Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells

Diabetologia

Volumn 52, Issue 8, 2009, Pages 1656-1664

  Pivovarova, O ^a,b   Gogebakan O ^a,b   Pfeiffer, A F H ^a,b   Rudovich, N ^a,b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Euglycaemichyperinsulinaemic clamp; HepG2 cells; Hyperglycaemichyperinsulinaemic clamp; Insulin degrading enzyme; Subcutaneous adipose tissue; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; INSULIN; INSULINASE; MESSENGER RNA;

ADIPOSE TISSUE; ARTICLE; BIOPSY; CATALYSIS; CELL LINE; CHROMOSOME; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EUGLYCEMIC HYPERINSULINEMIC CLAMP; GENE; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERGLYCEMIA; HYPERINSULINEMIA; IDE GENE; IN VIVO STUDY; INSULIN DEGRADATION; LIVER CELL; LIVER CELL CARCINOMA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; SUBCUTANEOUS FAT; TECHNIQUE;

ADIPOSE TISSUE; BIOPSY; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA PRIMERS; ENZYME ACTIVATION; GLUCOSE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INSULIN; INSULYSIN; LIVER NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL;

EID: 67650697447     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1350-7     Document Type: Article

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