Resolving the complex role of enzyme conformational dynamics in catalytic function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5699-5704

  Doshi, Urmi ^a   McGowan, Lauren C ^a   Ladani, Safieh Tork ^a   Hamelberg, Donald ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Cis trans isomerization; Cyclophilin A; Enzyme catalysis; Enzyme dynamics; Kramers' rate theory

Indexed keywords

CYCLOPHILIN A; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; DIFFUSION COEFFICIENT; ENZYME CONFORMATION; ISOMERIZATION; MOLECULAR DYNAMICS; PLASTICITY; PRIORITY JOURNAL; PROTEIN BINDING; VISCOSITY;

BIOCATALYSIS; CYCLOPHILIN A; ISOMERISM; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 84859560854     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117060109     Document Type: Article

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