A bull's eye for targeted lung cancer therapy

Science

Volumn 304, Issue 5676, 2004, Pages 1458-1461

  Minna, John D ^a   Gazdar, Adi F ^a   Sprang, Stephen R ^b   Herz, Joachim ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; LIGAND; QUINAZOLINE DERIVATIVE;

CANCER; DISEASE TREATMENT;

CANCER CHEMOTHERAPY; CANCER PATIENT; COLON CANCER; DRUG TARGETING; ENDOCYTOSIS; GENE SEQUENCE; HUMAN; HUMAN GENOME; LUNG CANCER; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; TREATMENT OUTCOME; ADENOCARCINOMA; AMINO ACID SUBSTITUTION; CHEMISTRY; CONTROLLED CLINICAL TRIAL; DRUG ANTAGONISM; GENE DELETION; GENETICS; JAPAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; MUTATION; NOTE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; PROTO ONCOGENE; SMOKING; UNITED STATES;

ADENOCARCINOMA; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CONTROLLED CLINICAL TRIALS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; GENES, ERBB-1; HUMANS; JAPAN; LIGANDS; LUNG NEOPLASMS; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE DELETION; SMOKING; TREATMENT OUTCOME; UNITED STATES;

EID: 2642570917     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099578     Document Type: Review

References (7)

1. T. J. Lynch et al., N. Engl. J. Med 350, 2129 (2004).
2. J. G. Paez et al., Science 304, 1497 (2004); published online 29 April 2004 (10.1126/science.1099314).
3. J. D. Patel. et al., J. Am. Med. Assoc. 291, 1763 (2004).
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5. F. Ciardiello et al., Curr. Opin. Oncol. 16, 130 (2004).
6. B. J. Druker, Trends Mol. Med. 8, S14 (2002).
7. Supported by Lung Cancer Special Program of Research Excellence PS0CA70907.