Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo

Circulation

Volumn 108, Issue 6, 2003, Pages 661-663

  Zhang, YuZhen ^a   Zanotti, Ilaria ^b   Reilly, Muredach P ^a   Glick, Jane M ^a   Rothblat, George H ^b   Rader, Daniel J ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apolipoproteins; Atherosclerosis; Cholesterol; Cholesterol, reverse transport; Macrophages

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; APOLIPOPROTEIN A1; CHOLESTEROL; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FECES; FOAM CELL; GENE OVEREXPRESSION; LIVER; MACROPHAGE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOLIPOPROTEIN A-I; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; FEASIBILITY STUDIES; FECES; FOAM CELLS; GENE TRANSFER TECHNIQUES; LIPOPROTEINS, LDL; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; TRITIUM;

EID: 0041662117     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000086981.09834.E0     Document Type: Article

References (16)

1. Rubin E, Krauss R, Spangler E, et al. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature. 1991;353:265-267.
2. Plump A, Scott C, Breslow J. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acid Sci U S A. 1994;91:9607-9611.
3. Tangirala RK, Tsukamoto K, Chun SH, et al. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation. 1999;100:1816-1822.
4. Duverger N, Kruth H, Emmanuel F, et al. Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits. Circulation. 1996;94:713-717.
5. Barter PJ, Rye K. Molecular mechanisms of reverse cholesterol transport. Curr Opin Lipidol. 1996;7:82-87.
6. Stein O, Dabach Y, Hollander G, et al. High levels of human apolipoprotein A-I and high density lipoproteins in transgenic mice do not enhance efflux of cholesterol from a depot of injected lipoproteins. Atherosclerosis. 1999;144:367-374.
7. Osono Y, Woollett LA, Marotti KR, et al. Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma. Proc Natl Acad Sci USA. 1996;93:4114-4119.
8. Jolley CD, Woollett LA, Turley SD, et al. Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration, J Lipid Res. 1998;39:2143-2149.
9. Alam K, Meidell RS, Spady DK. Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice. J Biol Chem. 2001;276:15641-15649.
10. Tall AR, Wang N, Mucksavage P. Is it time to modify the reverse cholesterol transport model? J Clin Invest. 2001;108:1273-1275.
11. Kellner-Weibel G, Jerome WG, Small DM, et al. Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler Thromb Vasc Biol. 1998;18:423-431.
12. Klansek JJ, Yancey P, St Clair RW, et al. Cholesterol quantitation by GLC: artifactual formation of short-chain steryl esters. J Lipid Res. 1995;36:2243-2250.
13. Batta AK, Salen G, Rapole KR, et al. Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. J Lipid Res. 1999;40:1148-1154.
14. Iverson SJ, Lang SL, Cooper MH. Comparison of the Bligh and Dyer and Folch methods for total lipid determination in a broad range of marine tissue. Lipids. 2001;36:1283-1287.
15. Tietge UJ, Maugeais C, Lund-Katz S, et al. Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol. 2002;22:1213-1218.
16. Millar JS, Lichtenstein AH, Ordovas JM, et al. Human triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100 metabolism. Atherosclerosis. 2001;155:477-485.