Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis

PLoS Medicine

Volumn 3, Issue 2, 2006, Pages 0245-0252

  Badellino, Karen O ^a   Wolfe, Megan L ^a   Reilly, Muredach P ^a   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ENDOTHELIUM LIPASE; HEPARIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HORMONE; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VASOACTIVE AGENT; VERY LOW DENSITY LIPOPROTEIN; ANTICOAGULANT AGENT; LIPG PROTEIN, HUMAN;

ADULT; AGE DISTRIBUTION; AGED; ARTERY CALCIFICATION; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE; BLOOD SAMPLING; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ELECTRON BEAM TOMOGRAPHY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; FAMILY HISTORY; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; METABOLIC SYNDROME X; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS; REGRESSION ANALYSIS; RISK FACTOR; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; CHEMISTRY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDY; GENETIC PREDISPOSITION; GENETICS; LABORATORY DIAGNOSIS; METABOLISM; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY;

ADULT; AGED; ANTICOAGULANTS; CHOLESTEROL, HDL; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEPARIN; HUMANS; LIPASE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OVERWEIGHT; RISK FACTORS; SPECIMEN HANDLING;

EID: 33644842749     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030022     Document Type: Article

References (54)

1. Hokanson JE, Kamboh MI, Scarboro S, Eckel RH, Hamman RF (2003) Effects of the hepatic lipase gene and physical activity on coronary heart disease risk. Am J Epidemiol 158: 836-843.
2. Dugi KA, Brandauer K, Schmidt N, Nau B, Schneider JG, et al. (2001) Low hepatic lipase activity is a novel risk factor for coronary artery disease. Circulation 104: 3057-3062.
3. Dugi KA, Feuerstein IM, Hill S, Shih J, Santamarina-Fojo S, et al. (1997) Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 17: 354-364.
4. Arca M, Campagna F, Montali A, Barilla F, Mangieri E, et al. (2000) The common mutations in the lipoprotein lipase gene in Italy: Effects on plasma lipids and angiographically assessed coronary atherosclerosis. Clin Genet 58: 369-374.
5. Stein Y, Stein O (2003) Lipoprotein lipase and atherosclerosis. Atherosclerosis 170: 1-9.
6. Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, et al. (1999) A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 21: 424-428.
7. Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, et al. (1999) Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 274: 14170-14175.
8. Maugeais C, Tietge UJ, Broedl UC, Marchadier D, Cain W, et al. (2003) Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation 108: 2121-2126.
9. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, et al. (2003) Endothelial lipase is a major determinant of HDL level. J Clin Invest 111: 347-355.
10. Jin W, Millar JS, Broedl U, Glick JM, Rader DJ (2003) Inhibition of endothelial lipase causes increased HDL cholesterol concentrations in vivo. J Clin Invest 111: 357-362.
11. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, et al. (2003) Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A 100: 2748-2753.
12. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, et al. (2004) Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279: 45085-45092.
13. deLemos AS, Wolfe ML, Long CJ, Sivapackianathan R, Rader DJ (2002) Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation 106: 1321-1326.
14. Yamakawa-Kobayashi K, Yanagi H, Endo K, Arinami T, Hamaguchi H (2003) Relationship between serum HDL-C concentrations and common genetic variants of the endothelial lipase gene in Japanese school-aged children. Hum Genet 113: 311-315.
15. Rumberger JA, Sheedy PF 2nd, Breen JF, Fitzpatrick LA, Schwartz RS (1996) Electron beam computed tomography and coronary artery disease: Scanning for coronary artery calcification. Mayo Clin Proc 71: 369-377.
16. Devries S, Wolfkiel C, Fusman B, Bakdash H, Ahmed A, et al. (1995) Influence of age and gender on the presence of coronary calcium detected by ultrafast computed tomography. J Am Coll Cardiol 25: 76-82.
17. Nallamothu BK, Saint S, Bielak LF, Sonnad SS, Peyser PA, et al. (2001) Electron-beam computed tomography in the diagnosis of coronary artery disease: A meta-analysis. Arch Intern Med 161: 833-838.
18. Valdes AM, Wolfe ML, Tate HC, Gefter W, Rut A, et al. (2001) Association of traditional risk factors with coronary calcification in persons with a family history of premature coronary heart disease: The study of the inherited risk of coronary atherosclerosis. J Investig Med 49: 353-361.
19. Reilly MP, Wolfe ML, Localio AR, Rader DJ (2003) C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA). Arterioscler Thromb Vasc Biol 23: 1851-1856.
20. Otvos J (1999) Measurement of triglyceride-rich lipoproteins by nuclear magnetic resonance spectroscopy. Clin Cardiol 22: II21-27.
21. Kuller L, Arnold A, Tracy R, Otvos J, Burke G, et al. (2002) Nuclear magnetic resonance spectroscopy of lipoproteins and risk of coronary heart disease in the cardiovascular health study. Arterioscler Thromb Vasc Biol 22: 1175-1180.
22. Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, et al. (2005) Hormone therapy, lipoprotein subclasses and coronary calcification. Arch Intern Med 165: 510-515.
23. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr., et al. (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15: 827-832.
24. Bello N, Mosca L (2004) Epidemiology of coronary heart disease in women. Prog Cardiovasc Dis 46: 287-295.
25. Chrysohoou C, Panagiotakos DB, Pitsavos C, Kokkinos P, Marinakis N, et al. (2003) Gender differences on the risk evaluation of acute coronary syndromes: The CARDIO2000 study. Prev Cardiol 6: 71-77.
26. Reilly MP, Wolfe ML, Localio AR, Rader DJ (2004) Coronary artery calcification and cardiovascular risk factors: Impact of the analytic approach. Atherosclerosis 173: 69-78.
27. Rumberger JA, Brundage BH, Rader DJ, Kondos G (1999) Electron beam computed tomographic coronary calcium scanning: A review and guidelines for use in asymptomatic persons. Mayo Clin Proc 74: 243-252.
28. Reilly MP, Wolfe ML, Rhodes T, Girman C, Mehta N, et al. (2004) Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation 110: 803-809.
29. Fu,V (1998) Estimating generalized ordered logit models. STATA Tech Bulletin 44: 27-30.
30. Schoenborn CA, Adams PF, Barnes PM (2002) Body weight status of adults: United States, 1997-98. Adv Data 2002: 1-15.
31. Tande DL, Hotchkiss L, Cotugna N (2004) The associations between blood lipids and the Food Guide Pyramid: Findings from the Third National Health and Nutrition Examination Survey. Prev Med 38: 452-457.
32. Ehnholm C, Shaw W, Greten H, Brown WV (1975) Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids. J Biol Chem 250: 6756-6761.
33. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, et al. (2000) Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 23: 57-63.
34. Ikeda Y, Takagi A, Ohkaru Y, Nogi K, Iwanaga T, et al. (1990) A sandwich-enzyme immunoassay for the quantification of lipoprotein lipase and hepatic triglyceride lipase in human postheparin plasma using monoclonal antibodies to the corresponding enzymes. J Lipid Res 31: 1911-1924.
35. Kobayashi J, Hashimoto H, Fukamachi I, Tashiro J, Shirai K, et al. (1993) Lipoprotein lipase mass and activity in severe hypertriglyceridemia. Clin Chim Acta 216: 113-123.
36. Kobayashi J (2004) Pre-heparin lipoprotein lipase mass. J Atheroscler Thromb 11: 1-5.
37. Kimura H, Ohkaru Y, Katoh K, Ishii H, Sunahara N, et al. (1999) Development and evaluation of a direct sandwich enzyme-linked immunosorbent assay for the quantification of lipoprotein lipase mass in human plasma. Clin Biochem 32: 15-23.
38. Nishimura M, Ohkaru Y, Ishii H, Sunahara N, Takagi A, et al. (2000) Development and evaluation of a direct sandwich-enzyme-linked immunosorbent assay for the quantification of human hepatic triglyceride lipase mass in human plasma. J Immunol Methods 235: 41-51.
39. Broedl UC, Maugeais C, Millar JS, Jin W, Moore RE, et al. (2004) Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94: 1554-1561.
40. Murdoch SJ, Carr MC, Kennedy H, Brunzell JD, Albers JJ (2002) Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution. J Lipid Res 43: 1256-1263.
41. van Wijk JP, Halkes CJ, Erkelens DW, Castro Cabezas M (2003) Fasting and daylong triglycerides in obesity with and without type 2 diabetes. Metabolism 52: 1043-1049.
42. Barrans A, Collet X, Barbaras R, Jaspard B, Manent J, et al. (1994) Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem 269: 11572-11577.
43. Jahangiri A, Rader DJ, Marchadier D, Curtiss LK, Bonnet DJ, et al. (2005) Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I. J Lipid Res 46: 896-903.
44. Patsch JR, Prasad S, Gotto AM Jr, Patsch W (1987) High density lipoprotein 2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase. J Clin Invest 80: 341-347.
45. Mowri HO, Patsch JR, Gotto AM Jr, Patsch W (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler Thromb Vasc Biol 16: 755-762.
46. Hedrick CC, Castellani LW, Wong H, Lusis AJ (2001) In vivo interactions of apolipoprotein A-II, apolipoprotein A-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions. J Lipid Res 42: 563-570.
47. Boucher J, Ramsamy TA, Biaschi S, Sahoo D, Neville TA, et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-858.
48. Caiazza D, Jahangiri A, Rader DJ, Marchadier D, Rye KA (2004) Apolipoproteins regulate kinetics of endothelial lipase-mediated hydrolysis of phospholipids in reconstituted high-density lipoproteins. Biochemistry 43: 11898-11905.
49. Jin W, Sun GS, Marchadier D, Octtaviani E, Glick JM, et al. (2003) Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 92: 644-650.
50. Hirata K, Ishida T, Matsushita H, Tsao PS, Quertermous T (2000) Regulated expression of endothelial cell-derived lipase. Biochem Biophys Res Commun 272: 90-93.
51. Nilsson J, Jovinge S, Niemann A, Reneland R, Lithell H (1998) Relationship between plasma tumor necrosis factor-α and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 18: 1199-1202.
52. Carr MC, Hokanson JE, Zambon A, Deeb SS, Barrett PH, et al. (2001) The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J Clin Endocrinol Metab 86: 2831-2837.
53. DeGeest BR, Van Lithout SA, Collen D (2003) Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells. Blood 101: 2551-2556.
54. Ruel IL, Couture P, Cohn JS, Bensadoun A, Marcil M, et al. (2004) Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism. J Lipid Res 45: 1528-1537.