004; 91:S28-S33.
4. Han JS, Thompson KA, Chou CL, Knepper MA. Experimental tests of three-dimensional model of urinary concentrating mechanism. J Am Soc Nephrol 1992; 2:1677-1688.
5. Hebert SC, Culpepper RM, Andreoli TE. NaCl transport in mouse medullary thick ascending limbs. I: functional nephron heterogeneity and ADH-stimu-lated NaCl cotransport. Am J Physiol 1981; 241:F412-F431.
6. Hebert SC, Culpepper RM, Andreoli TE. NaCl transport in mouse medullary thick ascending limbs. II: ADH enhancement of transcellular NaCl cotran-sport; origin of transepithelial voltage. Am J Physiol 1981; 241:F432-F442.
7. Tang VW, Goodenough DA. Paracellular ion channel at the tight junction. Biophys J 2003; 84:1660-1673.
8. Simon DB, Lu Y, Choate KA, et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2\+ resorption. Science 1999; 285:103-106.
9. Konrad M, Schaller A, Seelow D, et al. Mutations in the tight-junction gene claudin-19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet 2006; 79:949-957.
10. Mandon B, Siga E, Roinel N, et al. Ca2\+, Mg2\+ and K\+ transport in the cortical and medullary thick ascending limb of the rat nephron: influence of transepithelial voltage. Pflü gers Arch 1993; 424:558-560.
11. Burg M, Good D. Sodium chloride coupled transport in mammalian nephrons. Annu Rev Physiol 1983; 45:533-547.
12. Burg MB, Green N. Function of the thick ascending limb of Henle's loop. Am J Physiol 1973; 224:659-668.
13. Greger R. Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney. Pflü gers Arch 1981; 390:30-37.
14. Di Stefano A, Roinel N, De Rouffignac C, et al. Transepithelial Ca2\+ and Mg2\+ transportin the cortical thick ascending limbofHenle's loop of the mouse is a voltage-dependent process. Renal Physiol Biochem 1993; 16:157-166.
15. Hebert JC, Andreoli TE. Ionic conductance pathways in the mouse medullary thick ascending limb of Henle. J Gen Physiol 1986; 87:567-590.
16. Weber S, Schneider L, Peters M, et al. Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalci-nosis. J Am Soc Nephrol 2001; 12:1872-1881.
17. Manz F, Scharer K, Janka P, Lombeck J. Renal magnesium wasting, incomplete tubular acidosis, hypercalciuria and nephrocalcinosis in siblings. Eur J Pediatr 1978; 128:67-79.
18. Praga M, Vara J, Gonzalez-Parra E, et al. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Kidney Int 1995; 47:1419-1425.
19. Günzel D, Haisch L, Pfaffenbach S, et al. Claudin function in the thick ascending limb of Henle's loop. Ann N Y Acad Sci 2009; 1165:152-162.
20. Alexander RT, Hoenderop JG, Bindels RJ. Molecular determinants of magnesium homeostasis: insights from human disease. J Am Soc Nephrol 2008; 19:1451-1458.
21. Schlingmann KP, Weber S, Peters M, et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6: a new member of the TRPM gene family. Nat Genet 2002; 31:166-170.
22. Ikari A, Hirai N, Shiroma M, et al. Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. J Biol Chem 2004; 279:54826-54832.
23. 2+ transport function of claudin-16. J Clin Invest 2006; 116:878-891.
24. Hou J, Paul DL, Goodenough DA. Paracellin-1 and the modulation of ion selectivity of tight junctions. J Cell Sci 2005; 118:5109-5118.
25. Diamond JM, Wright EM. Biological membranes: the physical basis of ion and nonelectrolyte selectivity. Annu Rev Physiol 1969; 31:581-646.
26. EisenmanG, Horn R.Ionic selectivity revisited: the role of kinetic and equilibrium processes in ion permeation through channels. J Membr Biol 1983; 76:197-225.
27. Konrad M, Hou J, Weber S, etal. CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol 2008; 19:171-181.
28. Steed E, Balda MS, Matter K. Dynamics and functions of tight junctions. Trends Cell Biol 2010; 20:142-149.
29. Van Itallie CM, Holmes J, Bridges A, et al. The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci 2008; 121:298-305.
30. Yu AS, Cheng MH, Angelow S, et al. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interac tion site. J Gen Physiol 2009; 133:111-127.
31. Colegio OR, Van Itallie C, Rahner C, et al. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 2003; 284:C1246-C1254.
32. Van Itallie CM, Fanning AS, Anderson JM. Reversal of charge selectivity in cation or anion selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol 2003; 285:F1078-F1084.
33. Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147:891-903.
34. Hou J, ReniguntaA, Konrad M,etal. Claudin-16 and claudin- 19interactandforma cation-selective tight junction complex. J Clin Invest 2008; 118:619-628.
35. Hou J, Shan Q, Wang T, et al. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J Biol Chem 2007; 282:17114-17122.
36. Hebert SC, Reeves WB, Molony DA, etal. The medullary thick limb: function and modulation of the single-effect multiplier. Kidney Int 1987; 31:580-589.
37. Hou J, ReniguntaA, Gomes AS, et al. Claudin-1 6 and claudin-1 9 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci USA 2009; 106:15350-15355.
38. Mitic LL, Unger VM, Anderson JM. Expression, solubilization, and biochemical characterization of the tightjunction transmembrane protein claudin-4. Protein Sci 2003; 12:218-227.
39. Amasheh S, Milatz S, Krug SM, et al. Tight junction proteins as channel formers and barrier builders. Ann NY Acad Sci 2009; 1165:211-219.