Sterile inflammation in the liver and pancreas

Journal of Gastroenterology and Hepatology (Australia)

Volumn 28, Issue SUPPL 1, 2013, Pages 61-67

  Hoque, Rafaz ^a   Farooq, Ahmad ^a   Mehal, Wajahat Z ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Alcoholic steatohepatitis; Damage associated moeleular patterns; Inflammasome; Inflammation; Non alcoholic steatohepatitis; Sterile; TOLL receptors

Indexed keywords

ALCOHOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; PURINERGIC P2X7 RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ALCOHOL LIVER DISEASE; CHRONIC PANCREATITIS; GENE DELETION; HEPATITIS; HUMAN; INNATE IMMUNITY; KUPFFER CELL; LIVER HISTOLOGY; LONG TERM EXPOSURE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PANCREAS NECROSIS; PANCREATITIS; PRIORITY JOURNAL; REVIEW; TOXIC HEPATITIS; UPREGULATION;

EID: 84880419694     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12018     Document Type: Review

References (87)

1. Di Virgilio F. Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol. Sci. 2007; 28: 465-472.
2. Martin-Murphy BV, Holt MP, Ju C. The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice. Toxicol. Lett. 2009; 192: 387-394.
3. Pereira AF, Pereira LB, Vale EC, Tanure LA. Four cases of Muckle-Wells syndrome within the same family. An. Bras. Dermatol. 2010; 85: 907-911.
4. Ishii KJ, Suzuki K, Coban C etal. Genomic DNA released by dying cells induces the maturation of APCs. J. Immunol. 2001; 167: 2602-2607.
5. Hefeneider SH, Cornell KA, Brown LE, Bakke AC, McCoy SL, Bennett RM. Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production. Clin. Immunol. Immunopathol. 1992; 63: 245-251.
6. Boule MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 2004; 199: 1631-1640.
7. Imaeda AB, Watanabe A, Sohail MA etal. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J. Clin. Invest. 2009; 119: 305-314.
8. Hoque R, Sohail M, Malik A etal. TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis. Gastroenterology 2011; 141: 358-369.
9. Zhang Q, Raoof M, Chen Y etal. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464: 104-107.
10. Shimada K, Crother TR, Karlin J etal. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012; 36: 401-414.
11. Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 2011; 29: 139-162.
12. Sims GP, Rowe DC, Rietdijk ST etal. HMGB1 and RAGE in inflammation and cancer. Annu. Rev. Immunol. 2010; 28: 367-388.
13. Andersson U, Wang H, Palmblad K etal. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J. Exp. Med. 2000; 192: 565-570.
14. Kokkola R, Andersson A, Mullins G etal. RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand. J. Immunol. 2005; 61: 1-9.
15. Feng H, Zeng Y, Graner MW, Likhacheva A, Katsanis E. Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood 2003; 101: 245-252.
16. Asea A, Kraeft SK, Kurt-Jones EA etal. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 2000; 6: 435-442.
17. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 2000; 164: 558-561.
18. Basu S, Binder RJ, Ramalingam T, Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 2001; 14: 303-313.
19. Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic SS. Activation and regulation of purinergic P2X receptor channels. Pharmacol. Rev. 2011; 63: 641-683.
20. Romagnoli R, Baraldi PG, Cruz-Lopez O etal. The P2X7 receptor as a therapeutic target. Expert Opin. Ther. Targets 2008; 12: 647-661.
21. Hofmann MA, Drury S, Fu C, Qu W etal. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 1999; 97: 889-901.
22. Yang D, Chertov O, Bykovskaia SN etal. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999; 286: 525-528.
23. Biragyn A, Ruffini PA, Leifer CA etal. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002; 298: 1025-1029.
24. Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu. Rev. Immunol. 2004; 22: 181-215.
25. Lillard JW Jr, Boyaka PN, Chertov O, Oppenheim JJ, McGhee JR. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc. Natl Acad. Sci. U.S.A. 1999; 96: 651-656.
26. Carp H. Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils. J. Exp. Med. 1982; 155: 264-275.
27. Gawlowski DM, Benoit JN, Granger HJ. Microvascular pressure and albumin extravasation after leukocyte activation in hamster cheek pouch. Am. J. Physiol. 1993; 264 (2 Pt 2): H541-546.
28. Sozzani S, Sallusto F, Luini W etal. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol. 1995; 155: 3292-3295.
29. Jiang D, Liang J, Fan J etal. Regulation of lung injury and repair by toll-like receptors and hyaluronan. Nat. Med. 2005; 11: 1173-1179.
30. Mummert DI, Takashima A, Ellinger L, Mummert ME. Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo. J. Dermatol. Sci. 2003; 33: 91-97.
31. Gao B, Seki E, Brenner DA etal. Innate immunity in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2011; 300: G516-525.
32. Brenner DA, Seki E, Taura K etal. Non-alcoholic steatohepatitis-induced fibrosis: toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol. Res. 2010; 41: 683-686.
33. Maher JJ. DAMPs ramp up drug toxicity. J. Clin. Invest. 2009; 119: 246-249.
34. Yin M, Bradford BU, Wheeler MD etal. Reduced early alcohol-induced liver injury in CD14-deficient mice. J. Immunol. 2001; 166: 4737-4742.
35. Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995; 108: 218-224.
36. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001; 34: 101-108.
37. Henao-Mejia J, Elinav E, Jin C, Hao L etal. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179-185.
38. Szabo G, Mandrekar P, Petrasek J, Catalano D. The unfolding web of innate immune dysregulation in alcoholic liver injury. Alcohol. Clin. Exp. Res. 2011; 35: 782-786.
39. Hritz I, Mandrekar P, Velayudham A etal. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2008; 48: 1224-1231.
40. Bauernfeind F, Ablasser A, Bartok E etal. Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 2011; 68: 765-783.
41. Jan Petrasek DL, Kodys K, Kurt-Jones EA, Szabo G. IL-1 receptor antagonist treatment attenuates alcoholic liver disease induced by inflammasome-mediated activation of IL-1β. Hepatology 2011; 54 (S1): 968A.
42. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J. Immunol. 2009; 183: 1320-1327.
43. Frazier TH, DiBaise JK, McClain CJ. Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. JPEN J. Parenter. Enteral Nutr. 2011; 35 (5 Suppl.): 14S-20S.
44. Chait A, Kim F. Saturated fatty acids and inflammation: who pays the toll? Arterioscler. Thromb. Vasc. Biol. 2010; 30: 692-693.
45. Miura K, Kodama Y, Inokuchi S etal. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010; 139: 323-334 e327.
46. Rivera CA, Adegboyega P, van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 2007; 47: 571-579.
47. Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 2009; 50: 1094-1104.
48. Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology 2011; 140: 697-708 e694.
49. Williams AM, Langley PG, Osei-Hwediah J, Wendon JA, Hughes RD. Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity. Liver Int. 2003; 23: 110-115.
50. Bramley PN, Rathbone BJ, Forbes MA, Cooper EH, Losowsky MS. Serum hyaluronate as a marker of hepatic derangement in acute liver damage. J. Hepatol. 1991; 13: 8-13.
51. Dear JW, Simpson KJ, Nicolai MP etal. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J. Immunol. 2011; 187: 3347-3352.
52. Jaeschke H, Williams CD. Comment on "Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury". J. Immunol. 2011; 187: 6168.
53. Antoine DJ, Jenkins RE, Dear JW, Williams DP etal. Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J. Hepatol. 2009; 56: 1070-1079.
54. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191-195.
55. Ekong U, Zeng S, Dun H, Feirt N etal. Blockade of the receptor for advanced glycation end products attenuates acetaminophen-induced hepatotoxicity in mice. J. Gastroenterol. Hepatol. 2006; 21: 682-688.
56. Yohe HC, O'Hara KA, Hunt JA etal. Involvement of toll-like receptor 4 in acetaminophen hepatotoxicity. Am. J. Physiol. Gastrointest. Liver Physiol. 2006; 290: G1269-1279.
57. Hoque R, Sohail MA, Salhanick S etal. P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2012; 302: G1171-1179.
58. Williams CD, Antoine DJ, Shaw PJ etal. Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol. Appl. Pharmacol. 2011; 252: 289-297.
59. Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 2007; 13: 851-856.
60. Williams CD, Farhood A, Jaeschke H. Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol. Appl. Pharmacol. 2010; 247: 169-178.
61. Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Curr. Opin. Gastroenterol. 2008; 24: 580-585.
62. Kloppel G. Chronic pancreatitis, pseudotumors and other tumor-like lesions. Mod. Pathol. 2007; 20 (Suppl. 1): S113-131.
63. Su KH, Cuthbertson C, Christophi C. Review of experimental animal models of acute pancreatitis. HPB (Oxford) 2006; 8: 264-286.
64. Hofbauer B, Friess H, Weber A etal. Hyperlipaemia intensifies the course of acute oedematous and acute necrotising pancreatitis in the rat. Gut 1996; 38: 753-758.
65. Laukkarinen JM, Van Acker GJ, Weiss ER, Steer ML, Perides G. A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate. Gut 2007; 56: 1590-1598.
66. Otsuki M, Yamamoto M, Yamaguchi T. Animal models of chronic pancreatitis. Gastroenterol. Res. Pract. 2010; 2010: 403295. doi: 10.1155/2010/403295.
67. Ramsingh AI. CVB-induced pancreatitis and alterations in gene expression. Curr. Top. Microbiol. Immunol. 2008; 323: 241-258.
68. Norman J, Yang J, Fink G etal. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). J. Interferon Cytokine Res. 1997; 17: 113-118.
69. Norman JG, Franz MG, Fink GS etal. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann. Surg. 1995; 221: 625-631; discussion 631-624.
70. Norman JG, Fink G, Franz M etal. Active interleukin-1 receptor required for maximal progression of acute pancreatitis. Ann. Surg. 1996; 223: 163-169.
71. Marrache F, Tu SP, Bhagat G etal. Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. Gastroenterology 2008; 135: 1277-1287.
72. Sennello JA, Fayad R, Pini M etal. Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. Proc. Natl Acad. Sci. U.S.A. 2008; 105: 8085-8090.
73. Sandoval D, Gukovskaya A, Reavey P etal. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 1996; 111: 1081-1091.
74. Gukovskaya AS, Vaquero E, Zaninovic V etal. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002; 122: 974-984.
75. Nakamichi I, Habtezion A, Zhong B, Contag CH, Butcher EC, Omary MB. Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. J. Clin. Invest. 2005; 115: 3007-3014.
76. Dugernier TL, Laterre PF, Wittebole X etal. Compartmentalization of the inflammatory response during acute pancreatitis: correlation with local and systemic complications. Am. J. Respir. Crit. Care Med. 2003; 168: 148-157.
77. Powell JJ, Fearon KC, Siriwardena AK, Ross JA. Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery 2001; 129: 633-640.
78. Wereszczynska-Siemiatkowska U, Mroczko B, Siemiatkowski A. Serum profiles of interleukin-18 in different severity forms of human acute pancreatitis. Scand. J. Gastroenterol. 2002; 37: 1097-1102.
79. Aoun E, Chen J, Reighard D, Gleeson FC, Whitcomb DC, Papachristou GI. Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. Pancreatology 2009; 9: 777-785.
80. Sharif R, Dawra R, Wasiluk K etal. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Gut 2009; 58: 813-819.
81. Sawa H, Ueda T, Takeyama Y etal. Role of toll-like receptor 4 in the pathophysiology of severe acute pancreatitis in mice. Surg. Today 2007; 37: 867-873.
82. Sawa H, Ueda T, Takeyama Y etal. Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis. World J. Gastroenterol. 2006; 12: 7666-7670.
83. Takagi Y, Masamune A, Kume K etal. Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan. Hum. Immunol. 2009; 70: 200-204.
84. Awla D, Abdulla A, Regner S, Thorlacius H. TLR4 but not TLR2 regulates inflammation and tissue damage in acute pancreatitis induced by retrograde infusion of taurocholate. Inflamm. Res. 2011; 60: 1093-1098.
85. Wu BU, Hwang JQ, Gardner TH etal. Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin. Gastroenterol. Hepatol. 2011; 9: 710-717 e711.
86. Hollenbach M, Hintersdorf A, Huse K etal. Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors. Biochem. Pharmacol. 2008; 76: 631-644.
87. Luan ZG, Ma XC, Zhang H, Zhang C, Guo RX. Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis. J. Surg. Res. 2012 Jun 12. [Epub ahead of print] PMID: 22717227.