The Effects of Cholesterol Ester Transfer Protein Inhibition on Cholesterol Efflux

American Journal of Cardiology

Volumn 104, Issue 10 SUPPL., 2009, Pages 39E-45E

  Tall, Alan R ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; APOLIPOPROTEIN E; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN 2; OXYSTEROL; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; SCAVENGER RECEPTOR BI; TORCETRAPIB;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; CELL CULTURE; CHOLESTEROL TRANSPORT; CLINICAL TRIAL; DIFFUSION; DRUG EFFECT; ENDOTHELIUM; FOAM CELL; HOMOZYGOTE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; INTRAVASCULAR ULTRASOUND; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MACROPHAGE; NONHUMAN; PASSIVE TRANSPORT; PRIORITY JOURNAL; REMISSION; SPECIES;

EID: 71749086157     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.09.018     Document Type: Article

References (45)

1. Moore R.E., Kawashiri M.A., Kitajima K., Secreto A., Millar J.S., Pratico D., and Rader D.J. Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. Arterioscler Thromb Vasc Biol 23 (2003) 1914-1920
2. Plump A.S., Scott C.J., and Breslow J.L. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A 91 (1994) 9607-9611
3. Rubin E.M., Krauss R.M., Spangler E.A., Verstuyft J.G., and Clift S.M. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature 353 (1991) 265-267
4. Glass C.K., and Witztum J.L. Atherosclerosis: the road ahead. Cell 104 (2001) 503-516
5. Tall A.R., Yvan-Charvet L., Terasaka N., Pagler T., and Wang N. HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab 7 (2008) 365-375
6. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83 (1991) 391-401
7. Gimbrone Jr. M.A., Topper J.N., Nagel T., Anderson K.R., and Garcia-Cardena G. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci 902 (2000) 230-239 discussion 239-240
8. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87 (2000) 840-844
9. Terasaka N., Yu S., Yvan-Charvet L., Wang N., Mzhavia N., Langlois R., Pagler T., Li R., Welch C.L., Goldberg I.J., et al. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest 118 (2008) 3701-3713
10. Kuvin J.T., Patel A.R., Sidhu M., Rand W.M., Sliney K.A., Pandian N.G., and Karas R.H. Relation between high-density lipoprotein cholesterol and peripheral vasomotor function. Am J Cardiol 92 (2003) 275-279
11. Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., Heath S.C., Timpson N.J., Najjar S.S., Stringham H.M., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40 (2008) 161-169
12. Barter P.J., Caulfield M., Eriksson M., Grundy S.M., Kastelein J.J., Komajda M., Lopez-Sendon J., Mosca L., Tardif J.C., Waters D.D., et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357 (2007) 2109-2122
13. Matsuura F., Wang N., Chen W., Jiang X.C., and Tall A.R. HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J Clin Invest 116 (2006) 1435-1442
14. Yvan-Charvet L., Matsuura F., Wang N., Bamberger M.J., Nguyen T., Rinninger F., Jiang X.C., Shear C.L., and Tall A.R. Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. Arterioscler Thromb Vasc Biol 27 (2007) 1132-1138
15. Francis G.A., Knopp R.H., and Oram J.F. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. J Clin Invest 96 (1995) 78-87
16. Wang N., Lan D., Chen W., Matsuura F., and Tall A.R. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 101 (2004) 9774-9779
17. Kennedy M.A., Venkateswaran A., Tarr P.T., Xenarios I., Kudoh J., Shimizu N., and Edwards P.A. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 276 (2001) 39438-39447
18. Costet P., Luo Y., Wang N., and Tall A.R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 275 (2000) 28240-28245
19. Terasaka N., Wang N., Yvan-Charvet L., and Tall A.R. High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. Proc Natl Acad Sci U S A 104 (2007) 15093-15098
20. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383 (1996) 728-731
21. Sankaranarayanan S., Oram J.F., Asztalos B.F., Vaughan A.M., Lund-Katz S., Adorni M.P., Phillips M.C., and Rothblat G.H. Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res 50 (2009) 275-284
22. Adorni M.P., Zimetti F., Billheimer J.T., Wang N., Rader D.J., Phillips M.C., and Rothblat G.H. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48 (2007) 2453-2462
23. Ji Y., Jian B., Wang N., Sun Y., Moya M.L., Phillips M.C., Rothblat G.H., Swaney J.B., and Tall A.R. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem 272 (1997) 20982-20985
24. Wang X., Collins H.L., Ranalletta M., Fuki I.V., Billheimer J.T., Rothblat G.H., Tall A.R., and Rader D.J. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117 (2007) 2216-2224
25. Aiello R.J., Brees D., Bourassa P.A., Royer L., Lindsey S., Coskran T., Haghpassand M., and Francone O.L. Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages. Arterioscler Thromb Vasc Biol 22 (2002) 630-637
26. Baldan A., Pei L., Lee R., Tarr P., Tangirala R.K., Weinstein M.M., Frank J., Li A.C., Tontonoz P., and Edwards P.A. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26 (2006) 2301-2307
27. Ranalletta M., Wang N., Han S., Yvan-Charvet L., Welch C., and Tall A.R. Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26 (2006) 2308-2315
28. Out R., Hoekstra M., Hildebrand R.B., Kruit J.K., Meurs I., Li Z., Kuipers F., Van Berkel T.J., and Van Eck M. Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 26 (2006) 2295-2300
29. Yvan-Charvet L., Ranalletta M., Wang N., Han S., Terasaka N., Li R., Welch C., and Tall A.R. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117 (2007) 3900-3908
30. Inazu A., Brown M.L., Hesler C.B., Agellon L.B., Koizumi J., Takata K., Maruhama Y., Mabuchi H., and Tall A.R. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med 323 (1990) 1234-1238
31. Brousseau M.E., Schaefer E.J., Wolfe M.L., Bloedon L.T., Digenio A.G., Clark R.W., Mancuso J.P., and Rader D.J. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med 350 (2004) 1505-1515
32. Koizumi J., Inazu A., Yagi K., Koizumi I., Uno Y., Kajinami K., Miyamoto S., Moulin P., Tall A.R., Mabuchi H., et al. Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiency. Atherosclerosis 90 (1991) 189-196
33. Mahley R.W., Huang Y., and Weisgraber K.H. Putting cholesterol in its place: apoE and reverse cholesterol transport. J Clin Invest 116 (2006) 1226-1229
34. Ishigami M., Yamashita S., Sakai N., Arai T., Hirano K., Hiraoka H., Kameda-Takemura K., and Matsuzawa Y. Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins. J Biochem 116 (1994) 257-262
35. Nicholls S.J., Tuzcu E.M., Brennan D.M., Tardif J.C., and Nissen S.E. Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). Circulation 118 (2008) 2506-2514
36. Tall A.R., Yvan-Charvet L., and Wang N. The failure of torcetrapib: was it the molecule or the mechanism?. Arterioscler Thromb Vasc Biol 27 (2007) 257-260
37. Asztalos B.F., Horvath K.V., Kajinami K., Nartsupha C., Cox C.E., Batista M., Schaefer E.J., Inazu A., and Mabuchi H. Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency. J Lipid Res 45 (2004) 448-455
38. Valenta D.T., Bulgrien J.J., Bonnet D.J., and Curtiss L.K. Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency. J Lipid Res 49 (2008) 24-32
39. Yvan-Charvet L., Welch C., Pagler T.A., Ranalletta M., Lamkanfi M., Han S., Ishibashi M., Li R., Wang N., and Tall A.R. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 118 (2008) 1837-1847
40. Zhu X., Lee J.Y., Timmins J.M., Brown J.M., Boudyguina E., Mulya A., Gebre A.K., Willingham M.C., Hiltbold E.M., Mishra N., et al. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem 283 (2008) 22930-22941
41. Sano O., Kobayashi A., Nagao K., Kumagai K., Kioka N., Hanada K., Ueda K., and Matsuo M. Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1. J Lipid Res 48 (2007) 2377-2384
42. Bjorkbacka H., Kunjathoor V.V., Moore K.J., Koehn S., Ordija C.M., Lee M.A., Means T.HalmenK., Luster A.D., Golenbock D.T., et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 10 (2004) 416-421
43. Zhu M., Fu Y., Hou Y., Wang N., Guan Y., Tang C., Shyy J.Y., and Zhu Y. Laminar shear stress regulates liver X receptor in vascular endothelial cells. Arterioscler Thromb Vasc Biol 28 (2008) 527-533
44. Hermann F., Enseleit F., Spieker L.E., Periat D., Sudano I., Hermann M., Corti R., Noll G., Ruschitzka F., and Luscher T.F. Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia. Thromb Res 123 (2009) 460-465
45. Tanigawa H., Billheimer J.T., Tohyama J., Zhang Y., Rothblat G., and Rader D.J. Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation 116 (2007) 1267-1273