Intramural delivery of recombinant apolipoprotein A-IMilano/phospholipid complex (ETC-216) inhibits in-stent stenosis in porcine coronary arteries

Circulation

Volumn 107, Issue 20, 2003, Pages 2551-2554

  Kaul, Sanjay ^a,b   Rukshin, Vladimir ^a   Santos, Raul ^a   Azarbal, Babak ^a   Bisgaier, Charles L ^c   Johansson, Jan ^c   Tsang, Vivian T ^a   Chyu, Kuang Yuh ^a   Cercek, Bojan ^a   Mirocha, James ^a   Shah, Prediman K ^a  

^a Department of Medicine   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Esperion Therapeutics Inc   (United States)

Author keywords

Lipoproteins; Restenosis; Stents

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; APOLIPOPROTEIN A1; ETC 216; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CATHETER; ARTERY INTIMA; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CORONARY STENT; DRUG DELIVERY SYSTEM; DRUG EFFICACY; NONHUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; RESTENOSIS; SCORING SYSTEM; SWINE; TREATMENT OUTCOME;

ANIMALS; APOLIPOPROTEIN A-I; CORONARY RESTENOSIS; CORONARY VESSELS; DISEASE MODELS, ANIMAL; INJECTIONS, INTRA-ARTERIAL; MACROMOLECULAR SUBSTANCES; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; RECOMBINANT PROTEINS; STENTS; SWINE; TREATMENT OUTCOME; VASCULAR PATENCY;

EID: 0038012797     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000074042.19447.B1     Document Type: Article

References (11)

1. Franceschini G, Sirtori CR, Capurso A, et al. A-I Milano apoprotein: decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest. 1980;66:892-900.
2. Milano reduces intimal thickening after balloon injury in hypercholesterolemic rabbits. Circulation. 1994;90:1935-1941.
3. Milano dimer inhibits carotid intimal thickening induced by perivascular manipulation in rabbits. Circ Res. 1995;76:405-411.
4. Milano on aortic atherosclerosis in apolipoprotein E-deficient mice. Circulation. 1998;97:780-785.
5. Milano mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein E-deficient mice: potential implications for acute plaque stabilization. Circulation. 2001;103:3047-3050.
6. Paris exhibit an antioxidant activity distinct from that of wild-type apolipoprotein A-I. Biochemistry. 2002;41:2089-2096.
7. Liu MW, Roubin GS, King SB III. Restenosis after coronary angioplasty: potential biologic determinants and role of intimal hyperplasia. Circulation. 1989;79:1374-1387.
8. Barath P, Popov A, Dillehay GL, et al. Infiltrator angioplasty balloon catheter: a device for combined angioplasty and intramural site-specific treatment. Cathet Cardiovasc Diagn. 1997;41:333-341.
9. Rosenthal EA, Bohlmeyer TJ, Monnet E, et al. An iron-binding exochelin prevents restenosis due to coronary artery balloon injury in a porcine model. Circulation. 2001;104:2222-2227.
10. Varenne O, Pislaru S, Gillijns H, et al. Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs. Circulation. 1998;98:919-926.
11. Schwartz RS, Huber KC, Murphy JG, et al. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol. 1992;19:267-274.