Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: A hydrogen exchange mass spectrometry study

Biochemistry

Volumn 52, Issue 29, 2013, Pages 5016-5026

  Karageorgos, Ioannis ^a   Wales, Thomas E ^a   Janero, David R ^a   Zvonok, Nikolai ^a   Vemuri, V Kiran ^a   Engen, John R ^a   Makriyannis, Alexandros ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL ENSEMBLE; CONFORMATIONAL RESPONSE; COVALENT REACTION; DYNAMIC PROPERTY; ENZYME CONFORMATIONS; HYDROGEN EXCHANGE; HYDROGEN/DEUTERIUM EXCHANGE; SOLUTION CONFORMATIONS;

ENZYMES; GLYCEROL; MASS SPECTROMETRY;

CONFORMATIONS;

ACYLGLYCEROL LIPASE; HYDROGEN;

ARTICLE; CARBAMOYLATION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; HUMAN; MASS SPECTROMETRY; MOLECULAR INTERACTION; PRIORITY JOURNAL;

CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; HYDROGEN; MASS SPECTROMETRY; MODELS, MOLECULAR; MONOACYLGLYCEROL LIPASES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 84880639454     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400430k     Document Type: Article

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