-
1
-
-
33748703859
-
The endocannabinoid system as an emerging target of pharmacotherapy
-
Pacher, P., Bátkai, S., and Kunos, G. ( 2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol. Rev. 58, 389-462.
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 389-462
-
-
Pacher, P.1
Bátkai, S.2
Kunos, G.3
-
2
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
-
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., and Bonner, T. I. ( 1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
-
(1990)
Nature
, vol.346
, pp. 561-564
-
-
Matsuda, L.A.1
Lolait, S.J.2
Brownstein, M.J.3
Young, A.C.4
Bonner, T.I.5
-
3
-
-
0027515373
-
Molecular characterization of a peripheral receptor for cannabinoids
-
Munro, S., Thomas, K. L., and Abu-Shaar, M. ( 1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61-65.
-
(1993)
Nature
, vol.365
, pp. 61-65
-
-
Munro, S.1
Thomas, K.L.2
Abu-Shaar, M.3
-
4
-
-
77249107540
-
Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
-
De Petrocellis, L. and Di Marzo, V. ( 2010) Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. J. Neuroimmune Pharmacol. 5, 103-121.
-
(2010)
J. Neuroimmune Pharmacol.
, vol.5
, pp. 103-121
-
-
De Petrocellis, L.1
Di Marzo, V.2
-
5
-
-
21044439407
-
Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidyl-ethanolamine-hydrolyzing phospholipase D
-
Ueda, N., Okamoto, Y., and Tsuboi, K. ( 2005) Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidyl-ethanolamine-hydrolyzing phospholipase D. Curr. Med. Chem. 12, 1413-1422.
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 1413-1422
-
-
Ueda, N.1
Okamoto, Y.2
Tsuboi, K.3
-
6
-
-
0027078685
-
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
-
Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., and Mechoulam, R. ( 1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949.
-
(1992)
Science
, vol.258
, pp. 1946-1949
-
-
Devane, W.A.1
Hanus, L.2
Breuer, A.3
Pertwee, R.G.4
Stevenson, L.A.5
Griffin, G.6
Gibson, D.7
Mandelbaum, A.8
Etinger, A.9
Mechoulam, R.10
-
7
-
-
0029012014
-
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
-
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., Pertwee, R. G., Griffin, G., Bayewitch, M., Barg, J., and Vogel, Z. ( 1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, L.3
Ligumsky, M.4
Kaminski, N.E.5
Schatz, A.R.6
Gopher, A.7
Almog, S.8
Martin, B.R.9
Compton, D.R.10
Pertwee, R.G.11
Griffin, G.12
Bayewitch, M.13
Barg, J.14
Vogel, Z.15
-
8
-
-
0028970517
-
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain
-
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., and Waku, K. ( 1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 215, 89-97.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.215
, pp. 89-97
-
-
Sugiura, T.1
Kondo, S.2
Sukagawa, A.3
Nakane, S.4
Shinoda, A.5
Itoh, K.6
Yamashita, A.7
Waku, K.8
-
9
-
-
33745195042
-
Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
-
Sugiura, T., Kishimoto, S., Oka, S., and Gokoh, M. ( 2006) Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog. Lipid Res. 45, 405-446.
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 405-446
-
-
Sugiura, T.1
Kishimoto, S.2
Oka, S.3
Gokoh, M.4
-
10
-
-
0020659765
-
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate
-
Prescott, S. M. and Majerus, P. W. ( 1983) Characterization of 1, 2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J. Biol. Chem. 258, 764-769.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 764-769
-
-
Prescott, S.M.1
Majerus, P.W.2
-
11
-
-
58249113979
-
Endocannabinoid-mediated control of synaptic transmission
-
Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M., and Watanabe, M. ( 2009) Endocannabinoid-mediated control of synaptic transmission. Physiol. Rev. 89, 309-380.
-
(2009)
Physiol. Rev.
, vol.89
, pp. 309-380
-
-
Kano, M.1
Ohno-Shosaku, T.2
Hashimotodani, Y.3
Uchigashima, M.4
Watanabe, M.5
-
12
-
-
43249100162
-
Targeting the endocannabinoid system: to enhance or reduce?
-
Di Marzo, V. ( 2008) Targeting the endocannabinoid system: to enhance or reduce? Nat. Rev. Drug Discov. 7, 438-455.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 438-455
-
-
Di Marzo, V.1
-
13
-
-
44849141696
-
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
-
Ahn, K., McKinney, M. K., and Cravatt, B. F. ( 2008) Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem. Rev. 108, 1687-1707.
-
(2008)
Chem. Rev.
, vol.108
, pp. 1687-1707
-
-
Ahn, K.1
McKinney, M.K.2
Cravatt, B.F.3
-
14
-
-
77956393864
-
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)
-
Ueda, N., Tsuboi, K., and Uyama, T. ( 2010) N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog. Lipid Res. 49, 299-315.
-
(2010)
Prog. Lipid Res.
, vol.49
, pp. 299-315
-
-
Ueda, N.1
Tsuboi, K.2
Uyama, T.3
-
15
-
-
77957944897
-
Enzymological studies on the biosynthesis of N-acylethanolamines
-
Ueda, N., Tsuboi, K., and Uyama, T. ( 2010) Enzymological studies on the biosynthesis of N-acylethanolamines. Biochim. Biophys. Acta. 1801, 1274-1285.
-
(2010)
Biochim. Biophys. Acta.
, vol.1801
, pp. 1274-1285
-
-
Ueda, N.1
Tsuboi, K.2
Uyama, T.3
-
16
-
-
77956392921
-
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
-
Fukami, K., Inanobe, S., Kanemaru, K., and Nakamura, Y. ( 2010) Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog. Lipid Res. 49, 429-437.
-
(2010)
Prog. Lipid Res.
, vol.49
, pp. 429-437
-
-
Fukami, K.1
Inanobe, S.2
Kanemaru, K.3
Nakamura, Y.4
-
17
-
-
12344311450
-
2+ dependency for triggering retrograde endocannabinoid signal
-
2+ dependency for triggering retrograde endocannabinoid signal. Neuron 45, 257-268.
-
(2005)
Neuron
, vol.45
, pp. 257-268
-
-
Hashimotodani, Y.1
Ohno-Shosaku, T.2
Tsubokawa, H.3
Ogata, H.4
Emoto, K.5
Maejima, T.6
Araishi, K.7
Shin, H.S.8
Kano, M.9
-
18
-
-
22544438407
-
2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cβ4 signaling cascade in the cerebellum
-
2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cβ4 signaling cascade in the cerebellum. J. Neurosci. 25, 6826-6835.
-
(2005)
J. Neurosci.
, vol.25
, pp. 6826-6835
-
-
Maejima, T.1
Oka, S.2
Hashimotodani, Y.3
Ohno-Shosaku, T.4
Aiba, A.5
Wu, D.6
Waku, K.7
Sugiura, T.8
Kano, M.9
-
19
-
-
0033006123
-
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin
-
Bisogno, T., Melck, D., De Petrocellis, L., and Di Marzo, V. ( 1999) Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin. J. Neurochem. 72, 2113-2119.
-
(1999)
J. Neurochem.
, vol.72
, pp. 2113-2119
-
-
Bisogno, T.1
Melck, D.2
De Petrocellis, L.3
Di Marzo, V.4
-
20
-
-
24044514656
-
Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear
-
Oka, S., Yanagimoto, S., Ikeda, S., Gokoh, M., Kishimoto, S., Waku, K., Ishima, Y., and Sugiura, T. ( 2005) Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. J. Biol. Chem. 280, 18488-18497.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18488-18497
-
-
Oka, S.1
Yanagimoto, S.2
Ikeda, S.3
Gokoh, M.4
Kishimoto, S.5
Waku, K.6
Ishima, Y.7
Sugiura, T.8
-
22
-
-
0028049622
-
Lysophosphoinositide-specific phospholipase C in rat brain synaptic plasma membranes
-
Tsutsumi, T., Kobayashi, T., Ueda, H., Yamauchi, E., Watanabe, S., and Okuyama, H. ( 1994) Lysophosphoinositide-specific phospholipase C in rat brain synaptic plasma membranes. Neurochem. Res. 19, 399-406.
-
(1994)
Neurochem. Res.
, vol.19
, pp. 399-406
-
-
Tsutsumi, T.1
Kobayashi, T.2
Ueda, H.3
Yamauchi, E.4
Watanabe, S.5
Okuyama, H.6
-
23
-
-
0036612968
-
2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain
-
Nakane, S., Oka, S., Arai, S., Waku, K., Ishima, Y., Tokumura, A., and Sugiura, T. ( 2002) 2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain. Arch. Biochem. Biophys. 402, 51-58.
-
(2002)
Arch. Biochem. Biophys.
, vol.402
, pp. 51-58
-
-
Nakane, S.1
Oka, S.2
Arai, S.3
Waku, K.4
Ishima, Y.5
Tokumura, A.6
Sugiura, T.7
-
24
-
-
0019797081
-
Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera
-
Okazaki, T., Sagawa, N., Okita, J. R., Bleasdale, J. E., MacDonald, P. C., and Johnston, J. M. ( 1981) Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera. J. Biol. Chem. 256, 7316-7321.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 7316-7321
-
-
Okazaki, T.1
Sagawa, N.2
Okita, J.R.3
Bleasdale, J.E.4
MacDonald, P.C.5
Johnston, J.M.6
-
25
-
-
0019870311
-
Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase
-
Chau, L. Y. and Tai, H. H. ( 1981) Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase. Biochem. Biophys. Res. Commun. 100, 1688-1695.
-
(1981)
Biochem. Biophys. Res. Commun.
, vol.100
, pp. 1688-1695
-
-
Chau, L.Y.1
Tai, H.H.2
-
26
-
-
0032782097
-
Purification and characterization of diacylglycerol lipase from human platelets
-
Moriyama, T., Urade, R., and Kito, M. ( 1999) Purification and characterization of diacylglycerol lipase from human platelets. J. Biochem. 125, 1077-1085.
-
(1999)
J. Biochem.
, vol.125
, pp. 1077-1085
-
-
Moriyama, T.1
Urade, R.2
Kito, M.3
-
27
-
-
10744229235
-
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
-
Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E. J., Gangadharan, U., Hobbs, C., Di Marzo, V., and Doherty, P. ( 2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell Biol. 163, 463-468.
-
(2003)
J. Cell Biol.
, vol.163
, pp. 463-468
-
-
Bisogno, T.1
Howell, F.2
Williams, G.3
Minassi, A.4
Cascio, M.G.5
Ligresti, A.6
Matias, I.7
Schiano-Moriello, A.8
Paul, P.9
Williams, E.J.10
Gangadharan, U.11
Hobbs, C.12
Di Marzo, V.13
Doherty, P.14
-
28
-
-
34548336389
-
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization
-
Jung, K. M., Astarita, G., Zhu, C., Wallace, M., Mackie, K., and Piomelli, D. ( 2007) A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol. Pharmacol. 72, 612-621.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 612-621
-
-
Jung, K.M.1
Astarita, G.2
Zhu, C.3
Wallace, M.4
Mackie, K.5
Piomelli, D.6
-
29
-
-
75949116246
-
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
-
Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K., and Kano, M. ( 2010) The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron 65, 320-327.
-
(2010)
Neuron
, vol.65
, pp. 320-327
-
-
Tanimura, A.1
Yamazaki, M.2
Hashimotodani, Y.3
Uchigashima, M.4
Kawata, S.5
Abe, M.6
Kita, Y.7
Hashimoto, K.8
Shimizu, T.9
Watanabe, M.10
Sakimura, K.11
Kano, M.12
-
30
-
-
76649137560
-
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice
-
Gao, Y., Vasilyev, D. V., Goncalves, M. B., Howell, F. V., Hobbs, C., Reisenberg, M., Shen, R., Zhang, M. Y., Strassle, B. W., Lu, P., Mark, L., Piesla, M. J., Deng, K., Kouranova, E. V., Ring, R. H., Whiteside, G. T., Bates, B., Walsh, F. S., Williams, G., Pangalos, M. N., Samad, T. A., and Doherty, P. ( 2010) Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J. Neurosci. 30, 2017-2024.
-
(2010)
J. Neurosci.
, vol.30
, pp. 2017-2024
-
-
Gao, Y.1
Vasilyev, D.V.2
Goncalves, M.B.3
Howell, F.V.4
Hobbs, C.5
Reisenberg, M.6
Shen, R.7
Zhang, M.Y.8
Strassle, B.W.9
Lu, P.10
Mark, L.11
Piesla, M.J.12
Deng, K.13
Kouranova, E.V.14
Ring, R.H.15
Whiteside, G.T.16
Bates, B.17
Walsh, F.S.18
Williams, G.19
Pangalos, M.N.20
Samad, T.A.21
Doherty, P.22
more..
-
31
-
-
55249111745
-
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
-
Hoover, H. S., Blankman, J. L., Niessen, S., and Cravatt, B. F. ( 2008) Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg. Med. Chem. Lett. 18, 5838-5841.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5838-5841
-
-
Hoover, H.S.1
Blankman, J.L.2
Niessen, S.3
Cravatt, B.F.4
-
32
-
-
33646472897
-
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
-
Bisogno, T., Cascio, M. G., Saha, B., Mahadevan, A., Urbani, P., Minassi, A., Appendino, G., Saturnino, C., Martin, B., Razdan, R., and Di Marzo, V. ( 2006) Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim. Biophys. Acta 1761, 205-212.
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 205-212
-
-
Bisogno, T.1
Cascio, M.G.2
Saha, B.3
Mahadevan, A.4
Urbani, P.5
Minassi, A.6
Appendino, G.7
Saturnino, C.8
Martin, B.9
Razdan, R.10
Di Marzo, V.11
-
33
-
-
67049136364
-
Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol
-
Bisogno, T., Burston, J. J., Rai, R., Allarà, M., Saha, B., Mahadevan, A., Razdan, R. K., Wiley, J. L., and Di Marzo, V. ( 2009) Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. ChemMedChem. 4, 946- 950.
-
(2009)
ChemMedChem.
, vol.4
, pp. 946-950
-
-
Bisogno, T.1
Burston, J.J.2
Rai, R.3
Allarà, M.4
Saha, B.5
Mahadevan, A.6
Razdan, R.K.7
Wiley, J.L.8
Di Marzo, V.9
-
34
-
-
37149013708
-
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
-
Blankman, J. L., Simon, G. M., and Cravatt, B. F. ( 2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem. Biol. 14, 1347-1356.
-
(2007)
Chem. Biol.
, vol.14
, pp. 1347-1356
-
-
Blankman, J.L.1
Simon, G.M.2
Cravatt, B.F.3
-
35
-
-
0023024389
-
Immunological characterization of sn-1,2-diacylglycerol and sn-2-monoacylglycerol kinase from pig brain
-
Kanoh, H., Iwata, T., Ono, T., and Suzuki, T. ( 1986) Immunological characterization of sn-1, 2-diacylglycerol and sn-2-monoacylglycerol kinase from pig brain. J. Biol. Chem. 261, 5597-5602.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 5597-5602
-
-
Kanoh, H.1
Iwata, T.2
Ono, T.3
Suzuki, T.4
-
36
-
-
0024312441
-
The purification and properties of monoacylglycerol kinase from bovine brain
-
Shim, Y. H., Lin, C. H., and Strickland, K. P. ( 1989) The purification and properties of monoacylglycerol kinase from bovine brain. Biochem. Cell Biol. 67, 233-241.
-
(1989)
Biochem. Cell Biol.
, vol.67
, pp. 233-241
-
-
Shim, Y.H.1
Lin, C.H.2
Strickland, K.P.3
-
37
-
-
0022576897
-
Monoacylglycerol acyltransferase. Evidence that the activities from rat intestine and suckling liver are tissue-specific isoenzymes
-
Coleman, R. A. and Haynes, E. B. ( 1986) Monoacylglycerol acyltransferase. Evidence that the activities from rat intestine and suckling liver are tissue-specific isoenzymes. J. Biol. Chem. 261, 224-228.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 224-228
-
-
Coleman, R.A.1
Haynes, E.B.2
-
39
-
-
43749115768
-
Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids
-
Rouzer, C. A. and Marnett, L. J. ( 2008) Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids. J. Biol. Chem. 283, 8065-8069.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 8065-8069
-
-
Rouzer, C.A.1
Marnett, L.J.2
-
40
-
-
77955614363
-
A review on the monoacylglycerol lipase: at the interface between fat and endocannabinoid signalling
-
Labar, G., Wouters, J., and Lambert, D. M. ( 2010) A review on the monoacylglycerol lipase: at the interface between fat and endocannabinoid signalling. Curr. Med. Chem. 17, 2588-2607.
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 2588-2607
-
-
Labar, G.1
Wouters, J.2
Lambert, D.M.3
-
41
-
-
0017295234
-
Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue
-
Tornqvist, H. and Belfrage, P. ( 1976) Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue. J. Biol. Chem. 251, 813-819.
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 813-819
-
-
Tornqvist, H.1
Belfrage, P.2
-
42
-
-
0030767295
-
cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases
-
Karlsson, M., Contreras, J. A., Hellman, U., Tornqvist, H., and Holm, C. ( 1997) cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J. Biol. Chem. 272, 27218-27223.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27218-27223
-
-
Karlsson, M.1
Contreras, J.A.2
Hellman, U.3
Tornqvist, H.4
Holm, C.5
-
43
-
-
0035845011
-
Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene
-
Karlsson, M., Reue, K., Xia, Y. R., Lusis, A. J., Langin, D., Tornqvist, H., and Holm, C. ( 2001) Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene 272, 11-18.
-
(2001)
Gene
, vol.272
, pp. 11-18
-
-
Karlsson, M.1
Reue, K.2
Xia, Y.R.3
Lusis, A.J.4
Langin, D.5
Tornqvist, H.6
Holm, C.7
-
44
-
-
0036678094
-
Brain monoglyceride lipase participating in endocannabinoid inactivation
-
and Erratum ( 2002) 99, 13961.
-
Dinh, T. P., Carpenter, D., Leslie, F. M., Freund, T. F., Katona, I., Sensi, S. L., Kathuria, S., and Piomelli, D. ( 2002) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl. Acad. Sci. USA 99, 10819-10824; Erratum ( 2002) 99, 13961.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10819-10824
-
-
Dinh, T.P.1
Carpenter, D.2
Leslie, F.M.3
Freund, T.F.4
Katona, I.5
Sensi, S.L.6
Kathuria, S.7
Piomelli, D.8
-
45
-
-
76649126721
-
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
-
Labar, G., Bauvois, C., Borel, F., Ferrer, J. L., Wouters, J., and Lambert, D. M. ( 2010) Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. ChemBioChem. 11, 218-227.
-
(2010)
ChemBioChem.
, vol.11
, pp. 218-227
-
-
Labar, G.1
Bauvois, C.2
Borel, F.3
Ferrer, J.L.4
Wouters, J.5
Lambert, D.M.6
-
46
-
-
6944247598
-
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
-
Dinh, T. P., Kathuria, S., and Piomelli, D. ( 2004) RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Mol. Pharmacol. 66, 1260-1264.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1260-1264
-
-
Dinh, T.P.1
Kathuria, S.2
Piomelli, D.3
-
47
-
-
0032559369
-
Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand
-
Goparaju, S. K., Ueda, N., Yamaguchi, H., and Yamamoto, S. ( 1998) Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. FEBS Lett. 422, 69-73.
-
(1998)
FEBS Lett.
, vol.422
, pp. 69-73
-
-
Goparaju, S.K.1
Ueda, N.2
Yamaguchi, H.3
Yamamoto, S.4
-
48
-
-
0032898720
-
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors
-
Goparaju, S. K., Ueda, N., Taniguchi, K., and Yamamoto, S. ( 1999) Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. Biochem. Pharmacol. 57, 417-423.
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 417-423
-
-
Goparaju, S.K.1
Ueda, N.2
Taniguchi, K.3
Yamamoto, S.4
-
49
-
-
33947330328
-
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells
-
Muccioli, G. G., Xu, C., Odah, E., Cudaback, E., Cisneros, J. A., Lambert, D. M., López Rodríguez, M. L., Bajjalieh, S., and Stella, N. ( 2007) Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. J. Neurosci. 27, 2883-2889.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2883-2889
-
-
Muccioli, G.G.1
Xu, C.2
Odah, E.3
Cudaback, E.4
Cisneros, J.A.5
Lambert, D.M.6
López Rodríguez, M.L.7
Bajjalieh, S.8
Stella, N.9
-
50
-
-
77955053537
-
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
-
Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S., Woodruff, G., Fung, S., Lafourcade, M., Alexander, J. P., Long, J. Z., Li, W., Xu, C., Möller, T., Mackie, K., Manzoni, O. J., Cravatt, B. F., and Stella, N. ( 2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat. Neurosci. 13, 951-957.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 951-957
-
-
Marrs, W.R.1
Blankman, J.L.2
Horne, E.A.3
Thomazeau, A.4
Lin, Y.H.5
Coy, J.6
Bodor, A.L.7
Muccioli, G.G.8
Hu, S.S.9
Woodruff, G.10
Fung, S.11
Lafourcade, M.12
Alexander, J.P.13
Long, J.Z.14
Li, W.15
Xu, C.16
Möller, T.17
Mackie, K.18
Manzoni, O.J.19
Cravatt, B.F.20
Stella, N.21
more..
-
51
-
-
77954379126
-
Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors
-
Minkkilä, A., Saario, S., and Nevalainen, T. ( 2010) Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. Curr. Top. Med. Chem. 10, 828-858.
-
(2010)
Curr. Top. Med. Chem.
, vol.10
, pp. 828-858
-
-
Minkkilä, A.1
Saario, S.2
Nevalainen, T.3
-
52
-
-
74549185125
-
FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels
-
Petrosino, S. and Di Marzo, V. ( 2010) FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. Curr. Opin. Investig. Drugs 11, 51-62.
-
(2010)
Curr. Opin. Investig. Drugs
, vol.11
, pp. 51-62
-
-
Petrosino, S.1
Di Marzo, V.2
-
53
-
-
24944508307
-
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
-
Saario, S. M., Salo, O. M., Nevalainen, T., Poso, A., Laitinen, J. T., Järvinen, T., and Niemi, R. ( 2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem. Biol. 12, 649-656.
-
(2005)
Chem. Biol.
, vol.12
, pp. 649-656
-
-
Saario, S.M.1
Salo, O.M.2
Nevalainen, T.3
Poso, A.4
Laitinen, J.T.5
Järvinen, T.6
Niemi, R.7
-
54
-
-
34547483026
-
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling
-
Labar, G., Bauvois, C., Muccioli, G. G., Wouters, J., and Lambert, D. M. ( 2007) Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. ChemBioChem. 8, 1293-1297.
-
(2007)
ChemBioChem.
, vol.8
, pp. 1293-1297
-
-
Labar, G.1
Bauvois, C.2
Muccioli, G.G.3
Wouters, J.4
Lambert, D.M.5
-
55
-
-
71149108705
-
Discovery of potent and reversible monoacylglycerol lipase inhibitors
-
King, A. R., Dotsey, E. Y., Lodola, A., Jung, K. M., Ghomian, A., Qiu, Y., Fu, J., Mor, M., and Piomelli, D. ( 2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem. Biol. 16, 1045-1052.
-
(2009)
Chem. Biol.
, vol.16
, pp. 1045-1052
-
-
King, A.R.1
Dotsey, E.Y.2
Lodola, A.3
Jung, K.M.4
Ghomian, A.5
Qiu, Y.6
Fu, J.7
Mor, M.8
Piomelli, D.9
-
56
-
-
21344444379
-
An endocannabinoid mechanism for stress-induced analgesia
-
Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Walker, J. M., Holmes, P. V., Crystal, J. D., Duranti, A., Tontini, A., Mor, M., Tarzia, G., and Piomelli, D. ( 2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435, 1108-1112.
-
(2005)
Nature
, vol.435
, pp. 1108-1112
-
-
Hohmann, A.G.1
Suplita, R.L.2
Bolton, N.M.3
Neely, M.H.4
Fegley, D.5
Mangieri, R.6
Krey, J.F.7
Walker, J.M.8
Holmes, P.V.9
Crystal, J.D.10
Duranti, A.11
Tontini, A.12
Mor, M.13
Tarzia, G.14
Piomelli, D.15
-
57
-
-
33846551684
-
Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro
-
Vandevoorde, S., Jonsson, K.-O., Labar, G., Persson, E., Lambert, D. M., and Fowler, C. J. ( 2007) Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro. Br. J. Pharmacol. 150, 186-191.
-
(2007)
Br. J. Pharmacol.
, vol.150
, pp. 186-191
-
-
Vandevoorde, S.1
Jonsson, K.-O.2
Labar, G.3
Persson, E.4
Lambert, D.M.5
Fowler, C.J.6
-
58
-
-
33746605204
-
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases
-
Alexander, J. P. and Cravatt, B. F. ( 2006) The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J. Am. Chem. Soc. 128, 9699-9704.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 9699-9704
-
-
Alexander, J.P.1
Cravatt, B.F.2
-
59
-
-
59449101653
-
CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay
-
Muccioli, G. G., Labar, G., and Lambert, D. M. ( 2008) CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. ChemBioChem. 9, 2704-2710.
-
(2008)
ChemBioChem.
, vol.9
, pp. 2704-2710
-
-
Muccioli, G.G.1
Labar, G.2
Lambert, D.M.3
-
60
-
-
57649192489
-
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo
-
and Endocannabinoid Research Group
-
Bisogno, T., Ortar, G., Petrosino, S., Morera, E., Palazzo, E., Nalli, M., Maione, S., Di Marzo, V., and Endocannabinoid Research Group ( 2009) Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochim. Biophys. Acta 1791, 53-60.
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 53-60
-
-
Bisogno, T.1
Ortar, G.2
Petrosino, S.3
Morera, E.4
Palazzo, E.5
Nalli, M.6
Maione, S.7
Di Marzo, V.8
-
61
-
-
57749087828
-
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
-
Long, J. Z., Li, W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavon, F. J., Serrano, A. M., Selley, D. E., Parsons, L. H., Lichtman, A. H., and Cravatt, B. F. ( 2009) Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat. Chem. Biol. 5, 37-44.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 37-44
-
-
Long, J.Z.1
Li, W.2
Booker, L.3
Burston, J.J.4
Kinsey, S.G.5
Schlosburg, J.E.6
Pavon, F.J.7
Serrano, A.M.8
Selley, D.E.9
Parsons, L.H.10
Lichtman, A.H.11
Cravatt, B.F.12
-
62
-
-
67651100845
-
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
-
Long, J. Z., Nomura, D. K., and Cravatt, B. F. ( 2009) Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chem. Biol. 16, 744-753.
-
(2009)
Chem. Biol.
, vol.16
, pp. 744-753
-
-
Long, J.Z.1
Nomura, D.K.2
Cravatt, B.F.3
-
63
-
-
43749096323
-
Activation of the endocannabinoid system by organophosphorus nerve agents
-
Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., and Casida, J. E. ( 2008) Activation of the endocannabinoid system by organophosphorus nerve agents. Nat. Chem. Biol. 4, 373-378.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 373-378
-
-
Nomura, D.K.1
Blankman, J.L.2
Simon, G.M.3
Fujioka, K.4
Issa, R.S.5
Ward, A.M.6
Cravatt, B.F.7
Casida, J.E.8
-
64
-
-
73949109254
-
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
-
Long, J. Z., Nomura, D. K., Vann, R. E., Walentiny, D. M., Booker, L., Jin, X., Burston, J. J., Sim-Selley, L. J., Lichtman, A. H., Wiley, J. L., and Cravatt, B. F. ( 2009) Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc. Natl. Acad. Sci. USA 106, 20270-20275.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20270-20275
-
-
Long, J.Z.1
Nomura, D.K.2
Vann, R.E.3
Walentiny, D.M.4
Booker, L.5
Jin, X.6
Burston, J.J.7
Sim-Selley, L.J.8
Lichtman, A.H.9
Wiley, J.L.10
Cravatt, B.F.11
-
65
-
-
77956181836
-
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
-
Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., Sim-Selley, L. J., Liu, Q. S., Lichtman, A. H., and Cravatt, B. F. ( 2010) Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat. Neurosci. 13, 1113-1119.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 1113-1119
-
-
Schlosburg, J.E.1
Blankman, J.L.2
Long, J.Z.3
Nomura, D.K.4
Pan, B.5
Kinsey, S.G.6
Nguyen, P.T.7
Ramesh, D.8
Booker, L.9
Burston, J.J.10
Thomas, E.A.11
Selley, D.E.12
Sim-Selley, L.J.13
Liu, Q.S.14
Lichtman, A.H.15
Cravatt, B.F.16
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