Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 3, 2012, Pages

  Xu, Hua ^a   Zhang, Bo ^a   Li, Jing ^a   Wang, Chunhui ^a   Chen, Huacong ^a   Ghishan, Fayez K ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

3; And 8; Downregulated in adenoma; Mucin 2; Sodium hydrogen exchanger 2

Indexed keywords

BICARBONATE; MUCIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 8; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON ABSORPTION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; INTESTINE EPITHELIUM CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SODIUM ABSORPTION; SODIUM BLOOD LEVEL;

ANIMALS; ANTIPORTERS; BICARBONATES; CECUM; COLON; FEMALE; MALE; MICE; MICE, KNOCKOUT; MUCIN-2; SODIUM; SODIUM-HYDROGEN ANTIPORTER;

EID: 84864777096     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00146.2012     Document Type: Article

References (37)

1. + exchanger 3 (NHE3). J Clin Invest 103: 429-435, 1999.
2. + exchanger isoforms NHE2 and NHE4 in rat intestine and kidney. Am J Physiol Cell Physiol 273: C1496-C1505, 1997.
3. + exchanger isoform, NHE3. Am J Physiol Cell Physiol 269: C198-C206, 1995.
4. Byeon MK, Westerman MA, Maroulakou IG, Henderson KW, Suster S, Zhang XK, Papas TS, Vesely J, Willingham MC, Green JE, Schweinfest CW. The down-regulated in adenoma (DRA) gene encodes an intestinespecific membrane glycoprotein. Oncogene 12: 387-396, 1996.
5. Chen EY, Yang N, Quinton PM, Chin WC. A new role for bicarbonate in mucus formation. Am J Physiol Lung Cell Mol Physiol 299: L542-L549, 2010.
6. + exchange expression and activity in region-and tissue-specific manner. Am J Physiol Cell Physiol 267: C796-C803, 1994.
7. Choijookhuu N, Sato Y, Nishino T, Endo D, Hishikawa Y, Koji T. Estrogen-dependent regulation of sodium/hydrogen exchanger-3 (NHE3) expression via estrogen receptor beta in proximal colon of pregnant mice. Histochem Cell Biol 137: 575-587, 2012.
8. Collins JF, Kiela PR, Xu H, Zeng J, Ghishan FK. Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated. Am J Physiol Cell Physiol 275: C1143-C1150, 1998.
9. Collins JF, Xu H, Kiela PR, Zeng J, Ghishan FK. Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium. Am J Physiol Cell Physiol 273: C1937-C1946, 1997.
10. Collins JF, Xu H, Kiela PR, Zeng J, Ghishan FK. Ontogeny of basolateral membrane sodium-hydrogen exchange (NHE) activity and mRNA expression of NHE-1 and NHE-4 in rat kidney and jejunum. Biochim Biophys Acta 1369: 247-258, 1998.
11. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44: 1041-1045, 1993.
12. Flemstrom G, Isenberg JI. Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16: 23-28, 2001.
13. Gawenis LR, Stien X, Shull GE, Schultheis PJ, Woo AL, Walker NM, Clarke LL. Intestinal NaCl transport in NHE2 and NHE3 knockout mice. Am J Physiol Gastrointest Liver Physiol 282: G776-G784, 2002.
14. Gum JR Jr, Hicks JW, Gillespie AM, Carlson EJ, Komuves L, Karnik S, Hong JC, Epstein CJ, Kim YS. Goblet cell-specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice. Am J Physiol Gastrointest Liver Physiol 276: G666-G676, 1999.
15. + antiporter (NHE3). Kidney Int 60: 173-181, 2001.
16. Haila S, Saarialho-Kere U, Karjalainen-Lindsberg ML, Lohi H, Airola K, Holmberg C, Hastbacka J, Kere J, Hoglund P. The congenital chloride diarrhea gene is expressed in seminal vesicle, sweat gland, inflammatory colon epithelium, and in some dysplastic colon cells. Histochem Cell Biol 113: 279-286, 2000.
17. Hoglund P, Haila S, Socha J, Tomaszewski L, Saarialho-Kere U, Karjalainen-Lindsberg ML, Airola K, Holmberg C, de la Chapelle A, Kere J. Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet 14: 316-319, 1996.
18. 3 + exchange in rabbit, rat, and human duodenum. Gastroenterology 122: 709-724, 2002.
19. Kiela PR, Guner YS, Xu H, Collins JF, Ghishan FK. Age-and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine. Am J Physiol Cell Physiol 278: C629-C637, 2000.
20. Lamprecht G, Schaefer J, Dietz K, Gregor M. Chloride and bicarbonate have similar affinities to the intestinal anion exchanger DRA (down regulated in adenoma). Pflügers Arch 452: 307-315, 2006.
21. Laubitz D, Larmonier CB, Bai A, Midura-Kiela MT, Lipko MA, Thurston RD, Kiela PR, Ghishan FK. Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis. Am J Physiol Gastrointest Liver Physiol 295: G63-G77, 2008.
22. + exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol 281: G1385-G1396, 2001.
23. + exchanger family, regulates osteoclast differentiation and survival [corrected]. Biochem Biophys Res Commun 369: 320-326, 2008.
24. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
25. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest 101: 1243-1253, 1998.
26. + exchanger. Nat Genet 19: 282-285, 1998.
27. Tytgat KM, Opdam FJ, Einerhand AW, Buller HA, Dekker J. MUC2 is the prominent colonic mucin expressed in ulcerative colitis. Gut 38: 554-563, 1996.
28. van Klinken BJ, Einerhand AW, Duits LA, Makkink MK, Tytgat KM, Renes IB, Verburg M, Buller HA, Dekker J. Gastrointestinal expression and partial cDNA cloning of murine Muc2. Am J Physiol Gastrointest Liver Physiol 276: G115-G124, 1999.
29. Xu H, Chen H, Dong J, Lynch R, Ghishan FK. Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8). Cell Physiol Biochem 21: 109-116, 2008.
30. Xu H, Chen R, Ghishan FK. Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8. Am J Physiol Gastrointest Liver Physiol 289: G36-G41, 2005.
31. i-IIb gene promoter by epidermal growth factor. Am J Physiol Cell Physiol 280: C628-C636, 2001.
32. Xu H, Collins JF, Bai L, Kiela PR, Lynch RM, Ghishan FK. Epidermal growth factor regulation of rat NHE2 gene expression. Am J Physiol Cell Physiol 281: C504-C513, 2001.
33. Xu H, Li J, Chen R, Zhang B, Wang C, King N, Chen H, Ghishan FK. NHE2X3 DKO mice exhibit gender-specific NHE8 compensation. Am J Physiol Gastrointest Liver Physiol 300: G647-G653, 2011.
34. Xu H, Zhang B, Li J, Chen H, Tooley J, Ghishan FK. Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription. Am J Physiol Cell Physiol 299: C51-C57, 2010.
35. Xu H, Zhang B, Li J, Chen H, Wang C, Ghishan FK. Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5. Am J Physiol Gastrointest Liver Physiol 299: G921-G927, 2010.
36. + exchanger gene family: structure and function studies. Am J Physiol Gastrointest Liver Physiol 269: G1-G11, 1995.
37. + exchange. Annu Rev Physiol 67: 411-443, 2005.