Endocannabinoid enzyme engineering: Soluble human thio-monoacylglycerol lipase (sol-S-hMGL)

ACS Chemical Neuroscience

Volumn 3, Issue 5, 2012, Pages 393-399

  Karageorgos, Ioannis ^a   Zvonok, Nikolai ^a   Janero, David R ^a   Vemuri, V Kiran ^a   Shukla, Vidyanand ^a   Wales, Thomas E ^a   Engen, John R ^a   Makriyannis, Alexandros ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Active site; catalytic mechanism; drug design; enzyme inhibition; serine hydrolase

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; AM 10212; AM 6580; CYSTEINE; ENDOCANNABINOID; ENZYME INHIBITOR; LEUCINE; N ARACHIDONYLMALEIMIDE; SERINE; SOLUBLE HUMAN THIO MONOACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ALKYLATION; CARBAMOYLATION; CATALYSIS; CONFERENCE PAPER; ENZYME ENGINEERING; HUMAN; HYDROLYSIS; INHIBITION KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; WILD TYPE;

ACTIVE SITE; CATALYTIC MECHANISM; DRUG DESIGN; ENZYME INHIBITION; SERINE HYDROLASE;

AMINO ACID SUBSTITUTION; ENDOCANNABINOIDS; ENZYME INHIBITORS; HUMANS; MONOACYLGLYCEROL LIPASES; MUTATION; PROTEIN ENGINEERING; SOLUBILITY; SULFHYDRYL COMPOUNDS;

MAMMALIA;

EID: 84862103822     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn3000263     Document Type: Conference Paper

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