-
1
-
-
84862583029
-
Intestinal iron absorption
-
Fuqua, B.K.; Vulpe, C.D.; Anderson, G.J. Intestinal iron absorption. J. Trace Elem. Med. Biol. 2012, 26, 115-119.
-
(2012)
J. Trace Elem. Med. Biol
, vol.26
, pp. 115-119
-
-
Fuqua, B.K.1
Vulpe, C.D.2
Anderson, G.J.3
-
2
-
-
34250865977
-
The molecular mechanism of hepcidin-mediated ferroportin down-regulation
-
De Domenico, I.; Ward, D.M.; Langelier, C.; Vaughn, M.B.; Nemeth, E.; Sundquist, W.I.; Ganz, T.; Musci, G.; Kaplan, J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol. Biol. Cell 2007, 18, 2569-2578.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 2569-2578
-
-
de Domenico, I.1
Ward, D.M.2
Langelier, C.3
Vaughn, M.B.4
Nemeth, E.5
Sundquist, W.I.6
Ganz, T.7
Musci, G.8
Kaplan, J.9
-
3
-
-
4143051431
-
Transferrin receptor 1
-
Aisen, P. Transferrin receptor 1. Int. J. Biochem. Cell Biol. 2004, 36, 2137-2143.
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 2137-2143
-
-
Aisen, P.1
-
4
-
-
0000241799
-
pH and the recycling of transferrin during receptor-mediated endocytosis
-
Dautry-Varsat, A.; Ciechanover, A.; Lodish, H.F. pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Natl. Acad. Sci. USA 1983, 80, 2258-2262.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 2258-2262
-
-
Dautry-Varsat, A.1
Ciechanover, A.2
Lodish, H.F.3
-
5
-
-
0021337104
-
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site
-
Graf, E.; Mahoney, J.R.; Bryant, R.G.; Eaton, J.W. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J. Biol. Chem. 1984, 259, 3620-3624.
-
(1984)
J. Biol. Chem
, vol.259
, pp. 3620-3624
-
-
Graf, E.1
Mahoney, J.R.2
Bryant, R.G.3
Eaton, J.W.4
-
6
-
-
38449094356
-
Iron-regulatory proteins: Molecular biology and pathophysiological implications
-
Cairo, G.; Recalcati, S. Iron-regulatory proteins: Molecular biology and pathophysiological implications. Expert Rev. Mol. Med. 2007, 9, 1-13.
-
(2007)
Expert Rev. Mol. Med
, vol.9
, pp. 1-13
-
-
Cairo, G.1
Recalcati, S.2
-
7
-
-
0028928738
-
Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the -free iron pool
-
Cairo, G.; Tacchini, L.; Pogliaghi, G.; Anzon, E.; Tomasi, A.; Bernelli-Zazzera, A. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the -free iron pool. J. Biol. Chem. 1995, 270, 700-703.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 700-703
-
-
Cairo, G.1
Tacchini, L.2
Pogliaghi, G.3
Anzon, E.4
Tomasi, A.5
Bernelli-Zazzera, A.6
-
8
-
-
10844282789
-
Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo
-
Meyron-Holtz, E.G.; Ghosh, M.C.; Rouault, T.A. Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 2004, 306, 2087-2090.
-
(2004)
Science
, vol.306
, pp. 2087-2090
-
-
Meyron-Holtz, E.G.1
Ghosh, M.C.2
Rouault, T.A.3
-
9
-
-
33645421347
-
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: Expression and regulation in hereditary hemochromatosis and iron deficiency
-
Recalcati, S.; Alberghini, A.; Campanella, A.; Gianelli, U.; de Camilli, E.; Conte, D.; Cairo, G. Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: Expression and regulation in hereditary hemochromatosis and iron deficiency. Haematologica 2006, 91, 303-310.
-
(2006)
Haematologica
, vol.91
, pp. 303-310
-
-
Recalcati, S.1
Alberghini, A.2
Campanella, A.3
Gianelli, U.4
de Camilli, E.5
Conte, D.6
Cairo, G.7
-
10
-
-
0027081042
-
Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein
-
Kennedy, M.C.; Mende-Mueller, L.; Blondin, G.A.; Beinert, H. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc. Natl. Acad. Sci. USA 1992, 89, 11730-11734.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11730-11734
-
-
Kennedy, M.C.1
Mende-Mueller, L.2
Blondin, G.A.3
Beinert, H.4
-
11
-
-
0014962872
-
Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas
-
Elford, H.L.; Freese, M.; Passamani, E.; Morris, H.P. Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas. J. Biol. Chem. 1970, 245, 5228-5233.
-
(1970)
J. Biol. Chem
, vol.245
, pp. 5228-5233
-
-
Elford, H.L.1
Freese, M.2
Passamani, E.3
Morris, H.P.4
-
12
-
-
0029953577
-
Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression
-
Trinder, D.; Zak, O.; Aisen, P. Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology 1996, 23, 1512-1520.
-
(1996)
Hepatology
, vol.23
, pp. 1512-1520
-
-
Trinder, D.1
Zak, O.2
Aisen, P.3
-
13
-
-
0025341256
-
The uptake of iron and transferrin by the human malignant melanoma cell
-
Richardson, D.R.; Baker, E. The uptake of iron and transferrin by the human malignant melanoma cell. Biochim. Biophys. Acta 1990, 1053, 1-12.
-
(1990)
Biochim. Biophys. Acta
, vol.1053
, pp. 1-12
-
-
Richardson, D.R.1
Baker, E.2
-
14
-
-
84859171807
-
Myc on the path to cancer
-
Dang, C.V. Myc on the path to cancer. Cell 2012, 149, 22-35.
-
(2012)
Cell
, vol.149
, pp. 22-35
-
-
Dang, C.V.1
-
15
-
-
23144464363
-
Transcriptional regulation and transformation by myc proteins
-
Adhikary, S.; Eilers, M. Transcriptional regulation and transformation by myc proteins. Nat. Rev. Mol. Cell. Biol. 2005, 6, 635-645.
-
(2005)
Nat. Rev. Mol. Cell. Biol
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
16
-
-
0032905924
-
C-myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang, C.V. C-myc target genes involved in cell growth, apoptosis, and metabolism. Mol. Cell. Biol. 1999, 19, 1-11.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
17
-
-
0033613854
-
Coordinated regulation of iron-controlling genes, h-ferritin and irp2, by c-myc
-
Wu, K.J.; Polack, A.; Dalla-Favera, R. Coordinated regulation of iron-controlling genes, h-ferritin and irp2, by c-myc. Science 1999, 283, 676-679.
-
(1999)
Science
, vol.283
, pp. 676-679
-
-
Wu, K.J.1
Polack, A.2
Dalla-Favera, R.3
-
18
-
-
0020490615
-
Characterization of the free radical of mammalian ribonucleotide reductase
-
Graslund, A.; Ehrenberg, A.; Thelander, L. Characterization of the free radical of mammalian ribonucleotide reductase. J. Biol. Chem. 1982, 257, 5711-5715.
-
(1982)
J. Biol. Chem
, vol.257
, pp. 5711-5715
-
-
Graslund, A.1
Ehrenberg, A.2
Thelander, L.3
-
19
-
-
0035181433
-
Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: Effect on the r2 subunit of ribonucleotide reductase
-
Green, D.A.; Antholine, W.E.; Wong, S.J.; Richardson, D.R.; Chitambar, C.R. Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: Effect on the r2 subunit of ribonucleotide reductase. Clin. Cancer Res. 2001, 7, 3574-3579.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 3574-3579
-
-
Green, D.A.1
Antholine, W.E.2
Wong, S.J.3
Richardson, D.R.4
Chitambar, C.R.5
-
20
-
-
79952003165
-
Molecular analysis and functions of p53r2 in zebrafish
-
Shang, H.; Li, Q.; Feng, G.; Cui, Z. Molecular analysis and functions of p53r2 in zebrafish. Gene 2011, 475, 30-38.
-
(2011)
Gene
, vol.475
, pp. 30-38
-
-
Shang, H.1
Li, Q.2
Feng, G.3
Cui, Z.4
-
21
-
-
33751556356
-
Circular dichroism and magnetic circular dichroism studies of the active site of p53r2 from human and mouse: Iron binding and nature of the biferrous site relative to other ribonucleotide reductases
-
Wei, P.P.; Tomter, A.B.; Rohr, A.K.; Andersson, K.K.; Solomon, E.I. Circular dichroism and magnetic circular dichroism studies of the active site of p53r2 from human and mouse: Iron binding and nature of the biferrous site relative to other ribonucleotide reductases. Biochemistry 2006, 45, 14043-14051.
-
(2006)
Biochemistry
, vol.45
, pp. 14043-14051
-
-
Wei, P.P.1
Tomter, A.B.2
Rohr, A.K.3
Andersson, K.K.4
Solomon, E.I.5
-
22
-
-
0038529602
-
Direct interactions between hif-1 αand mdm2 modulate p53 function
-
Chen, D.; Li, M.; Luo, J.; Gu, W. Direct interactions between hif-1 αand mdm2 modulate p53 function. J. Biol. Chem. 2003, 278, 13595-13598.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 13595-13598
-
-
Chen, D.1
Li, M.2
Luo, J.3
Gu, W.4
-
23
-
-
0141891251
-
Activation of p53 by oxidative stress involves platelet-derived growth factor-βreceptor-mediated ataxia telangiectasia mutated (atm) kinase activation
-
Chen, K.; Albano, A.; Ho, A.; Keaney, J.F., Jr. Activation of p53 by oxidative stress involves platelet-derived growth factor-βreceptor-mediated ataxia telangiectasia mutated (atm) kinase activation. J. Biol. Chem. 2003, 278, 39527-39533.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 39527-39533
-
-
Chen, K.1
Albano, A.2
Ho, A.3
Keaney Jr., J.F.4
-
24
-
-
0029379698
-
Iron deprivation results in an increase in p53 expression
-
Fukuchi, K.; Tomoyasu, S.; Watanabe, H.; Kaetsu, S.; Tsuruoka, N.; Gomi, K. Iron deprivation results in an increase in p53 expression. Biol. Chem. Hoppe-Seyler 1995, 376, 627-630.
-
(1995)
Biol. Chem. Hoppe-Seyler
, vol.376
, pp. 627-630
-
-
Fukuchi, K.1
Tomoyasu, S.2
Watanabe, H.3
Kaetsu, S.4
Tsuruoka, N.5
Gomi, K.6
-
25
-
-
0142154312
-
The effect of potent iron chelators on the regulation of p53: Examination of the expression, localization and DNA-binding activity of p53 and the transactivation of waf1
-
Liang, S.X.; Richardson, D.R. The effect of potent iron chelators on the regulation of p53: Examination of the expression, localization and DNA-binding activity of p53 and the transactivation of waf1. Carcinogenesis 2003, 24, 1601-1614.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1601-1614
-
-
Liang, S.X.1
Richardson, D.R.2
-
26
-
-
77149125234
-
Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53
-
Saletta, F.; Suryo Rahmanto, Y.; Noulsri, E.; Richardson, D.R. Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol. Pharmacol. 2010, 77, 443-458.
-
(2010)
Mol. Pharmacol
, vol.77
, pp. 443-458
-
-
Saletta, F.1
Suryo, R.Y.2
Noulsri, E.3
Richardson, D.R.4
-
27
-
-
76149107519
-
Iron-dependent regulation of mdm2 influences p53 activity and hepatic carcinogenesis
-
Dongiovanni, P.; Fracanzani, A.L.; Cairo, G.; Megazzini, C.P.; Gatti, S.; Rametta, R.; Fargion, S.; Valenti, L. Iron-dependent regulation of mdm2 influences p53 activity and hepatic carcinogenesis. Am. J. Pathol. 2010, 176, 1006-1017.
-
(2010)
Am. J. Pathol
, vol.176
, pp. 1006-1017
-
-
Dongiovanni, P.1
Fracanzani, A.L.2
Cairo, G.3
Megazzini, C.P.4
Gatti, S.5
Rametta, R.6
Fargion, S.7
Valenti, L.8
-
28
-
-
57749094952
-
Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest
-
Zhang, F.; Wang, W.; Tsuji, Y.; Torti, S.V.; Torti, F.M. Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. J. Biol. Chem. 2008, 283, 33911-33918.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 33911-33918
-
-
Zhang, F.1
Wang, W.2
Tsuji, Y.3
Torti, S.V.4
Torti, F.M.5
-
29
-
-
34250881181
-
Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53
-
Weizer-Stern, O.; Adamsky, K.; Margalit, O.; Ashur-Fabian, O.; Givol, D.; Amariglio, N.; Rechavi, G. Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53. Br. J. Haematol. 2007, 138, 253-262.
-
(2007)
Br. J. Haematol
, vol.138
, pp. 253-262
-
-
Weizer-Stern, O.1
Adamsky, K.2
Margalit, O.3
Ashur-Fabian, O.4
Givol, D.5
Amariglio, N.6
Rechavi, G.7
-
30
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001, 11, S27-S31.
-
(2001)
Trends Cell Biol
, vol.11
-
-
Campisi, J.1
-
31
-
-
0037383786
-
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/waf1/cip1 gene
-
Lagger, G.; Doetzlhofer, A.; Schuettengruber, B.; Haidweger, E.; Simboeck, E.; Tischler, J.; Chiocca, S.; Suske, G.; Rotheneder, H.; Wintersberger, E. The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/waf1/cip1 gene. Mol. Cell. Biol. 2003, 23, 2669-2679.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 2669-2679
-
-
Lagger, G.1
Doetzlhofer, A.2
Schuettengruber, B.3
Haidweger, E.4
Simboeck, E.5
Tischler, J.6
Chiocca, S.7
Suske, G.8
Rotheneder, H.9
Wintersberger, E.10
-
32
-
-
67649424560
-
P21 in cancer: Intricate networks and multiple activities
-
Abbas, T.; Dutta, A. P21 in cancer: Intricate networks and multiple activities. Nat. Rev. Cancer 2009, 9, 400-414.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 400-414
-
-
Abbas, T.1
Dutta, A.2
-
33
-
-
0032947853
-
Induction of p21(waf1/cip1) and inhibition of cdk2 mediated by the tumor suppressor p16(ink4a)
-
Mitra, J.; Dai, C.Y.; Somasundaram, K.; El-Deiry, W.S.; Satyamoorthy, K.; Herlyn, M.; Enders, G.H. Induction of p21(waf1/cip1) and inhibition of cdk2 mediated by the tumor suppressor p16(ink4a). Mol. Cell. Biol. 1999, 19, 3916-3928.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 3916-3928
-
-
Mitra, J.1
Dai, C.Y.2
Somasundaram, K.3
El-Deiry, W.S.4
Satyamoorthy, K.5
Herlyn, M.6
Enders, G.H.7
-
34
-
-
0032556952
-
P21 binding to pcna causes g1 and g2 cell cycle arrest in p53-deficient cells
-
Cayrol, C.; Knibiehler, M.; Ducommun, B. P21 binding to pcna causes g1 and g2 cell cycle arrest in p53-deficient cells. Oncogene 1998, 16, 311-320.
-
(1998)
Oncogene
, vol.16
, pp. 311-320
-
-
Cayrol, C.1
Knibiehler, M.2
Ducommun, B.3
-
35
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein, G.H.; Drullinger, L.F.; Soulard, A.; Dulic, V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 1999, 19, 2109-2117.
-
(1999)
Mol. Cell. Biol
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
36
-
-
0033521889
-
Caspase-mediated cleavage of p21waf1/cip1 converts cancer cells from growth arrest to undergoing apoptosis
-
Zhang, Y.; Fujita, N.; Tsuruo, T. Caspase-mediated cleavage of p21waf1/cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 1999, 18, 1131-1138.
-
(1999)
Oncogene
, vol.18
, pp. 1131-1138
-
-
Zhang, Y.1
Fujita, N.2
Tsuruo, T.3
-
37
-
-
0038339635
-
P21(waf1/cip1/sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human t-cell leukemia virus type 1-encoded tax
-
Kawata, S.; Ariumi, Y.; Shimotohno, K. P21(waf1/cip1/sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human t-cell leukemia virus type 1-encoded tax. J. Virol. 2003, 77, 7291-7299.
-
(2003)
J. Virol
, vol.77
, pp. 7291-7299
-
-
Kawata, S.1
Ariumi, Y.2
Shimotohno, K.3
-
38
-
-
0037298925
-
Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma
-
Biankin, A.V.; Kench, J.G.; Dijkman, F.P.; Biankin, S.A.; Henshall, S.M. Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma. Pathology 2003, 35, 14-24.
-
(2003)
Pathology
, vol.35
, pp. 14-24
-
-
Biankin, A.V.1
Kench, J.G.2
Dijkman, F.P.3
Biankin, S.A.4
Henshall, S.M.5
-
39
-
-
0347628818
-
P21waf1/cip1 as a therapeutic target in breast and other cancers
-
Weiss, R.H. P21waf1/cip1 as a therapeutic target in breast and other cancers. Cancer Cell 2003, 4, 425-429.
-
(2003)
Cancer Cell
, vol.4
, pp. 425-429
-
-
Weiss, R.H.1
-
40
-
-
0035123524
-
A new molecular role for iron in regulation of cell cycling and differentiation of hl-60 human leukemia cells: Iron is required for transcription of p21(waf1/cip1) in cells induced by phorbol myristate acetate
-
Gazitt, Y.; Reddy, S.V.; Alcantara, O.; Yang, J.; Boldt, D.H. A new molecular role for iron in regulation of cell cycling and differentiation of hl-60 human leukemia cells: Iron is required for transcription of p21(waf1/cip1) in cells induced by phorbol myristate acetate. J. Cell. Physiol. 2001, 187, 124-135.
-
(2001)
J. Cell. Physiol
, vol.187
, pp. 124-135
-
-
Gazitt, Y.1
Reddy, S.V.2
Alcantara, O.3
Yang, J.4
Boldt, D.H.5
-
41
-
-
0036113621
-
Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (waf1/cip1) and requires iron
-
Kramer, J.L.; Baltathakis, I.; Alcantara, O.S.; Boldt, D.H. Differentiation of functional dendritic cells and macrophages from human peripheral blood monocyte precursors is dependent on expression of p21 (waf1/cip1) and requires iron. Br. J. Haematol. 2002, 117, 727-734.
-
(2002)
Br. J. Haematol
, vol.117
, pp. 727-734
-
-
Kramer, J.L.1
Baltathakis, I.2
Alcantara, O.S.3
Boldt, D.H.4
-
42
-
-
34547137681
-
Iron chelation and regulation of the cell cycle: 2 Mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21cip1/waf1 by iron depletion
-
Fu, D.; Richardson, D.R. Iron chelation and regulation of the cell cycle: 2 Mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21cip1/waf1 by iron depletion. Blood 2007, 110, 752-761.
-
(2007)
Blood
, vol.110
, pp. 752-761
-
-
Fu, D.1
Richardson, D.R.2
-
43
-
-
18344372831
-
Cyclins and cdks in development and cancer: A perspective
-
Deshpande, A.; Sicinski, P.; Hinds, P.W. Cyclins and cdks in development and cancer: A perspective. Oncogene 2005, 24, 2909-2915.
-
(2005)
Oncogene
, vol.24
, pp. 2909-2915
-
-
Deshpande, A.1
Sicinski, P.2
Hinds, P.W.3
-
44
-
-
0035437183
-
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, iv: The mechanisms involved in inhibiting cell-cycle progression
-
Gao, J.; Richardson, D.R. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, iv: The mechanisms involved in inhibiting cell-cycle progression. Blood 2001, 98, 842-850.
-
(2001)
Blood
, vol.98
, pp. 842-850
-
-
Gao, J.1
Richardson, D.R.2
-
45
-
-
0030601987
-
Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin d/cdk4 protein levels in asynchronous mda-mb-453 human breast cancer cells
-
Kulp, K.S.; Green, S.L.; Vulliet, P.R. Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin d/cdk4 protein levels in asynchronous mda-mb-453 human breast cancer cells. Exp. Cell Res. 1996, 229, 60-68.
-
(1996)
Exp. Cell Res
, vol.229
, pp. 60-68
-
-
Kulp, K.S.1
Green, S.L.2
Vulliet, P.R.3
-
46
-
-
34247373460
-
Iron chelation regulates cyclin d1 expression via the proteasome: A link to iron deficiency-mediated growth suppression
-
Nurtjahja-Tjendraputra, E.; Fu, D.; Phang, J.M.; Richardson, D.R. Iron chelation regulates cyclin d1 expression via the proteasome: A link to iron deficiency-mediated growth suppression. Blood 2007, 109, 4045-4054.
-
(2007)
Blood
, vol.109
, pp. 4045-4054
-
-
Nurtjahja-Tjendraputra, E.1
Fu, D.2
Phang, J.M.3
Richardson, D.R.4
-
47
-
-
69249155033
-
Cyclin d1 degradation is sufficient to induce g1 cell cycle arrest despite constitutive expression of cyclin e2 in ovarian cancer cells
-
Masamha, C.P.; Benbrook, D.M. Cyclin d1 degradation is sufficient to induce g1 cell cycle arrest despite constitutive expression of cyclin e2 in ovarian cancer cells. Cancer Res. 2009, 69, 6565-6572.
-
(2009)
Cancer Res
, vol.69
, pp. 6565-6572
-
-
Masamha, C.P.1
Benbrook, D.M.2
-
48
-
-
0032705369
-
Iron-dependent changes in cellular energy metabolism: Influence on citric acid cycle and oxidative phosphorylation
-
Oexle, H.; Gnaiger, E.; Weiss, G. Iron-dependent changes in cellular energy metabolism: Influence on citric acid cycle and oxidative phosphorylation. Biochim. Biophys. Acta 1999, 1413, 99-107.
-
(1999)
Biochim. Biophys. Acta
, vol.1413
, pp. 99-107
-
-
Oexle, H.1
Gnaiger, E.2
Weiss, G.3
-
49
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
King, A.; Selak, M.A.; Gottlieb, E. Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer. Oncogene 2006, 25, 4675-4682.
-
(2006)
Oncogene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
50
-
-
0036682499
-
C-myc proto-oncogene expression in hemophilic synovitis: In vitro studies of the effects of iron and ceramide
-
Wen, F.Q.; Jabbar, A.A.; Chen, Y.X.; Kazarian, T.; Patel, D.A.; Valentino, L.A. C-myc proto-oncogene expression in hemophilic synovitis: In vitro studies of the effects of iron and ceramide. Blood 2002, 100, 912-916.
-
(2002)
Blood
, vol.100
, pp. 912-916
-
-
Wen, F.Q.1
Jabbar, A.A.2
Chen, Y.X.3
Kazarian, T.4
Patel, D.A.5
Valentino, L.A.6
-
51
-
-
0035114278
-
Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells
-
Fan, L.; Iyer, J.; Zhu, S.; Frick, K.K.; Wada, R.K.; Eskenazi, A.E.; Berg, P.E.; Ikegaki, N.; Kennett, R.H.; Frantz, C.N. Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. Cancer Res. 2001, 61, 1073-1079.
-
(2001)
Cancer Res
, vol.61
, pp. 1073-1079
-
-
Fan, L.1
Iyer, J.2
Zhu, S.3
Frick, K.K.4
Wada, R.K.5
Eskenazi, A.E.6
Berg, P.E.7
Ikegaki, N.8
Kennett, R.H.9
Frantz, C.N.10
-
52
-
-
0030921103
-
C-myc transactivation of ldh-a: Implications for tumor metabolism and growth
-
Shim, H.; Dolde, C.; Lewis, B.C.; Wu, C.S.; Dang, G.; Jungmann, R.A.; Dalla-Favera, R.; Dang, C.V. C-myc transactivation of ldh-a: Implications for tumor metabolism and growth. Proc. Natl. Acad. Sci. USA 1997, 94, 6658-6663.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla-Favera, R.7
Dang, C.V.8
-
53
-
-
84655161946
-
Hif1α and hif2α: Sibling rivalry in hypoxic tumour growth and progression
-
Keith, B.; Johnson, R.S.; Simon, M.C. Hif1α and hif2α: Sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2012, 12, 9-22.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
54
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors hif-1α and hif-2α in normal human tissues, cancers, and tumor-associated macrophages
-
Talks, K.L.; Turley, H.; Gatter, K.C.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.; Harris, A.L. The expression and distribution of the hypoxia-inducible factors hif-1α and hif-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 2000, 157, 411-421.
-
(2000)
Am. J. Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
55
-
-
12944266844
-
The expression of hypoxia-inducible factor 1α is a favorable independent prognostic factor in renal cell carcinoma
-
Lidgren, A.; Hedberg, Y.; Grankvist, K.; Rasmuson, T.; Vasko, J.; Ljungberg, B. The expression of hypoxia-inducible factor 1α is a favorable independent prognostic factor in renal cell carcinoma. Clin. Cancer Res. 2005, 11, 1129-1135.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 1129-1135
-
-
Lidgren, A.1
Hedberg, Y.2
Grankvist, K.3
Rasmuson, T.4
Vasko, J.5
Ljungberg, B.6
-
56
-
-
73149112785
-
Hif-1α and hif-2α are differentially regulated in vivo in neuroblastoma: High hif-1α correlates negatively to advanced clinical stage and tumor vascularization
-
Noguera, R.; Fredlund, E.; Piqueras, M.; Pietras, A.; Beckman, S.; Navarro, S.; Pahlman, S. Hif-1α and hif-2α are differentially regulated in vivo in neuroblastoma: High hif-1α correlates negatively to advanced clinical stage and tumor vascularization. Clin. Cancer Res. 2009, 15, 7130-7136.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 7130-7136
-
-
Noguera, R.1
Fredlund, E.2
Piqueras, M.3
Pietras, A.4
Beckman, S.5
Navarro, S.6
Pahlman, S.7
-
57
-
-
18844413584
-
Nitric oxide reverses desferrioxamine-and hypoxia-evoked hif-1α accumulation-Implications for prolyl hydroxylase activity and iron
-
Callapina, M.; Zhou, J.; Schnitzer, S.; Metzen, E.; Lohr, C.; Deitmer, J.W.; Brune, B. Nitric oxide reverses desferrioxamine-and hypoxia-evoked hif-1α accumulation-Implications for prolyl hydroxylase activity and iron. Exp. Cell Res. 2005, 306, 274-284.
-
(2005)
Exp. Cell Res
, vol.306
, pp. 274-284
-
-
Callapina, M.1
Zhou, J.2
Schnitzer, S.3
Metzen, E.4
Lohr, C.5
Deitmer, J.W.6
Brune, B.7
-
58
-
-
38849111785
-
Ndrg1, a growth and cancer related gene: Regulation of gene expression and function in normal and disease states
-
Ellen, T.P.; Ke, Q.; Zhang, P.; Costa, M. Ndrg1, a growth and cancer related gene: Regulation of gene expression and function in normal and disease states. Carcinogenesis 2008, 29, 2-8.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2-8
-
-
Ellen, T.P.1
Ke, Q.2
Zhang, P.3
Costa, M.4
-
59
-
-
7244239197
-
Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation
-
Le, N.T.; Richardson, D.R. Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation. Blood 2004, 104, 2967-2975.
-
(2004)
Blood
, vol.104
, pp. 2967-2975
-
-
Le, N.T.1
Richardson, D.R.2
-
60
-
-
0033972140
-
Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer
-
Guan, R.J.; Ford, H.L.; Fu, Y.; Li, Y.; Shaw, L.M.; Pardee, A.B. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res. 2000, 60, 749-755.
-
(2000)
Cancer Res
, vol.60
, pp. 749-755
-
-
Guan, R.J.1
Ford, H.L.2
Fu, Y.3
Li, Y.4
Shaw, L.M.5
Pardee, A.B.6
-
61
-
-
0037447321
-
The drg-1 gene suppresses tumor metastasis in prostate cancer
-
Bandyopadhyay, S.; Pai, S.K.; Gross, S.C.; Hirota, S.; Hosobe, S.; Miura, K.; Saito, K.; Commes, T.; Hayashi, S.; Watabe, M. The drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 2003, 63, 1731-1736.
-
(2003)
Cancer Res
, vol.63
, pp. 1731-1736
-
-
Bandyopadhyay, S.1
Pai, S.K.2
Gross, S.C.3
Hirota, S.4
Hosobe, S.5
Miura, K.6
Saito, K.7
Commes, T.8
Hayashi, S.9
Watabe, M.10
-
62
-
-
59249093993
-
N-myc downstream regulated gene 1 (ndrg1)/cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma
-
Akiba, J.; Ogasawara, S.; Kawahara, A.; Nishida, N.; Sanada, S.; Moriya, F.; Kuwano, M.; Nakashima, O.; Yano, H. N-myc downstream regulated gene 1 (ndrg1)/cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol. Rep. 2008, 20, 1329-1335.
-
(2008)
Oncol. Rep
, vol.20
, pp. 1329-1335
-
-
Akiba, J.1
Ogasawara, S.2
Kawahara, A.3
Nishida, N.4
Sanada, S.5
Moriya, F.6
Kuwano, M.7
Nakashima, O.8
Yano, H.9
-
63
-
-
33845705732
-
Overexpression of ndrg1 is an indicator of poor prognosis in hepatocellular carcinoma
-
Chua, M.S.; Sun, H.; Cheung, S.T.; Mason, V.; Higgins, J.; Ross, D.T.; Fan, S.T.; So, S. Overexpression of ndrg1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod. Pathol. 2007, 20, 76-83.
-
(2007)
Mod. Pathol
, vol.20
, pp. 76-83
-
-
Chua, M.S.1
Sun, H.2
Cheung, S.T.3
Mason, V.4
Higgins, J.5
Ross, D.T.6
Fan, S.T.7
So, S.8
-
64
-
-
0023092624
-
Antineuroblastoma activity of desferoxamine in human cell lines
-
Blatt, J.; Stitely, S. Antineuroblastoma activity of desferoxamine in human cell lines. Cancer Res. 1987, 47, 1749-1750.
-
(1987)
Cancer Res
, vol.47
, pp. 1749-1750
-
-
Blatt, J.1
Stitely, S.2
-
65
-
-
0022652631
-
Inhibition of proliferation of human leukaemic cell populations by deferoxamine
-
Foa, P.; Maiolo, A.T.; Lombardi, L.; Villa, L.; Polli, E.E. Inhibition of proliferation of human leukaemic cell populations by deferoxamine. Scand. J. Haematol. 1986, 36, 107-110.
-
(1986)
Scand. J. Haematol
, vol.36
, pp. 107-110
-
-
Foa, P.1
Maiolo, A.T.2
Lombardi, L.3
Villa, L.4
Polli, E.E.5
-
66
-
-
0022371544
-
Cell cycle effects of iron depletion on t-47d human breast cancer cells
-
Reddel, R.R.; Hedley, D.W.; Sutherland, R.L. Cell cycle effects of iron depletion on t-47d human breast cancer cells. Exp. Cell Res. 1985, 161, 277-284.
-
(1985)
Exp. Cell Res
, vol.161
, pp. 277-284
-
-
Reddel, R.R.1
Hedley, D.W.2
Sutherland, R.L.3
-
67
-
-
1242295296
-
Effect on ribonucleotide reductase of novel lipophilic iron chelators: The desferri-exochelins
-
Hodges, Y.K.; Antholine, W.E.; Horwitz, L.D. Effect on ribonucleotide reductase of novel lipophilic iron chelators: The desferri-exochelins. Biochem. Biophys. Res. Commun. 2004, 315, 595-598.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.315
, pp. 595-598
-
-
Hodges, Y.K.1
Antholine, W.E.2
Horwitz, L.D.3
-
68
-
-
29844457587
-
The evolution of iron chelators for the treatment of iron overload disease and cancer
-
Kalinowski, D.S.; Richardson, D.R. The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev. 2005, 57, 547-583.
-
(2005)
Pharmacol. Rev
, vol.57
, pp. 547-583
-
-
Kalinowski, D.S.1
Richardson, D.R.2
-
69
-
-
7444249085
-
The biochemistry of desferrioxamine and its relation to iron metabolism
-
Keberle, H. The biochemistry of desferrioxamine and its relation to iron metabolism. Ann. N. Y. Acad. Sci. 1964, 119, 758-768.
-
(1964)
Ann. N. Y. Acad. Sci
, vol.119
, pp. 758-768
-
-
Keberle, H.1
-
70
-
-
84862529448
-
Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors
-
Pullarkat, V.; Sehgal, A.; Li, L.; Meng, Z.; Lin, A.; Forman, S.; Bhatia, R. Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors. Leuk. Res. 2012, 36, 966-973.
-
(2012)
Leuk. Res
, vol.36
, pp. 966-973
-
-
Pullarkat, V.1
Sehgal, A.2
Li, L.3
Meng, Z.4
Lin, A.5
Forman, S.6
Bhatia, R.7
-
71
-
-
65349129409
-
The oral iron chelator deferasirox represses signaling through the mtor in myeloid leukemia cells by enhancing expression of redd1
-
Ohyashiki, J.H.; Kobayashi, C.; Hamamura, R.; Okabe, S.; Tauchi, T.; Ohyashiki, K. The oral iron chelator deferasirox represses signaling through the mtor in myeloid leukemia cells by enhancing expression of redd1. Cancer Sci. 2009, 100, 970-977.
-
(2009)
Cancer Sci
, vol.100
, pp. 970-977
-
-
Ohyashiki, J.H.1
Kobayashi, C.2
Hamamura, R.3
Okabe, S.4
Tauchi, T.5
Ohyashiki, K.6
-
72
-
-
81255203710
-
The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase
-
Kim, J.L.; Kang, H.N.; Kang, M.H.; Yoo, Y.A.; Kim, J.S.; Choi, C.W. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase. Acta Haematol. 2011, 126, 241-245.
-
(2011)
Acta Haematol
, vol.126
, pp. 241-245
-
-
Kim, J.L.1
Kang, H.N.2
Kang, M.H.3
Yoo, Y.A.4
Kim, J.S.5
Choi, C.W.6
-
73
-
-
33745261785
-
The new orally active iron chelator icl670a exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox
-
Chantrel-Groussard, K.; Gaboriau, F.; Pasdeloup, N.; Havouis, R.; Nick, H.; Pierre, J.L.; Brissot, P.; Lescoat, G. The new orally active iron chelator icl670a exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox. Eur. J. Pharmacol. 2006, 541, 129-137.
-
(2006)
Eur. J. Pharmacol
, vol.541
, pp. 129-137
-
-
Chantrel-Groussard, K.1
Gaboriau, F.2
Pasdeloup, N.3
Havouis, R.4
Nick, H.5
Pierre, J.L.6
Brissot, P.7
Lescoat, G.8
-
74
-
-
0032529333
-
Tumor cell cytotoxicity of a novel metal chelator
-
Torti, S.V.; Torti, F.M.; Whitman, S.P.; Brechbiel, M.W.; Park, G.; Planalp, R.P. Tumor cell cytotoxicity of a novel metal chelator. Blood 1998, 92, 1384-1389.
-
(1998)
Blood
, vol.92
, pp. 1384-1389
-
-
Torti, S.V.1
Torti, F.M.2
Whitman, S.P.3
Brechbiel, M.W.4
Park, G.5
Planalp, R.P.6
-
75
-
-
0037014639
-
Mechanisms underlying the cytotoxic effects of tachpyr-A novel metal chelator
-
Samuni, A.M.; Krishna, M.C.; DeGraff, W.; Russo, A.; Planalp, R.P.; Brechbiel, M.W.; Mitchell, J.B. Mechanisms underlying the cytotoxic effects of tachpyr-A novel metal chelator. Biochim. Biophys. Acta 2002, 1571, 211-218.
-
(2002)
Biochim. Biophys. Acta
, vol.1571
, pp. 211-218
-
-
Samuni, A.M.1
Krishna, M.C.2
Degraff, W.3
Russo, A.4
Planalp, R.P.5
Brechbiel, M.W.6
Mitchell, J.B.7
-
76
-
-
27644552326
-
Tachpyridine, a metal chelator, induces g2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
-
Turner, J.; Koumenis, C.; Kute, T.E.; Planalp, R.P.; Brechbiel, M.W.; Beardsley, D.; Cody, B.; Brown, K.D.; Torti, F.M.; Torti, S.V. Tachpyridine, a metal chelator, induces g2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood 2005, 106, 3191-3199.
-
(2005)
Blood
, vol.106
, pp. 3191-3199
-
-
Turner, J.1
Koumenis, C.2
Kute, T.E.3
Planalp, R.P.4
Brechbiel, M.W.5
Beardsley, D.6
Cody, B.7
Brown, K.D.8
Torti, F.M.9
Torti, S.V.10
-
77
-
-
0022386084
-
Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture
-
Baker, E.; Vitolo, M.L.; Webb, J. Iron chelation by pyridoxal isonicotinoyl hydrazone and analogues in hepatocytes in culture. Biochem. Pharmacol. 1985, 34, 3011-3017.
-
(1985)
Biochem. Pharmacol
, vol.34
, pp. 3011-3017
-
-
Baker, E.1
Vitolo, M.L.2
Webb, J.3
-
78
-
-
0024920255
-
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II) and zinc(II)
-
Richardson, D.R.; Hefter, G.T.; May, P.M.; Webb, J.; Baker, E. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. III. Formation constants with calcium(II), magnesium(II) and zinc(II). Biol. Metals 1989, 2, 161-167.
-
(1989)
Biol. Metals
, vol.2
, pp. 161-167
-
-
Richardson, D.R.1
Hefter, G.T.2
May, P.M.3
Webb, J.4
Baker, E.5
-
79
-
-
0023115572
-
Effectiveness of oral iron chelators assayed in the rat
-
Kim, B.K.; Huebers, H.A.; Finch, C.A. Effectiveness of oral iron chelators assayed in the rat. Am. J. Hematol. 1987, 24, 277-284.
-
(1987)
Am. J. Hematol
, vol.24
, pp. 277-284
-
-
Kim, B.K.1
Huebers, H.A.2
Finch, C.A.3
-
80
-
-
0019518135
-
Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal
-
Hershko, C.; Avramovici-Grisaru, S.; Link, G.; Gelfand, L.; Sarel, S. Mechanism of in vivo iron chelation by pyridoxal isonicotinoyl hydrazone and other imino derivatives of pyridoxal. J. Lab. Clin. Med. 1981, 98, 99-108.
-
(1981)
J. Lab. Clin. Med
, vol.98
, pp. 99-108
-
-
Hershko, C.1
Avramovici-Grisaru, S.2
Link, G.3
Gelfand, L.4
Sarel, S.5
-
81
-
-
0037351292
-
Identification of the di-pyridyl ketone isonicotinoyl hydrazone (pkih) analogues as potent iron chelators and anti-tumour agents
-
Becker, E.M.; Lovejoy, D.B.; Greer, J.M.; Watts, R.; Richardson, D.R. Identification of the di-pyridyl ketone isonicotinoyl hydrazone (pkih) analogues as potent iron chelators and anti-tumour agents. Br. J. Pharmacol. 2003, 138, 819-830.
-
(2003)
Br. J. Pharmacol
, vol.138
, pp. 819-830
-
-
Becker, E.M.1
Lovejoy, D.B.2
Greer, J.M.3
Watts, R.4
Richardson, D.R.5
-
82
-
-
0020567471
-
Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction
-
Thelander, L.; Graslund, A. Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction. J. Biol. Chem. 1983, 258, 4063-4066.
-
(1983)
J. Biol. Chem
, vol.258
, pp. 4063-4066
-
-
Thelander, L.1
Graslund, A.2
-
83
-
-
0015362471
-
Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone
-
DeConti, R.C.; Toftness, B.R.; Agrawal, K.C.; Tomchick, R.; Mead, J.A.; Bertino, J.R.; Sartorelli, A.C.; Creasey, W.A. Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone. Cancer Res. 1972, 32, 1455-1462.
-
(1972)
Cancer Res
, vol.32
, pp. 1455-1462
-
-
Deconti, R.C.1
Toftness, B.R.2
Agrawal, K.C.3
Tomchick, R.4
Mead, J.A.5
Bertino, J.R.6
Sartorelli, A.C.7
Creasey, W.A.8
-
84
-
-
34249888204
-
Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, in adults with advanced hematologic malignancies
-
Gojo, I.; Tidwell, M.L.; Greer, J.; Takebe, N.; Seiter, K.; Pochron, M.F.; Johnson, B.; Sznol, M.; Karp, J.E. Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, in adults with advanced hematologic malignancies. Leuk. Res. 2007, 31, 1165-1173.
-
(2007)
Leuk. Res
, vol.31
, pp. 1165-1173
-
-
Gojo, I.1
Tidwell, M.L.2
Greer, J.3
Takebe, N.4
Seiter, K.5
Pochron, M.F.6
Johnson, B.7
Sznol, M.8
Karp, J.E.9
-
85
-
-
4444248453
-
Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment
-
Yuan, J.; Lovejoy, D.B.; Richardson, D.R. Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment. Blood 2004, 104, 1450-1458.
-
(2004)
Blood
, vol.104
, pp. 1450-1458
-
-
Yuan, J.1
Lovejoy, D.B.2
Richardson, D.R.3
-
86
-
-
33749515083
-
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
-
Whitnall, M.; Howard, J.; Ponka, P.; Richardson, D.R. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc. Natl. Acad. Sci. USA 2006, 103, 14901-14906.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14901-14906
-
-
Whitnall, M.1
Howard, J.2
Ponka, P.3
Richardson, D.R.4
-
87
-
-
70449466605
-
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells
-
Eberhard, Y.; McDermott, S.P.; Wang, X.; Gronda, M.; Venugopal, A.; Wood, T.E.; Hurren, R.; Datti, A.; Batey, R.A.; Wrana, J. Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood 2009, 114, 3064-3073.
-
(2009)
Blood
, vol.114
, pp. 3064-3073
-
-
Eberhard, Y.1
McDermott, S.P.2
Wang, X.3
Gronda, M.4
Venugopal, A.5
Wood, T.E.6
Hurren, R.7
Datti, A.8
Batey, R.A.9
Wrana, J.10
-
88
-
-
84864053179
-
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation
-
Roth, M.; Will, B.; Simkin, G.; Narayanagari, S.; Barreyro, L.; Bartholdy, B.; Tamari, R.; Mitsiades, C.S.; Verma, A.; Steidl, U. Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood 2012, 120, 386-394.
-
(2012)
Blood
, vol.120
, pp. 386-394
-
-
Roth, M.1
Will, B.2
Simkin, G.3
Narayanagari, S.4
Barreyro, L.5
Bartholdy, B.6
Tamari, R.7
Mitsiades, C.S.8
Verma, A.9
Steidl, U.10
-
89
-
-
84871846692
-
Wnt signalling pathways as therapeutic targets in cancer
-
Anastas, J.N.; Moon, R.T. Wnt signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer 2013, 13, 11-26.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 11-26
-
-
Anastas, J.N.1
Moon, R.T.2
-
90
-
-
0034989543
-
Iron and colorectal cancer risk: Human studies
-
Nelson, R.L. Iron and colorectal cancer risk: Human studies. Nutr. Rev. 2001, 59, 140-148.
-
(2001)
Nutr. Rev
, vol.59
, pp. 140-148
-
-
Nelson, R.L.1
-
91
-
-
76749122831
-
Iron: An emerging factor in colorectal carcinogenesis
-
Chua, A.C.; Klopcic, B.; Lawrance, I.C.; Olynyk, J.K.; Trinder, D. Iron: An emerging factor in colorectal carcinogenesis. World J. Gastroenterol. 2010, 16, 663-672.
-
(2010)
World J. Gastroenterol
, vol.16
, pp. 663-672
-
-
Chua, A.C.1
Klopcic, B.2
Lawrance, I.C.3
Olynyk, J.K.4
Trinder, D.5
-
92
-
-
50049100893
-
Signaling mechanisms for activation of extracytoplasmic function (ecf) sigma factors
-
Brooks, B.E.; Buchanan, S.K. Signaling mechanisms for activation of extracytoplasmic function (ecf) sigma factors. Biochim. Biophys. Acta 2008, 1778, 1930-1945.
-
(2008)
Biochim. Biophys. Acta
, vol.1778
, pp. 1930-1945
-
-
Brooks, B.E.1
Buchanan, S.K.2
-
93
-
-
84255199531
-
Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers
-
Song, S.; Christova, T.; Perusini, S.; Alizadeh, S.; Bao, R.Y.; Miller, B.W.; Hurren, R.; Jitkova, Y.; Gronda, M.; Isaac, M. Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers. Cancer Res. 2011, 71, 7628-7639.
-
(2011)
Cancer Res
, vol.71
, pp. 7628-7639
-
-
Song, S.1
Christova, T.2
Perusini, S.3
Alizadeh, S.4
Bao, R.Y.5
Miller, B.W.6
Hurren, R.7
Jitkova, Y.8
Gronda, M.9
Isaac, M.10
-
94
-
-
84855758079
-
Modulation of wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
-
Coombs, G.S.; Schmitt, A.A.; Canning, C.A.; Alok, A.; Low, I.C.; Banerjee, N.; Kaur, S.; Utomo, V.; Jones, C.M.; Pervaiz, S. Modulation of wnt/beta-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene 2012, 31, 213-225.
-
(2012)
Oncogene
, vol.31
, pp. 213-225
-
-
Coombs, G.S.1
Schmitt, A.A.2
Canning, C.A.3
Alok, A.4
Low, I.C.5
Banerjee, N.6
Kaur, S.7
Utomo, V.8
Jones, C.M.9
Pervaiz, S.10
-
95
-
-
84857371220
-
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
-
Daniels, T.R.; Bernabeu, E.; Rodriguez, J.A.; Patel, S.; Kozman, M.; Chiappetta, D.A.; Holler, E.; Ljubimova, J.Y.; Helguera, G.; Penichet, M.L. The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochim. Biophys. Acta 2012, 1820, 291-317.
-
(2012)
Biochim. Biophys. Acta
, vol.1820
, pp. 291-317
-
-
Daniels, T.R.1
Bernabeu, E.2
Rodriguez, J.A.3
Patel, S.4
Kozman, M.5
Chiappetta, D.A.6
Holler, E.7
Ljubimova, J.Y.8
Helguera, G.9
Penichet, M.L.10
-
96
-
-
33747179250
-
The steap proteins are metalloreductases
-
Ohgami, R.S.; Campagna, D.R.; McDonald, A.; Fleming, M.D. The steap proteins are metalloreductases. Blood 2006, 108, 1388-1394.
-
(2006)
Blood
, vol.108
, pp. 1388-1394
-
-
Ohgami, R.S.1
Campagna, D.R.2
McDonald, A.3
Fleming, M.D.4
-
97
-
-
84861142181
-
Steap proteins: From structure to applications in cancer therapy
-
Gomes, I.M.; Maia, C.J.; Santos, C.R. Steap proteins: From structure to applications in cancer therapy. Mol. Cancer Res. 2012, 10, 573-587.
-
(2012)
Mol. Cancer Res
, vol.10
, pp. 573-587
-
-
Gomes, I.M.1
Maia, C.J.2
Santos, C.R.3
-
98
-
-
84867913804
-
The steap protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions
-
Grunewald, T.G.; Bach, H.; Cossarizza, A.; Matsumoto, I. The steap protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. Biol. Cell 2012, 104, 641-657.
-
(2012)
Biol. Cell
, vol.104
, pp. 641-657
-
-
Grunewald, T.G.1
Bach, H.2
Cossarizza, A.3
Matsumoto, I.4
-
99
-
-
0024343393
-
Antileukemic effects of deferoxamine on human myeloid leukemia cell lines
-
Becton, D.L.; Roberts, B. Antileukemic effects of deferoxamine on human myeloid leukemia cell lines. Cancer Res. 1989, 49, 4809-4812.
-
(1989)
Cancer Res
, vol.49
, pp. 4809-4812
-
-
Becton, D.L.1
Roberts, B.2
-
100
-
-
62949221047
-
Antitumor activity and mechanism of action of the iron chelator, dp44mt, against leukemic cells
-
Noulsri, E.; Richardson, D.R.; Lerdwana, S.; Fucharoen, S.; Yamagishi, T.; Kalinowski, D.S.; Pattanapanyasat, K. Antitumor activity and mechanism of action of the iron chelator, dp44mt, against leukemic cells. Am. J. Hematol. 2009, 84, 170-176.
-
(2009)
Am. J. Hematol
, vol.84
, pp. 170-176
-
-
Noulsri, E.1
Richardson, D.R.2
Lerdwana, S.3
Fucharoen, S.4
Yamagishi, T.5
Kalinowski, D.S.6
Pattanapanyasat, K.7
-
101
-
-
77951046942
-
Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia
-
Callens, C.; Coulon, S.; Naudin, J.; Radford-Weiss, I.; Boissel, N.; Raffoux, E.; Wang, P.H.; Agarwal, S.; Tamouza, H.; Paubelle, E. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J. Exp. Med. 2010, 207, 731-750.
-
(2010)
J. Exp. Med
, vol.207
, pp. 731-750
-
-
Callens, C.1
Coulon, S.2
Naudin, J.3
Radford-Weiss, I.4
Boissel, N.5
Raffoux, E.6
Wang, P.H.7
Agarwal, S.8
Tamouza, H.9
Paubelle, E.10
-
102
-
-
80054999211
-
Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant b cells
-
Rodriguez, J.A.; Luria-Perez, R.; Lopez-Valdes, H.E.; Casero, D.; Daniels, T.R.; Patel, S.; Avila, D.; Leuchter, R.; So, S.; Ortiz-Sanchez, E. Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant b cells. Leuk. Lymphoma 2011, 52, 2169-2178.
-
(2011)
Leuk. Lymphoma
, vol.52
, pp. 2169-2178
-
-
Rodriguez, J.A.1
Luria-Perez, R.2
Lopez-Valdes, H.E.3
Casero, D.4
Daniels, T.R.5
Patel, S.6
Avila, D.7
Leuchter, R.8
So, S.9
Ortiz-Sanchez, E.10
-
103
-
-
79958124637
-
Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia
-
Fukushima, T.; Kawabata, H.; Nakamura, T.; Iwao, H.; Nakajima, A.; Miki, M.; Sakai, T.; Sawaki, T.; Fujita, Y.; Tanaka, M. Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia. Anticancer Res. 2011, 31, 1741-1744.
-
(2011)
Anticancer Res
, vol.31
, pp. 1741-1744
-
-
Fukushima, T.1
Kawabata, H.2
Nakamura, T.3
Iwao, H.4
Nakajima, A.5
Miki, M.6
Sakai, T.7
Sawaki, T.8
Fujita, Y.9
Tanaka, M.10
-
104
-
-
0023135326
-
In vitro and in vivo effects of deferoxamine in neonatal acute leukemia
-
Estrov, Z.; Tawa, A.; Wang, X.H.; Dube, I.D.; Sulh, H.; Cohen, A.; Gelfand, E.W.; Freedman, M.H. In vitro and in vivo effects of deferoxamine in neonatal acute leukemia. Blood 1987, 69, 757-761.
-
(1987)
Blood
, vol.69
, pp. 757-761
-
-
Estrov, Z.1
Tawa, A.2
Wang, X.H.3
Dube, I.D.4
Sulh, H.5
Cohen, A.6
Gelfand, E.W.7
Freedman, M.H.8
-
105
-
-
33744526999
-
Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome
-
Yee, K.W.; Cortes, J.; Ferrajoli, A.; Garcia-Manero, G.; Verstovsek, S.; Wierda, W.; Thomas, D.; Faderl, S.; King, I.; O'Brien, S.M. Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome. Leuk. Res. 2006, 30, 813-822.
-
(2006)
Leuk. Res
, vol.30
, pp. 813-822
-
-
Yee, K.W.1
Cortes, J.2
Ferrajoli, A.3
Garcia-Manero, G.4
Verstovsek, S.5
Wierda, W.6
Thomas, D.7
Faderl, S.8
King, I.9
O'Brien, S.M.10
-
106
-
-
84874077087
-
Effects of oral iron chelator deferasirox on human malignant lymphoma cells
-
Choi, J.G.; Kim, J.L.; Park, J.; Lee, S.; Park, S.J.; Kim, J.S.; Choi, C.W. Effects of oral iron chelator deferasirox on human malignant lymphoma cells. Korean J. Hematol. 2012, 47, 194-201.
-
(2012)
Korean J. Hematol
, vol.47
, pp. 194-201
-
-
Choi, J.G.1
Kim, J.L.2
Park, J.3
Lee, S.4
Park, S.J.5
Kim, J.S.6
Choi, C.W.7
-
107
-
-
84879529296
-
Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma
-
Vazana-Barad, L.; Granot, G.; Mor-Tzuntz, R.; Levi, I.; Dreyling, M.; Nathan, I.; Shpilberg, O. Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma. Leuk. Lymphoma 2013, 54, 851-859.
-
(2013)
Leuk. Lymphoma
, vol.54
, pp. 851-859
-
-
Vazana-Barad, L.1
Granot, G.2
Mor-Tzuntz, R.3
Levi, I.4
Dreyling, M.5
Nathan, I.6
Shpilberg, O.7
-
108
-
-
77953523121
-
Recent advances in neuroblastoma
-
Maris, J.M. Recent advances in neuroblastoma. N. Engl. J. Med. 2010, 362, 2202-2211.
-
(2010)
N. Engl. J. Med
, vol.362
, pp. 2202-2211
-
-
Maris, J.M.1
-
109
-
-
0028585886
-
Deferoxamine in children with recurrent neuroblastoma
-
Blatt, J. Deferoxamine in children with recurrent neuroblastoma. Anticancer Res. 1994, 14, 2109-2112.
-
(1994)
Anticancer Res
, vol.14
, pp. 2109-2112
-
-
Blatt, J.1
-
110
-
-
0037237032
-
Examination of the antiproliferative activity of iron chelators: Multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311
-
Chaston, T.B.; Lovejoy, D.B.; Watts, R.N.; Richardson, D.R. Examination of the antiproliferative activity of iron chelators: Multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311. Clin. Cancer Res. 2003, 9, 402-414.
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 402-414
-
-
Chaston, T.B.1
Lovejoy, D.B.2
Watts, R.N.3
Richardson, D.R.4
-
111
-
-
0025126032
-
Effects of a single course of deferoxamine in neuroblastoma patients
-
Donfrancesco, A.; Deb, G.; Dominici, C.; Pileggi, D.; Castello, M.A.; Helson, L. Effects of a single course of deferoxamine in neuroblastoma patients. Cancer Res. 1990, 50, 4929-4930.
-
(1990)
Cancer Res
, vol.50
, pp. 4929-4930
-
-
Donfrancesco, A.1
Deb, G.2
Dominici, C.3
Pileggi, D.4
Castello, M.A.5
Helson, L.6
-
112
-
-
0029066979
-
Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: Preliminary results. Italian neuroblastoma cooperative group
-
Donfrancesco, A.; de Bernardi, B.; Carli, M.; Mancini, A.; Nigro, M.; de Sio, L.; Casale, F.; Bagnulo, S.; Helson, L.; Deb, G. Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: Preliminary results. Italian neuroblastoma cooperative group. Eur. J. Cancer 1995, 31A, 612-615.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 612-615
-
-
Donfrancesco, A.1
de Bernardi, B.2
Carli, M.3
Mancini, A.4
Nigro, M.5
de Sio, L.6
Casale, F.7
Bagnulo, S.8
Helson, L.9
Deb, G.10
-
113
-
-
84871575976
-
The iron chelator, deferasirox, as a novel strategy for cancer treatment: Oral activity against human lung tumor xenografts and molecular mechanism of action
-
Lui, G.Y.; Obeidy, P.; Ford, S.J.; Tselepis, C.; Sharp, D.M.; Jansson, P.J.; Kalinowski, D.S.; Kovacevic, Z.; Lovejoy, D.B.; Richardson, D.R. The iron chelator, deferasirox, as a novel strategy for cancer treatment: Oral activity against human lung tumor xenografts and molecular mechanism of action. Mol. Pharmacol. 2013, 83, 179-190.
-
(2013)
Mol. Pharmacol
, vol.83
, pp. 179-190
-
-
Lui, G.Y.1
Obeidy, P.2
Ford, S.J.3
Tselepis, C.4
Sharp, D.M.5
Jansson, P.J.6
Kalinowski, D.S.7
Kovacevic, Z.8
Lovejoy, D.B.9
Richardson, D.R.10
-
114
-
-
84874405929
-
Deferasirox (icl670a) effectively inhibits oesophageal cancer growth in vitro and in vivo
-
Ford, S.; Obeidy, P.; Lovejoy, D.; Bedford, M.; Nichols, L.; Chadwick, C.; Tucker, O.; Lui, G.; Kalinowski, D.; Jansson, P. Deferasirox (icl670a) effectively inhibits oesophageal cancer growth in vitro and in vivo. Br. J. Pharmacol. 2013, 168, 1316-1328.
-
(2013)
Br. J. Pharmacol
, vol.168
, pp. 1316-1328
-
-
Ford, S.1
Obeidy, P.2
Lovejoy, D.3
Bedford, M.4
Nichols, L.5
Chadwick, C.6
Tucker, O.7
Lui, G.8
Kalinowski, D.9
Jansson, P.10
-
115
-
-
84873737776
-
Dp44mt targets the akt, tgf-beta and erk pathways via the metastasis suppressor ndrg1 in normal prostate epithelial cells and prostate cancer cells
-
Dixon, K.M.; Lui, G.Y.; Kovacevic, Z.; Zhang, D.; Yao, M.; Chen, Z.; Dong, Q.; Assinder, S.J.; Richardson, D.R. Dp44mt targets the akt, tgf-beta and erk pathways via the metastasis suppressor ndrg1 in normal prostate epithelial cells and prostate cancer cells. Br. J. Cancer 2013, 108, 409-419.
-
(2013)
Br. J. Cancer
, vol.108
, pp. 409-419
-
-
Dixon, K.M.1
Lui, G.Y.2
Kovacevic, Z.3
Zhang, D.4
Yao, M.5
Chen, Z.6
Dong, Q.7
Assinder, S.J.8
Richardson, D.R.9
-
116
-
-
59149089078
-
The iron chelator dp44mt causes DNA damage and selective inhibition of topoisomerase iiα in breast cancer cells
-
Rao, V.A.; Klein, S.R.; Agama, K.K.; Toyoda, E.; Adachi, N.; Pommier, Y.; Shacter, E.B. The iron chelator dp44mt causes DNA damage and selective inhibition of topoisomerase iiα in breast cancer cells. Cancer Res. 2009, 69, 948-957.
-
(2009)
Cancer Res
, vol.69
, pp. 948-957
-
-
Rao, V.A.1
Klein, S.R.2
Agama, K.K.3
Toyoda, E.4
Adachi, N.5
Pommier, Y.6
Shacter, E.B.7
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