메뉴 건너뛰기




Volumn 138, Issue 2, 2007, Pages 253-262

Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53

Author keywords

Anaemia; Cancer; Hepcidin; Inflammation; Iron; p53

Indexed keywords

HEPCIDIN; INTERLEUKIN 6; PROTEIN P53; SMALL INTERFERING RNA;

EID: 34250881181     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06638.x     Document Type: Article
Times cited : (77)

References (78)
  • 3
    • 33947306574 scopus 로고    scopus 로고
    • Apaf1 in chronic myelogenous leukemia (CML) progression: Reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis
    • Ashur-Fabian, O., Adamsky, K., Trakhtenbrot, L., Cohen, Y., Raanani, P., Hardan, I., Nagler, A., Rechavi, G. Amariglio, N. (2007) Apaf1 in chronic myelogenous leukemia (CML) progression: reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis. Cell Cycle, 6, 589 594.
    • (2007) Cell Cycle , vol.6 , pp. 589-594
    • Ashur-Fabian, O.1    Adamsky, K.2    Trakhtenbrot, L.3    Cohen, Y.4    Raanani, P.5    Hardan, I.6    Nagler, A.7    Rechavi, G.8    Amariglio, N.9
  • 4
    • 0029112458 scopus 로고
    • Interleukin-6-associated anemia: Determination of the underlying mechanism
    • Atkins, M.B., Kappler, K., Mier, J.W., Isaacs, R.E. Berkman, E.M. (1995) Interleukin-6-associated anemia: determination of the underlying mechanism. Blood, 86, 1288 1291.
    • (1995) Blood , vol.86 , pp. 1288-1291
    • Atkins, M.B.1    Kappler, K.2    Mier, J.W.3    Isaacs, R.E.4    Berkman, E.M.5
  • 5
    • 0027459198 scopus 로고
    • Mdm2 expression is induced by wild type p53 activity
    • Barak, Y., Juven, T., Haffner, R. Oren, M. (1993) mdm2 expression is induced by wild type p53 activity. The EMBO journal, 12, 461 468.
    • (1993) The EMBO Journal , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 7
    • 0028880675 scopus 로고
    • Endogenous interleukin 6 is a resistance factor for cis- diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines
    • Borsellino, N., Belldegrun, A. Bonavida, B. (1995) Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Research, 55, 4633 4639.
    • (1995) Cancer Research , vol.55 , pp. 4633-4639
    • Borsellino, N.1    Belldegrun, A.2    Bonavida, B.3
  • 9
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp, T.R., Bernards, R. Agami, R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550 553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 11
    • 0037631496 scopus 로고    scopus 로고
    • Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity
    • Chaston, T.B. Richardson, D.R. (2003) Iron chelators for the treatment of iron overload disease: relationship between structure, redox activity, and toxicity. American Journal of Hematology, 73, 200 210.
    • (2003) American Journal of Hematology , vol.73 , pp. 200-210
    • Chaston, T.B.1    Richardson, D.R.2
  • 12
    • 0031404849 scopus 로고    scopus 로고
    • P53 as a target for anti-cancer immunotherapy
    • Chen, H.L. Carbone, D.P. (1997) p53 as a target for anti-cancer immunotherapy. Molecular Medicine Today, 3, 160 167.
    • (1997) Molecular Medicine Today , vol.3 , pp. 160-167
    • Chen, H.L.1    Carbone, D.P.2
  • 14
    • 33947095427 scopus 로고    scopus 로고
    • ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3
    • Choi, S., Cho, Y., Kim, H. Park, J. (2007) ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochemical and Biophysical Research Communications, 356, 312 317.
    • (2007) Biochemical and Biophysical Research Communications , vol.356 , pp. 312-317
    • Choi, S.1    Cho, Y.2    Kim, H.3    Park, J.4
  • 17
    • 0029874983 scopus 로고    scopus 로고
    • Increased p53 mRNA expression in liver and kidney apoptosis
    • Cummings, M.C. (1996) Increased p53 mRNA expression in liver and kidney apoptosis. Biochimica et biophysica acta, 1315, 100 104.
    • (1996) Biochimica et Biophysica Acta , vol.1315 , pp. 100-104
    • Cummings, M.C.1
  • 20
    • 0035437183 scopus 로고    scopus 로고
    • The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression
    • Gao, J. Richardson, D.R. (2001) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progression. Blood, 98, 842 850.
    • (2001) Blood , vol.98 , pp. 842-850
    • Gao, J.1    Richardson, D.R.2
  • 21
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    • Gehrke, S.G., Kulaksiz, H., Herrmann, T., Riedel, H.-D., Bents, K., Veltkamp, C. Stremmel, W. (2003) Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood, 102, 371 376.
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3    Riedel, H.-D.4    Bents, K.5    Veltkamp, C.6    Stremmel, W.7
  • 23
    • 0026690240 scopus 로고
    • Antitumor effects of human recombinant interleukin-6 on acute myeloid leukemia in mice and in cell cultures
    • Givon, T., Slavin, S., Haran-Ghera, N., Michalevicz, R. Revel, M. (1992) Antitumor effects of human recombinant interleukin-6 on acute myeloid leukemia in mice and in cell cultures. Blood, 79, 2392 2398.
    • (1992) Blood , vol.79 , pp. 2392-2398
    • Givon, T.1    Slavin, S.2    Haran-Ghera, N.3    Michalevicz, R.4    Revel, M.5
  • 25
    • 0029947671 scopus 로고    scopus 로고
    • Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein
    • Gudas, J.M., Nguyen, H., Li, T., Sadzewicz, L., Robey, R., Wosikowski, K. Cowan, K.H. (1996) Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein. Carcinogenesis, 17, 1417 1427.
    • (1996) Carcinogenesis , vol.17 , pp. 1417-1427
    • Gudas, J.M.1    Nguyen, H.2    Li, T.3    Sadzewicz, L.4    Robey, R.5    Wosikowski, K.6    Cowan, K.H.7
  • 27
    • 0034789521 scopus 로고    scopus 로고
    • Molecular response to ischemia-reperfusion of rat skin: Study of expression of p53, p21WAF-1, and Bax proteins, and apoptosis
    • Hatoko, M., Tanaka, A., Kuwahara, M. Yurugi, S. (2001) Molecular response to ischemia-reperfusion of rat skin: study of expression of p53, p21WAF-1, and Bax proteins, and apoptosis. Annals of Plastic Surgery, 47, 425 430.
    • (2001) Annals of Plastic Surgery , vol.47 , pp. 425-430
    • Hatoko, M.1    Tanaka, A.2    Kuwahara, M.3    Yurugi, S.4
  • 28
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze, M.W., Muckenthaler, M.U. Andrews, N.C. (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell, 117, 285 297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 32
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • Kaeser, M.D. Iggo, R.D. (2002) Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proceedings of the National Academy of Sciences of the United States of America, 99, 95 100.
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2
  • 33
    • 0029132960 scopus 로고
    • Inhibition of lymphoma growth in vivo by combined treatment with hydroxyethyl starch deferoxamine conjugate and IgG monoclonal antibodies against the transferrin receptor
    • Kemp, J.D., Cardillo, T., Stewart, B.C., Kehrberg, E., Weiner, G., Hedlund, B. Naumann, P.W. (1995) Inhibition of lymphoma growth in vivo by combined treatment with hydroxyethyl starch deferoxamine conjugate and IgG monoclonal antibodies against the transferrin receptor. Cancer Research, 55, 3817 3824.
    • (1995) Cancer Research , vol.55 , pp. 3817-3824
    • Kemp, J.D.1    Cardillo, T.2    Stewart, B.C.3    Kehrberg, E.4    Weiner, G.5    Hedlund, B.6    Naumann, P.W.7
  • 36
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323 331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 37
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine, A.J., Momand, J. Finlay, C.A. (1991) The p53 tumour suppressor gene. Nature, 351, 453 456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 38
    • 3242888285 scopus 로고    scopus 로고
    • RVISTA 2·0: Evolutionary analysis of transcription factor binding sites
    • Loots, G.G. Ovcharenko, I. (2004) rVISTA 2·0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Research, 32, W217 221.
    • (2004) Nucleic Acids Research , vol.32
    • Loots, G.G.1    Ovcharenko, I.2
  • 39
    • 0027244682 scopus 로고
    • Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species
    • Margulies, L. Sehgal, P.B. (1993) Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species. The Journal of biological chemistry, 268, 15096 15100.
    • (1993) The Journal of Biological Chemistry , vol.268 , pp. 15096-15100
    • Margulies, L.1    Sehgal, P.B.2
  • 41
    • 6344284684 scopus 로고    scopus 로고
    • Hepcidin and anaemia
    • Means, Jr., R.T. 2004) Hepcidin and anaemia. Blood Reviews, 18, 219 225.
    • (2004) Blood Reviews , vol.18 , pp. 219-225
    • Means Jr., R.T.1
  • 42
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz, D., Halevy, O. Oren, M. (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62, 671 680.
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 43
    • 33846403691 scopus 로고    scopus 로고
    • The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT
    • Milward, E., Johnstone, D., Trinder, D., Ramm, G. Olynyk, J. (2007) The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT. Hepatology, 45, 253 256.
    • (2007) Hepatology , vol.45 , pp. 253-256
    • Milward, E.1    Johnstone, D.2    Trinder, D.3    Ramm, G.4    Olynyk, J.5
  • 45
    • 0031458812 scopus 로고    scopus 로고
    • Molecular mechanisms in cell-mediated cytotoxicity
    • Moretta, A. (1997) Molecular mechanisms in cell-mediated cytotoxicity. Cell, 90, 13 18.
    • (1997) Cell , vol.90 , pp. 13-18
    • Moretta, A.1
  • 48
    • 0037513467 scopus 로고    scopus 로고
    • Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins
    • Nakao, S., Kuwano, T., Ishibashi, T., Kuwano, M. Ono, M. (2003) Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins. Journal of Immunology, 170, 5704 5711.
    • (2003) Journal of Immunology , vol.170 , pp. 5704-5711
    • Nakao, S.1    Kuwano, T.2    Ishibashi, T.3    Kuwano, M.4    Ono, M.5
  • 49
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A. Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 101, 2461 2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 50
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., Ganz, T. Kaplan, J. (2004a) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, 2090 2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 52
    • 0027505575 scopus 로고
    • P53 gene mutations in multiple myeloma are associated with advanced forms of malignancy
    • Neri, A., Baldini, L., Trecca, D., Cro, L., Polli, E. Maiolo, A.T. (1993) p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy. Blood, 81, 128 135.
    • (1993) Blood , vol.81 , pp. 128-135
    • Neri, A.1    Baldini, L.2    Trecca, D.3    Cro, L.4    Polli, E.5    Maiolo, A.T.6
  • 54
    • 0027246644 scopus 로고
    • P53 overexpression and Epstein-Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas
    • Niedobitek, G., Agathanggelou, A., Barber, P., Smallman, L.A., Jones, E.L. Young, L.S. (1993) P53 overexpression and Epstein-Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas. The Journal of Pathology, 170, 457 461.
    • (1993) The Journal of Pathology , vol.170 , pp. 457-461
    • Niedobitek, G.1    Agathanggelou, A.2    Barber, P.3    Smallman, L.A.4    Jones, E.L.5    Young, L.S.6
  • 59
    • 0031859080 scopus 로고    scopus 로고
    • Regulation of IL-6 signaling by p53: STAT3- and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines
    • Rayanade, R.J., Ndubuisi, M.I., Etlinger, J.D. Sehgal, P.B. (1998) Regulation of IL-6 signaling by p53: STAT3- and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines. Journal of Immunology, 161, 325 334.
    • (1998) Journal of Immunology , vol.161 , pp. 325-334
    • Rayanade, R.J.1    Ndubuisi, M.I.2    Etlinger, J.D.3    Sehgal, P.B.4
  • 60
    • 0036269005 scopus 로고    scopus 로고
    • Iron chelators as therapeutic agents for the treatment of cancer
    • Richardson, D.R. (2002) Iron chelators as therapeutic agents for the treatment of cancer. Critical Reviews in Oncology/Hematology, 42, 267 281.
    • (2002) Critical Reviews in Oncology/Hematology , vol.42 , pp. 267-281
    • Richardson, D.R.1
  • 64
    • 0026046039 scopus 로고
    • Nuclear localization is essential for the activity of p53 protein
    • Shaulsky, G., Goldfinger, N., Tosky, M., Levine, A.J. Rotter, V. (1991b) Nuclear localization is essential for the activity of p53 protein. Oncogene, 6, 2055 2065.
    • (1991) Oncogene , vol.6 , pp. 2055-2065
    • Shaulsky, G.1    Goldfinger, N.2    Tosky, M.3    Levine, A.J.4    Rotter, V.5
  • 65
    • 2642571660 scopus 로고    scopus 로고
    • Vascular-targeting therapies for treatment of malignant disease
    • Siemann, D.W., Chaplin, D.J. Horsman, M.R. (2004) Vascular-targeting therapies for treatment of malignant disease. Cancer, 100, 2491 2499.
    • (2004) Cancer , vol.100 , pp. 2491-2499
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 68
    • 0034142176 scopus 로고    scopus 로고
    • Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases
    • Tak, P.P., Zvaifler, N.J., Green, D.R. Firestein, G.S. (2000) Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunology Today, 21, 78 82.
    • (2000) Immunology Today , vol.21 , pp. 78-82
    • Tak, P.P.1    Zvaifler, N.J.2    Green, D.R.3    Firestein, G.S.4
  • 72
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden, K.H. Lu, X. (2002) Live or let die: the cell's response to p53. Nature Reviews Cancer, 2, 594 604.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 73
    • 0032997261 scopus 로고    scopus 로고
    • Iron loading and disease surveillance
    • Weinberg, E.D. (1999a) Iron loading and disease surveillance. Emerging Infectious Diseases, 5, 346 352.
    • (1999) Emerging Infectious Diseases , vol.5 , pp. 346-352
    • Weinberg, E.D.1
  • 74
    • 0032867670 scopus 로고    scopus 로고
    • Development of clinical methods of iron deprivation for suppression of neoplastic and infectious diseases
    • Weinberg, E.D. (1999b) Development of clinical methods of iron deprivation for suppression of neoplastic and infectious diseases. Cancer Investigation, 17, 507 513.
    • (1999) Cancer Investigation , vol.17 , pp. 507-513
    • Weinberg, E.D.1
  • 75
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting, D.M. Andrews, N.C. (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood, 108, 3204 3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 76
    • 0034903090 scopus 로고    scopus 로고
    • Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene
    • Yang, D.C., Jiang, X.P., Elliott, R.L. Head, J.F. (2001) Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene. Anticancer Research, 21, 1777 1787.
    • (2001) Anticancer Research , vol.21 , pp. 1777-1787
    • Yang, D.C.1    Jiang, X.P.2    Elliott, R.L.3    Head, J.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.