메뉴 건너뛰기




Volumn 167, Issue 3, 2013, Pages 646-655

HDL-C: Does it matter? An update on novel HDL-directed pharmaco-therapeutic strategies

Author keywords

Cardiovascular; Coronary artery disease; HDL C therapeutics; High density lipoprotein (HDL C)

Indexed keywords

ANACETRAPIB; APOLIPOPROTEIN A1; ATORVASTATIN; CERIVASTATIN; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; DALCETRAPIB; ENDOTHELIAL LIPASE INHIBITOR; ENZYME INHIBITOR; EZETIMIBE; FIBRIC ACID DERIVATIVE; FISH OIL; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIVER X RECEPTOR AGONIST; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; OMEGA 3 FATTY ACID; PLACEBO; PRAVASTATIN; RECOMBINANT HIGH DENSITY LIPOPROTEINCHOLESTEROL; RECOMBINANT PROTEIN; ROSUVASTATIN; RVX 208; SIMVASTATIN; TORCETRAPIB; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84880919554     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.05.052     Document Type: Review
Times cited : (23)

References (117)
  • 2
    • 33744982042 scopus 로고    scopus 로고
    • AHA/ACC guidelines for secondary prevention for patients with coronary artery disease other atherosclerotic vascular disease: 2006 update: Endorsed by the National Heart, Lung, and Blood Institute
    • S.C. Smith, J. Allen, and S.N. Blair AHA/ACC guidelines for secondary prevention for patients with coronary artery disease other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute Circulation 113 2006 2363e72
    • (2006) Circulation , vol.113
    • Smith, S.C.1    Allen, J.2    Blair, S.N.3
  • 3
    • 69849109122 scopus 로고    scopus 로고
    • Update on strategies to increase HDL quantity and function
    • D. Duffy, and D.J. Rader Update on strategies to increase HDL quantity and function Nat Rev Cardiol 6 2009 455e63
    • (2009) Nat Rev Cardiol , vol.6
    • Duffy, D.1    Rader, D.J.2
  • 4
    • 36349011270 scopus 로고    scopus 로고
    • High-density lipoprotein metabolism: Potential therapeutic targets
    • M.H. Davidson, and P.P. Toth High-density lipoprotein metabolism: potential therapeutic targets Am J Cardiol 100 11A 2007 n32e40
    • (2007) Am J Cardiol , vol.100 , Issue.11 A
    • Davidson, M.H.1    Toth, P.P.2
  • 5
    • 74049117620 scopus 로고    scopus 로고
    • Focus on HDL as a therapeutic target for CAD risk reduction
    • M.H. Davidson Focus on HDL as a therapeutic target for CAD risk reduction Am J Cardiol 104 Suppl. 10 2009 1Ee2E
    • (2009) Am J Cardiol , vol.104 , Issue.SUPPL. 10
    • Davidson, M.H.1
  • 6
    • 0018427626 scopus 로고
    • HDL-cholesterol levels in the Multiple Risk Factor Intervention Trial (MRFIT) by the MRFIT Research Group 1,2
    • S. Hulley, P. Ashman, L. Kuller, N. Lasser, and R. Sherwin HDL-cholesterol levels in the Multiple Risk Factor Intervention Trial (MRFIT) by the MRFIT Research Group 1,2 Lipids 14 1979 119 123
    • (1979) Lipids , vol.14 , pp. 119-123
    • Hulley, S.1    Ashman, P.2    Kuller, L.3    Lasser, N.4    Sherwin, R.5
  • 7
    • 0018860747 scopus 로고
    • Alpha lipoprotein (HDL) cholesterol in the serum and the risk of coronary heart disease and death
    • A. Keys Alpha lipoprotein (HDL) cholesterol in the serum and the risk of coronary heart disease and death Lancet 2 1980 603 606
    • (1980) Lancet , vol.2 , pp. 603-606
    • Keys, A.1
  • 8
    • 84859001144 scopus 로고    scopus 로고
    • HDL cholesterol and cardiovascular risk
    • W.A. Ghali, and N. Rodondi HDL cholesterol and cardiovascular risk BMJ 338 2009 a3065
    • (2009) BMJ , vol.338 , pp. 3065
    • Ghali, W.A.1    Rodondi, N.2
  • 9
    • 65249152032 scopus 로고    scopus 로고
    • Elevated high-density lipoprotein (HDL) levels due to hepatic lipase mutations do not reduce cardiovascular disease risk: Another strike against the HDL dogma
    • S. Fazio, and M.F. Linton Elevated high-density lipoprotein (HDL) levels due to hepatic lipase mutations do not reduce cardiovascular disease risk: another strike against the HDL dogma J Clin Endocrinol Metab 94 2009 1081 1083
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1081-1083
    • Fazio, S.1    Linton, M.F.2
  • 10
    • 33748754457 scopus 로고    scopus 로고
    • Sorting out the complexities of reverse cholesterol transport: CETP polymorphisms, HDL, and coronary disease
    • S. Fazio, and M.F. Linton Sorting out the complexities of reverse cholesterol transport: CETP polymorphisms, HDL, and coronary disease J Clin Endocrinol Metab 91 2006 3273 3275
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3273-3275
    • Fazio, S.1    Linton, M.F.2
  • 11
    • 2142806793 scopus 로고    scopus 로고
    • Apolipoprotein AI as therapy for atherosclerosis: Does the future of preventive cardiology include weekly injections of the HDL protein?
    • S. Fazio, and M.F. Linton Apolipoprotein AI as therapy for atherosclerosis: does the future of preventive cardiology include weekly injections of the HDL protein? Mol Interv 3 2003 436 440
    • (2003) Mol Interv , vol.3 , pp. 436-440
    • Fazio, S.1    Linton, M.F.2
  • 12
    • 0019226420 scopus 로고
    • A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family
    • G. Franceschini, C.R. Sirtori, A. Capurso II, K.H. Weisgraber, and R.W. Mahley A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family J Clin Invest 66 1980 892 900
    • (1980) J Clin Invest , vol.66 , pp. 892-900
    • Franceschini, G.1    Sirtori, C.R.2    Capurso, I.I.A.3    Weisgraber, K.H.4    Mahley, R.W.5
  • 13
    • 0034712706 scopus 로고    scopus 로고
    • Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene
    • B. Agerholm-Larsen, B.G. Nordestgaard, R. Steffensen, G. Jensen, and A. Tybjaerg-Hansen Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene Circulation 101 2000 1907 1912
    • (2000) Circulation , vol.101 , pp. 1907-1912
    • Agerholm-Larsen, B.1    Nordestgaard, B.G.2    Steffensen, R.3    Jensen, G.4    Tybjaerg-Hansen, A.5
  • 14
    • 34548336725 scopus 로고    scopus 로고
    • High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides
    • S.E. Borggreve, H.L. Hillege, and G.M. Dallinga-Thie High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides Eur Heart J 28 2007 1012 1018
    • (2007) Eur Heart J , vol.28 , pp. 1012-1018
    • Borggreve, S.E.1    Hillege, H.L.2    Dallinga-Thie, G.M.3
  • 15
    • 0032087597 scopus 로고    scopus 로고
    • Is cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia
    • Y. Saito Is cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia Intern Med 37 1998 495 496
    • (1998) Intern Med , vol.37 , pp. 495-496
    • Saito, Y.1
  • 16
    • 0029948968 scopus 로고    scopus 로고
    • Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels
    • S. Zhong, D.S. Sharp, and J.S. Grove Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels J Clin Invest 97 1996 2917 2923
    • (1996) J Clin Invest , vol.97 , pp. 2917-2923
    • Zhong, S.1    Sharp, D.S.2    Grove, J.S.3
  • 17
    • 33748746326 scopus 로고    scopus 로고
    • An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: A population-based study
    • S.E. Borggreve, H.L. Hillege, and B.H. Wolffenbuttel An increased coronary risk is paradoxically associated with common cholesteryl ester transfer protein gene variations that relate to higher high-density lipoprotein cholesterol: a population-based study J Clin Endocrinol Metab 91 2006 3382 3388
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3382-3388
    • Borggreve, S.E.1    Hillege, H.L.2    Wolffenbuttel, B.H.3
  • 18
    • 65249148632 scopus 로고    scopus 로고
    • Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease
    • T.H. Johannsen, P.R. Kamstrup, and R.V. Andersen Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease J Clin Endocrinol Metab 94 2009 1264 1273
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1264-1273
    • Johannsen, T.H.1    Kamstrup, P.R.2    Andersen, R.V.3
  • 19
    • 44449103671 scopus 로고    scopus 로고
    • Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches
    • E.M. deGoma, R.L. deGoma, and D.J. Rader Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches J Am Coll Cardiol 51 2008 2199 2211
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2199-2211
    • Degoma, E.M.1    Degoma, R.L.2    Rader, D.J.3
  • 22
    • 10744224101 scopus 로고    scopus 로고
    • Inflammatory/anti-inflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    • B.J. Ansell, M. Navab, and S. Hama Inflammatory/anti-inflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment Circulation 108 2003 2751 2756
    • (2003) Circulation , vol.108 , pp. 2751-2756
    • Ansell, B.J.1    Navab, M.2    Hama, S.3
  • 23
    • 38749102779 scopus 로고    scopus 로고
    • High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: Significance for cardiovascular risk: The IDEAL and EPIC-Norfolk studies
    • W.A. van der Steeg, I. Holme, and S.M. Boekholdt High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies J Am Coll Cardiol 51 2008 634 642
    • (2008) J Am Coll Cardiol , vol.51 , pp. 634-642
    • Van Der Steeg, W.A.1    Holme, I.2    Boekholdt, S.M.3
  • 24
    • 0027537270 scopus 로고
    • High density lipoproteins, reverse transport of cholesterol, and coronary artery disease. Insights from mutations
    • G. Assmann, A. von Eckardstein, and H. Funke High density lipoproteins, reverse transport of cholesterol, and coronary artery disease. Insights from mutations Circulation 87 1993 III28 III34
    • (1993) Circulation , vol.87
    • Assmann, G.1    Von Eckardstein, A.2    Funke, H.3
  • 25
    • 70449333618 scopus 로고    scopus 로고
    • Recent advances on the antiatherogenic effects of HDL-derived proteins and mimetic peptides
    • M.P. Petraki, P.T. Mantani, and A.D. Tselepis Recent advances on the antiatherogenic effects of HDL-derived proteins and mimetic peptides Curr Pharm Des 15 2009 3146 3166
    • (2009) Curr Pharm des , vol.15 , pp. 3146-3166
    • Petraki, M.P.1    Mantani, P.T.2    Tselepis, A.D.3
  • 26
    • 34447341178 scopus 로고    scopus 로고
    • The paradox of dysfunctional high-density lipoprotein
    • B.J. Ansell, G.C. Fonarow, and A.M. Fogelman The paradox of dysfunctional high-density lipoprotein Curr Opin Lipidol 18 2007 427 434
    • (2007) Curr Opin Lipidol , vol.18 , pp. 427-434
    • Ansell, B.J.1    Fonarow, G.C.2    Fogelman, A.M.3
  • 27
    • 0030046797 scopus 로고    scopus 로고
    • Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    • S. Acton, A. Rigotti, K.T. Landschulz, S. Xu, H.H. Hobbs, and M. Krieger Identification of scavenger receptor SR-BI as a high density lipoprotein receptor Science 271 1996 518 520
    • (1996) Science , vol.271 , pp. 518-520
    • Acton, S.1    Rigotti, A.2    Landschulz, K.T.3    Xu, S.4    Hobbs, H.H.5    Krieger, M.6
  • 28
    • 0026073955 scopus 로고
    • Role of cholesteryl ester transfer protein in reverse cholesterol transport
    • R. McPherson, and Y. Marcel Role of cholesteryl ester transfer protein in reverse cholesterol transport Clin Cardiol 14 1991 I31 I34
    • (1991) Clin Cardiol , vol.14
    • McPherson, R.1    Marcel, Y.2
  • 29
    • 49349095088 scopus 로고    scopus 로고
    • A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II
    • J.H. Graversen, G. Castro, and A. Kandoussi A pivotal role of the human kidney in catabolism of HDL protein components apolipoprotein A-I and A-IV but not of A-II Lipids 43 2008 467 470
    • (2008) Lipids , vol.43 , pp. 467-470
    • Graversen, J.H.1    Castro, G.2    Kandoussi, A.3
  • 30
    • 0034697043 scopus 로고    scopus 로고
    • Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
    • S.M. Hammad, J.L. Barth, C. Knaak, and W.S. Argraves Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins J Biol Chem 275 2000 12003 12008
    • (2000) J Biol Chem , vol.275 , pp. 12003-12008
    • Hammad, S.M.1    Barth, J.L.2    Knaak, C.3    Argraves, W.S.4
  • 31
    • 33645422718 scopus 로고    scopus 로고
    • Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
    • V.I. Zannis, A. Chroni, and M. Krieger Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL J Mol Med 84 2006 276 294
    • (2006) J Mol Med , vol.84 , pp. 276-294
    • Zannis, V.I.1    Chroni, A.2    Krieger, M.3
  • 32
    • 48749114654 scopus 로고    scopus 로고
    • Lipidation of apolipoprotein A-I by ATP-binding cassette transporter (ABC) A1 generates an interaction partner for ABCG1 but not for scavenger receptor BI
    • I. Lorenzi, A. von Eckardstein, S. Radosavljevic, and L. Rohrer Lipidation of apolipoprotein A-I by ATP-binding cassette transporter (ABC) A1 generates an interaction partner for ABCG1 but not for scavenger receptor BI Biochim Biophys Acta 1781 2008 306 313
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 306-313
    • Lorenzi, I.1    Von Eckardstein, A.2    Radosavljevic, S.3    Rohrer, L.4
  • 33
    • 33845580066 scopus 로고    scopus 로고
    • ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
    • A.M. Vaughan, and J.F. Oram ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL J Lipid Res 47 2006 2433 2443
    • (2006) J Lipid Res , vol.47 , pp. 2433-2443
    • Vaughan, A.M.1    Oram, J.F.2
  • 34
    • 34248226770 scopus 로고    scopus 로고
    • Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI
    • P.G. Yancey, W.G. Jerome, and H. Yu Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI J Lipid Res 48 2007 1140 1149
    • (2007) J Lipid Res , vol.48 , pp. 1140-1149
    • Yancey, P.G.1    Jerome, W.G.2    Yu, H.3
  • 35
    • 33847368173 scopus 로고    scopus 로고
    • Shotgun proteomics implicates protease inhibition and complement activation in the anti-inflammatory properties of HDL
    • T. Vaisar, S. Pennathur, and P.S. Green Shotgun proteomics implicates protease inhibition and complement activation in the anti-inflammatory properties of HDL J Clin Invest 117 2007 746 756
    • (2007) J Clin Invest , vol.117 , pp. 746-756
    • Vaisar, T.1    Pennathur, S.2    Green, P.S.3
  • 36
    • 2542460047 scopus 로고    scopus 로고
    • The oxidation hypothesis of atherogenesis: The role of oxidized phospholipids and HDL
    • M. Navab, G.M. Ananthramaiah, and S.T. Reddy The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL J Lipid Res 45 2004 993 1007
    • (2004) J Lipid Res , vol.45 , pp. 993-1007
    • Navab, M.1    Ananthramaiah, G.M.2    Reddy, S.T.3
  • 37
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Panel Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 106 2002 3143e421
    • (2002) Circulation , vol.106
    • Cholesterol Education Panel, N.1
  • 38
    • 72049107205 scopus 로고    scopus 로고
    • Novel targets that affect high-density lipoprotein metabolism: The next frontier
    • M.H. Davidson, and R.S. Rosenson Novel targets that affect high-density lipoprotein metabolism: the next frontier Am J Cardiol 104 10 Suppl. 2009 52Ee7E
    • (2009) Am J Cardiol , vol.104 , Issue.10 SUPPL.
    • Davidson, M.H.1    Rosenson, R.S.2
  • 39
    • 84880921122 scopus 로고    scopus 로고
    • Study of Coronary Atheroma by Intravascular Ultrasound: effect of Rosuvastatin Versus Atorvastatin (SATURN). show/NCT00620542. Accessed October 30
    • Study of Coronary Atheroma by Intravascular Ultrasound: effect of Rosuvastatin Versus Atorvastatin (SATURN). Available at: http://clinicaltrials. gov/ct2/ show/NCT00620542. Accessed October 30, 2010
    • (2010)
  • 40
    • 0026021035 scopus 로고
    • Coronary drug project: Experience with niacin. Coronary Drug Project Research Group
    • K.G. Berge, and P.L. Canner Coronary drug project: experience with niacin. Coronary Drug Project Research Group Eur J Clin Pharmacol 40 Suppl. 1 1991 S49e51
    • (1991) Eur J Clin Pharmacol , vol.40 , Issue.SUPPL. 1
    • Berge, K.G.1    Canner, P.L.2
  • 41
    • 0033751381 scopus 로고    scopus 로고
    • Mechanism of action of niacin on lipoprotein metabolism
    • V.S. Kamanna, and M.L. Kashyap Mechanism of action of niacin on lipoprotein metabolism Curr Atheroscler Rep 2 2000 36e46
    • (2000) Curr Atheroscler Rep , vol.2
    • Kamanna, V.S.1    Kashyap, M.L.2
  • 42
    • 31044441839 scopus 로고    scopus 로고
    • Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acid
    • N.B. Pike Flushing out the role of GPR109A (HM74A) in the clinical efficacy of nicotinic acid J Clin Invest 115 12 2005 3400e3
    • (2005) J Clin Invest , vol.115 , Issue.12
    • Pike, N.B.1
  • 43
    • 33646258753 scopus 로고    scopus 로고
    • Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    • K. Cheng, T.J. Wu, and K.K. Wu Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans Proc Natl Acad Sci U S A 103 2006 6682e7
    • (2006) Proc Natl Acad Sci U S A , vol.103
    • Cheng, K.1    Wu, T.J.2    Wu, K.K.3
  • 44
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • J.R. Guyton, and H.E. Bays Safety considerations with niacin therapy Am J Cardiol 99 2007 22C 31C
    • (2007) Am J Cardiol , vol.99
    • Guyton, J.R.1    Bays, H.E.2
  • 45
    • 10044281651 scopus 로고    scopus 로고
    • Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2
    • A.J. Taylor, L.E. Sullenberger, and H.J. Lee Arterial biology for the investigation of the treatment effects of reducing cholesterol (ARBITER) 2 Circulation 110 2004 3512e7
    • (2004) Circulation , vol.110
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3
  • 48
    • 77950127995 scopus 로고    scopus 로고
    • Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: Results of a pooled subgroup analysis from three randomized, controlled, double-blind trials
    • P.H. Jones, K. Cusi, and M.H. Davidson Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials Am J Cardiovasc Drugs 10 2010 73e84
    • (2010) Am J Cardiovasc Drugs , vol.10
    • Jones, P.H.1    Cusi, K.2    Davidson, M.H.3
  • 49
    • 74549173160 scopus 로고    scopus 로고
    • Efficacy and tolerability of atorvastatin/fenofibrate fixed-dose combination tablet compared with atorvastatin and fenofibrate monotherapies in patients with dyslipidemia: A 12-week, multicenter, double-blind, randomized, parallel-group study
    • M.H. Davidson, M.W. Rooney, and J. Drucker Efficacy and tolerability of atorvastatin/fenofibrate fixed-dose combination tablet compared with atorvastatin and fenofibrate monotherapies in patients with dyslipidemia: a 12-week, multicenter, double-blind, randomized, parallel-group study Clin Ther 12 2009 2824e38
    • (2009) Clin Ther , vol.12
    • Davidson, M.H.1    Rooney, M.W.2    Drucker, J.3
  • 50
    • 0025322265 scopus 로고
    • Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
    • J.J. Badimon, L. Badimon, and V. Fuster Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit J Clin Invest 85 1990 1234 1241
    • (1990) J Clin Invest , vol.85 , pp. 1234-1241
    • Badimon, J.J.1    Badimon, L.2    Fuster, V.3
  • 51
    • 0037124010 scopus 로고    scopus 로고
    • Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks
    • G. Chiesa, E. Monteggia, and M. Marchesi Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks Circ Res 90 2002 974 980
    • (2002) Circ Res , vol.90 , pp. 974-980
    • Chiesa, G.1    Monteggia, E.2    Marchesi, M.3
  • 52
    • 40649126377 scopus 로고    scopus 로고
    • Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: In vivo assessment by intravascular ultrasound and magnetic resonance imaging
    • C. Parolini, M. Marchesi, and P. Lorenzon Dose-related effects of repeated ETC-216 (recombinant apolipoprotein A-I Milano/1-palmitoyl-2-oleoyl phosphatidylcholine complexes) administrations on rabbit lipid-rich soft plaques: in vivo assessment by intravascular ultrasound and magnetic resonance imaging J Am Coll Cardiol 51 2008 1098 1103
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1098-1103
    • Parolini, C.1    Marchesi, M.2    Lorenzon, P.3
  • 53
    • 0024550898 scopus 로고
    • High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits
    • J.J. Badimon, L. Badimon, A. Galvez, R. Dische, and V. Fuster High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits Lab Invest 60 1989 455 461
    • (1989) Lab Invest , vol.60 , pp. 455-461
    • Badimon, J.J.1    Badimon, L.2    Galvez, A.3    Dische, R.4    Fuster, V.5
  • 54
    • 0032478183 scopus 로고    scopus 로고
    • Effects of recombinant apolipoprotein A-I(Milano) on aortic atherosclerosis in apolipoprotein E-deficient mice
    • P.K. Shah, J. Nilsson, and S. Kaul Effects of recombinant apolipoprotein A-I(Milano) on aortic atherosclerosis in apolipoprotein E-deficient mice Circulation 97 1998 780 785
    • (1998) Circulation , vol.97 , pp. 780-785
    • Shah, P.K.1    Nilsson, J.2    Kaul, S.3
  • 55
    • 0041662117 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo
    • Y. Zhang, I. Zanotti, and M.P. Reilly Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo Circulation 108 2003 661 663
    • (2003) Circulation , vol.108 , pp. 661-663
    • Zhang, Y.1    Zanotti, I.2    Reilly, M.P.3
  • 56
    • 6344253356 scopus 로고    scopus 로고
    • Antiinflammatory properties of HDL
    • P.J. Barter, S. Nicholls, and K.A. Rye Antiinflammatory properties of HDL Circ Res 95 2004 764 772
    • (2004) Circ Res , vol.95 , pp. 764-772
    • Barter, P.J.1    Nicholls, S.2    Rye, K.A.3
  • 57
    • 16344390798 scopus 로고    scopus 로고
    • Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits
    • S.J. Nicholls, G.J. Dusting, and B. Cutri Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits Circulation 111 2005 1543 1550
    • (2005) Circulation , vol.111 , pp. 1543-1550
    • Nicholls, S.J.1    Dusting, G.J.2    Cutri, B.3
  • 58
    • 0242577955 scopus 로고    scopus 로고
    • Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
    • S.E. Nissen, T. Tsunoda, and E.M. Tuzcu Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial JAMA 290 2003 2292 2300
    • (2003) JAMA , vol.290 , pp. 2292-2300
    • Nissen, S.E.1    Tsunoda, T.2    Tuzcu, E.M.3
  • 59
    • 0035901577 scopus 로고    scopus 로고
    • Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: The Limone sul Garda study
    • C.R. Sirtori, L. Calabresi, and G. Franceschini Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study Circulation 103 2001 1949 1954
    • (2001) Circulation , vol.103 , pp. 1949-1954
    • Sirtori, C.R.1    Calabresi, L.2    Franceschini, G.3
  • 60
    • 0038012797 scopus 로고    scopus 로고
    • Intramural delivery of recombinant apolipoprotein A-IMilano/phospholipid complex (ETC-216) inhibits in-stent stenosis in porcine coronary arteries
    • S. Kaul, V. Rukshin, and R. Santos Intramural delivery of recombinant apolipoprotein A-IMilano/phospholipid complex (ETC-216) inhibits in-stent stenosis in porcine coronary arteries Circulation. 107 20 2003 2551 2554
    • (2003) Circulation. , vol.107 , Issue.20 , pp. 2551-2554
    • Kaul, S.1    Rukshin, V.2    Santos, R.3
  • 61
    • 0027994776 scopus 로고
    • Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits
    • S. Ameli, A. Hultgardh-Nilsson, and B. Cercek Recombinant apolipoprotein A-I Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits Circulation 90 1994 1935 1941
    • (1994) Circulation , vol.90 , pp. 1935-1941
    • Ameli, S.1    Hultgardh-Nilsson, A.2    Cercek, B.3
  • 62
    • 0035954267 scopus 로고    scopus 로고
    • High-dose recombinant apolipoprotein A-I(Milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization
    • P.K. Shah, J. Yano, and O. Reyes High-dose recombinant apolipoprotein A-I(Milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization Circulation 103 2001 3047 3050
    • (2001) Circulation , vol.103 , pp. 3047-3050
    • Shah, P.K.1    Yano, J.2    Reyes, O.3
  • 63
    • 34247397359 scopus 로고    scopus 로고
    • Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: A randomized controlled trial
    • J.C. Tardif, J. Gregoire, and P.L. L'Allier Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial JAMA 297 15 2007 1675e82
    • (2007) JAMA , vol.297 , Issue.15
    • Tardif, J.C.1    Gregoire, J.2    L'Allier, P.L.3
  • 64
    • 58149153296 scopus 로고    scopus 로고
    • Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque
    • J.A. Shaw, A. Bobik, and A. Murphy Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque Circ Res 103 10 2008 1084e91
    • (2008) Circ Res , vol.103 , Issue.10
    • Shaw, J.A.1    Bobik, A.2    Murphy, A.3
  • 65
    • 77953107241 scopus 로고    scopus 로고
    • A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome
    • R. Waksman, R. Torguson, and K.M. Kent A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome J Am Coll Cardiol 55 2010 2727 2735
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2727-2735
    • Waksman, R.1    Torguson, R.2    Kent, K.M.3
  • 66
    • 77952713824 scopus 로고    scopus 로고
    • RVX-208: A small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo
    • D. Bailey, R. Jahagirdar, and A. Gordon RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo J Am Coll Cardiol 55 2010 2580 2589
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2580-2589
    • Bailey, D.1    Jahagirdar, R.2    Gordon, A.3
  • 67
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • S. Tunaru, J. Kero, and A. Schaub PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect Nat Med 9 2003 352 355
    • (2003) Nat Med , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3
  • 68
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • D. Maccubbin, M.J. Koren, and M. Davidson Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease Am J Cardiol 104 2009 74 81
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • Maccubbin, D.1    Koren, M.J.2    Davidson, M.3
  • 69
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • [see comment] 2231-2231C
    • J.R. Guyton, and H.E. Bays Safety considerations with niacin therapy [see comment] Am J Cardiol 99 6A 2007 2231-2231C
    • (2007) Am J Cardiol , vol.99 , Issue.6 A
    • Guyton, J.R.1    Bays, H.E.2
  • 70
    • 77955300428 scopus 로고    scopus 로고
    • Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
    • J. Hanson, A. Gille, and S. Zwykiel Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice J Clin Invest 120 2010 2910 2919
    • (2010) J Clin Invest , vol.120 , pp. 2910-2919
    • Hanson, J.1    Gille, A.2    Zwykiel, S.3
  • 71
    • 77955302309 scopus 로고    scopus 로고
    • Seeing red: Flushing out instigators of niacin-associated skin toxicity
    • R.L. Dunbar, and J.M. Gelfand Seeing red: flushing out instigators of niacin-associated skin toxicity J Clin Invest 120 2010 2651 2655
    • (2010) J Clin Invest , vol.120 , pp. 2651-2655
    • Dunbar, R.L.1    Gelfand, J.M.2
  • 73
    • 2542460047 scopus 로고    scopus 로고
    • The oxidation hypothesis of atherogenesis: The role of oxidized phospholipids and HDL
    • M. Navab, G.M. Ananthramaiah, and S.T. Reddy The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL J Lipid Res 45 2004 993 1007
    • (2004) J Lipid Res , vol.45 , pp. 993-1007
    • Navab, M.1    Ananthramaiah, G.M.2    Reddy, S.T.3
  • 74
    • 34548439900 scopus 로고    scopus 로고
    • Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides
    • G.M. Anantharamaiah, V.K. Mishra, and D.W. Garber Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides J Lipid Res 48 2007 1915 1923
    • (2007) J Lipid Res , vol.48 , pp. 1915-1923
    • Anantharamaiah, G.M.1    Mishra, V.K.2    Garber, D.W.3
  • 75
    • 48549103014 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients
    • L.T. Bloedon, R. Dunbar, and D. Duffy Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients J Lipid Res 49 2008 1344 1352
    • (2008) J Lipid Res , vol.49 , pp. 1344-1352
    • Bloedon, L.T.1    Dunbar, R.2    Duffy, D.3
  • 76
    • 71749086157 scopus 로고    scopus 로고
    • The effects of cholesterol ester transfer protein inhibition on cholesterol efflux
    • A.R. Tall The effects of cholesterol ester transfer protein inhibition on cholesterol efflux Am J Cardiol 104 Suppl. 2009 39Ee45E
    • (2009) Am J Cardiol , vol.104 , Issue.SUPPL.
    • Tall, A.R.1
  • 77
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • P.J. Barter, M. Caulfield, and M. Eriksson Effects of torcetrapib in patients at high risk for coronary events N Engl J Med 357 2007 2109 2122
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 78
    • 34447265547 scopus 로고    scopus 로고
    • Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomised, double-blind trial
    • M.L. Bots, F.L. Visseren, and G.W. Evans Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial Lancet 370 2007 153 160
    • (2007) Lancet , vol.370 , pp. 153-160
    • Bots, M.L.1    Visseren, F.L.2    Evans, G.W.3
  • 80
    • 33646409606 scopus 로고    scopus 로고
    • HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway
    • F. Matsuura, N. Wang, W. Chen, X.C. Jiang, and A.R. Tall HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway J Clin Invest 116 2006 1435 1442
    • (2006) J Clin Invest , vol.116 , pp. 1435-1442
    • Matsuura, F.1    Wang, N.2    Chen, W.3    Jiang, X.C.4    Tall, A.R.5
  • 81
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • M.J. Forrest, D. Bloomfield, and R.J. Briscoe Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone Br J Pharmacol 154 2008 1465 1473
    • (2008) Br J Pharmacol , vol.154 , pp. 1465-1473
    • Forrest, M.J.1    Bloomfield, D.2    Briscoe, R.J.3
  • 82
    • 0028111063 scopus 로고
    • Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins
    • M. Ishigami, S. Yamashita, and N. Sakai Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins J Biochem 116 1994 257 262
    • (1994) J Biochem , vol.116 , pp. 257-262
    • Ishigami, M.1    Yamashita, S.2    Sakai, N.3
  • 83
    • 34247352806 scopus 로고    scopus 로고
    • Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    • L. Yvan-Charvet, F. Matsuura, and N. Wang Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL Arterioscler Thromb Vasc Biol 27 2007 1132 1138
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1132-1138
    • Yvan-Charvet, L.1    Matsuura, F.2    Wang, N.3
  • 84
    • 77953961808 scopus 로고    scopus 로고
    • Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    • L. Yvan-Charvet, J. Kling, and T. Pagler Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib Arterioscler Thromb Vasc Biol 30 2010 1430 1438
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1430-1438
    • Yvan-Charvet, L.1    Kling, J.2    Pagler, T.3
  • 85
    • 34948860018 scopus 로고    scopus 로고
    • Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport
    • H. Tanigawa, J.T. Billheimer, and J. Tohyama Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport Circulation 116 2007 1267 1273
    • (2007) Circulation , vol.116 , pp. 1267-1273
    • Tanigawa, H.1    Billheimer, J.T.2    Tohyama, J.3
  • 86
    • 71749117374 scopus 로고    scopus 로고
    • The pharmacology and off-target effects of some cholesterol ester transfer protein inhibitors
    • M. Vergeer, and E.S. Stroes The pharmacology and off-target effects of some cholesterol ester transfer protein inhibitors Am J Cardiol 104 10 Suppl. 2009 32E 38E
    • (2009) Am J Cardiol , vol.104 , Issue.10 SUPPL.
    • Vergeer, M.1    Stroes, E.S.2
  • 87
    • 78650054881 scopus 로고    scopus 로고
    • Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    • E.J. Niesor, C. Magg, and N. Ogawa Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport J Lipid Res 51 2010 3443 3454
    • (2010) J Lipid Res , vol.51 , pp. 3443-3454
    • Niesor, E.J.1    Magg, C.2    Ogawa, N.3
  • 88
    • 0037035459 scopus 로고    scopus 로고
    • Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomized phase II dose-response study
    • G.J. de Grooth, J.A. Kuivenhoven, and A.F. Stalenhoef Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study Circulation 105 2002 2159 2165
    • (2002) Circulation , vol.105 , pp. 2159-2165
    • De Grooth, G.J.1    Kuivenhoven, J.A.2    Stalenhoef, A.F.3
  • 89
    • 17444372760 scopus 로고    scopus 로고
    • Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    • J.A. Kuivenhoven, G.J. de Grooth, and H. Kawamura Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia Am J Cardiol 95 2005 1085 1088
    • (2005) Am J Cardiol , vol.95 , pp. 1085-1088
    • Kuivenhoven, J.A.1    De Grooth, G.J.2    Kawamura, H.3
  • 90
    • 77249100745 scopus 로고    scopus 로고
    • Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from a 48-week trial
    • E.A. Stein, E.M. Roth, and J.M. Rhyne Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial Eur Heart J 31 2010 480 488
    • (2010) Eur Heart J , vol.31 , pp. 480-488
    • Stein, E.A.1    Roth, E.M.2    Rhyne, J.M.3
  • 95
    • 77956513064 scopus 로고    scopus 로고
    • Biochemical characterization of cholesteryl ester transfer protein inhibitors
    • M. Ranalletta, K.K. Bierilo, and Y. Chen Biochemical characterization of cholesteryl ester transfer protein inhibitors J Lipid Res 51 2010 2739 2752
    • (2010) J Lipid Res , vol.51 , pp. 2739-2752
    • Ranalletta, M.1    Bierilo, K.K.2    Chen, Y.3
  • 96
    • 36549078679 scopus 로고    scopus 로고
    • Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: Two double-blind, randomised placebo-controlled phase i studies
    • R. Krishna, M.S. Anderson, and A.J. Bergman Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies Lancet 370 2007 1907 1914
    • (2007) Lancet , vol.370 , pp. 1907-1914
    • Krishna, R.1    Anderson, M.S.2    Bergman, A.J.3
  • 97
    • 58649091088 scopus 로고    scopus 로고
    • Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
    • D. Bloomfield, G.L. Carlson, and A. Sapre Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients Am Heart J 157 2009 352 360
    • (2009) Am Heart J , vol.157 , pp. 352-360
    • Bloomfield, D.1    Carlson, G.L.2    Sapre, A.3
  • 98
    • 70349213361 scopus 로고    scopus 로고
    • Design of the DEFINE trial: Determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib
    • C.P. Cannon, H.M. Dansky, and M. Davidson Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib Am Heart J 158 2009 513 519
    • (2009) Am Heart J , vol.158 , pp. 513-519
    • Cannon, C.P.1    Dansky, H.M.2    Davidson, M.3
  • 99
    • 78549235583 scopus 로고    scopus 로고
    • Safety of anacetrapib in patients with or at high risk for coronary heart disease
    • C.P. Cannon, S. Shah, and H.M. Dansky Safety of anacetrapib in patients with or at high risk for coronary heart disease N Engl J Med 363 2010 2406 2415
    • (2010) N Engl J Med , vol.363 , pp. 2406-2415
    • Cannon, C.P.1    Shah, S.2    Dansky, H.M.3
  • 101
    • 36348932064 scopus 로고    scopus 로고
    • Liver X receptor and farnesoid X receptor as therapeutic targets
    • D.J. Rader Liver X receptor and farnesoid X receptor as therapeutic targets Am J Cardiol 100 Suppl. 1 2007 S15 S19
    • (2007) Am J Cardiol , vol.100 , Issue.SUPPL. 1
    • Rader, D.J.1
  • 102
    • 26244463785 scopus 로고    scopus 로고
    • Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages
    • E. Rigamonti, L. Helin, and S. Lestavel Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages Circ Res 97 2005 682 689
    • (2005) Circ Res , vol.97 , pp. 682-689
    • Rigamonti, E.1    Helin, L.2    Lestavel, S.3
  • 103
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • P. Costet, Y. Luo, N. Wang, and A.R. Tall Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J Biol Chem 275 2000 28240 28245
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 104
    • 33645502340 scopus 로고    scopus 로고
    • Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
    • L.R. Brunham, J.K. Kruit, and J. Iqbal Intestinal ABCA1 directly contributes to HDL biogenesis in vivo J Clin Invest 116 2006 1052 1062
    • (2006) J Clin Invest , vol.116 , pp. 1052-1062
    • Brunham, L.R.1    Kruit, J.K.2    Iqbal, J.3
  • 105
    • 0037072732 scopus 로고    scopus 로고
    • Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    • A. Grefhorst, B.M. Elzinga, and P.J. Voshol Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles J Biol Chem 277 2002 34182 34190
    • (2002) J Biol Chem , vol.277 , pp. 34182-34190
    • Grefhorst, A.1    Elzinga, B.M.2    Voshol, P.J.3
  • 107
    • 0037314398 scopus 로고    scopus 로고
    • Endothelial lipase is a major determinant of HDL level
    • T. Ishida, S. Choi, and R.K. Kundu Endothelial lipase is a major determinant of HDL level J Clin Invest 111 2003 347 355
    • (2003) J Clin Invest , vol.111 , pp. 347-355
    • Ishida, T.1    Choi, S.2    Kundu, R.K.3
  • 108
    • 0037316555 scopus 로고    scopus 로고
    • Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo
    • W. Jin, J.S. Millar, U. Broedl, J.M. Glick, and D.J. Rader Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo J Clin Invest 111 2003 357 362
    • (2003) J Clin Invest , vol.111 , pp. 357-362
    • Jin, W.1    Millar, J.S.2    Broedl, U.3    Glick, J.M.4    Rader, D.J.5
  • 109
    • 0032901331 scopus 로고    scopus 로고
    • A novel endothelial-derived lipase that modulates HDL metabolism
    • M. Jaye, K.J. Lynch, and J. Krawiec A novel endothelial-derived lipase that modulates HDL metabolism Nat Genet 21 1999 424 428
    • (1999) Nat Genet , vol.21 , pp. 424-428
    • Jaye, M.1    Lynch, K.J.2    Krawiec, J.3
  • 110
    • 65249186429 scopus 로고    scopus 로고
    • Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    • A.C. Edmondson, R.J. Brown, and S. Kathiresan Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans J Clin Invest 119 2009 1042 1050
    • (2009) J Clin Invest , vol.119 , pp. 1042-1050
    • Edmondson, A.C.1    Brown, R.J.2    Kathiresan, S.3
  • 111
    • 33644842749 scopus 로고    scopus 로고
    • Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    • K.O. Badellino, M.L. Wolfe, M.P. Reilly, and D.J. Rader Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis PLoS Med 3 2006 e22
    • (2006) PLoS Med , vol.3 , pp. 22
    • Badellino, K.O.1    Wolfe, M.L.2    Reilly, M.P.3    Rader, D.J.4
  • 112
    • 40149083940 scopus 로고    scopus 로고
    • Endothelial lipase is increased in vivo by inflammation in humans
    • K.O. Badellino, M.L. Wolfe, M.P. Reilly, and D.J. Rader Endothelial lipase is increased in vivo by inflammation in humans Circulation 117 2008 678 685
    • (2008) Circulation , vol.117 , pp. 678-685
    • Badellino, K.O.1    Wolfe, M.L.2    Reilly, M.P.3    Rader, D.J.4
  • 113
    • 38949176388 scopus 로고    scopus 로고
    • Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    • N.P. Tang, LS. Wang, and L. Yang Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population J Lipid Res 49 2008 369 375
    • (2008) J Lipid Res , vol.49 , pp. 369-375
    • Tang, N.P.1    Wang, L.S.2    Yang, L.3
  • 114
    • 77955281827 scopus 로고    scopus 로고
    • Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT
    • M. Vergeer, D.M. Cohn, and S.M. Boekholdt Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT Atherosclerosis 211 2010 558 564
    • (2010) Atherosclerosis , vol.211 , pp. 558-564
    • Vergeer, M.1    Cohn, D.M.2    Boekholdt, S.M.3
  • 115
    • 67650092295 scopus 로고    scopus 로고
    • The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations
    • M.K. Jensen, E.B. Rimm, and K.J. Mukamal The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations Eur Heart J 30 2009 1584 1589
    • (2009) Eur Heart J , vol.30 , pp. 1584-1589
    • Jensen, M.K.1    Rimm, E.B.2    Mukamal, K.J.3
  • 116
    • 77956628427 scopus 로고    scopus 로고
    • Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins
    • R.J. Brown, W.R. Lagor, and S. Sankaranaravanan Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins Circ Res 107 2010 357 364
    • (2010) Circ Res , vol.107 , pp. 357-364
    • Brown, R.J.1    Lagor, W.R.2    Sankaranaravanan, S.3
  • 117
    • 57749083133 scopus 로고    scopus 로고
    • Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors
    • K.B. Goodman, M.J. Bury, and M. Cheung Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors Bioorg Med Chem Lett 19 2009 27 30
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 27-30
    • Goodman, K.B.1    Bury, M.J.2    Cheung, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.